I think they spent all their money on the fancy toilet paper. ~NSHA

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The newly qualified social worker conference titled, Shaping our future: relationships matter, was held on 31 May 2019 in at the University of Strathclyde in Glasgow. 

Iona Colvin, Chief Social Work Adviser at Scottish Government, spoke about the importance of relationships at strategic level, within and across government, and how the role of social work has changed to be located within organisational partnerships with the aim of delivering more seamless services for people.

She also talks about the unique contribution of social work as a holistic relationship-based profession, what they are doing with others to raise its profile, plan for the future and support newly qualified social workers.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

The newly qualified social worker conference titled, Shaping our future: relationships matter, was held on 31 May 2019 in at the University of Strathclyde in Glasgow.

Jackie Irvine, Chief Social Work Officer at Edinburgh City Council and past President of social work Scotland, takes some time to reflect on how the practice environment in which social work operates has changed. She provides advice on making the most of relationships at work, as well as self-care strategies.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

OK, I am going to reveal two article marketing domination tips that you can use to get a boat load of Global Domains International leads. Many people underestimate the power of this simple strategy. The key to succeeding with your article marketing is finding the tricks that work.

Watching the Superb Owl with this magnificent fluffer Frank. https://ift.tt/2Ok6r0O

I'll be teaching a workshop Nov. 13 at the Queer Influx conference in Columbus!
Check it out at http://queerinflux.wordpress.com/convergence-schedule/

A mint Viscount is a real luxury biscuit, the green foil wrapper tells you it’s strictly for the intelligentsia.

Princeton ecologists Peter and Rosemary Grant led a team of researchers to discover how genetics and hybridization affected the beak shape of finches on the Galápagos Islands.

A new National Association of Realtors report revealed the ways that legalizing marijuana has impacted real estate.

New data from NASA’s Curiosity rover suggests that water vacated Mars in fits and starts.

The 1918 pandemic has lessons for the 2020. Namely, we got through it. And social distancing works.

Dispatch from the pandemic: Circumstances have forced my family to practice extreme social distancing

We already know far more about this virus than scientists ever knew during the Spanish flu epidemic

At Uptown Records, Harrell took on Sean "Diddy" Combs as an intern. The future music mogul quickly became the record label’s full-time talent director and helped develop the careers of several R&B stars during the early 1990s including Mary H. Blige and Jodeci.

Fashion designer turned lifestyle guru Jenni Kayne renovated a property she calls "The Lake House," an all-white, three-level cabin tucked away in the mountains in Lake Arrowhead. We got a peek inside.

Most people who get COVID-19 will experience mild symptoms and will recover with rest and plenty of fluids. Over-the-counter drugs can help with fever.

The coronavirus has ended big budget brand deals for some influencers, but the focus has shifted to engaging with a potentially bigger audience more authentically.

Fluffy and hot all at the same time, diner-style pancakes are the best breakfast for two.

Fluffy and hot all at the same time, diner-style pancakes are the best breakfast for two.

Oscar's big winner, 'Parasite,' and war tale '1917' show how interactive entertainment is shaping linear storytelling — often for the better.

Manchester United are one of the biggest football clubs in the world, but the Red Devils are not considered among the most influential Premier League sides according to new research.

Manchester United hero Wayne Rooney has been named as the most influential Premier League player of all time, but who else makes the top 20?

Members of Trail Hero and other local outdoor enthusiasts step up to keep Sand Hollow State Park clean after a wave of non-locals ended in vandalism.

Shapiro's delicatessen, a Kosher eatery just south of Downtown Indianapolis, is adapting to a carryout model amid the coronavirus pandemic.

The spread of swine flu has been positive for Japanese karaoke clubs. Find out more with Take Away English.

There has been a sharp increase in swine flu cases in the UK. How worried are people about this disease?

• Millions of people have quickly had to adapt to working from home during the pandemic, leading some to scramble to look presentable over video chats with colleagues.
• One strategy workers have used is the purchase of a ring light, a product that can be used in your video set-up to to improve lighting of your face on-camera.
• Right lights have already been popular buys for influencers, vloggers, and TikTok creators who adopt various tools to produce professional-quality videos uploaded online.
• Visit Business Insider's homepage for more stories.

The ring light is beloved by YouTubers and aspiring TikTok creators for casting a flattering, even glow across anyone's face. Now, ring lights are seeing widespread interest among people tuning into Zoom work calls from their poorly lit homes during the pandemic.

Video conferencing software has exponentially grown in use in recent months, and employees now find themselves in situations online creators have been dealing with for years: Looking their best in front of the camera while in the comfort of their own homes.

Lockdown orders have coincided with a recent surge of interest in ring lights, especially in the U.S. where work-from-home rolled out to non-essential employees starting in early March. Twitter users have been sharing with followers their recent ring light purchases for classes, work meetings, and happy hours taking place over Zoom and FaceTime.

Ring light set-ups provide the benefits of a professional photo studio without the cost, casting your face in a shadow-free, flattering hue while you're in front of the camera. Ring lights on Amazon go for between $60 and $150, depending on how powerful of a light or complicated of a set-up you want. Many of these ring-lights come with tripods and pieces to hold your phone or camera.

Although newly work-from-home employees may just be discovering ring lights for the first time, they've long been a trick for creators whose bedrooms have doubled as their studios. While ring lights have been especially vital for makeup tutorials and beauty vloggers, they've since become commonplace to set-ups for young people starting out on YouTube and TikTok. Now, they're just one of the products with appearance-adjusting features catered to influencers, such as specific camera models that come with skin-smoothing filters.

As dates for returning to the office continue to get pushed back at some companies, sales will likely continue to rise for ring lights. However, it's probably on the more expensive side of simple tips and tricks to implement to look for presentable on your video calls. For those that don't want to splash out cash for a ring light, Zoom has a little-known filter on its platform that users can apply to give their faces a softer look and minimize imperfections. The "touch up my appearance" can be turned on directly within the Zoom app (you can find the steps for activating it on Business Insider).

SEE ALSO: WhatsApp is touting steps taken to cut the viral spread of coronavirus misinformation, but experts question whether it's done enough

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NOW WATCH: What makes 'Parasite' so shocking is the twist that happens in a 10-minute sequence

velocityconf: RT @courtneynash: Bill Scott's #fluentconf keynote theme also rings true re #velocityconf: tech change is really about people/culture change

If you’re an entrepreneur nurturing your own company to a full-blown success, you are always looking for insights and ideas to take your business to the next level, right? But you’re probably super busy as well, and don’t always have the time to figure out where you should be looking for those insights.

I have a love/hate relationship with musical reaction videos. There are kids reacting to heavy metal (or The Beatles), vocal teachers and opera singers reacting to rock vocalists, millennials reacting to classic rock, and on and on. Some of these are quite moving, for instance, a 20-something hearing Zep's "Since I've Been Loving You" for the first time or a vocal teacher reacting to a Black Metal vocalist's cookie monster growl.

In these two videos, Heline, a classical flutist and music teacher, listens to Jethro Tull's Ian Anderson performing "Bouree" at a 1969 concert and then she listens and reacts to a performance from 1976.

I didn't realize that Anderson had only been playing the flute for a year and had no formal training at the time of the 69 video (their first tour). Heline can appreciate his chutzpah in the first performance and the fact that he's only been playing for a year(!), but is perhaps predictably critical of his playing. She is more impressed with what she sees and hears in the 76 performance.

Personally, I always thought his playing was inspired and his playing, vocalizing, singing and playing, and his other stage antics (the goofy one-legged stance) were a perfect example of "the street finding its own uses for things," using technology in ways in which it was never intended. As with all things artistic, your mileage may vary.

Image: YouTube Read the rest

Michael Tiffany, co-founder and president of ad verification and fraud prevention firm White Ops, discusses the next evolution of fraudulent practices for 2018.

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.

12 February 2020

6 May 2016 , Volume 92, Number 3

A British exit from the EU would add to growing strains on the United States’relations with Britain and the rest of Europe, but by itself would not lead to a breakdown in transatlantic relations. It would, however, add to pressures on the US that could change the direction of the transatlantic relationship. From the perspective of Washington, Britain risks becoming an awkward inbetweener.

Ilka Wittig
Jul 1, 2007; 6:1215-1225
Research

Ileana M. Cristea
Dec 1, 2005; 4:1933-1941
Research

Ulrich Rothbauer
Feb 1, 2008; 7:282-289
Research

Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative functional cross-talk between GFRa1 and RET. Here, using biochemical techniques, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists. We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent. Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 expression. We used these analogs to examine RET–GFRa1 interactions and show that GFRa1 can influence RET-mediated signaling and enhance or diminish AKT Ser/Thr kinase or extracellular signal-regulated kinase signaling in a biased manner. In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. This work uncovers key components of the dynamic relationships between RET and its GFRa co-receptor and provides RET agonist scaffolds for drug development.