If you’re a local businessperson, an entrepreneur, a tribal partner, a community organizer; a decision-maker for a school district, college, or hospital; a government leader; a project developer; an industry leader; or an equipment manufacturer, the Alaska Community Handbook will be helpful to you.

The North East enjoyed a spell of warm weather on Saturday but did people stick to social distancing? These pictures show what the scene was like in some popular Tynesidea areas

During the COVID-19 lockdown, and during the gradual re-opening of communities, cities and businesses there is a lot information you've got that your listeners need. And, they are looking … more

To celebrate it's 40th birthday, WWF-France, the first French environmental NGO, offers a new interactive sensory experience based on a parallax effect. Developed on HTML5, this photographic exhibition is organized around five main themes: species, climate change, forests, ecological footprint, oceans, fresh water. WWF invites the user to share 40 years of action through videos, photos and stories.

The landscape of news has changed so much over the last few years that news about a particular topic or platform is readily available to anyone within an instant. With WordPress, I imagine that could be one of the perks of powering over 16% of the web, but it’s true that news is becoming incredibly accessible. In short, news is everywhere. Speaking of WordPress in general, you can of course acquire official direct news from WordPress News, but you can also take a peak behind the curtain and follow news in the making at Make WordPress.org. Though it’s only specific to the WordPress.com blogging platform, WordPress.com News is also worth watching for WordPress development news, as WordPress.com users often get access to new WordPress features before they’re released, so you’ll be able to try new features rather than just read about them. There’s more news than just direct official news, like I […]

Remember "cybersecurity"?

Mysterious hooded computer guys doing mysterious hooded computer guy .. things! Who knows what kind of naughty digital mischief they might be up to?

Unfortunately, we now live in a world where this kind of digital mischief is literally rewriting the world's history. For proof of that,

The news is true, we completely redesigned the best blog in the world, Web Design Ledger! Okay, maybe we’re a little bit biased, but there’s no denying that the new web design layout is amazing. We are so excited to show you guys the finished product. Let me just hit you with the most satisfying […]

Read More at We Redesigned Web Design Ledger – Here’s It Is!

Pictures and video from an action camera can be awesome. But how do you get the best shots? It’s all about the mounting of the camera and we’re going to tell you how to do it. How and where do you mount an action camera? The most popular place to mount an action camera is on a helmet using a Continue Reading

The post How (And Where) To Mount an Action Camera (On Anything!) appeared first on Photodoto.

By The University of Sheffield Giant icebergs leave trail of carbon sequestration in their wake – a month after they have passed Geographers analysed 175 satellite images of ocean colour which is an indicator of phytoplankton productivity at the ocean’s … Continue reading →

If you look for a place to find academic papers for sale, you should know that there are lots of writing services on the Internet. But your task is to find a reliable online resource that would offer...

The Traversty DOM utility has as its purpose to allow you to traverse the DOM and manage collections of DOM elements. Proponents admit core Traversty traversal methods are inspired by Prototype’s DOM Traversal toolkit, but now in a multi-element environment that is more like jQuery and less like Prototype’s single element implementation.

We're so excited to have a huge guest on the show – big time comedian and noted metalhead, Brian Posehn,...

The post METAL INJECTION LIVECAST #551 - Where Nickelback Shines with special guest Comedian Brian Posehn appeared first on Metal Injection.

I was asked to close out WordCamp Vancouver with a short 20 minute keynote on something interesting. After some thought, I put together a list of 10 trends I see in the web community and where we are headed in the immediate future. 0. The Future Keeps Arriving In my +15 years working on and with the […]

The post Where We Go From Here: 10 Thoughts on the Immediate Future of the Web appeared first on MOR10.

There are 7106 languages on earth and yet there are a few universal languages that transcends the language barrier. In this episode we explore one of the first universal languages of human history: music. My guest today is Clemency Burton-Hill. From underground DJ to the Creative Director at New York Public Radio, she is an author, a musician, and host of multiple podcasts including The Open Ears Project, Classical Fix, and Moments that Made Me. Her latest book, Year of Wonder helps readers explore and experience a new classical musical piece every day. In this episode: Classical music has a bad rap for being stuffy, boring, and largely inaccessible. Clemency expands on what’s available, and how it’s really the soundtrack of our lives. The universality of music and how we use music to explore, express, and share. Of course, Clemency drops so many names of musical artists to explore who are crushing it today. Enjoy! FOLLOW CLEMENCY: instagram | twitter | website Listen to the Podcast  Subscribe   This podcast is brought to you by CreativeLive. CreativeLive is the world’s largest hub for online creative education in photo/video, art/design, music/audio, craft/maker, money/life and the ability to make a living in […]

The post There Is Only One You with Clemency Burton-Hill appeared first on Chase Jarvis Photography.

This book from 1945 contains a very interesting mix of different charts made by the ISOTYPE Institute, some classic and some quite unusual. As a book about labor and unemployment, it also makes extensive use of Gerd Arntz’s famous unemployed man icon. Michael Young and Theodor Prager’s There’s Work for All is part of a […]

In this paper, for a family of second-order parabolic equation with rapidly oscillating and time-dependent periodic coefficients, we are interested in an approximate two-sphere one-cylinder inequality for these solutions in parabolic periodic homogenization, which implies an approximate quantitative propagation of smallness. The proof relies on the asymptotic behavior of fundamental solutions and the Lagrange interpolation technique.

We use the classical Fourier analysis to introduce analytic families of weighted differential operators on the unit sphere. These operators are polynomial functions of the usual Beltrami-Laplace operator. New inversion formulas are obtained for totally geodesic Funk transforms on the sphere and the correpsonding lambda-cosine transforms.

For decades, two-player (antagonistic) games on graphs have been a framework of choice for many important problems in theoretical computer science. A notorious one is controller synthesis, which can be rephrased through the game-theoretic metaphor as the quest for a winning strategy of the system in a game against its antagonistic environment. Depending on the specification, optimal strategies might be simple or quite complex, for example having to use (possibly infinite) memory. Hence, research strives to understand which settings allow for simple strategies.

In 2005, Gimbert and Zielonka provided a complete characterization of preference relations (a formal framework to model specifications and game objectives) that admit memoryless optimal strategies for both players. In the last fifteen years however, practical applications have driven the community toward games with complex or multiple objectives, where memory -- finite or infinite -- is almost always required. Despite much effort, the exact frontiers of the class of preference relations that admit finite-memory optimal strategies still elude us.

In this work, we establish a complete characterization of preference relations that admit optimal strategies using arena-independent finite memory, generalizing the work of Gimbert and Zielonka to the finite-memory case. We also prove an equivalent to their celebrated corollary of great practical interest: if both players have optimal (arena-independent-)finite-memory strategies in all one-player games, then it is also the case in all two-player games. Finally, we pinpoint the boundaries of our results with regard to the literature: our work completely covers the case of arena-independent memory (e.g., multiple parity objectives, lower- and upper-bounded energy objectives), and paves the way to the arena-dependent case (e.g., multiple lower-bounded energy objectives).

We argue that "Question Answering with Knowledge Base" and "Question Answering over Linked Data" are currently two instances of the same problem, despite one explicitly declares to deal with Linked Data. We point out the lack of existing methods to evaluate question answering on datasets which exploit external links to the rest of the cloud or share common schema. To this end, we propose the creation of new evaluation settings to leverage the advantages of the Semantic Web to achieve AI-complete question answering.

We introduce $Psimathrm{ec}$, a local spectral exterior calculus for the two-sphere $S^2$. $Psimathrm{ec}$ provides a discretization of Cartan's exterior calculus on $S^2$ formed by spherical differential $r$-form wavelets. These are well localized in space and frequency and provide (Stevenson) frames for the homogeneous Sobolev spaces $dot{H}^{-r+1}( Omega_{ u}^{r} , S^2 )$ of differential $r$-forms. At the same time, they satisfy important properties of the exterior calculus, such as the de Rahm complex and the Hodge-Helmholtz decomposition. Through this, $Psimathrm{ec}$ is tailored towards structure preserving discretizations that can adapt to solutions with varying regularity. The construction of $Psimathrm{ec}$ is based on a novel spherical wavelet frame for $L_2(S^2)$ that we obtain by introducing scalable reproducing kernel frames. These extend scalable frames to weighted sampling expansions and provide an alternative to quadrature rules for the discretization of needlet-like scale-discrete wavelets. We verify the practicality of $Psimathrm{ec}$ for numerical computations using the rotating shallow water equations. Our numerical results demonstrate that a $Psimathrm{ec}$-based discretization of the equations attains accuracy comparable to those of spectral methods while using a representation that is well localized in space and frequency.

Different state-of-the-art methods of the detection of schizophrenia symptoms based on the estimation of text coherence have been analyzed. The analysis of a text at the level of phrases has been suggested. The method based on the graph of the consistency of phrases has been proposed to evaluate the semantic coherence and the cohesion of a text. The semantic coherence, cohesion, and other linguistic features (lexical diversity, lexical density) have been taken into account to form feature vectors for the training of a model-classifier. The training of the classifier has been performed on the set of English-language interviews. According to the retrieved results, the impact of each feature on the output of the model has been analyzed. The results obtained can indicate that the proposed method based on the graph of the consistency of phrases may be used in the different tasks of the detection of mental illness.

The Cannabis Issue It's been almost a month since the COVID-19 pandemic forced folks inside and made "social distancing" part of our daily lexicons.…

Sam Mendes' 1917, which took Best Picture and Best Director awards at the Golden Globes earlier this week, looks like a standard period piece.…

We at the Inlander remain committed to keeping people informed and connected during the coronavirus outbreak, supporting our readers and local businesses in the ways we always have. We have experienced some disruption in where we distribute papers, but we're stocking and restocking thousands of copies at local Rosauers, Super 1, URM Cash & Carry, Yoke's, Albertson's and Safeway stores, plus Papa Murphy's locations, My Fresh Basket and more.…

You'll be forgiven if, during the daily deluge of COVID-19-related updates, you didn't notice that some seriously great musicians recently booked shows in and around Spokane for later in the year.…

Don't be caught empty-handed (or empty-hearted) this Valentine's Day, coming up Friday, Feb. 14.…

Before my car broke down, I didn't ride the bus.…

The present invention relates to a compound of formula A, wherein R is alkyl. Compound A may be used as an intermediate in the preparation of O-desmethyl venlafaxine or a salt thereof, and the present invention provides such a preparation, as well as a process for preparing the compound of formula A.

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1): wherein Z represents a hydroxyl group-removed residue of pentaerythritol or dipentaerythritol, OA1 and OA2 represent an oxyalkylene group having 2 to 4 carbon atoms, L1, L2 and L3 represent an alkylene group or an alkylene group that contains an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group or a urea bond, X and Y are different from each other and represent a functional group capable of a chemical reaction; m and n are an average number of moles of the oxyalkylene group added, m represents 5 to 1,000, n represents 0 to 1,000, and p, q and r represent 0 or 1; and s1 is an integer of 2 or more and s1+s2=4 or 6.

An information providing apparatus for vehicle has a remaining capacity detecting section 110 that detects a remaining capacity of a battery; a power consumption amount detecting section 130 that detects a power consumption amount of the battery; a power consumption amount history generating section 130 that generates a power consumption amount history on the basis of the power consumption amount detected by the power consumption amount detecting section 130; a charge necessity judgment information generating section 130 that generates, on the basis of the power consumption amount history generated by the power consumption amount history generating section 130, charge necessity judgment information which is information for user's judgment about whether or not charging of the battery is necessary; and a providing section 150 that provides information of the remaining capacity of the battery and the charge necessity judgment information with these information correlated with each other to the user. The information providing apparatus can properly provide the information for user's judgment about whether or not charging of the battery to the user.

The invention relates to polyglycol ether-free, polyglycerol partial ester-based sulphosuccinates, the preparation thereof, and the use of these in cosmetic formulations and also in cleaning compositions in the industrial and domestic sector and formulations comprising these sulphosuccinates.

Described herein are nitrated lipids and methods of making and using the nitrated lipids.

The invention relates to ceramide dimers which are constructed from two ceramide molecules which are crosslinked to each other via their lipophilic end. The ceramide molecules thereby have at least one hydrophilic group at their hydrophilic end for increasing the hydration shell of the dimer. The ceramide dimers according to the invention can be used as pharmaceutical preparation or as cosmetic preparation.

Novel compounds of formula (1) wherein: A is especially a linear or branched divalent alkylene radical having between 1 and 10 carbon atoms, and Y is especially a hydrogen atom.

The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R2 represents a hydrogen atom, a halogen atom, a cyano group, —NRcRd, —N═CHN(CH3)2, or an C1-3 alkyl group; Ar1 and Ar2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.

Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like ; ring B represents aryl or heteroaryl; RB represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E1 and E2 represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO2—Y, —O—(alkylene)—Y, —O—Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.

The present invention relates to a novel acid addition salt of risperidone, wherein acid counterion is selected from the group consisting of pamoic acid, caproic acid, cypionic acid, decanoic acid, camphor sulfonic acid, enanthic acid, palmitic acid, fusidic acid, gluceptic acid, gluconic acid, lactobionic acid, lauric acid, levulinic acid and valeric acid, a process for the preparation and pharmaceutical composition comprising the same. Further, the invention relates to the use of said pharmaceutical composition comprising the acid addition salt of risperidone in the treatment of patient suffering from psychotic disorders.

A rubber composition that can be used in applications such as automotive tires and can improve the fuel efficiency performance and driving stability of automobiles and the like, a method for producing a rubber composition, and a tire using the same are provided. A rubber composition comprising: (A) a conjugated diene rubber which is obtained by polymerizing a conjugated diene compound or polymerizing a conjugated diene compound and an aromatic vinyl compound and has a group having an active hydrogen and a group capable of chemically binding to a silica, (B) a silica, (C) a silane coupling agent (I) capable of reacting with a carbon-carbon double bond of the conjugated diene in the conjugated diene rubber, and (D) a silane coupling agent (II) capable of reacting with the group having an active hydrogen; a method for producing a rubber composition, which comprises mixing the above-mentioned composition; and a tire which is obtained by crosslinking and molding the rubber composition obtained by the method for production.

A long-fiber-reinforced resin composition including (A) a long-fiber-reinforced thermoplastic resin pellet including a thermoplastic resin, a modified polyolefin-based resin modified with an unsaturated carboxylic acid or its derivative and reinforcing fiber and satisfying (A-1) the melt index of the thermoplastic resin is 100-250 g/10 min, (A-2) the relaxation time λ of the thermoplastic resin is 0.1 (sec) or less, (A-3) the content of the reinforcing fiber is 40-70 wt %, and (A-4) the content of the modified polyolefin-based resin is 1-5 wt %; and (B) a polyolefin-based resin satisfying (B-1) the melt index of the polyolefin-based resin is 20-70 g/10 min, and (B-2) the relaxation time λ of the polyolefin-based resin is 0.23 (sec) or less; wherein the content of reinforcing fiber contained in (A) is 20-60 wt % relative to the total amount of the fiber-reinforced resin composition.

Titanocenes containing two 5-membered cyclodienyl groups, for example cyclopentadienyl, and one or two 6-membered carbocyclic or 5- or 6-membered heterocyclic aromatic rings which are substituted by a fluorine atom in at least one of the two ortho-positions to the titanium-carbon bond and contain, as a further substituent, unsubstituted or substituted 1-pyrryl, are suitable as photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds.

Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxyamido or amidino groups; one of R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.

A method of producing a bis(2-carboxyethyl)-alkyl phosphine oxide represented by the following general formula (1) is disclosed. ##STR1## The method comprises the following Steps 1-4: step 1 wherein phosphine is reacted with acrylonitrile to produce bis(2-cyanoethyl)phosphine and then, in step 2, reacted with an alkene to produce a bis(2-cyanoethyl)alkyl phosphine, and in step 3, reacted with an oxidizing agent to produce a bis(2-cyanoethyl)alkyl phosphine oxide, and in step 4, said bis(2-cyanoethyl)alkyl phosphine oxide is reacted with water or a lower alcohol to give a bis(2-carboxyethyl)alkyl phosphine oxide or a derivative thereof.

Metallocene compounds having two fluorenyl ligands bridged with a single silicon or germanium atom, said atom having two substituent groups containing a total of at least four carbon atoms, are useful as catalyst components for the polymerization of olefins. Particularly, it is possible to prepare high molecular weight atactic polypropylene with improved yields with respect to the known catalysts.

A metallocene compound is provided wherein to a transition metal compound is bonded a multidentate compound wherein a substituted cycloalkadienyl ring CA1 having therein a heteroaromatic group Ra containing an oxygen, sulfur or nitrogen atom on a cycloalkadienyl ring, preferably the five-membered ring thereof, and an unsubstituted or substituted cycloalkadienyl group CA2 or --(R1)N--, --O--, --S-- or --(R1)P--, preferably CA2, more preferably a substituted cycloalkadienyl group identical with CA1 are bonded through a divalent linking group. The metallocene compound is suitable as a principal ingredient of a catalyst for the polymerization of olefins, particularly achieving a very high effect in making the molecular weight of a polypropylene higher.

A metal complex having a β-diketonate represented by the following formula (1): wherein M represents a metal atom of the VIII group, R1, R2 and R3 represent a group or an atom selected from the group consisting of an alkyl group, an aryl group, a hydroxyl group, an amino group, an alkoxy group, a hydrogen atom and a halogen atom; X−1 represents an ion selected from a halogen, nitric acid, sulfonic acid, fluoroboric acid, fluorophosphoric acid, or perchloric acid ion; L1 or L2 represents a 2,2'-bipyridine or 1,10-phenanthroline group where these groups may be substituted with a group or an atom selected from an alkyl group, a carboxyl group, a sulfonic acid group, a phosphonic acid group, a hydroxyl group, an amino group, a hydrogen atom and a halogen atom. A photoelectric conversion element and a photochemical cell using the above-mentioned metal complex.

The present invention relates to a biocompatible ceramic material comprising Baghdadite (Ca3ZrSi2O9), and a method for its preparation. Preferably the Baghdadite is synthetically prepared. The present invention also relates to an implantable medical device comprising biocompatible Baghdadite, and a method for its production. The present invention further relates to a method for improving the long term stability of an implantable medical device and an implantable drug delivery device comprising Baghdadite. Further, the present invention relates to the use of comprising biocompatible Baghdadite in the regeneration or resurfacing of tissue.

A method for manufacturing a plurality of glass microspheres comprises: melting a batch into a first glass melt in a melter system, processing the first glass melt into a second glass, pulverizing the second glass into a plurality of glass fragments, thermally processing the plurality of glass fragments into a plurality of glass microspheres, providing at least one of a plurality of redox reactions and a plurality of events in at least one of the first glass melt and a melt of the second glass, and the plurality of redox reactions and the plurality of events are induced by a plurality of redox active group (RAG) components.