The Egyptian Armed Forces' removal of President Morsi has created a number of challenges related to democracy, political stability and the role of Islam.

At the table: Maintaining the massive 12,000-square-foot compound amounts to many thousands of shekels a month, and the owners are eager for a return to normalcy.

The Democratic Party’s defeat has many causes, but its anti-Zionist wing has clearly contributed to its electoral collapse.

Accused, who was being kept in custody over the theft of jewellery from a Sliema store, knocked out two of his cellmate’s teeth in an assault at the Corradino Correctional Facility

The United Nations continues to be virtually paralyzed – and remains politically impotent amidst two raging conflicts—as Russia and Israel keep defying the world body. The killings of civilians and the destruction of cities, particularly by Israel, are devastating and continue despite repeated warnings from the UN, its humanitarian agencies, the International Criminal Court (ICC), […]

MANILA, Philippines — Interior Secretary Jonvic Remulla touted local government units’ (LGUs) preemptive evacuation in response to Typhoon Nika (International name: Toraji), saying they took “lessons” from Severe Tropical Storm Kristine (International name: Trami). In a phone interview aired on People’s Television Network on Wednesday morning, Remulla said LGUs evacuated around 8,000 families from geohazard zones identified by the Department of Environment and Natural Resources as Nika crossed Northern Luzon. “If they didn’t evacuate, perhaps, 100 would have died because many of the houses there were really destroyed,” he said in Filipino. Nika left the Philippine Area of Responsibility at […]...

Keep on reading: Remulla: Preemptive evacuation a ‘lesson’ from Storm Kristine

Kremlin denies Putin spoke with Trump over de-escalation in Ukraine

King Charles leads Remembrance Sunday ceremony

World record set at extreme Antarctica Ice Ultra race

Nicole Kidman shared she was afraid to sing in the movie. Nicole Kidman brought back her iconic '90s look with her curly hair.The 57-year-old was spotted flaunting her strawberry blonde curls at the Spellbound premiere on November 11th. The American and Australian actress stunned in a...

Denzel Washington made his debut in 1981 film 'Carbon Copy'Danzel Washington has spilled beans about his retirement, but before that there are a few films lined up ahead that he wishes to first. The Equalizer actor even confirmed the making of Black Panther 3, however, Marvel has not yet said...

It’s no coincidence that extreme heat is engulfing huge swaths of Asia, Europe and North America all at the same time.

This infographic examines how extreme heat disproportionately impacts women in Asia and the Pacific, presenting data on health and economic vulnerabilities shaped by intersecting factors like age, hormonal influences, caregiving roles, and limited cooling access.

Extreme heat is an invisible but increasingly tangible climate risk. It varies by time and place and has wide-reaching but unequal impacts, particularly to women and vulnerable people. As global temperatures rise, extreme heat events (heat waves) are becoming more frequent and severe.

Colorado voters will decide whether to repeal the state constitution's now-defunct marriage definition that only recognizes unions between a man and a woman.

The Supreme Court (SC) on Tuesday announced that the recently established constitutional bench will start hearing cases on November 14 and 15.

Earlier, the SC constituted a three-judge committee to fix cases, issue court rosters, form benches, and decide weekly caseload for its recently established constitutional bench.

The committee held a meeting today which was chaired by Justice Aminud Din Khan (head of the constitutional bench) and attended by Justice Jamal Khan Mandokhail and Justice Muhammad Ali Mazhar, who participated through a telephone call from Karachi.

The SC said in a press release, a copy of which is available with Dawn.com, that the purpose of the meeting was to discuss matters for the formation of the constitutional bench.

During the meeting, the committee was briefed by the court’s registrar’s office regarding the pending constitutional cases, the statement said adding, “[The] committee resolved that priority shall be accorded to the oldest cases.”

On Nov 5, the Judicial Commission of Pakistan (JCP), in its maiden session, had picked Justice Amin as head of the constitutional bench by a seven-to-five majority.

Chaired by Chief Jus­tice of Pakistan (CJP) Jus­tice Yahya Afridi, the reconstituted JCP for­m­ed a seven-member con­stitutional bench, inc­­luding Justices Ami­nud Din Khan, Jamal Khan Mandokhail, Muha­m­mad Ali Mazhar, Ayesha A. Malik, Hassan Azhar Rizvi, Musarrat Hilali and Naeem Akhtar Afghan.

Today’s press release mentioned that Justice Ayesha Malik will not be available on Nov 14 and 15 and “a bench comprising all available Judges shall be constituted to proceed with cases on these dates.”

The SC Registrar Muh­ammad Salim Khan released the court roster of a six-member constitutional bench which will begin hearing cases at 9:30am on Nov 14.

The bench will include Justice Jamal Khan Mandokhail, Justice Muhammad Ali Mazhar, Justice Hasan Azhar Rizvi, Justice Musarrat Hilali and Justice Naeem Akhtar Afghan.

The SC directed the Registrar to schedule cases for hearing before the bench.

The next meeting of the committee will be held on Nov 13 at 12:30pm after Justice Muhammad Ali Mazhar arrives in Islamabad.

Tremors were felt in various cities of Khyber Pakhtunkhwa as well as Islamabad on Wednesday after a quake jolted Afghanistan’s Badakhshan region.

According to the United States Geological Survey (USGS), the earthquake had a magnitude of 5.1, while the Pakistan Meteorological Department (PMD) reported it as having a 5.3 magnitude.

The USGS said the quake’s centre was located 37 kilometres west-southwest of Afghanistan’s Ishkashim town and had a 220.7km depth.

The earthquake struck at 10:13am (Pakistan time), both the USGS and PMD confirmed.

No casualties have been reported so far.

DawnNewsTV reported that the tremors were felt in Peshawar and its adjoining areas, as well as Islamabad.

Speaking to DawnNewsTV, two correspondents based in the cities said the quake caused people to evacuate buildings.

More to follow

to make yourself happy and remarkably less disturbable

Strange solids called temporal metamaterials finally make it possible to investigate the controversial idea of quantum friction – and push special relativity to its limits

Climate change means extreme heat will become the norm for millions across the world. We joined an experiment in the Saudi Arabian desert designed to find out what that means for our brains and bodies

A better understanding of what happens to our bodies when we get fitter can unlock ways to speed up the journey – and it might be simpler than you think

Strange solids called temporal metamaterials finally make it possible to investigate the controversial idea of quantum friction – and push special relativity to its limits

In an experiment simulating what happens deep in the interiors of planets, scientists have found that liquid can be compressed into ice crystals – even at extremely high temperatures

This photo of Tungurahua, a volcano exploding in the Ecuadorian night, comes from an illustrated book to accompany a TV series about Earth’s deep history

When most people are asked to name a river, they often reach for the Amazon or Nile, but these aren’t the only remarkable rivers out there. Here are 10 more from around the world – and solar system

Microbes that rapidly convert CO2 to rock could lock away the greenhouse gas in deep underground storage sites, such as depleted oil and gas reservoirs

Last year’s marine heatwaves saw an unprecedented decline in the growth of phytoplankton and algae, which many animals in the oceans depend on for food

This year could bring up to 25 named tropical storms in the Atlantic Ocean due to a shift to La Niña conditions, says the US National Oceanic and Atmospheric Administration

A Neanderthal skeleton was discovered encased in rock in an Italian cave 30 years ago, but it hasn’t been studied much due to a long-running impasse about how to safely excavate it

In a wetland on the south coast of England, archaeologists dug up one of the oldest and most complete wooden tools ever found in Britain, which is around 3500 years old

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Background

Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function.

The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both anatomically and functionally, and have important yet distinct roles in not only conveying peripheral bodily signals to the rest of the brain but in the generation of behavioral and physiological responses. Reports on the new discoveries in these structures were highlights of the symposium. In this outlook, we focus on the roles of the area postrema in mediating brain–body interactions and its potential utility as a therapeutic target, especially in cancer cachexia.

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.

BACKGROUND AND PURPOSE:

Alterations of the basilar artery (BA) anatomy have been suggested as a possible MRA feature of Fabry disease (FD). Nonetheless, no information about their clinical or pathophysiologic correlates is available, limiting our comprehension of the real impact of vessel remodeling in FD.