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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Introduction to the themed collection on ‘AI in Medicinal Chemistry’

RSC Med. Chem., 2024, 15,3284-3285
DOI: 10.1039/D4MD90035A, Editorial
Jian Zhang, Ola Engkvist, Gerhard Hessler
Jian Zhang, Ola Engkvist and Gerhard Hessler introduce the RSC Medicinal Chemistry themed collection on ‘AI in Medicinal Chemistry’.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Introduction to the themed collection in honour of Professor Christian Leumann

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90039A, Editorial
Marcel Hollenstein, Eugen Stulz
Marcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Tiruchi Today (November 7, 2024)




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Case filed against actor Kasthuri over remarks on Telugu community




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Urban Primary Health Centre stuck in cramped, temporary facility




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Property owners block the entrance to Balasubramanya temple in Karur




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




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Power shutdown in parts of Tiruchi on November 9




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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Advanced baggage handling system introduced in Tiruchi airport




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Man attempts to end life, kills his wife and daughter




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IECD holds graduation ceremony of SUITS

As many as 93,435 students from Grade V to Grade IX in 358 schools across the State appeared for 2023-2024 BDU examinations




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558: Esoteric Weird Content Editable Problems with Kristin Valentine

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"




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559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS

Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server?




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560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS!

After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS.




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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




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601: Brad Frost on A Global Design System + Frostapalooza

Brad Frost has got design systems on his mind—at a global scale. What is a global design system? Are two design systems ever the same? How would this slot inside atomic design? What has been the response from the web community to global design system as an idea? And what's Frostapalooza?




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604: VS Code Plugins, Git as a Radical Statement, Tailwind & Arc Drama

A follow up on jQuery conversation, Microsoft owning all the things, what VS Code plugins are your ride or die, the ability to Git from wherever you want, Tailwind drama, global design system follow up, Arc Search gets roasted, and Frontend Design Conference is back!




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Don’t trash them

Here’s how to give used wrapping paper, scrapbooks and old newspapers new life, says Teja Lele Desai




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Beware of excess cement

Cement deteriorates with age, and has an inherent weakness of cracking.




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The management of sludge

There is a need for building bye-laws to insist on a range of on-plot sanitation as mandatory, depending on the location and the groundwater table.




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A premium for cleanliness

If you’re looking at buying a home, take a pick from one of India’s cleanest cities.




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Soft skills are most in demand

Why headhunters go for traits like leadership, communication, and emotional intelligence




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A rising star in retirement planning

Amid a steadily swelling subscriber base, how the NPS can build on the momentum to reach its full potential




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Fem-tech: Niche and fertile for growth

Offering tech-enabled healthcare solutions exclusively for women, the fem-tech segment is clocking steady growth




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Lure of emergent tech ventures

Venture Catalysts backs startups that come with unique solutions and first-mover advantages




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Keeping track of Scope-3 emissions from supply chains

Gurgaon-based startup OnlyGood FutureTech helps companies measure emissions generated by supply partners




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To the eMAX 7

The new BYD eMAX 7 aims to reduce pollution and keep fuel bills in check without compromising on space and practicality




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Time to embrace ‘re-sign’ from resign

Rehiring your ex-colleagues is no longer an emotional decision but the most logical one




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₹200-crore decentralised green hydrogen scheme 

Decentralised use of green hydrogen could include cooking, off-grid electricity generation




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Attempts to douse Alipur warehouse fire continue on second day




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Two juveniles apprehended for dragging policemen on car’s bonnet 




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MCD mayoral polls slated for November 14




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Several Delhi govt. schemes to tackle toxic air yet to take off

AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP




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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge

Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed




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Police rule out communal angle in clash near Jahangirpuri temple