An arm bone from an ancient human that lived 700,000 years ago on the island of Flores is the smallest ever found from an adult hominin, adding a new piece to the puzzle of Homo floresiensis

A young boy who lived towards the end of the last glacial period had dark skin, blue eyes and a congenital heart condition, a study of his genome reveals

Genetic analysis of five individuals preserved as plaster casts in the ruins of Pompeii contradicts established beliefs about the people and their relationships

Title: Thyroid Storm vs Thyrotoxicosis: Differences
Category: Diseases and Conditions
Created: 7/8/2022 12:00:00 AM
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Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

BACKGROUND AND PURPOSE:

Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.

Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors to have robust antioxidant defenses and high metabolic synthesis rates to regenerate the outer segments every 10 days. Both processes required high levels of glucose uptake and utilization. Retinitis pigmentosa is a prevalent form of inherited retinal degeneration characterized by initial loss of low-light vision caused by the death of rod photoreceptors. In this disease, rods die as a direct effect of an inherited mutation. Following the loss of rods, cones eventually degenerate, resulting in complete blindness. The progression of vision loss in retinitis pigmentosa suggested that rod photoreceptors were necessary to maintain healthy cones. We identified a protein secreted by rods that functions to promote cone survival, and we named it rod-derived cone viability factor (RdCVF). RdCVF is encoded by an alternative splice product of the nucleoredoxin-like 1 (NXNL1) gene, and RdCVF was found to accelerate the uptake of glucose by cones. Without RdCVF, cones eventually die because of compromised glucose uptake and utilization. The NXNL1 gene also encodes for the thioredoxin RdCVFL, which reduces cysteines in photoreceptor proteins that are oxidized, providing a defense against radical oxygen species. We will review here the main steps of discovering this novel intercellular signaling currently under translation as a broad-spectrum treatment for retinitis pigmentosa.

Missing or inaccessible lung function measurements, gathered over time, have the potential to stagnate or impair clinical care decisions being made. This jeopardises patient safety and often contributes to excessive resource utilisation. Data integration is fundamental to clinical decision-making and entails amalgamating lung function data from multiple sources in a user-friendly format. Despite this, current systems for recording lung function data are suboptimal, with copious gaps in the clinical picture arising from missing or inaccessible lung function measurements. This article discusses the importance of data integration for lung function, with a call to action for key stakeholders involved in the performance, management and interpretation of such tests.

Cassian's on a new mission to steal a familiar ship in the next season of his self-titled Star Wars show.

Sony has released the US and European PlayStation Store downloads charts for September 2024.

Call of Duty: Black Ops 6 topped the PlayStation 5 charts in the US and Canada, as well as on the European charts. Dragon Ball: Sparking! Zero was number two in the US and Canada, as well as in Europe. Undisputed was number three in the US and Canada, while it was EA Sports FC 25 in Europe.

Call of Duty: Black Ops 6 was the most downloaded game on the PlayStation 4 charts in the US and Canada, while it was EA Sports FC 25 on the European charts. Minecraft was number two in the US and Canada, while it was Call of Duty: Black Ops 6 in Europe. Red Dead Redemption 2 was number three in the US and Canada, while it was The Forest in Europe.

Arizona Sunshine Remake topped the PlayStation VR2 charts in the US and Canada, as well as in Europe. Beat Saber VR was number two in the US and Canada, while it was The Dark Pictures: Switchback VR in Europe. The Dark Pictures: Switchback VR was number three in the US and Canada, while it was Metro Awakening in Europe.

ASTRO BOT Rescue Mission topped the PlayStation VR charts in the US and Canada, while it was Batman: Arkham VR in Europe. The Elder Scrolls V: Skyrim VR was number two in the US and Canada, while it was The Exorcist: Legion VR in Europe.

Throne and Liberty topped the free-to-play US and Canada charts, and in Europe. Fortnite was number two in the US and Canada, and in Europe.

Here is the complete list of charts:

PS5 Games

PS4 Games

PS VR2 Games*

PS VR Games

Free to Play (PS5 + PS4)

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463025/call-of-duty-black-ops-6-tops-the-ps5-ps-store-download-charts-in-october/

Liam Payne was seemingly having a “lovely day in Argentina” just hours before his death on Wednesday, according to what appear to be a series of final posts made to his Snapchat account.

The former One Direction member was found dead in the courtyard of a Buenos Aires hotel, having apparently plunged 13 to 14 meters from his balcony, according to local police. A cause of death has not officially been determined, and it was unclear whether the fall was accidental or intentional.

On his Snapchat Story, however, it would have appeared to any fan that Payne was having a relaxing vacation. In since-deleted posts in the hours before his death, he posted a front-facing video in which he told followers, “It’s a lovely day here in Argentina. This is the breakfast table. Just enjoying coffee and breakfast even though it’s 1 p.m.”

Read more at The Daily Beast.

It appears Donald Trump is once again attempting to silence Stormy Daniels, despite his recent convictions in that category.

MSNBC’s Rachel Maddow reports that Trump’s lawyers tried to “get another hush money deal” with the adult film star, to keep her from making any “public or private statements related to any alleged past interactions” with the former president. In exchange for her written agreement, Trump’s team reportedly offered to adjust the debt she owes Trump for the unsuccessful defamation case her lawyer brought against him in 2018.

Daniels still needs to pay “hundreds of thousands of dollars” in legal fees, Maddow explained, and in hammering out the exact amount, Trump’s lawyers allegedly offered to “pretend” she owed their client “less than they actually believed” she did. Whereas they first estimated Daniels’ debt at $650,000, Maddow reported, they said they would settle her tab for $620,000, if she promised not to make any “defamatory or disparaging statements about him, his business, and/or any affiliates, or his suitability as a candidate for president.” They then adjusted the fee, asking $635,000 if she refused to sign a non-disclosure agreement. Daniels reportedly turned them down, paying $627,500 and declining to sign the NDA.

Read more at The Daily Beast.

Some days, I wonder if every word written before a trailer is actually superfluous. It’s a visual medium, after all. What can a description achieve save to clumsily gesture at the true shape of something; a dog-eared tour brochure for a thrilling weekend spelunking in Plato’s cave? I can usually shake this feeling, but gory zombie action game Showa American Story is my breaking point. There is nothing I can impart about this thing that will not be conveyed better by allowing its new trailer to wash over you like a tide of sheer videogame. Here’s it:

Read more

Put your hand up if you'd forgotten that every Assassin's Creed game is, strictly speaking, set in the present day. I know I had. That's not the actual distant past you're parkouring through. That isn't actual Renaissance architecture you're clambering on. It's a holographic Animus simulation, conjured from ancestral memories flash-frozen within your DNA - convenient, inasmuch as it means that any inconsistencies are your DNA's fault, not Ubisoft's. If the ledge-mantling animations are glitchy, that's simply because you have bad genes.

We can both be forgiven for losing sight of Assassin's Creed's modern day narrative frame. Ubisoft themselves have downplayed it since the era of Desmond Miles, the watery Peter Parker figure who served as puppetmaster protagonist for AC games up to Assassin's Creed 3. In Assassin's Creed Shadows, however, they're planning to bring back the modern day setting in a big way, though details are scanty.

Read more

The developers of hero shooter Overwatch 2 must have dropped a box full of old photographs while clearing the attic, spilling old snapshots of Route 66 onto the floor and getting snared in a nostalgic daze. The game is launching a "Classic" mode today that will let you play the first-person payload pusher as it (mostly) was back in 2016 when the first Overwatch launched. That means 6v6 fights, the original abilities of its heroes, and no limits to stop the entire team picking the same character.

Read more

After nearly a year of public beta honing, the Nvidia App – Team Green’s new one-stop shop for desktop GPU management – is out in full. Not alongside the upcoming RTX 50 series, as rumoured, but right-now-today-this-minute. I’ve been testing out the launch version and while it’s not without some dud features, it does agreeably achieve its stated goal of combining the functions within Nvidia Control Panel and GeForce Experience. And if installing it means never having to use the latter again, well, that’s 149MB well spent.

Read more

Samantha Harvey has won the UK's top fiction prize for a novel that takes place over 24 hours on the International Space Station

Cyborg: A documentary tells the intriguing story of Neil Harbisson, who wears an antenna to “hear” colour, but it is lacking in depth and should have probed its subject more, says Simon Ings

A quantum computing protocol makes it possible to extract energy from seemingly empty space, teleport it to a new location, then store it for later use

Researchers have managed to encode enormous amounts of information, including images, into DNA at a rate hundreds of times faster than was previously possible

The finale doesn’t look to provide a definitive answer to what drove Aaron’s actions, much to the show’s credit.

Unknown host Charlie Stone analyzes Trump's unprecedented victory with Obama Homeland Security Secretary, Jeh Johnson

As we share our truths and witness each other's, we build unity and community.

Comet Nishimura (C/2023 P1) was discovered in August and is now whizzing by Earth, but finding it in the sky will be a challenge.

Online group Girls Who Chase has created a global community of women who head into severe weather to record images, report damage and help scientists understand the impact of storms to be better prepared

By Tom Garry, in Salford

A coronal mass ejection could strike the Earth's magnetosphere this week and cause a geomagnetic storm due to conditions caused by the autumnal equinox.

The sun blasted a coronal mass at Earth earlier this week, and after back-to-back major hurricanes, some are concerned it could impact the power grid.

SpaceX pulled off a stunning achievement this week, conducting four launches in less than 48 hours with huge implications for the future of space exploration.

This is a sponsored article brought to you by BESydney.

In July 2024, Sydney woman Katherine Bennell-Pegg made history as the first astronaut to graduate under the Australian flag and the first female astronaut in Australia. Her journey, marked by determination and discipline, showcases Australia’s growing prominence in space exploration and research.

From her academic achievements at the University of Sydney (USYD) to her rigorous training at the European Space Agency (ESA), Bennell-Pegg’s success has paved a path forward for aspiring space and aerospace professionals in Australia and globally.

A journey to the stars begins in Sydney

Katherine Bennell-Pegg was born in Sydney, New South Wales, and grew up in the Northern Beaches area. Her fascination with space began at an early age.

“I always dreamed of being an astronaut,” Bennell-Pegg shared in her “Insights from an Australian Astronaut” Space Forum Speech in July 2024. “When I was young, it was for the adventure, but after more than a decade working in space, it’s now because I know the role it plays in tackling real-world problems and developing new knowledge that can benefit our society, environment and science.”

Sydney: A Hub for Space Innovation

Sydney, the vibrant heart of the state of New South Wales (NSW), stands at the forefront of aerospace innovation in Australia. With its world-class research facilities, leading academic institutions and strategic geographic positioning, Sydney is not only Australia’s gateway to the Indo-Pacific but also a burgeoning hub for international aerospace endeavours.

NSW is home to more than 40 per cent of Australia’s aerospace industry. Substantial investments from both the state and federal governments support this concentration of capabilities, underpinning Sydney’s role as a leader in aerospace. From advanced manufacturing and cybersecurity to quantum technologies and space exploration, this progressive city is truly thriving.

Sydney’s appeal as a desirable location for hosting aerospace conferences and business events is bolstered by its comprehensive infrastructure, vibrant startup community and strategic position as a transport hub.

Sydney’s track record of successfully hosting events highlights the city’s ability to organise impactful international gatherings, including:

• Australian Space Summit
• New Horizons Summit
• CubeSatPlus2024 - NEW SPACE: Unbounded Skies

Sydney will also host the 76th International Astronautical Congress from 29 September to 3 October 2025 and the 34th Congress of the International Council for the Aeronautical Sciences (ICAS) to be held 13 to 17 September 2026. Both will take place at ICC Sydney, further solidifying Sydney’s status as a central hub for aerospace events.

Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au

Sydney proved to be the ideal location for Bennell-Pegg’s journey to begin. She studied at the University of Sydney, where she earned a Bachelor of Engineering (Honors) in Aeronautical Engineering (Space) and a Bachelor of Science (Advanced) in Physics.

Sydney’s universities are at the forefront of aerospace education and research. Institutions such as the University of Sydney (USYD), the University of New South Wales (UNSW Sydney) and the University of Technology Sydney (UTS) attract students from around the world. UNSW Sydney, with its School of Aerospace, Mechanical, and Mechatronic Engineering, is renowned for its innovative research in space technology and satellite systems, while UTS provides cutting-edge programs in aerospace engineering and physics, emphasizing practical applications and industry partnerships. USYD excels in aeronautical engineering and space science, supported by advanced facilities and strong ties to major aerospace organisations. Together, these universities offer comprehensive programs that integrate theoretical knowledge with hands-on experience, preparing students for dynamic careers in the rapidly evolving aerospace and space sectors.

Having excelled in her studies at USYD, Bennell-Pegg was awarded the Charles Kuller Graduation Prize for her top-placed undergraduate thesis. Subsequently, her quest for knowledge took her to Europe, where she earned two Master of Science degrees: one in Astronautics and Space Engineering from Cranfield University and another in Space Technology from Luleå University of Technology.

Reflecting on her educational path, Bennell-Pegg stated, “With the encouragement of my parents, I researched what it would take to become an astronaut and worked hard at school, participating in everything from aerobatic flying lessons to amateur astronomy.”

Inside the rigorous training regimen of an astronaut

Bennell-Pegg’s professional career began with roles at Airbus UK, where she contributed to numerous space missions and concept studies, such as Martian in-situ resource utilisation and space debris removal. Her expertise led her to the Australian Space Agency, where she became the Director of Space Technology.

In 2021, Bennell-Pegg was invited by the European Space Agency (ESA) to undertake Basic Astronaut Training at the European Astronaut Centre in Germany. When the ESA application opened in 2021, it was the first opening in 15 years. Bennell-Pegg jumped at the opportunity to apply alongside over 22,000 others from 22 countries. She endured six knock-out rounds, including medical, psychometrics, psychology and technical tests and made it to the group of 25 who passed.

This historic invitation marked the first time an international astronaut candidate was offered training by the ESA.

“The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.”—Katherine Bennell-Pegg

Bennell-Pegg’s training regimen was intense, encompassing physical conditioning, complex simulations, and theoretical classes designed to prepare candidates for long-duration missions to the International Space Station (ISS) and beyond. This included:

• Studies in biology, astronomy, earth sciences, meteorology, materials, medical and fluids, both in theory and in labs.
• Radiation research – an area of expertise for Australia. This will increase as humans travel back to the Moon.
• Medical operations: Astronauts need to be able to perform medical procedures on themselves and others.
• Training for expeditions: This included honing team dynamics through behavioral training, ocean and winter survival training, rescue and firefighting.

Sharing her thoughts on this transformative experience, Bennell-Pegg said, “The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.”

In April 2024, Bennell-Pegg completed her training, graduating with her ESA classmates from “The Hoppers” group. Upon graduation, she became fully qualified for assignments on long-duration missions to the ISS, making her the first Australian female astronaut and the first person to train as an astronaut under the Australian flag.

“I want to use this experience to open doors for Australian scientists and engineers to utilize space for their discoveries,” Bennell-Pegg said. “I hope to inspire the pursuit of STEM careers and show all Australians that they too can reach for the stars.”

Elevating Australia’s role in space exploration

Katherine Bennell-Pegg’s achievements represent a significant milestone. Her journey from the University of Sydney to the rigorous training programs at the European Astronaut Centre showcases the potential of Australian talent in the global space community.

“Being the first astronaut trained under the Australian flag is an incredible honor,” Bennell-Pegg said. “I’m grateful for the support that has fueled me through intense training and opened doors for more Australians in space exploration. Whether I fly or not, there is much to accomplish here on Earth. I’m excited to leverage this experience to inspire future generations in STEM and elevate Australia’s presence in the global space community. Becoming an astronaut is just the beginning.”

Bennell-Pegg’s dream to become an Australian astronaut is more than just a personal triumph; it is a win for anyone who aspires to a career in space or aerospace. Sydney, with its world-class educational institutions, advanced manufacturing facilities scheduled for the Western Sydney Aerotropolis and expanding opportunities in aerospace and defence, is an ideal starting point for anyone looking to make their mark in these sectors.

Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au

Humans perfected how to identify wild animals over millennia, and now biologists are rediscovering the exceptional worth of the tracks and marks left behind

Harris has made history multiple times over.

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The former president thinks Joe Biden 'nailed this decision.'

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Solar storms have the ability to harm astronauts and force massive blackouts

New NatGeo documentary was directed by the same duo who brought us the Oscar-winning Free Solo.

On “The Alex Marlow Show” on Tuesday, Breitbart Editor-in-Chief and host Alex Marlow mocked Ivy League schools like Yale for degrading themselves with things like Yale’s Beyoncé course. Marlow said, “Yale University’s going to offer a Beyoncé makes history course in 2025. So, that’s what they’re doing. We’re just kicking butt and taking names and then they’re — they’ve got a new Beyoncé course over at Yale. Do the Ivy Leagues know that they degrade themselves and debase themselves? I love it. Because, as people have been pointing out, there’s no surer sign of people moving to the left than…when they go to college. That’s where it’s at. That is the fountain of leftism in our society…the universities. … And, not to mention, they infect our cities.” “The Alex Marlow Show,” hosted by Breitbart Editor-in-Chief Alex Marlow, is a weekday podcast produced by Breitbart News and Salem Podcast Network. You can subscribe to the podcast on YouTube, Rumble, Apple Podcasts, and Spotify. Follow Breitbart.tv on Twitter @BreitbartVideo

The post Alex Marlow: Yale Embarrasses Itself with Woke ‘Beyonce Makes History’ Course appeared first on Breitbart.

Marvel Animation’s ‘What If...?’ Season 3 trailer has revealed new characters and genres. The final season will premiere on Disney Plus on December 22, 2024

At Anime NYC this weekend, Aniplex USA shared more details for its upcoming 3D action RPG Alterna Vvelt: Blue Exorcist …

Continue reading "3D Action RPG ‘Alterna Vvelt: Blue Exorcist Another Story’ From Aniplex Gets a New Trailer Ahead of Its Launch on Mobile and PC"