With more than 8,200 islands sprawled around Australia, there's a good chance you can't name them all so we've listed some of them to inspire your next getaway.

New York-based 3D printing marketplace Shapeways is partnering with Industrial 3D printing specialist EOS to offer and supply market-ready orthosis and prosthesis to designers and businesses.

Temperatures in parts of NSW are expected to exceed 40 degrees including the outskirts of Sydney.

In the early 1970s a company spent millions of dollars developing a cattle and cropping empire near Katherine in the NT. What went wrong?

Farmers say they should be able to make enough money to look after themselves. But as they contend with one of Australia's worst droughts, it's set to produce a billion-dollar welfare bill as taxpayers help keep them afloat.

Calypso may be blind and deaf, but the gelding turns 50 today the day all horses in Australia have their birthday.

All fires across New South Wales and Queensland are downgraded to watch and act or advice as nightfall eases conditions somewhat. Look back at out coverage as firefighters battled blazes across two states.

Controversial changes enforcing quotas on Queensland fisheries have led to a critical breakdown in the relationship between industry and government.

With the global coronavirus pandemic continuing to damage health systems and economies worldwide, there is a desperate need to start transitioning out of lockdown and reopen communities and cities in the safest way possible. Shapes AI, a computer vision and artificial intelligence company, has launched a platform to support this transition by tracking and monitoring social distancing and the wearing of masks.

I can’t stop laughing at this.

By now I understood that the story I was telling about Val Kilmer, which I’d thought had been about a man’s relentless faith and optimism, was really about reconciliation: the squaring of two opposing things into something we swear is true despite all evidence to the contrary. Your beauty can sentence you to misery; Val Kilmer uses a tracheostomy tube, but he can talk; his brother is dead but only to our senses. Mark Twain despised Mary Baker Eddy, until you can will him into a dream where he doesn’t. God is good, and there are no ventilators. My beautiful friend has cancer, and the treatment exists, but it’s unavailable to her right now.

(United States Ninth Circuit) - Reversing the district court's denial of a writ of habeas corpus as to the guilt phase claims relating to first degree murder, vacating the convictions and remanding because if counsel had performed effectively by investigating and presenting evidence of the defendant's diminished mental capacity defense based on mental impairment there was a reasonable probability at least one juror would have had a reasonable doubt about his ability to form the requisite mental state for first degree murder.

A very long scam e-mail from Linda Zhong who lives in another dimension in time.

New Happy Song "Your Turn Me All Around" By CHICAGOBOY Out Now

Diskery.com Celebrates 20 Years On-line!

Queen guitarist Brian May is sharing his thoughts on the likelihood of a sequel to the band's 2018 biopic

Diskery.com Celebrates 20 Years On-line!

(United States Ninth Circuit) - Affirmed. Even assuming there was no reasonable basis for the state court to deny the claim as to the first two requirements under Napue v. Illinois, the panel could not say that it would be unreasonable to conclude that the testimony did not satisfy the materiality requirement.

Critics of a plan that makes tracts of public lands in western Colorado available to oil and gas drilling say the final insult is its release in the middle of the coronavirus pandemic when people are dealing with health and economic concerns.

Neiman Marcus has filed for Chapter 11 bankruptcy protection, the first department store chain and second major retailer to be toppled by the coronavirus pandemic.

Neiman Marcus has filed for Chapter 11 bankruptcy protection, the first department store chain and second major retailer to be toppled by the coronavirus pandemic.

Tina Campbell talks about how the Bible changed her mindset.

"My king, my heart, my best friend."

The experience has made her appreciate her mother even more.

The singer says she’s having her butt enhancements removed.

Resolutions beware, actor takes fitness kick to a new level.

Boy Scouts of America (BSA) filed for Chapter 11 bankruptcy to achieve two key objectives ...

We all need to tighten our belts

For the first time in over three decades, BT has suspended its dividend scheme as the former state-owned teleco grapples with the fallout from the novel coronavirus pandemic, and the financial uncertainty that'll inevitably ensue.…

Schneider Electric patches vulns after Trustwave raises alarm

Two Schneider Electric SCADA products had vulnerabilities similar to the ones exploited in the Iran-bothering Stuxnet worm, an infosec outfit has claimed.…

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

Lymph node stromal cells (LNSCs) regulate immunity through constructing lymphocyte niches. LNSC-produced laminin α5 (Lama5) regulates CD4+ T cells but the underlying mechanisms of its functions are poorly understood. Here we show that depleting Lama5 in LNSCs resulted in decreased Lama5 protein in the LN cortical ridge (CR) and around high endothelial venules (HEVs). Lama5 depletion affected LN structure with increased HEVs, upregulated chemokines, and cell adhesion molecules, and led to greater numbers of Tregs in the T cell zone. Mouse and human T cell transendothelial migration and T cell entry into LNs were suppressed by Lama5 through the receptors α6 integrin and α-dystroglycan. During immune responses and allograft transplantation, depleting Lama5 promoted antigen-specific CD4+ T cell entry into the CR through HEVs, suppressed T cell activation, and altered T cell differentiation to suppressive regulatory phenotypes. Enhanced allograft acceptance resulted from depleting Lama5 or blockade of T cell Lama5 receptors. Lama5 and Lama4/Lama5 ratios in allografts were associated with the rejection severity. Overall, our results demonstrated that stromal Lama5 regulated immune responses through altering LN structures and T cell behaviors. This study delineated a stromal Lama5–T cell receptor axis that can be targeted for immune tolerance modulation.

Platform: Javascript/HTML5 — Bearing the fruit of thoughtful craftsmanship, Rudowski Brothers gifts us with The Trader of Stories - Chapter 2. After spending nearly a Blossoming in the human city of Bark, Little Willow's life seems fairly ordered. She works as a waitress... Tagged as: adventure, bigoldtreethatdreams, browser, free, game, html5, linux, mac, mobile, mrudowski, narrative, pointandclick, traderofstories

Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

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Criminal Minds newcomer Damon Gupton (Stephen Walker) celebrated his birthday yesterday, January 4. He was born on that day in 1973. Here...