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Vintage railway posters redesigned to encourage tourists to delay holidays until after lockdown

Posters have been reimagined to include slogans including 'visit when this is all over' and 'no swimming today'




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Coronavirus: Holidays at risk as Boris Johnson set to announce 14 day quarantine for travellers arriving in UK

'Quarantine would not only have a devastating impact on the UK aviation industry, but also on the wider economy,' said Karen Dee, chief executive of the Airport Operators' Association




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Max Verstappen lifts lid on life in lockdown as Red Bull star picks between F1 and esports



Max Verstappen is keeping himself busy by taking part in esports races.




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Maldives holidays: Why you’ll never be bored at paradise resort Kandima Maldives



MALDIVES holidays are on the bucket list of so many Britons thanks to the picture postcard-worthy scenery and year-round sun. Kandima Maldives is one of many hotels in the Indian Ocean nation, so what makes it stand out? This writer headed to the resort to find out.




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Greece holidays: Take the plunge in amazing Athens



From classic culture to stylish food, enjoy being pampered in Greece.




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5 Tips To Keep In Mind When Planning A Schengen Holiday

The Schengen area comprises of 26 beautiful countries and each of them offers an array of unique and awesome destinations for the travellers looking for a wonderful holiday. There are the popular places like Paris...

The post 5 Tips To Keep In Mind When Planning A Schengen Holiday appeared first on Geeky Traveller.




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When can we go on holiday again? The experts have their say on when we can travel again



HOLIDAYS have been put on hold due to the coronavirus pandemic which has killed more than 100,000 people worldwide. When can we go on holiday again?




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UK holidays: Travel experts reveal their best staycation spots in the UK for post-lockdown



UK HOLIDAYS and staycations are becoming more sought after since the coronavirus pandemic sent most the world into lockdown back in March. With many planning their next staycation, the Trip Sisters gave their verdict on the best UK destinations for your next trip.




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UK arrivals now face a mandatory 14-day quarantine - could holidays be changed forever?



THE GOVERNMENT is to enforce a new rule which will see all travellers arriving into the UK being instructed to go into a 14-day quarantine period. It is not yet known how this rule will be enforced, or for how long, but it has the potential to change the way we experience holidays.




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Dubai holidays: Hotels could be up to 60 percent cheaper in a bid to lure back tourism



DUBAI hotels are slashing prices by up to 60 percent as part of its wider plans to boost tourism to the country.




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Summer holidays banned? Leaked travel quarantine plan 'shuts down UK borders for months'



UK HOLIDAYMAKERS have been urged not to book a summer holiday abroad following the Government's leaked airport quarantine plan, according to a leading aviation expert.




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Unemployment fears mount in UK holiday hotspots with mass job cuts predicted



BRITAIN'S summer holiday destinations will face some of the biggest economic hits of the coronavirus pandemic with fears of massive job losses in coastal communities, a study has claimed.




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Top 12 dreamy infinity pool holidays to recoup from coronavirus crisis



INFINITY pools can offer a dreamy escape from the current situation with seamless views over dazzling skylines, land and sea.




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If you're planning to spend Bank Holiday weekend in the garden you need to read this



A little TLC can create a lovely green oasis in your garden to be proud of




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Garden centres open: When will garden centres reopen? Will they be open in bank holiday?



GARDEN CENTRES closed their doors as the UK lockdown began but many are now facing calls to reopen as Brits up and down the country look for new ways to spend their extra hours at home. When will garden centres reopen? Will they be open in bank holiday?




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VE Day movies: The Top 8 war movies to watch over the Bank Holiday



VE DAY is one of the most important anniversaries in British history - and in time for the bank holiday, a huge number of incredible war films are available to watch.




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UK holidays: Travel experts reveal their best staycation spots in the UK for post-lockdown



UK HOLIDAYS and staycations are becoming more sought after since the coronavirus pandemic sent most the world into lockdown back in March. With many planning their next staycation, the Trip Sisters gave their verdict on the best UK destinations for your next trip.




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UK holidays: The best hiking locations in the UK for post-lockdown breaks



UK HOLIDAYS have become even more popular as holidaymakers ditch their summer holiday plans for future staycation breaks. Here's a list of the best hiking destinations in the UK to get you ready for that post-lockdown break.




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UK arrivals now face a mandatory 14-day quarantine - could holidays be changed forever?



THE GOVERNMENT is to enforce a new rule which will see all travellers arriving into the UK being instructed to go into a 14-day quarantine period. It is not yet known how this rule will be enforced, or for how long, but it has the potential to change the way we experience holidays.




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Dubai holidays: Hotels could be up to 60 percent cheaper in a bid to lure back tourism



DUBAI hotels are slashing prices by up to 60 percent as part of its wider plans to boost tourism to the country.




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Summer holidays banned? Leaked travel quarantine plan 'shuts down UK borders for months'



UK HOLIDAYMAKERS have been urged not to book a summer holiday abroad following the Government's leaked airport quarantine plan, according to a leading aviation expert.




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Liverpool and Newcastle lead Kalidou Koulibaly transfer race after Man Utd and PSG move



Liverpool and Newcastle are leading the way for Kalidou Koulibaly.




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Cruise: Norwegian Cruises extend travel suspension - can holidaymakers get refunds?



NORWEGIAN CRUISES is the latest cruise line to extend its sailing suspension, with holidays now cancelled right up until June 30. Can cruisers get their money back?




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Cruise: How to plan for a cruise holiday without breaking the bank



CRUISE holidays are on hold for now, however, many cruise enthusiasts continue to hold out hope for future cruises. For those looking to cruise in the future, but faced with a tighter budget, the good news is there are some ways you can save on sailings.




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WATCH: Top travel writers reveal why they love cruise holidays in inspiring video



CRUISE ship holidays were a popular vacation choice for many Britons before the coronavirus pandemic struck. The crisis has hit the industry hard, leaving some reluctant to go on a cruise again - but now 12 travel writers have united to reveal why they love cruising so much.




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Cruise: Travellers must abide by these strict protocols for future cruise holidays



CRUISE holidays are currently on hold, but new plans to implement safety regulations means that travellers must fit certain health criteria in order to sail. What will the new measures entail?




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Great way to spend holiday cash: '100 Years, 500 Miles' historic Indy 500 book

Coffee table picture book tells the 100-year history of the famous race

       




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'Coronavírus pode acabar com minha oportunidade de ser mãe': mulheres sofrem com suspensão de tratamento de fertilidade

Casais com problemas de fertilidade que estavam passando por processo de fertilização in vitro no Brasil temem perder chance de ter filhos por causa da pandemia.




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A China vai superar os EUA como liderança do mundo pós-coronavírus?

Como política de Trump amplia espaço para China conquistar influência.




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When Michael Jordan collided with Bloomington, Bob Knight and the Olympic Trials in 1984

Michael Jordan spent the spring of 1984 in Bloomington before he became Michael Jordan

       




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Holiday brothers would be eager to team up: 'We'd be good, too'

Justin (the oldest) and Aaron (the youngest) Holiday play for the Indiana Pacers; Jrue Holiday is the best-known of the brothers in the NBA.

      




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10 things that annoy me when booking holidays online

Today I read a great post on Travelrants called Ten things that annoy me about booking holidays online. Darren made a list of 10 things that annoy him while booking holidays online. It’s clearly the kind of feedback/information people that work for Online Travel Agencies or Hotel Portals would love to gather from their visitors. That’s [...]




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Coronavirus: Bank holiday warning to avoid beauty spots

Emergency services and other authorities say travel to beaches and national parks will "cost lives".




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Teen injured after colliding with two cars while cycling in Streatham

A 16-year-old boy suffers life-threatening injuries in an apparent double hit-and-run, police say.




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VE Day: Berlin marks end of WW2 in Europe with unprecedented holiday

It is a one-off holiday in the German capital, but some think it should be marked nationally each year.




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Baby Yoda toys are finally arriving. Sure, they missed the holidays — but at least that prevented spoilers.

Products for the popular character from the Disney Plus hit "The Mandalorian" are about to hit stores.




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The newest hope to beat the traffic: a ‘flying’ water taxi that glides across town

The SeaBubble is a new form of urban transportation that could offer Parisians a watery alternative to hailing a taxi, driving a car or hopping on an electric scooter.




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Week 16 waiver wire tips: Surprisingly solid options to win your fantasy football league

Sleep easy knowing that no matter what next week’s injury report reveals, you will have the players you need to secure a year’s worth of bragging rights.




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The Digital Development Group is Seeing Tremendous Growth in Holiday Sales for Internet TV Devices

The Digital Development Group foresees dynamic growth in its industry. “On Nov. 21st we launched our first channel. We are excited to announce 5 more channels coming before year-end. On the heels of those developments we believe it is important to continue to define our mission.”

DigiDev is targeting the revolutionary “OTT” technology arena. “OTT” or Over The Top devices piggyback on existing network services in consumers’ homes or offices; pull content from the Internet and deliver it to their TV or Internet enabled device. DigiDev uses OTT technology to deliver programming to billions of desktops, mobile and smart/Internet enabled TV devices around the world.

“The market for digital distribution to 'smart' (Internet enabled) devices (smart-TV, tablet, smart-phones) continues to grow at an astonishing rate,” states Martin W. Greenwald, Chairman and CEO of DigiDev. “AppleTV, GoogleTV, and Roku sales this Holiday season are running considerably ahead of last year’s tally.”




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velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform




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Woman, 70, airlifted in serious condition after car collides with transport truck in Huntsville




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BREAKING: MI Lawmakers File Lawsuit Challenging Governor’s “Improper” and “Invalid” Emergency Orders: “We’ve attempted to partner with our governor, but she’s rejected”

The following article, BREAKING: MI Lawmakers File Lawsuit Challenging Governor’s “Improper” and “Invalid” Emergency Orders: “We’ve attempted to partner with our governor, but she’s rejected”, was first published on 100PercentFedUp.com.

In addition to crushing Michigan's economy, the governor's reckless, one-size-fits-all executive orders are harming an untold number of Michigan citizens.

Continue reading: BREAKING: MI Lawmakers File Lawsuit Challenging Governor’s “Improper” and “Invalid” Emergency Orders: “We’ve attempted to partner with our governor, but she’s rejected” ...




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Latin America’s COVID-19 Moment: Differences and Solidarity

30 April 2020

Dr Christopher Sabatini

Senior Research Fellow for Latin America, US and the Americas Programme
There has been no better example of the political diversity in Latin America than the varying responses of governments to the coronavirus crisis.

2020-04-30-Chile-Covid.jpg

A municipal cleaning worker disinfects the central market in Santiago, Chile on 7 April 2020 amid the coronavirus pandemic. Photo: Getty Images.

Differing approaches across the hemisphere have had different impacts on presidential popularity and, at least in one case, on democratic institutions and human rights. Yet, even within that diversity, South America’s Southern Cone countries (Argentina, Chile, Paraguay and Uruguay) have shown a sign of solidarity: protecting and facilitating trade flows, sponsoring cross-border research and ensuring citizens’ return to their home countries.    

The response from populist leaders

On the extreme have been the responses of presidents of Brazil, Nicaragua and Mexico, all of whom have ignored the science of the virus and of experts and refused to implement isolation policies.  President Jair Bolsonaro of Brazil fired his health minister, Luis Henrique Mandetta on 16 April for contradicting him and earlier had claimed that the pandemic was a hoax or little more than a ‘measly cold.' 

Meanwhile, Nicaraguan president Daniel Ortega has resisted closing businesses and schools.  After a mysterious 34-day absence, Ortega appeared on television on 15 April reinforcing his refusal to close businesses saying that Nicaraguans must work or they will die and claiming that the virus was ‘imported.’ 

Mexico’s Andres Manuel Lopez Obrador (AMLO) has also resisted the call for strict stay-at-home policies, though with his Deputy Health Minister, Hugo López-Gatell, has closed schools – recently extending the closure to the 1st of June and urging non-essential businesses to close – but focusing primarily on social distancing. 

In contrast to his deputy health minister and Foreign Minister Marcelo Ebrard – who had declared the situation a health emergency on 30th March, later than many neighbouring countries – AMLO has largely attempted to avoid discussion of the pandemic, claiming that in his case he has lucky charms that prevent him from contracting the virus. 

And both Bolsonaro and AMLO have participated in large public rallies, doing all the things that politicians love, shaking hands and hugging babies, and in the case of the former even wiping his nose before embracing an elderly woman.

The Nicaraguan, Brazilian and Mexican presidents make an odd grouping since one (Bosonaro) is considered of the extreme populist right and the others (Ortega and AMLO) of the populist left. What unites them is good old-fashioned populism, a belief in a leader who represents the amorphous popular will and should be unfettered by checks and balances on his power, including something like… science.  

An eclectic group

At the other extreme have been the quick responses by governments in Peru, Argentina, Chile, El Salvador and Colombia which put quarantine measures in place in mid-March. In these cases, governments have even banned outdoor activities and in the case of Peru and Colombia (in the large cities) have imposed alternating days for when women and men can leave the house so as to better control outside movement.  

This too, though, is an eclectic group. It includes a Peronist president Alberto Fernández in Argentina, conservative presidents Sebastian Piñera in Chile and Ivan Duque in Colombia, interim president and relative political neophyte Martin Vizcarra in Peru and outsider president Nayib Bukele in El Salvador. 

El Salvador’s strict quarantine measures have led to rising concerns that Bukele is using the crisis to consolidate personal power, using the national police and the armed forces to enforce the quarantine and ignoring three rulings by the Supreme Court urging the president to end the abuses. In Argentina, Peronist Fernández has shown a surprising commitment to containment even as it hurts his party’s working-class base, not something typically expected of the populist Peronist Party.   

In all of these cases, the quick, strong responses by the presidents shored up their popularity. Peru’s Vizcarra saw his popularity shoot up 35 points in a week to 82 per cent according to surveys taken in March. In late March 2020, Fernández in Argentina saw his approval ratings swell to 79.2 per cent with 94.7 percent of citizens approving of the government’s strict shelter-at-home policies.   Even presidents Piñera and Duque who had struggled with low approval ratings throughout 2019 and saw those numbers sink even lower after the social protests that ended the year have seen their numbers rise.  

According to an 20th April poll, Piñera’s popular approval rating swelled from 13 percent in March 18th at the start of the crisis to 25 per cent by 20th April; while hardly a sweeping popular mandate, even that level was unthinkable only a few months ago when administration was battered by social protests. 

In Colombia, after a series of political missteps and the popular protests, Duque’s popular approval rating had slumped to 26 per cent; by April 2nd, 62 percent of Colombians supported the once-beleaguered president.   (No recent surveys were available for Bukele in El Salvador.)

In contrast, Bolsonaro’s in Brazil has only nudged up.  Before the crisis hit, the president’s popularity had been in steady decline from a high of 49 per cent in January 2019 to 30 per cent by early December 2019. But by the first week in April, in the midst of a crisis in which other presidents saw their approval ratings increase by double digits, after his public disagreements with the health minister, Bolsonaro’s had sunk to 33 per cent while the soon-to-be-fired Mandetta’s stood at 76 per cent.  

AMLO in Mexico has fared no better. The populist leftist scored a high 86 per cent approval rating in February 1, 2019. By March 28, 2020 with concerns over his weak and flippant COVID-19 response and a severe contraction in economic growth, AMLO’s approval rating had sunk 26 points to 60 per cent and his disapproval stood at 37 per cent.    

In the midst of disharmony, coordination

Despite these differences, many countries in the region have shown the solidarity they often speak of but rarely follow in policy or practice. Peru, Chile and other countries have collaborated in repatriating citizens back to their home countries in the midst of the crisis.  

Even the countries of the Southern Cone common market, MERCOSUR, have pulled together on a number of fronts.  The trade bloc had effectively been ruled a dead-man-walking after its failed efforts to integrate Venezuela into the bloc, lowering its standards to let in the petroleum dependent semi-authoritarian government of then President Hugo Chávez. 

Even on the basics of internal cooperation, the block was struggling, unable to coordinate monetary policies and non-tariff trade barriers between the original founding member states, Argentina, Brazil, Paraguay and Uruguay.

The 35-year-old customs union seemed to get a breath a new life with the announcement that it had concluded 20-year-long negotiations with the EU for a free trade deal. Ratification of that deal, however, ran aground on the political differences between the recently elected governments of Bolsonaro in Brazil and the Peronist Fernández in Argentina. 

Bolsonaro refused to attend the Fernández December 2019 inauguration, in protest of the newly elected president’s leftist leanings.  And this was well before their sharply divergent reactions to the COVID-19 virus. 

How surprising then that Mercosur has served as an effective coordination mechanism for these different and once opposed governments. The trade body is collaborating among member states to ensure the repatriation of citizens and has agreed to coordinate to ensure that trade flows, especially of medical supplies, are not interrupted by shutdown measures

Mercosur has even gone one step further than several other bodies have failed to take.  In early April the bloc’s governing body, based in Montevideo, Uruguay created a $16 million (12 million pound) fund to augment country research and assist in the purchase of supplies needed to combat the virus.  

Now if Brazil, Argentina and the others could only coordinate their domestic coronavirus responses and economic policy. In late March Fernández announced he was pulling Argentina out of a possible Mercosur-EU trade deal.




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Latin America’s COVID-19 Moment: Differences and Solidarity

30 April 2020

Dr Christopher Sabatini

Senior Research Fellow for Latin America, US and the Americas Programme
There has been no better example of the political diversity in Latin America than the varying responses of governments to the coronavirus crisis.

2020-04-30-Chile-Covid.jpg

A municipal cleaning worker disinfects the central market in Santiago, Chile on 7 April 2020 amid the coronavirus pandemic. Photo: Getty Images.

Differing approaches across the hemisphere have had different impacts on presidential popularity and, at least in one case, on democratic institutions and human rights. Yet, even within that diversity, South America’s Southern Cone countries (Argentina, Chile, Paraguay and Uruguay) have shown a sign of solidarity: protecting and facilitating trade flows, sponsoring cross-border research and ensuring citizens’ return to their home countries.    

The response from populist leaders

On the extreme have been the responses of presidents of Brazil, Nicaragua and Mexico, all of whom have ignored the science of the virus and of experts and refused to implement isolation policies.  President Jair Bolsonaro of Brazil fired his health minister, Luis Henrique Mandetta on 16 April for contradicting him and earlier had claimed that the pandemic was a hoax or little more than a ‘measly cold.' 

Meanwhile, Nicaraguan president Daniel Ortega has resisted closing businesses and schools.  After a mysterious 34-day absence, Ortega appeared on television on 15 April reinforcing his refusal to close businesses saying that Nicaraguans must work or they will die and claiming that the virus was ‘imported.’ 

Mexico’s Andres Manuel Lopez Obrador (AMLO) has also resisted the call for strict stay-at-home policies, though with his Deputy Health Minister, Hugo López-Gatell, has closed schools – recently extending the closure to the 1st of June and urging non-essential businesses to close – but focusing primarily on social distancing. 

In contrast to his deputy health minister and Foreign Minister Marcelo Ebrard – who had declared the situation a health emergency on 30th March, later than many neighbouring countries – AMLO has largely attempted to avoid discussion of the pandemic, claiming that in his case he has lucky charms that prevent him from contracting the virus. 

And both Bolsonaro and AMLO have participated in large public rallies, doing all the things that politicians love, shaking hands and hugging babies, and in the case of the former even wiping his nose before embracing an elderly woman.

The Nicaraguan, Brazilian and Mexican presidents make an odd grouping since one (Bosonaro) is considered of the extreme populist right and the others (Ortega and AMLO) of the populist left. What unites them is good old-fashioned populism, a belief in a leader who represents the amorphous popular will and should be unfettered by checks and balances on his power, including something like… science.  

An eclectic group

At the other extreme have been the quick responses by governments in Peru, Argentina, Chile, El Salvador and Colombia which put quarantine measures in place in mid-March. In these cases, governments have even banned outdoor activities and in the case of Peru and Colombia (in the large cities) have imposed alternating days for when women and men can leave the house so as to better control outside movement.  

This too, though, is an eclectic group. It includes a Peronist president Alberto Fernández in Argentina, conservative presidents Sebastian Piñera in Chile and Ivan Duque in Colombia, interim president and relative political neophyte Martin Vizcarra in Peru and outsider president Nayib Bukele in El Salvador. 

El Salvador’s strict quarantine measures have led to rising concerns that Bukele is using the crisis to consolidate personal power, using the national police and the armed forces to enforce the quarantine and ignoring three rulings by the Supreme Court urging the president to end the abuses. In Argentina, Peronist Fernández has shown a surprising commitment to containment even as it hurts his party’s working-class base, not something typically expected of the populist Peronist Party.   

In all of these cases, the quick, strong responses by the presidents shored up their popularity. Peru’s Vizcarra saw his popularity shoot up 35 points in a week to 82 per cent according to surveys taken in March. In late March 2020, Fernández in Argentina saw his approval ratings swell to 79.2 per cent with 94.7 percent of citizens approving of the government’s strict shelter-at-home policies.   Even presidents Piñera and Duque who had struggled with low approval ratings throughout 2019 and saw those numbers sink even lower after the social protests that ended the year have seen their numbers rise.  

According to an 20th April poll, Piñera’s popular approval rating swelled from 13 percent in March 18th at the start of the crisis to 25 per cent by 20th April; while hardly a sweeping popular mandate, even that level was unthinkable only a few months ago when administration was battered by social protests. 

In Colombia, after a series of political missteps and the popular protests, Duque’s popular approval rating had slumped to 26 per cent; by April 2nd, 62 percent of Colombians supported the once-beleaguered president.   (No recent surveys were available for Bukele in El Salvador.)

In contrast, Bolsonaro’s in Brazil has only nudged up.  Before the crisis hit, the president’s popularity had been in steady decline from a high of 49 per cent in January 2019 to 30 per cent by early December 2019. But by the first week in April, in the midst of a crisis in which other presidents saw their approval ratings increase by double digits, after his public disagreements with the health minister, Bolsonaro’s had sunk to 33 per cent while the soon-to-be-fired Mandetta’s stood at 76 per cent.  

AMLO in Mexico has fared no better. The populist leftist scored a high 86 per cent approval rating in February 1, 2019. By March 28, 2020 with concerns over his weak and flippant COVID-19 response and a severe contraction in economic growth, AMLO’s approval rating had sunk 26 points to 60 per cent and his disapproval stood at 37 per cent.    

In the midst of disharmony, coordination

Despite these differences, many countries in the region have shown the solidarity they often speak of but rarely follow in policy or practice. Peru, Chile and other countries have collaborated in repatriating citizens back to their home countries in the midst of the crisis.  

Even the countries of the Southern Cone common market, MERCOSUR, have pulled together on a number of fronts.  The trade bloc had effectively been ruled a dead-man-walking after its failed efforts to integrate Venezuela into the bloc, lowering its standards to let in the petroleum dependent semi-authoritarian government of then President Hugo Chávez. 

Even on the basics of internal cooperation, the block was struggling, unable to coordinate monetary policies and non-tariff trade barriers between the original founding member states, Argentina, Brazil, Paraguay and Uruguay.

The 35-year-old customs union seemed to get a breath a new life with the announcement that it had concluded 20-year-long negotiations with the EU for a free trade deal. Ratification of that deal, however, ran aground on the political differences between the recently elected governments of Bolsonaro in Brazil and the Peronist Fernández in Argentina. 

Bolsonaro refused to attend the Fernández December 2019 inauguration, in protest of the newly elected president’s leftist leanings.  And this was well before their sharply divergent reactions to the COVID-19 virus. 

How surprising then that Mercosur has served as an effective coordination mechanism for these different and once opposed governments. The trade body is collaborating among member states to ensure the repatriation of citizens and has agreed to coordinate to ensure that trade flows, especially of medical supplies, are not interrupted by shutdown measures

Mercosur has even gone one step further than several other bodies have failed to take.  In early April the bloc’s governing body, based in Montevideo, Uruguay created a $16 million (12 million pound) fund to augment country research and assist in the purchase of supplies needed to combat the virus.  

Now if Brazil, Argentina and the others could only coordinate their domestic coronavirus responses and economic policy. In late March Fernández announced he was pulling Argentina out of a possible Mercosur-EU trade deal.




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Who Runs the Internet: Internet Consolidation and Control




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The grease trap: uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase [Research Articles]

Acne is one of the most common dermatological conditions, but the details of its pathology are unclear, and current management regimens often have adverse effects. Cutibacterium acnes is known as a major acne-associated bacterium that derives energy from lipase-mediated sebum lipid degradation. C. acnes is commensal, but lipase activity has been observed to differ among C. acnes types. For example, higher populations of the type IA strains are present in acne lesions with higher lipase activity. In the present study, we examined a conserved lipase in types IB and II that was truncated in type IA C. acnes strains. Closed, blocked, and open structures of C. acnes ATCC11828 lipases were elucidated by X-ray crystallography at 1.6–2.4 Å. The closed crystal structure, which is the most common form in aqueous solution, revealed that a hydrophobic lid domain shields the active site. By comparing closed, blocked, and open structures, we found that the lid domain-opening mechanisms of C. acnes lipases (CAlipases) involve the lid-opening residues, Phe-179 and Phe-211. To the best of our knowledge, this is the first structure-function study of CAlipases, which may help to shed light on the mechanisms involved in acne development and may aid in future drug design.





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Teste de sangue para detectar Alzheimer está próximo da realidade

Exame poderá detectar a doença na fase inicial. Pesquisadores da Faculdade de Medicina Osteopática da Universidade de Rowan, nos Estados Unidos, afirmam que estão perto de desenvolver um exame de sangue para detectar Alzheimer com precisão, o que dar...

The post Teste de sangue para detectar Alzheimer está próximo da realidade appeared first on Saúde Próspera.



  • Dicas de Saúde

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Housing Advocates Sound Alarm as May Rents Collide with Coronavirus

Wednesday, April 29, 2020 - 13:15




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CBD Communiqué: The Biodiversity Family Stands in Solidarity with the People and Government of the Historic Nagoya Biodiversity Summit: CBD Secretariat steps up to support disaster relief efforts in Japan.