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AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies




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Surrogate endpoints for overall survival for patients with metastatic hormone-sensitive prostate cancer in the CHAARTED trial




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South Korea’s THAAD decision: Neither a surprise nor a provocation


At a news conference in Seoul today, the United States and the Republic of Korea jointly announced the decision to deploy a Terminal High Altitude Area Defense (THAAD) missile defense system on the Korean Peninsula, with operational deployment planned by the end of 2017. Though many details are still pending, the decision is not a surprise, and the purposes of the deployment are wholly transparent.

As elaborated in the official announcement, the THAAD deployments are intended to defend the infrastructure and citizens of South Korea, and to protect core military capabilities underpinning the U.S.-Korea alliance. It is not a panacea for South Korea’s potential vulnerabilities to North Korean missile attack, but it will appreciably buttress Seoul’s still-limited air and missile defense capabilities, and explicitly link them to the far greater assets of the United States. 

Seoul did not undertake this commitment lightly. In recent years, South Korean strategic analysts have hotly debated the missile defense issue, but the political-military leadership has proceeded very deliberately. It was only in the aftermath of North Korea’s fourth nuclear test in early January and a long-range rocket test that soon followed that President Park Geun-hye’s administration agreed to initiate consultations on the “earliest possible” deployment of a THAAD missile battery. The North’s accelerated missile testing program, evident since April, reinforced the need for a meaningful response to Pyongyang’s actions.

Neither China nor Russia seems mollified by today’s announcement. Beijing and Moscow both perceive a malign U.S. strategic design, purportedly intended to detect and intercept Chinese and Russian strategic missiles, thereby invalidating their respective deterrence capabilities. But these worst-case estimates attribute technical reach and refinement to the Raytheon radar system likely to accompany the THAAD deployment that substantially exceeds even the manufacturer’s claims. 

China and Russia also contend that the THAAD deployment will further complicate the larger goal of denuclearization and threat reduction on the Korean Peninsula. But this places the cart before the horse. Pyongyang’s determination to expand and diversify its nuclear and missile programs has triggered the THAAD decision. Without the North’s accelerated military efforts, it is very doubtful that sentiment in Seoul would favor deployment of THAAD. Beijing and Moscow assuredly know how to connect the dots, but they seem unwilling to do so. 

At a time of increased Chinese wariness about U.S. military strategy along China’s periphery, it is not a surprise that Beijing has paid little heed to American and South Korean assurances.

Beijing also calculates that warning South Korea of unspecified consequences will convince Seoul to forego the THAAD decision. But this underestimates the South’s determination to proceed with missile defense, which will tie Seoul even more integrally to longer-term cooperation with the United States. This decision is unwelcome in China, but it is wholly within Seoul’s sovereign right to defend its vital interests by all appropriate means; China routinely does the same.

In meetings with Chinese counterparts, senior Korean officials have repeatedly stated that the THAAD deployment serves one irreducible purpose: the protection of South Korean vital national security interests. Seoul is keenly aware of Chinese strategic equities, and will remain very mindful of Beijing’s concerns as it moves ahead with this program. 

At the same time, Seoul and Washington have repeatedly conveyed their willingness to impart to officials in Beijing the limited purpose of the THAAD deployment. It will be directed entirely towards the North’s threats against the South; it will be exclusively bilateral in design; and it will not be targeted against the capabilities of any other party. 

At a time of increased Chinese wariness about U.S. military strategy along China’s periphery, it is not a surprise that Beijing has paid little heed to American and South Korean assurances, at least publicly. But officials and analysts in China must quietly grasp the reasons for the THAAD decision. The North’s nuclear and missile programs worry China deeply, as well. 

The need for a quiet, private conversation about the risks to stability on the peninsula has never been greater. The United States and South Korea are surely ready for this conversation. Whether China is ready remains to be seen.

      
 
 




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Islamists on Islamism: An interview with Rabih Dandachli, former leader in Lebanon’s Gamaa al-Islamiyya

We continue here Brookings’s ongoing video interview series with Islamist leaders and activists, as part of our Rethinking Political Islam initiative. We asked each participant to discuss the state of his or her movement and reflect on lessons learned from the crises of the Arab Spring era, including the rise of ISIS, the Syrian civil […]

      
 
 




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From Popular Revolutions to Effective Reforms: A Statesman's Forum with President Mikheil Saakashvili of Georgia


Event Information

March 17, 2011
2:00 PM - 3:00 PM EDT

Saul/Zilkha Rooms
The Brookings Institution
1775 Massachusetts Avenue, NW
Washington, DC 20036

Since the Rose Revolution in November 2003, Georgia has grappled with the many challenges of building a modern, Western-oriented state, including implementing political and economic reforms, fighting corruption, and throwing off the vestiges of the Soviet legacy. On the path toward a functioning and reliable democracy, Georgia has pursued these domestic changes in an often difficult international environment, as evidenced by the Russia-Georgia conflict in 2008.

On March 17, the Center on the United States and Europe at Brookings (CUSE) hosted President Mikheil Saakashvili to discuss Georgia’s approach to these challenges. A leader of Georgia’s 2003 Rose Revolution, Saakashvili was elected president of Georgia in January 2004 and reelected for a second term in January 2008.

Vice President Martin Indyk, director of Foreign Policy at Brookings, provided introductory remarks and Senior Fellow and CUSE Director Fiona Hill moderated the discussion. After the program, President Saakashvili took audience questions.

Video

Audio

Transcript

Event Materials

     
 
 




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Africa in the news: Nigeria establishes flexible exchange rate, Kenya reaffirms plan to close Dabaab refugee camp, and AfDB meetings focus on energy needs


Nigeria introduces dual exchange rate regime

On Tuesday, May 24, Nigerian Central Bank Governor Godwin Emefiele announced that the country will adopt a more flexible foreign exchange rate system in the near future. This move signals a major policy shift by Emefiele and President Muhammadu Buhari, who had until this point opposed calls to let the naira weaken. Many international oil-related currencies have depreciated against the dollar as oil prices began their decline in 2014. Nigeria, however, has held the naira at a peg of 197-199 per U.S. dollar since March 2015, depleting foreign reserves and deterring investors, who remain concerned about the repercussions of a potential naira devaluation. Following the announcement, Nigerian stocks jumped to a five-month high and bond prices rose in anticipation that a new flexible exchange rate regime would increase the supply of dollars and help attract foreign investors.

For now it remains unclear exactly what a more flexible system will entail for Nigeria, however, some experts suggest that the Central Bank may introduce a dual-rate system, which allows select importers in strategic industries to access foreign currency at the current fixed rate, while more generally foreign currency will be available at a weaker, market-related level. This new regime raises a number of questions, including how it will be governed and who will have access to foreign currency (and at what rate). On Wednesday, Nigeria’s parliament requested a briefing soon from Emefiele and Finance Minister Kemi Adeosun to provide additional clarity on the new system, although the date for such a meeting has not yet been set.

Kenya threatens to close the Dadaab refugee camp, the world’s largest

Earlier this month, Kenya announced plans to close the Dadaab refugee camp, located in northeast Kenya, amid security concerns. The move to close the camp has been widely criticized by international actors. United States State Department Press Relations Director Elizabeth Trudeau urged Kenya to “uphold its international obligations and not forcibly repatriate refugees.” The United Nations High Commissioner for Refugees stated that the closure of the refugee camp would have “devastating consequences.” Despite these concerns, this week, at the World Humanitarian Summit, Kenya stated that it will not go back on its decision and confirmed the closure of the refugee camps within a six-month period.

The camp houses 330,000 refugees, a majority of whom fled from conflict in their home country of Somalia. Kenya insists that the camp poses a threat to its national security, as it believes the camp is used to host and train extremists from Somalia’s Islamist group al-Shabab. Kenya also argued that the developed world, notably the United Kingdom, should host its fair share of African refugees. This is not the first time Kenya has threatened to close the refugee camp. After the Garissa University attacks last April, Kenya voiced its decision to close the refugee camps, although it did not follow through with the plan.

African Development Bank Meetings highlight energy needs and launch the 2016 African Economic Outlook

From May 23-27, Lusaka, Zambia hosted 5,000 delegates and participants for the 2016 Annual Meetings of the African Development Bank (AfDB), with the theme, “Energy and Climate Change.” Held in the wake of December’s COP21 climate agreement and in line with Sustainable Development Goals 7 (ensure access to affordable, reliable, sustainable and modern energy for all) and 13 (take urgent action to combat climate change and its impacts), the theme was timely and, as many speakers emphasized, urgent. Around 645 million people in Africa have no access to electricity, and only 16 percent are connected to an energy source. To that end, AfDB President Akinwumi Adesina outlined the bank’s ambitious aim: “Our goal is clear: universal access to energy for Africa within 10 years; Expand grid power by 160 gigawatts; Connect 130 million persons to grid power; Connect 75 million persons to off grid systems; And provide access to 150 million households to clean cooking energy."

As part of a push to transform Africa’s energy needs and uses, Rwandan President Paul Kagame joined Kenyan President Uhuru Kenyatta on a panel to support the AfDB’s “New Deal on Energy” that aims to deliver electricity to all Africans by 2025. Kenyatta specifically touted the potential of geothermal energy sources. Now, 40 percent of Kenya's power needs come from geothermal energy sources, he said, but there is still room for improvement—private businesses, which make up 30 percent of Kenya’s on-grid energy needs, have not made the switch yet.

As part of the meetings, the AfDB, the Organization for Economic Cooperation and Development (OECD), and United Nations Development Program (UNDP) also launched their annual African Economic Outlook, with the theme “Sustainable Cities and Structural Transformation.” In general, the report’s authors predict that the continent will maintain an average growth of 3.7 percent in 2016 before increasing to 4.5 percent in 2017, assuming commodity prices recover and the global economy improves.  However, the focus was on this year’s theme: urbanization. The authors provide an overview of urbanization trends and highlight that successful urban planning can discourage pollution and waste, slow climate change, support better social safety nets, enhance service delivery, and attract investment, among other benefits.

For more on urbanization in sub-Saharan Africa, see Chapter 4 of Foresight Africa 2016: Capitalizing on Urbanization: The Importance of Planning, Infrastructure, and Finance for Africa’s Growing Cities.

Authors

  • Amy Copley
     
 
 




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Architectural Valentines: Love means never having to say you’re Saarinen

They are all over the internet today; here are some that relate to buildings we have shown on TreeHugger




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Ecorazzi on DiCaprio + Van Jones, Worldchanging Interviews Wangari Maathai, Chevron Toxico, and More

Chevron Toxico: Chevron Produces Phony Online News Coverage to Spread Misinformation about Ecuador Disaster "To promote a misinformation campaign about its role in the oil contamination of a pristine area of the rainforest in Ecuador, Chevron recently




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Daan Roosegaarde lights things up without electricity

Glow-in-the-dark wonders are "techno-poetry".




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Remembering Wangari Maathai, Monday November 14th in NYC

A public memorial ceremony will be held in NYC for Wangari Maathai on November 14.




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Visiting Alvar Aalto's Nordic House

The Scandinavian master designed a gem of a building promoting Nordic cooperation.




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Event: Recycled Swimwear Designer Aaron Chang Opens Green Art Gallery

Image via: Aaron Chang Gallery Aaron Chang, popular recycled fashion swimwear designer and professional photographer, not to mention surfing legend, is opening a green art gallery in San Diego, February 28, 2009. Each of the pieces are printed with




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NOAA's new interactive map shows all the vegetation on the planet

This new map uses satellite technology to display the world's vegetation, and can be used for everything from weather predictions to deciding best land use practices.




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NOAA predicts dead zone size of New Jersey in Gulf of Mexico

This year, NOAA predicts a massive "dead zone" the size of New Jersey will bloom in the Gulf of Mexico. Brian Merchant reports on the cause and consequences of dead zones.




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Effects of Global Warming Inspire Alterations to Famous Aalto Vase

The vase designed and named after Finnish designer Alvar Aalto is an icon among the design-savvy. The now-classic piece was released in 1937 at the World Fair in Paris. Today, the vase is produced by Iittala, which has slightly changed the size and




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Joris Laarman Lab shows the future of digital design

An exhibition of their work is at the Cooper Hewitt in New York.




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Eero Saarinen's TWA terminal is restored, repurposed and reborn as the TWA Hotel

Did we say we hate concrete? Just the new stuff. This kind of concrete should be buffed, polished and treasured.




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AARP Unveils the 2016 Top 7 Travel Trends for Baby Boomers - AARP's Travel Ambassador Samantha Brown Unveils the 2016 Top Travel Trends for Baby Boomers

AARP's Travel Ambassador Samantha Brown Unveils the 2016 Top Travel Trends for Baby Boomers





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LG Gives Team Uniform Colors A New Purpose, Enlists Color Commentator Jay Bilas To Help NCAA March Madness Fans 'Do Game Day Right' - Jay Bilas shares his tips on how to do game day right.

ESPN College Basketball Analyst and LG Color Commentator Jay Bilas shares his tips on how to do game day right.





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LG Gives Team Uniform Colors A New Purpose, Enlists Color Commentator Jay Bilas To Help NCAA March Madness Fans 'Do Game Day Right' - Jay Bilas shares his tips on how to do game day right.

ESPN College Basketball Analyst and LG Color Commentator Jay Bilas shares his tips on how to do game day right.





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New PSAs Released as Part of Ad Council and AARP Caregiver Assistance Campaign Supported by NAB, RAB, and OAAA This Mother's and Father's Day - PERSPECTIVES :30

PERSPECTIVES :30




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American Association for Cancer Research National Survey Shows 74 Percent of Voters Want More Federal Funding for Cancer Research - AACR Survey and Cancer Progress Report 2015 Video

AACR Survey and Cancer Progress Report 2015 Video




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AARP Expert Amy Goyer Shares Tips for Caregiving Success in New Book for America’s 40 Million Caregivers - AARP Day in the Life of a Caregiver

AARP The Magazine spent 24 hours filming the emotional day in the life of caregivers across America




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USAA chief: Coronavirus 'cabin fever' may be behind car crash uptick after initial steep decline

"The last couple of weeks we've seen a slight uptick in those rates, certainly not because stores are reopening," USAA CEO Wayne Peacock told CNBC.





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Final Trades: JPM, GDX, AAPL & AGN

The Fast Money traders offer up their final trades of the week.




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Alan Pardew leaves Den Haag by mutual consent days after relegation reprieve

  • Pardew departs Dutch club after just eight games in charge
  • Assistants Chris Powell and Paul Butler also leave the club

Alan Pardew has left his position as the manager of Eredivisie club Den Haag by mutual consent, days after the Dutch season was cancelled.

Pardew was appointed in December and tasked with saving the club from relegation. The 58-year-old was unable to lead them out of the relegation zone, but the team were reprieved when the season was scrapped because of the coronavirus pandemic.

Continue reading...




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PGIM India Fixed Duration Fund - Series AA - Regular Plan - Quarterly Dividend Option

Category Income
NAV 1262.88
Repurchase Price
Sale Price
Date 04-May-2020




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PGIM India Fixed Duration Fund - Series AA - Regular Plan - Growth Option

Category Income
NAV 1262.3744
Repurchase Price
Sale Price
Date 04-May-2020




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PGIM India Fixed Duration Fund - Series AA - Regular Plan - Annual Dividend Option

Category Income
NAV 1262.393
Repurchase Price
Sale Price
Date 04-May-2020




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PGIM India Fixed Duration Fund - Series AA - Direct Plan - Quarterly Dividend Option

Category Income
NAV 1265.9426
Repurchase Price
Sale Price
Date 04-May-2020




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PGIM India Fixed Duration Fund - Series AA - Direct Plan - Growth Option

Category Income
NAV 1265.9735
Repurchase Price
Sale Price
Date 04-May-2020




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What is MSME(Udyog Aadhaar) and its benefits

What is MSME(Udyog Aadhaar) and its benefits




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Where to find SaaS Benchmarks across the Customer LifeCycle? (3 FAQ’s)

Where do you find SaaS operational benchmarks? How accurate and statistically valid are the available benchmarks? And how do you benchmark KPI’s without spending too much time and money? Ray Rike has answers.

Keep on reading: Where to find SaaS Benchmarks across the Customer LifeCycle? (3 FAQ’s)




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M.R. Asks 3 Questions: Tim McCormick, CEO, SaaSOptics

SaasOptics CEO, Tim McCormick has seen his share of businesses go from start-up to acquisition. Having helped businesses like ISS grow from $5M to over $400M and helped their IBM acquisition for $1.9B, he's the right person to detail how SaaS businesses can either misstep or experience rapid growth.

Keep on reading: M.R. Asks 3 Questions: Tim McCormick, CEO, SaaSOptics




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2019 KBCM Technology Group Private SaaS Company Survey

"As the SaaS industry continues to become more sophisticated, operators and investors are looking more closely at performance-driving metrics," said David Spitz, managing director of KBCM's Technology Group and primary author of the survey.

Keep on reading: 2019 KBCM Technology Group Private SaaS Company Survey




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COVID-19 SaaS Industry Research

In partnership with RevOps2, we are conducting research on how COVID-19 is impacting SaaS companies. Our goal is to use the collective knowledge and actions of our membership to provide insights and guidance to the overall SaaS industry. All information will be aggregated and anonymized to protect the privacy and confidentiality of every participant.

Keep on reading: COVID-19 SaaS Industry Research




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SaaS Financial Impact Research Report: The Impact of a Pandemic on B2B SaaS Companies

Between April 10 - April 30, 2020, RevOps Squared partnered with SandHill Group to conduct research that will help us understand how financial planning and 2020 forecasts within the SaaS industry have been impacted by COVID-19. This is the summary report of our findings.

Keep on reading: SaaS Financial Impact Research Report: The Impact of a Pandemic on B2B SaaS Companies




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GST Update on whether Rajasthan AAR competent to decide on registration requirement in another State?

The present update intends to discuss the Advance Ruling given in the case of M/s T & D Electricals. The question placed before the Advance Ruling was the requirement of separate registration for executing works contract in another State and leviability of tax-whether CGST/SGST or IGST if separate r




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U.S. rail carload and intermodal volumes see steep declines in April, reports AAR

U.S. rail carloads in April—at 980,535—were off 25.2%, or 329,693 carloads, annually, and intermodal containers and trailers—at 1,095,423—slipped 17.2%, or 227,165 units.





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QUERY REGARDING VIVAAD SE VISHVAS SCHEME

IN OUR CASE, THE CIT(A) ORDER HAS BEEN PASSED ON 17.12.2019 AND ON THE DAY OF 31.01.2020, THE TIME LIMIT FOR ITAT APPEAL IS STILL PENDING. BUT TILL TODAY THE ASSESSEE HAS NOT FILED ANY APPEAL.
CAN THE ASSESSEE OPT FOR VSV SCHEME ? AND IF YES, THEN GUIDE US THE PROCEDURE FOR THAT.





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Soren Kierkegaard

"Most men pursue pleasure with such breathless haste that they hurry past it."