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Clip-to-release on amplification (CRoA): a novel DNA amplification enhancer on and off microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper
Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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Nanocrystal synthesis, μfluidic sample dilution and direct extraction of single emission linewidths in continuous flow

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00213E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ioannis Lignos, Hendrik Utzat, Moungi G. Bawendi, Klavs F. Jensen
We present a flow-based system coupled with an optical interferometry setup for the extraction of single nanocrystal properties.
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Bioinspired reconfiguration of 3D printed microfluidic hydrogels via automated manipulation of magnetic inks

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication
Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology

Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper
Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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Multiscale brain research on a microfluidic chip

Lab Chip, 2020, 20,1531-1543
DOI: 10.1039/C9LC01010F, Critical Review
Yanan Zhao, Utkan Demirci, Yun Chen, Pu Chen
We report recent progress in applying innovative microfluidic chip-based neurotechnologies to promote multiscale brain research across the hierarchical organizations from the molecular, cellular, and tissue levels up to the whole organism level.
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Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper
Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Microfluidic device to study flow-free chemotaxis of swimming cells

Lab Chip, 2020, 20,1639-1647
DOI: 10.1039/D0LC00045K, Paper
Nicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier Theodoly
Permeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices

Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper
Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Lab Chip, 2020, 20,1562-1576
DOI: 10.1039/D0LC00121J, Paper
Open Access
Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro Grattoni
Control of molecular diffusion through nanofluidic channels using electrostatic gating.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels

Lab Chip, 2020, 20,1648-1657
DOI: 10.1039/D0LC00276C, Paper
Charuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. Crooks
A hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.
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A microfluidic platform for functional testing of cancer drugs on intact tumor slices

Lab Chip, 2020, 20,1658-1675
DOI: 10.1039/C9LC00811J, Paper
A. D. Rodriguez, L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, A. Folch
We have developed a digitally-manufacturable microfluidic platform that allows for multiplexed drug testing of intact tumor slices.
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In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper
Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper
Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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Microfluidic assessment of red blood cell mediated microvascular occlusion

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper
Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper
Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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Picoliter Agar Droplet Breakup in Microfluidics Meets Microbiology Application: Numerical and Experimental Approaches

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00300J, Paper
Asmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Jonmaleki, Razieh Salahandish, AbdulMajeed Mohamad, Amir Sanati Nezhad
Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environment, and live monitoring of growth and proliferation. The droplets are mainly generated from...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Exploring Conformational Space with Thermal Fluctuations Obtained by Normal-Mode Analysis

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01136




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A history of the Bible: the story of the world's most influential book / John Barton

Hayden Library - BS445.B328 2019




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The tiger flu: a novel / Larissa Lai

Hayden Library - PR9199.3.L2815 T54 2018




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How Outlaws Win Friends and Influence People [electronic resource] / by Tereza Kuldova

Kuldova, Tereza, author




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Studies of the labile lead pool using a rhodamine-based fluorescent probe

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00056F, Communication
Jianping Zhu, Jia Hao Yeo, Amy A. Bowyer, Nicholas Proschogo, Elizabeth J. New
A rhodamine-based fluorescent lead probe reports on the labile lead pool within cells.
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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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Atmen, bis die Flut kommt: Roman / Beate Rothmaier

Hayden Library - PT2718.O87 A93 2013




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Podcast: How farms made dogs love carbs, the role of dumb luck in science, and what your first flu exposure did to you

This week, we chat about some of our favorite stories—is Bhutan really a quake-free zone, how much of scientific success is due to luck, and what farming changed about dogs and us—with Science’s Online News Editor David Grimm. Plus, Science’s Alexa Billow talks to Katelyn Gostic of the University of California, Los Angeles, about how the first flu you came down with—which depends on your birth year—may help predict your susceptibility to new flu strains down the road.   Listen to previous podcasts.     [Image:monkeybusinessimages/iStockphoto; Music: Jeffrey Cook]




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Podcast: Watching shoes untie, Cassini’s last dive through the breath of a cryovolcano, and how human bias influences machine learning

This week, walk like an elephant—very far, with seeds in your guts, Cassini’s mission to Saturn wraps up with news on the habitability of its icy moon Enceladus, and how our shoes manage to untie themselves with Online News Editor David Grimm. Aylin Caliskan joins Sarah Crespi to discuss how biases in our writing may be perpetuated by the machines that learn from them. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: NASA/JPL-Caltech; Music: Jeffrey Cook]




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Odd new particles may be tunneling through the planet, and how the flu operates differently in big and small towns

Hoping to spot subatomic particles called neutrinos smashing into Earth, the balloon-borne Antarctic Impulsive Transient Antenna (ANITA) detector has circled the South Pole four times. ANITA has yet to detect those particles, but it has twice seen oddball radio signals that could be evidence of something even weirder: some heavier particle unknown to physicists’ standard model, burrowing up through Earth. Science writer Adrian Cho joins host Sarah Crespi to discuss the possibility that this reading could lead to a big change in physics. Next, host Meagan Cantwell asks researcher Ben Dalziel what makes a bad—or good—flu year. Traditionally, research has focused on two factors: climate, which impacts how long the virus stays active after a sneeze or cough, and changes in the virus itself, which can influence its infectiousness. But these factors don’t explain every pattern. Dalziel, a population biologist in the Departments of Integrative Biology and Mathematics at Oregon State University in Corvallis, explains how humidity and community size shape the way influenza spreads. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image: Stuart Rankin/Flickr; Music: Jeffrey Cook]




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Unearthing slavery in the Caribbean, and the Catholic Church’s influence on modern psychology

Most historical accounts of slavery were written by colonists and planters. Researchers are now using the tools of archaeology to learn more about the day-to-day lives of enslaved Africans—how they survived the conditions of slavery, how they participated in local economies, and how they maintained their own agency. Host Sarah Crespi talks with Contributing Correspondent Lizzie Wade about a Caribbean archaeology project based on St. Croix in the U.S. Virgin Islands and launched by the founders of the Society for Black Archaeologists that aims to unearth these details. Watch a related video here. Sarah also talks with Jonathan Schulz, a professor in the Department of Economics at George Mason University in Fairfax, Virginia, about a role for the medieval Roman Catholic Church in so-called WEIRD psychology—western, educated, industrialized, rich, democratic. The bulk of psychology experiments have used participants that could be described as WEIRD, and according to many psychological measures, WEIRD subjects tend to have some extreme traits, like a stronger tendency toward individuality and more friendliness with strangers. Schulz and colleagues used historical maps and measures of kinship structure to tie these traits to strict marriage rules enforced by the medieval Catholic Church in Western Europe. Read related commentary. This week’s episode was edited by Podigy. Ads on this week’s show: Bayer; KiwiCo Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast




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Nanotechnology for Microfluidics


 
The book focuses on microfluidics with applications in nanotechnology. The first part summarizes the recent advances and achievements in the field of microfluidic technology, with emphasize on the the influence of nanotechnology. The second part introduces various applications of microfluidics in nanotechnology, such as drug delivery, tissue engineering and biomedical diagnosis.

Read More...




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A fluorescence-positioned hybridization chain reaction system for sensitive detection of Salmonella in milk

Anal. Methods, 2020, 12,1958-1965
DOI: 10.1039/D0AY00184H, Paper
Guotai Yang, Shuang Yu, Yang Liu, Jin Huang, Qianying Li, Zoraida P. Aguilar, Hengyi Xu
In this study, a fluorescence-positioned hybridization chain reaction (HCR) system for the detection of single-stranded DNA (ssDNA) specific to Salmonella was developed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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3D-printed microfluidic device with in-line amperometric detection that also enables multi-modal detection

Anal. Methods, 2020, 12,2046-2051
DOI: 10.1039/D0AY00368A, Technical Note
Elizabeth A. Hayter, Andre D. Castiaux, R. Scott Martin
A 3D-printed microfluidic device with amperometric detection employs a parallel-opposed electrode configuration, with threaded electrodes being in contact with the flow stream. This makes downstream detection of ATP via chemiluminescence possible.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Detection of prostate-specific antigen in semen using DNA aptamers: an application of nucleic acid aptamers in forensic body fluid identification

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00371A, Paper
Tetsuya Satoh, Seiya Kouroki, Yusuke Kitamura, Toshihiro Ihara, Kazutoshi Matsumura, Susumu Iwase
In forensics, body fluid identification plays an important role because it aids in reconstructing the crime scene. Therefore, it is essential to develop simple and reliable techniques for body fluid...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A novel microfluidic paper-based analytical device based on chemiluminescence for the determination of β-agonists in swine hair

Anal. Methods, 2020, Advance Article
DOI: 10.1039/C9AY02754H, Paper
Wei Li, Yong Luo, Xiqing Yue, Junrui Wu, Rina Wu, Yu Qiao, Qing Peng, Bo Shi, Bingcheng Lin, Xu Chen
β-Agonists are illegal feed additives in the feed industries of many countries, especially China.
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Improving the determination of celecoxib in body fluids and pharmaceuticals using a new selective and thermosensitive molecularly imprinted poly(vinylidene fluoride) membrane

Anal. Methods, 2020, 12,2185-2195
DOI: 10.1039/D0AY00237B, Paper
Negin Yazdanian, Behrouz Akbari-Adergani, Maryam Kazemipour, Homayon Ahmad Panahi, Mehran Javanbakht
Molecularly imprinted membranes that demonstrated high selectivity for celecoxib were synthesized using N-vinylcaprolactam and 2-hydroxyethyl methacrylate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The influence of lateral flake size in graphene/graphite paste electrodes: an electroanalytical investigation

Anal. Methods, 2020, 12,2133-2142
DOI: 10.1039/D0AY00169D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alejandro García-Miranda Ferrari, Hadil M. Elbardisy, Valentine Silva, Tarek S. Belal, Wael Talaat, Hoda G. Daabees, Craig E. Banks, Dale A. C. Brownson
We report the electroanalytical properties of graphene and graphite paste electrodes comprising varying lateral flake sizes when applied for sensing relevant biomolecules and prominent drugs of abuse.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Aptamer-based fluorometric determination of chloramphenicol by controlling the activity of hemin as a peroxidase mimetic

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00389A, Paper
Ling-Chen Wang, Cheng-Yi Hong, Zheng-Zhong Lin, Xiao-Mei Chen, Zhi-Yong Huang
A method for the aptamer-based determination of chloramphenicol (CAP) was developed by exploiting the peroxidase mimicking activity of hemin.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Au nanoparticle preconcentration coupled with CE-electrochemiluminescence detection for sensitive analysis of fluoroquinolones in European eel (Anguilla anguilla)

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00264J, Paper
Longhua Guo, Meihua Liu, Yuechun Yin, Lifen Chen, Zhitao Chen, Jing-Jing Liu, Bin Qiu
In this work, a novel method based on gold nanoparticle preconcentration coupled with CE for electrochemiluminescent detection of ciprofloxacin, enrofloxacin, ofloxacin, and norfloxacin in European eels was developed. The addition...
The content of this RSS Feed (c) The Royal Society of Chemistry




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The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00334D, Paper
Hong-Lin Ding, Yan-Qing Pu, Da-Ying Ye, Zi-Yue Dong, Man Yang, Cheng-Wei Lü, Yue An
The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications are shown.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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One-step synthesis of mitochondrion-targeted fluorescence carbon dots and fluorescent detection of silver ions

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00622J, Paper
Yue Hou, Hanxiao Liu, Zhanxian Li, Hongyan Zhang, Liuhe Wei, Mingming Yu
Silver ions (Ag+) are the most representative harmful ions found in water pollution and widely used in many industries, excessive ingestion of Ag+ in the human body may interact with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A sensitive and selective fluorescent probe for the detection of endogenous peroxynitrite (ONOO-) in live cells

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00012D, Paper
Yaru Sun, Baoli Dong, Yaru Lu, Wenhui Song, Abdul Hadi Mehmood, Weiying Lin
Peroxynitrite (ONOO−) is one of reactive oxygen species, and plays a vital role in many physiological and pathological processes. Given that the ONOO− level is closely related with many serious...
The content of this RSS Feed (c) The Royal Society of Chemistry




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The Work of Raymond J. Carroll [electronic resource] : The Impact and Influence of a Statistician / edited by Marie Davidian, Xihong Lin, Jeffrey S. Morris, Leonard A. Stefanski

Cham : Springer International Publishing : Imprint: Springer, 2014




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Fluctuations of Lévy Processes with Applications [electronic resource] : Introductory Lectures / by Andreas E. Kyprianou

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014




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18th Conference of Power System Engineering, Thermodynamics and Fluid Mechanics: 11-13 June 2019, Pilsen, Czech Republic / editors, Lukáš Richter, Michal Volf, Michaela Vacková, Petr Pavlíček and Miroslav Krejčí

Online Resource




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Teaching religious influences in history in Australia : a submission on the National History Curriculum, framing paper / prepared by Mr Alex Mills

Mills, Alex, author




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[ASAP] Microfluidic Platform for the Isolation of Cancer-Cell Subpopulations Based on Single-Cell Glycolysis

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05738




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[ASAP] Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00697




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[ASAP] In Situ Incorporation of Fluorophores in Zeolitic Imidazolate Framework-8 (ZIF-8) for Ratio-Dependent Detecting a Biomarker of Anthrax Spores

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00499




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[ASAP] Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05855




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[ASAP] Temporal-Spatial-Color Multiresolved Chemiluminescence Imaging for Multiplex Immunoassays Using a Smartphone Coupled with Microfluidic Chip

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c01405




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[ASAP] Metal–Organic Framework-Enhanced Solid-Phase Microextraction Mass Spectrometry for the Direct and Rapid Detection of Perfluorooctanoic Acid in Environmental Water Samples

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05524