em Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Introduction to the themed collection on ‘AI in Medicinal Chemistry’ By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3284-3285DOI: 10.1039/D4MD90035A, EditorialJian Zhang, Ola Engkvist, Gerhard HesslerJian Zhang, Ola Engkvist and Gerhard Hessler introduce the RSC Medicinal Chemistry themed collection on ‘AI in Medicinal Chemistry’.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Introduction to the themed collection in honour of Professor Christian Leumann By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90039A, EditorialMarcel Hollenstein, Eugen StulzMarcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00632A, Review ArticleAshish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder KumarThe present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
em Changes in train services notified due to demolition of old bridge near Tiruchi junction By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:30:53 +0530 Full Article Tiruchirapalli
em Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents By www.thehindu.com Published On :: Tue, 05 Nov 2024 21:04:51 +0530 Full Article Tiruchirapalli
em Tiruchi Today (November 7, 2024) By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:16:44 +0530 Full Article Tiruchirapalli
em Ensure time-bound implementation of development schemes, says Thirumavalavan By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:29:00 +0530 Full Article Tiruchirapalli
em Case filed against actor Kasthuri over remarks on Telugu community By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:46:03 +0530 Full Article Tiruchirapalli
em Urban Primary Health Centre stuck in cramped, temporary facility By www.thehindu.com Published On :: Wed, 06 Nov 2024 20:31:50 +0530 Full Article Tiruchirapalli
em Property owners block the entrance to Balasubramanya temple in Karur By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:35:45 +0530 Full Article Tiruchirapalli
em Govt. urged to extend last date to pay crop insurance premium by farmers By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:45:02 +0530 Full Article Tiruchirapalli
em Deputy CM releases commemorative flag of Bharat Scouts and Guides By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:48:40 +0530 Full Article Tiruchirapalli
em Farmers demand withdrawal of Tamil Nadu Land Consolidation Act By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:59:18 +0530 The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands Full Article Tiruchirapalli
em Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
em HR&CE plans to bring properties around the Vennaimalai Temple under tenants list By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:36:32 +0530 The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders Full Article Tiruchirapalli
em Power shutdown in parts of Tiruchi on November 9 By www.thehindu.com Published On :: Fri, 08 Nov 2024 17:45:18 +0530 Full Article Tiruchirapalli
em NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:53 +0530 Full Article Tiruchirapalli
em Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
em Advanced baggage handling system introduced in Tiruchi airport By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:01:36 +0530 Full Article Tiruchirapalli
em Man attempts to end life, kills his wife and daughter By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:03:18 +0530 Full Article Tiruchirapalli
em IECD holds graduation ceremony of SUITS By www.thehindu.com Published On :: Sat, 09 Nov 2024 19:08:19 +0530 As many as 93,435 students from Grade V to Grade IX in 358 schools across the State appeared for 2023-2024 BDU examinations Full Article Tiruchirapalli
em 558: Esoteric Weird Content Editable Problems with Kristin Valentine By shoptalkshow.com Published On :: Mon, 27 Mar 2023 07:34:54 +0000 Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??" Full Article All Episodes CMS editor vox
em 559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS By shoptalkshow.com Published On :: Mon, 03 Apr 2023 07:14:35 +0000 Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server? Full Article All Episodes chatgpt dialog Go
em 560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS! By shoptalkshow.com Published On :: Mon, 10 Apr 2023 08:53:57 +0000 After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS. Full Article All Episodes cascade layers cite emoji trigonometric
em 572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements By shoptalkshow.com Published On :: Mon, 03 Jul 2023 08:24:15 +0000 Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […] Full Article All Episodes CSS figma stripe
em 601: Brad Frost on A Global Design System + Frostapalooza By shoptalkshow.com Published On :: Mon, 05 Feb 2024 11:00:03 +0000 Brad Frost has got design systems on his mind—at a global scale. What is a global design system? Are two design systems ever the same? How would this slot inside atomic design? What has been the response from the web community to global design system as an idea? And what's Frostapalooza? Full Article All Episodes atomic design design systems web componnets
em 604: VS Code Plugins, Git as a Radical Statement, Tailwind & Arc Drama By shoptalkshow.com Published On :: Mon, 26 Feb 2024 09:43:06 +0000 A follow up on jQuery conversation, Microsoft owning all the things, what VS Code plugins are your ride or die, the ability to Git from wherever you want, Tailwind drama, global design system follow up, Arc Search gets roasted, and Frontend Design Conference is back! Full Article All Episodes global design systems microsoft tailwind vs code
em Don’t trash them By www.thehindu.com Published On :: Fri, 06 Mar 2015 14:59:07 +0530 Here’s how to give used wrapping paper, scrapbooks and old newspapers new life, says Teja Lele Desai Full Article Green Living
em Beware of excess cement By www.thehindu.com Published On :: Fri, 27 Mar 2015 19:26:05 +0530 Cement deteriorates with age, and has an inherent weakness of cracking. Full Article Property Plus
em The management of sludge By www.thehindu.com Published On :: Fri, 18 Dec 2015 18:55:03 +0530 There is a need for building bye-laws to insist on a range of on-plot sanitation as mandatory, depending on the location and the groundwater table. Full Article Property Plus
em A premium for cleanliness By www.thehindu.com Published On :: Fri, 26 Feb 2016 15:16:24 +0530 If you’re looking at buying a home, take a pick from one of India’s cleanest cities. Full Article Property Plus
em Soft skills are most in demand By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 21:10:00 +0530 Why headhunters go for traits like leadership, communication, and emotional intelligence Full Article Corporate File
em A rising star in retirement planning By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 21:23:00 +0530 Amid a steadily swelling subscriber base, how the NPS can build on the momentum to reach its full potential Full Article Current Account
em Fem-tech: Niche and fertile for growth By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:36:26 +0530 Offering tech-enabled healthcare solutions exclusively for women, the fem-tech segment is clocking steady growth Full Article Emerging Entrepreneurs
em Lure of emergent tech ventures By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:53:32 +0530 Venture Catalysts backs startups that come with unique solutions and first-mover advantages Full Article Emerging Entrepreneurs
em Keeping track of Scope-3 emissions from supply chains By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:58:37 +0530 Gurgaon-based startup OnlyGood FutureTech helps companies measure emissions generated by supply partners Full Article Clean Tech
em To the eMAX 7 By www.thehindubusinessline.com Published On :: Sat, 02 Nov 2024 08:07:00 +0530 The new BYD eMAX 7 aims to reduce pollution and keep fuel bills in check without compromising on space and practicality Full Article Auto focus
em Time to embrace ‘re-sign’ from resign By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 19:03:45 +0530 Rehiring your ex-colleagues is no longer an emotional decision but the most logical one Full Article Corporate File
em ₹200-crore decentralised green hydrogen scheme By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:16:33 +0530 Decentralised use of green hydrogen could include cooking, off-grid electricity generation Full Article Clean Tech
em Attempts to douse Alipur warehouse fire continue on second day By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:00:26 +0530 Full Article Delhi
em Two juveniles apprehended for dragging policemen on car’s bonnet By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:06:53 +0530 Full Article Delhi
em MCD mayoral polls slated for November 14 By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:08:06 +0530 Full Article Delhi
em Several Delhi govt. schemes to tackle toxic air yet to take off By www.thehindu.com Published On :: Tue, 05 Nov 2024 03:07:30 +0530 AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP Full Article Delhi
em Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Tue, 05 Nov 2024 13:00:21 +0530 Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed Full Article Delhi
em Police rule out communal angle in clash near Jahangirpuri temple By www.thehindu.com Published On :: Wed, 06 Nov 2024 00:15:57 +0530 Full Article Delhi