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Suspected Metallic Embolization Distal to Coiled Intracranial Aneurysms Detectable by Susceptibility-Weighted MR Imaging [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

After endovascular coiling of intracranial aneurysms, round dark parenchymal lesions believed to be particulate metal are sometimes encountered in MR imaging studies of the brain. We used SWI to assess the frequency of such occurrences, in addition to exploring likely causes and clinical implications.

MATERIALS AND METHODS:

We reviewed 700 MR imaging studies performed between September 2018 and March 2019 at our institution as follow-up monitoring of coiled intracranial aneurysms. Any sizeable (>5 mm) rounded dark-signal lesions encountered were presumed to be metallic. The magnitudes and locations of such lesions were recorded. In patients with these lesions, pertinent procedural documentation was screened for devices used, including coils, microcatheters, microguidewires, and stents. Medical records were also examined to determine whether any related symptoms ensued.

RESULTS:

Twenty patients (2.8%) exhibited a total of 25 lesions on SWI. Diameters ranged from 5 to 11 mm (median, 8 mm). All except 2 lesions were located in brain regions downstream from aneurysms, but all lesions occupied vascular territories of vessels used to place guiding catheters. Other than the Synchro 14, which was routinely deployed, no device was regularly used in patients with SWI-detectable lesions; and none of the affected patients developed focal neurologic symptoms as a consequence.

CONCLUSIONS:

Although the origins remain unclear, distal embolization of particulate metal distal to coiled cerebral aneurysms is occasionally observed on follow-up MR imaging studies. Such lesions, however, seem to have no apparent clinical impact.




liz

Anoxic Brain Injury Detection with the Normalized Diffusion to ASL Perfusion Ratio: Implications for Blood-Brain Barrier Injury and Permeability [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Anoxic brain injury is a result of prolonged hypoxia. We sought to describe the nonquantitative arterial spin-labeling perfusion imaging patterns of anoxic brain injury, characterize the relationship of arterial spin-labeling and DWI, and evaluate the normalized diffusion-to-perfusion ratio to differentiate patients with anoxic brain injury from healthy controls.

MATERIALS AND METHODS:

We identified all patients diagnosed with anoxic brain injuries from 2002 to 2019. Twelve ROIs were drawn on arterial spin-labeling with coordinate-matched ROIs identified on DWI. Linear regression analysis was performed to examine the relationship between arterial spin-labeling perfusion and diffusion signal. Normalized diffusion-to-perfusion maps were generated using a custom-built algorithm.

RESULTS:

Thirty-five patients with anoxic brain injuries and 34 healthy controls were identified. Linear regression analysis demonstrated a significant positive correlation between arterial spin-labeling and DWI signal. By means of a combinatory cutoff of slope of >0 and R2 of > 0.78, linear regression using arterial spin-labeling and DWI showed a sensitivity of 0.86 (95% CI, 0.71–0.94) and specificity of 0.82 (95% CI, 0.66–0.92) for anoxic brain injuries. A normalized diffusion-to-perfusion color map demonstrated heterogeneous ratios throughout the brain in healthy controls and homogeneous ratios in patients with anoxic brain injuries.

CONCLUSIONS:

In anoxic brain injuries, a homogeneously positive correlation between qualitative perfusion and DWI signal was identified so that areas of increased diffusion signal showed increased ASL signal. By exploiting this relationship, the normalized diffusion-to-perfusion ratio color map may be a valuable imaging biomarker for diagnosing anoxic brain injury and potentially assessing BBB integrity.




liz

Do the Magic Angle Effects or Susceptibility Effects Affect the Visualization of Nigrosome 1? [LETTERS]




liz

A Practical Guide to Personalized Video Strategy (+ 5 Interactivity Types For Your Brand’s Videos)

There’s the technical definition of personalized marketing: the collection and analysis of prospect data to implement an enterprise marketing strategy for custom segments And then […]

The post A Practical Guide to Personalized Video Strategy (+ 5 Interactivity Types For Your Brand’s Videos) appeared first on e-Learning Feeds.




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Jason Kenney calls Elizabeth May, Yves-François Blanchet 'un-Canadian,' accuses them of 'blaming the victim'

David J. Climenhaga

Now that Premier Jason Kenney has declared it "un-Canadian" to say oil is dead, I wonder if it's OK to admit Alberta's fossil fuel industry is on the ropes?

Probably. Kenney said as much himself in a remarkable rant yesterday directed at the parliamentary leader of the Bloc Québécois and the former leader of the Green Party of Canada.

But if you don't want to be accused of un-Canadian activities, you'd better make it clear none of these troubles are the fault of anything that's ever been done by any Alberta government, except perhaps the NDP's, and especially not by the United Conservative Party Kenney leads.

There is acceptable speech in Alberta, you see, and it doesn't include saying that oil is done like dinner, which is probably not true just yet, but is nevertheless a position that can be argued in respectable company almost anywhere else in the world, including a number of countries known for producing what Kenney rather sophomorically calls "dictator oil."

As has become his practice lately, Kenney took over Chief Medical Officer of Health Deena Hinshaw's daily COVID-19 briefing in Edmonton yesterday afternoon for the sustained blast of gaslighting he directed at Yves-François Blanchet and Elizabeth May.

Blanchet had dared to suggest at a news conference Wednesday that oil "is never coming back" (uttered en francais, bien sûr) and that Ottawa's bailout package should really be directed at "something which is more green." May, for her part, opined at the same event that "oil is dead."

Specifically, the MP for Saanich-Gulf Islands told the media: "My heart bleeds for people who believe the sector is going to come back. It's not. Oil is dead and for people in the sector, it's very important there be just transition funds." This may be wrong, but outside Alberta I doubt it sounds like a stab in the back or a curb-stomping.

Nevertheless, that is what sent Kenney over the edge, in a calculated sort of way, responding to a set-up question provided by Calgary Sun political columnist Rick Bell, who can be counted on to get the first question at one of Hinshaw's frequently hijacked news conferences.

"I just think it's deeply regrettable that we would see national political leaders piling on Albertans and energy workers at a time of great trial for us," Kenney said piously, opening what appeared to be a carefully rehearsed answer. "This is the opposite of leadership. Leaders should be seeking to bring us together, not to divide us."

This is a bit of an irony, of course, coming from a premier who has been ginning up an Alberta separatist threat for months while denying the oil industry had anywhere to go but up, but let's just take it as a lesson in gaslighting 101.

In his remarks, Kenney trotted out benefits he said have been conferred on Quebec by Alberta's oil industry, noted the province's equalization complaints, blamed "predatory actions" by OPEC countries that "want to dominate the world with dictator oil," reminded Quebeckers they like to drive cars and go on airplane trips, and totted up the medical equipment recently sent by Alberta to other provinces.

Having said it in English, he said it over again in French.

Tsk-tsking and shaking his head, Kenney declared, "I would say to Mr. Blanchet and Madam May: Please stop kickin' us while we're down!"

"These attacks on our natural resource industries are unwarranted, they are divisive, they're, I believe, in a way, un-Canadian at a time like this. It's like blaming the victim!" (Italics added for emphasis. And, yes, Kenney really said that.)

Premier Kenney also took particular umbrage at Blanchet's remark that Quebec receives a string of insults from Alberta -- although anyone who has paid attention to political discourse in this province for the last half century would have trouble refuting the claim.

After the news conference, backup was provided in columns filed by Bell and his Postmedia colleague Don Braid.

Bell pronounced Blanchet and May to be "the Bobbsey Twins of B.S." and the "deluded duo," and accused them of choosing "to kick Alberta when we're down" and indulging "in a little curb-stomping."

Braid, the Dinger's bookend of acceptable oilpatch opinion, charged them with "the foulest kind of cheap shot," to wit, saying "Alberta's oil and gas industry should be left prostrate in the dust with no help from the federal government."

Well, there you have it: the debased state of political discourse in Alberta in the plague year 2020. It's not reassuring.

David Climenhaga, author of the Alberta Diary blog, is a journalist, author, journalism teacher, poet and trade union communicator who has worked in senior writing and editing positions at The Globe and Mail and the Calgary Herald. This post also appears on his blog, AlbertaPolitics.ca.

Image: Screenshot of Government of Alberta video/YouTube




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Dual personalities visualized for shape-shifting molecule

Researchers have made a breakthrough in understanding the structure of a key genetic molecule, called RNA, and revealing for the first time how these changes impact RNA's function. The research team developed a bioinformatics technique to resolve separate structures of RNA rather than viewing them as a 'blur' that averaged multiple structures. This underpinned their discovery that the structure of RNA can influence how cells function.




liz

'I Was A Feminist Activist In The '70s When The Pill Was Legalized For All Women'

It has been 60 years since the FDA first approved the birth control pill on May 9, 1960. It emerged as an essential pillar of women's ability to have good quality of life.




liz

Scientists Identify SARS-CoV-2-Neutralizing Antibody

A team of researchers from Utrecht University, the Erasmus Medical Center and Harbour BioMed has identified a human monoclonal antibody that neutralizes SARS-CoV-2 and SARS-CoV-1 coronaviruses in cell culture. Named 47D11, this cross-neutralizing antibody targets a communal epitope (antigenic determinant) on these viruses and may offer potential for prevention and treatment of COVID-19. “This research [...]




liz

Activision Blizzard and EA report a strong first-quarter

Stay home, keep gaming




liz

San Francisco COVID-19 testing reveals stark burden on the poor and marginalized

A COVID-19 mass testing effort within San Francisco's Mission District  — which aimed to broadly test individuals regardless of symptoms  — found stark inequalities in how the virus is affecting different groups. About 95% of the people who tested positive were Latino, and the vast majority could not work from home. Not a single white person tested positive, despite making up about a third of the people who were tested. 




liz

Invasive 'comb' jellyfish cannibalize their young when food is scarce, study reveals

An strange, invasive species of jellyfish in Europe eats its own young when food is low, a new study claims.




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Brookfield launches $5 billion ‘retail revitalization’ program to prop up retailers hit hard by pandemic

Brookfield, known for its contrarian bets on malls, will take minority stakes in struggling retailers



  • Retail & Marketing
  • FP Street
  • News
  • Brookfield Asset Management Inc.

liz

Trump finalizes plans to open Utah monuments for mining and drilling

Lawsuits are pending from groups who have challenged the constitutionality of shrinking Bears Ears and Grand Staircase-Escalante

Plans finalized on Thursday for two national monuments in Utah downsized by Donald Trump would ensure that lands previously off-limits to energy development will be open to mining and drilling.

The move comes despite pending lawsuits from conservation, tribal and paleontology groups, who have challenged the constitutionality of the president’s action. The Trump administration slashed the size of Bears Ears national monument by 85% and Grand Staircase-Escalante national monument by nearly half in December 2017, in what represented the largest elimination of public lands protections in US history.

Conservation groups criticized the Trump administration on Thursday for spending time on management plans they believe will become moot when the court sides with their assertion that Trump misused the Antiquities Act to reverse decisions by previous presidents.

Continue reading...




liz

When Illness Strikes, Vampire Bat Moms Will Still Socialize With Their Kids

Studying how bats behave when they’re feeling ill could help researchers better understand how pathogens move through close-knit populations




liz

Physicists shed light on the nanoscale dynamics of spin thermalization

In physics, thermalization, or the trend of sub-systems within a whole to gain a common temperature, is typically the norm. There are situations, however, where thermalization is slowed down or virtually suppressed; examples are when considering the dynamics of electron and nuclear spins in solids. Understanding why this happens and how it can be controlled is presently at the center of a broad effort, particularly for applications in the emerging field of quantum information technologies.




liz

Blood thinners may improve survival among hospitalized COVID-19 patients

Treating hospitalized COVID-19 patients with anticoagulants -- blood thinners that slow down clotting -- may improve their chances of survival, researchers report. The study could provide new insight on how to treat and manage coronavirus patients once they are admitted to the hospital.




liz

Individualized mosaics of microbial strains transfer from the maternal to the infant gut

Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes.




liz

Neutralizing antibody; new virus details to aid vaccine research

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.




liz

VDI in the Age of Covid-19: Remote Work and the Challenge of the Virtualized Client

These are trying times, not least because corporate life needs to go on, which for millions of businesses means delivering compute resources…




liz

'Never give up, never despair': Queen Elizabeth II's speech recalls royal father, WWII victory in 1945

Britons marked the 75th anniversary of WWII victory with a speech by Queen Elizabeth II, the only British leader left who was there on May 8, 1945.

      




liz

Big Night In: Coronation Street's Liz McDonald crashes EastEnders sketch

Liz McDonald crashed the Queen Vic's virtual pub quiz




liz

From Elizabeth Arden to Essie: Queen Elizabeth II's beauty cupboard contents revealed

Get the royally-approved glow




liz

Queen Elizabeth style file: a look back over the fashion choices of our longest-reigning monarch

As Queen Elizabeth II turns 94 today, we reminisce about her greatest-ever looks




liz

Book review: Looking for Eliza by Leaf Arbuthnot

A widow, a millennial and a cup of Lapsang tea




liz

Microsoft cloud annualized run rate hits $13bn in strong first quarter

Surface revenue was also strong, up 38 percent year on year.




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Jackie Mullins at the Lizard Lounge




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Pentagon: Coronavirus Hospitalizations ‘Permanently Disqualify’ U.S. Military Recruits

Applicants who have tested positive for the virus but did not require hospitalization will still be allowed to enlist




liz

Watch! Lizzo Reveals Her Vigorous Workout Routine On TikTok



See how the star is creating fitness goals!




liz

CCNY physicists shed light on the nanoscale dynamics of spin thermalization

In physics, thermalization, or the trend of sub-systems within a whole to gain a common temperature, is typically the norm. There are situations, however, where thermalization is slowed down or virtually suppressed; examples are when considering the dynamics of electron and nuclear spins in solids. Understanding why this happens and how it can be controlled is presently at the center of a broad effort, particularly for applications in the emerging field of quantum information technologies.




liz

Ancient DNA paints genetic portrait of Andes civilizations

An international team of researchers including the University of Adelaide, has completed the first large-scale study of DNA belonging to ancient humans of the central Andes in South America and found early genetic differences between groups of nearby regions, and surprising genetic continuity over thousands of years.




liz

Individualized mosaics of microbial strains transfer from the maternal to the infant gut

Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes.




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Three Drugs Better Than One in Hospitalized COVID-19 Patients

(MedPage Today) -- Patients hospitalized with COVID-19 who received a combination therapy with three antivirals -- protease inhibitor lopinavir-ritonavir (Kaletra), nucleoside analogue ribavirin, and injectable interferon beta-1b (Betaseron...




liz

Queen's Brian May hospitalized for butt injury after 'over-enthusiastic gardening'

"I managed to rip my Gluteus Maximus to shreds," Queen guitarist Brian May shared on Instagram, along with a photo of himself sporting a mask in the hospital.




liz

Toronto man looking for Elizabeth Gallagher inspires new ticket-sharing website


Connections allows users to post spare plane tickets and the name of the person the ticket is registered to in hopes of finding a traveler with the same name.




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TTB Finalizes Portions of Modernization of Advertising and Labeling Regulations for Wine, Distilled Spirits, and Malt Beverages Rule

#TTB just made changes to modernize the way that #wine, #distilledspirits, and #maltbeverages are labeled and advertised. KKB associate Dan Logan and partner Dan Dwyer highlight some of the key changes (and proposals that were rejected).

The post TTB Finalizes Portions of Modernization of Advertising and Labeling Regulations for Wine, Distilled Spirits, and Malt Beverages Rule appeared first on Kleinfeld Kaplan & Becker LLP.




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New Fluorescence Microscopy Technique for Nanostructure Visualization Within Cells

Researchers at Purdue University have developed a new technique to dramatically enhance the resolution achievable when imaging intracellular structures with super-resolution fluorescence microscopy. The technique uses the distortions created by a specimen to pinpoint the location of individual molecules, and thereby infer the location of intracellular structures. The technique could be particularly useful in studying […]




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Bayer launches pre-filled syringe to administer eye medication Eylea™ in Europe (for specialized target groups only)




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Southern Union Company Is Penalized $18 Million for Illegally Storing Mercury at a Rhode Island Site

A federal judge today assessed the Southern Union Company $18 million for illegally storing mercury at a company-owned site in Pawtucket.



  • OPA Press Releases

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Assistant Attorney General Thomas E. Perez Delivers Remarks at Naturalization Ceremony for 50 Citizenship Candidates

You are about to become our newest citizens. Hailing from 24 different countries, each of you represents a different culture, a different language, a different way of dress. But you will each now be American.




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Florida Man Who Served in Military Unit Linked to Massacres During the Bosnian Conflict of 1992-1995 Leaves United States Following Denaturalization

A former member of the Bosnian Serb Army has left the United States to return to Serbia after a federal judge ordered his denaturalization based on concealment during his application for U.S. citizenship that he served in the military during the Bosnian war.



  • OPA Press Releases

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Judge Orders State of Florida to Provide Community Services to Jacksonville Woman at Risk of Institutionalization

The state of Florida must provide Michele Haddad with services that will enable her to remain in her home, a U.S. District Court in Jacksonville, Fla., ruled Wednesday.



  • OPA Press Releases

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United States Takes Action to Reduce Hazards from Fertilizer Manufacturing Plant in Florida

CF Industries Inc. has agreed to spend approximately $12 million to implement facility-wide operational changes to reduce and properly manage hazardous wastes generated at its Plant City, Fla., phosphoric acid and ammoniated fertilizer manufacturing facility.



  • OPA Press Releases

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Former Guatemalan Special Forces Soldier Sentenced to 10 Years in Prison for Making False Statements on Naturalization Forms Regarding 1982 Massacre of Guatemalan Villagers

Gilberto Jordan, a former Guatemalan special forces soldier, was sentenced today by U.S. District Judge William J. Zloch in the Southern District of Florida to 10 years in prison for unlawfully procuring his U.S. citizenship by lying about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.



  • OPA Press Releases

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Justice Department Issues Report on 10th Anniversary of the Religious Land Use and Institutionalized Persons Act

The Justice Department today issued a report marking the 10th anniversary of the Religious Land Use and Institutionalized Persons Act (RLUIPA), showing that the law has had a positive impact on protecting the religious freedom of a wide range of faith groups, and had a particularly significant impact protecting the religious freedom of minorities.



  • OPA Press Releases

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U.S. Clean Water Act Settlement in Northeast Ohio to Protect Lake Erie, Revitalize Neighborhoods and Create Green Jobs

A comprehensive Clean Water Act settlement with the Northeast Ohio Regional Sewer District (NEORSD) will address the flow of untreated sewage into Cleveland area waterways and Lake Erie.



  • OPA Press Releases

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Iranian National Charged with Illegally Exporting Specialized Metals from the United States to Iran

Milad Jafari, 36, a citizen and resident of Iran has been indicted for illegally exporting and attempting to export specialized metals from the United States through companies in Turkey to several entities in Iran, including some entities that have been sanctioned for involvement in ballistic missile activities.



  • OPA Press Releases

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Wisconsin Man Charged with Sexual Exploitation of Minor in Belize

Today a grand jury in the Eastern District of Wisconsin returned a one-count indictment against U.S. citizen Roland J. Flath for traveling in foreign commerce and engaging in and attempting to engage in illicit sexual conduct with a minor less than 18 years of age.



  • OPA Press Releases

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Justice Department Announces More Than $130 Million in Cost Saving and Efficiency Measures to Utilize Resources More Effectively

As part of Attorney General Eric Holder’s call for cost-cutting measures to streamline operations and reduce spending during a time of constrained funding, the Department of Justice today announced that it will realign functions in various offices, lower lease costs by consolidating or reducing office space and continue to look for ways to more effectively utilize the department’s resources.



  • OPA Press Releases

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Deputy Attorney General James M. Cole Speaks at the Office of Small and Disadvantaged Business Utilization Small Business Procurement Conference

"At the Department of Justice, we know that small businesses are adaptable and innovative. We have come to rely on them to support many of our most important missions, from ensuring the national security to combating violent crime, fighting financial fraud, and protecting those most in need of our help – our children; the elderly; and victims of hate crimes, human trafficking and exploitation," said Deputy Attorney General Cole.




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Acting Associate Attorney General Tony West Speaks at the United Neighborhood Centers of America Neighborhood Revitalization Conference

"For more than a century, UNCA has worked to improve conditions in distressed neighborhoods and restore opportunity to those who live there," said Acting Associate Attorney General West.