Sandi M. Azab
Mar 31, 2020; 0:jlr.D120000630v1-jlr.D120000630
Methods

Nutritional studies rely on various biological specimens for fatty acid (FA) determination, yet it is unclear how levels of serum non-esterified FA (NEFAs) correlate with other circulating lipid pools. Here, we used a high throughput method (< 4 min/sample) based on multisegment injection-non-aqueous-capillary electrophoresis–mass spectrometry (MSI-NACE-MS) to investigate whether specific serum NEFAs have utility as biomarkers of dietary fat intake in women. We first  identified circulating NEFAs correlated with long-term/habitual food intake among pregnant women with contrasting dietary patterns (n=50). Acute changes in serum NEFA trajectories were also studied in non-pregnant women (n=18) following high-dose (5 g/day) fish oil (FO) supplementation or isoenergetic sunflower oil placebo over 56 days. In the cross-sectional study, serum omega-3 (-3) FA correlated with self-reported total -3 daily intake, notably eicosapentaenoic acid (EPA) as its NEFA (r=0.46; p=0.001), whereas pentadecanoic acid was associated with full-fat dairy intake (r=0.43; p=0.002), outcomes consistent with results from  total FA serum hydrolysates. In the intervention cohort, serum -3 NEFAs increased 2.5-fold from baseline within 28 days following FO supplementation, and this increase was most pronounced for EPA (p=0.0004). Unlike for docosahexaenoic acid, circulating EPA as its NEFA also strongly correlated to EPA concentrations measured from erythrocyte phospholipid hydrolysates (r=0.66; p=4.6 x 10-10), and was better suited to detect dietary non-adherence. We conclude that MSI-NACE-MS offers a rapid method to quantify serum NEFAs and objectively monitor dietary fat intake in women that is complementary to diet records or food frequency questionnaires.

1 November 2008 , Number 4

Russia is caught in the global crisis and cannot escape its impact. The crucial question is how the Dmitri Medvedev-Vladimir Putin leadership will respond. Putin has presided over a steadily strengthening economy; he now appears ill-equipped to handle crisis and contraction. The signs are not encouraging. Trust and confidence, two essential ingredients vital to resolving any financial crisis, are in short supply. The public could pay a heavy price for the hubris and schadenfreude of their leaders, still ‘dizzy with success’ from years of economic revival and what they perceive as a successful reaffirmation of the country’s great power status.

21 February 2020

  My shoes are not where I left them. There is a dog howling in the distance, And the sound reverberates, Lifting the dew off the dense canopy of trees outside. The bamboo lamp beside the sofa, Sheds dull orange light across the Persian carpet, And I am not casting a shadow. I have, A […]

Long before the existence of the Internet and going viral was a thing, reggae singer Jacob Miller, back in the ‘70s, coined a term that went viral – under heavy manners. Ian Lewis of Inner Circle band, the Bad Boys of Reggae, recalled that his...

At age 13, Nadeen Matthews Blair, chief executive officer of the NCB Foundation, challenged the tide to prove to a guidance counsellor at her United States-based school, that black girls can overcome all odds to become powerful leaders. Matthews...

The Astros logo outside the Ballpark of the Palm Beaches really is something to see, all the way from Haverhill Rd. The closer you get the bigger it gets, the white "H" right there in front of the huge orange star. Underneath the "H" is the following message, white against orange: "2017 World Champions." It would have been a simple matter to put "2018" down there, too. There was room.

Oversimplification and lack of evidence stigmatise people with mental illness and impede prevention efforts, says Simon Wessley, professor of psychiatry at King's College London, in an editorial published on thebmj.com. Read the full editorial: http://www.bmj.com/content/354/bmj.i4869

The number of people estimated to be latently infected with TB - that is infected with TB, which has not yet manifested symptoms - is around 2 billion. That is 1 in 3 people on the planet are infected by the bacteria. The World Health Organization’s website notes that on average 5-10% of those infected with TB will develop active TB. That number...

Jessica Perlo is the Director for Joy at Work at the Institute for Healthcare Improverment, and James Mountford is direct or of quality at the Royal Free London NHS Foundation Trust. Together they joined us at the International Forum on Quality and Safety in Healthcare to discuss joy at work - what that concept actually means, and practically,...

An “author pays” publishing model is the only fair way to make biomedical research findings accessible to all, say David Sanders, professor of gastroenterology at Sheffield University, but James Ashton and worries that it can lead to bias in the evidence base towards commercially driven results - as those are the researchers who can pay for open...

Margaret Heffernan has thought a lot about whistleblowing, and why companies don't respond well to it. She wrote the "Book Wilful Blindness: Why We Ignore the Obvious at our Peril". In this podcast she talks about how culture, and groupthink, leads to a culture where whistleblowers are ignored, and why the NHS needs to change the way it treats...

Is it possible to have a fair price for medicines? Yes, according to a new collection just published on bmj.com. The authors set out to evaluate how we could improve the functioning of the market for medicines, to honestly compensate industry for innovation, whilst allowing the poorest to afford them. Suerie Moon, co-director of global health at...

Sandra Ferguson resides with her children and grandchildren in a concrete dwelling that is sectioned into four living quarters in the Fort George Road area of Annotto Bay. With 10 of them sharing kitchen and bathroom facilities, Ferguson said...

Beat reporter Mark Sheldon answers questions about David Bell's managing style, free agents and who will play center field.

THE EDITOR, Madam: “WHY CAN’T vehicle registration be renewed online?” That’s the question asked by Dr Rory Dixon, senior medical officer, Sir John Golding Rehabilitation Centre, in his letter to The Gleaner on Tuesday, May 5. The first paragraph...

George A. Bray
Apr 1, 2014; 37:950-956
Current Concepts of Type 2 Diabetes Prevention

George A. Bray
Apr 1, 2014; 37:950-956
Current Concepts of Type 2 Diabetes Prevention

Parents are asked to sign paperwork when services begin, when changes are made, and if services end. Let's not stop there. Parents must sign before any assessments begin. Parents must sign that they attended meetings. Parents sign that they received a copy of special education rights. The reasoning is to protect everyone involved. It gives documentation to show who attended the meetings, shows parental consent for what is outlined in the plan, and documents what has occurred at the meeting.

While the coordinated attacks of Velociraptor dinosaurs depicted in the 1993 blockbuster made for compelling movie viewing, a study published this week claims raptors most likely hunted solo, not in packs.

The USS Montgomery and the USNS Cesar Chavez sailed into the South China Sea this week in support of the West Capella drill ship, according to U.S. Indo-Pacific Command.

The state leads the nation in poverty and homelessness while it's socialist elites live in absolute luxury. It's like some third world nation the US is obligated to invade on the basis of humanitarianism.

Oh would that 'less laws/more liberty/more state capital power' look anything like Mike Pence's Religious Freedom Restoration Act or in other words the 'we Conservative Republican Christians are such oppressed persecuted victims WAAAAA WAAAA' Bill. https://www.youtube.com/watch?v=KIikqPmbgvI 

Antiwar liberals last week got to savor the four most satisfying words in the English language: "I told you so."

Anecdotally, I’ve heard from a lot of people who have said that they reached out to (or heard from) and ex-partner since the COVID-19 coronavirus pandemic began. But just how many people have done so? And what motivated them to reconnect? Some of my colleagues and I at The Kinsey Institute are currently in the midst of researching how this pandemic is affecting people’s intimate lives (click here if you’d like to participate and learn more about the study), and our preliminary data suggest that reaching out to an ex isn’t a rare occurrence.

"Autism is not a disease; it's just another way of thinking," says Ethan Lisi. Offering a glimpse into the way he experiences the world, Lisi breaks down misleading stereotypes about autism, shares insights into common behaviors like stimming and masking and promotes a more inclusive understanding of the spectrum.

By Emma Young. Formerly religious are more prosocial than those who were never religious, researchers argue.

A collection of short news stories from this week.

A collection of short news stories from this week.

Private schools in New York soon will be required to report suspected sexual abuse of students in their schools to law enforcement, bringing the independent schools under the same rules as public schools.

Tennessee improved its teacher evaluation and training systems by integrating data and teacher voice, according to a new report. But value-added measures that evaluate teachers based on student test scores remain controversial.

A special state panel in Wisconsin has rejected a financially strapped district's request to dissolve.

The firing of a black staff member for repeating the n-word while telling a black student not to use it underscores how uneasy many districts, schools, and educators are with handling the use of racist language in any context.

Education Week catches you up on the week gone by with a thoughtful look at recent news in K-12 education.

"A light-hearted take on the Australian toilet paper shortage. With a lot of worry and fear in the world today (2020), it is important to be informed and make good decisions based on the facts at hand. Panic buying caused supply shortages for some products. In Australia, one of the bizarre products to fall to panic buying was toilet roll. This little book, produced as a light-hearted response, offers a reminder that there is always an alternative. Contained in this book are sixteen "sheets". It may be single ply, but we are sure you will agree the 70lb paper has plenty of bulk" -- from the introduction.

Motion pictures -- Reviews.

Berlin : A. Hirschwald, 1884.

Madras : printed by C. Foster, 1876.

It's pretty obvious by now that many Democrats are growing increasingly uncomfortable supporting charter schools. But New Hampshire lawmakers have taken the unusual step of rejecting federal charter school grant money.

Education Week catches you up on the week gone by with a thoughtful look at recent news in K-12 education.

A collection of short news stories from the last week.

Rockville, Maryland : National Institute on Drug Abuse, 1988.