TOKYO -- Japan's 7-Eleven convenience store chain owner Seven & i Holdings is considering plans to go private by means of a management buyout, Nikkei learned on Wednesday. In a statement responding to the reports, the retail giant has admitted that it has received such an offer from its founding…

1. 'There's a guy in Indian team whose Test average is 63...': Tim Paine wants Rohit and Gambhir to open their eyes  Hindustan Times
2. EXCLUSIVE | Dhruv Jurel can be the X-factor India are looking for in Australia, says Suresh Raina  The Times of India
3. Former Australia captain tips India youngster to shine Down Under  ICC Cricket
4. Not Rishabh Pant or Yashasvi Jaiswal; Ex- Australian captain backs this Indian young player to impress everyone in Border-Gavaskar Trophy, says 'class above all his teammates on this tour'  SportsTak
5. Why India should play Jurel as a specialist batsman at Perth  The Indian Express

The voters knew it instinctively on Tuesday, but the numbers also prove that Americans are worse off since Joe Biden became president. On Thursday, it was reported that real wages have declined since 2020 when Joe Biden took office. Per Zero Hedge: As Statista’s Felix Richter reports, according to exit polls, 46 percent of voters […]

The post Yes, America is Worse Off: Real Wages Declined in Biden Era appeared first on The Lid.

velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ

Conservative activist Scott Presler, whose organization Early Vote Action helped swing Pennsylvania to the right in the general election, announced Monday he will be working to do the same in […]

The post Democrats Have Another Problem to Worry About as Man Who Helped Trump Win Has Eyes on Blue State appeared first on The Western Journal.

Springbok coach Rassie Erasmus wants a tour whitewash and, with the Scotland win, he's a third of the way there. He didn't say it would be pretty, as Sunday's success at Murrayfield showed.

By Walter Donway, Savvy Street originally published on Dec. 4, 2022 Book Review: The Secret Apparatus: The Muslim Brotherhood’s Industry of Death by Cynthia Farahat, Post Hill Press, Bombardier Books (2022) A grim irony of twentieth-century history (but, of course, also predating it) is that the most horrendous threats to humanity have simply been too monstrously evil […]

Russia and China in Antarctica: Implications for the Five Eyes 15 December 2022 — 11:00AM TO 12:00PM Anonymous (not verified) 2 December 2022 Online

This event explores Russia’s and China’s postions on the Antarctic and offers a critical assessment of their actions in the region.

Ever since the 1959 Antarctic Treaty System (ATS), signed at the height of Cold War, Antarctica has remained a demilitarized continent.

Today, even though the ATS is not in immediate danger of collapse, Antarctica and the Southern Ocean are no longer insulated from wider geopolitical tension, with China and Russia posing challenges to regional governance. 
 
This event also discusses key recommendations for the Five Eyes regarding Russian and Chinese current and future efforts at undermining the ATS and Antarctic governance. 

The discussion is informed by Mathieu Boulègue’s paper ‘Russia and China in Antarctica and the Southern Ocean: Implications for the Five Eyes’ published by the Sea Power Centre of the Royal Australian Navy.

As the capability of mass spectrometry-based proteomics has matured, tens of thousands of peptides can be measured simultaneously, which has the benefit of offering a systems view of protein expression. However, a major challenge is that with an increase in throughput, protein quantification estimation from the native measured peptides has become a computational task. A limitation to existing computationally-driven protein quantification methods is that most ignore protein variation, such as alternate splicing of the RNA transcript and post-translational modifications or other possible proteoforms, which will affect a significant fraction of the proteome. The consequence of this assumption is that statistical inference at the protein level, and consequently downstream analyses, such as network and pathway modeling, have only limited power for biomarker discovery. Here, we describe a Bayesian model (BP-Quant) that uses statistically derived peptides signatures to identify peptides that are outside the dominant pattern, or the existence of multiple over-expressed patterns to improve relative protein abundance estimates. It is a research-driven approach that utilizes the objectives of the experiment, defined in the context of a standard statistical hypothesis, to identify a set of peptides exhibiting similar statistical behavior relating to a protein. This approach infers that changes in relative protein abundance can be used as a surrogate for changes in function, without necessarily taking into account the effect of differential post-translational modifications, processing, or splicing in altering protein function. We verify the approach using a dilution study from mouse plasma samples and demonstrate that BP-Quant achieves similar accuracy as the current state-of-the-art methods at proteoform identification with significantly better specificity. BP-Quant is available as a MatLab ® and R packages at https://github.com/PNNL-Comp-Mass-Spec/BP-Quant.

After undergoing surgery in late June to repair a torn left labrum in his left shoulder that required nine anchors to be inserted to keep everything in place, Zack Cozart is healthy and looking for a bounce-back season with the Angels.

Instead of creating change through compliance and extrinsic motivators, the new era of education and education policy will require ecosystems of policy, regulation, investment, and operating structure that enable, rather than dictate. Under New Hampshire's PACE accountability system districts and sc

Per GoBearcats:University of Cincinnati star forward Jillian Hayes has been named Big 12 Player of the Week, the conference announced on Monday. She becomes the first Bearcat to win a weekly Big 12 women's basketball honor in program history.

The wild canines have the same muscles used by domestic dogs to create the wide-eyed, pleading look that captures humans' hearts

The baby boy’s recovered genome suggests he’s related to a famous Ice Age population

Nathan Chen has accomplished just about everything that one can accomplish in the sport of figure skating. The only thing he's yet to accomplish? Winning Olympic gold.

U.K. company cut weeks out of design time, eliminated prototyping, and increased innovation with SOLIDWORKS and CircuitWorks

U.K. Company Designs Adjustable Eyeglasses to Solve Vision Problems

Passionate about making God’s Word available, OM Moldova’s literature ministry offers audio-Bibles to those who cannot read.

Infrastructure, materials, and mining group Raubex has reported a sharp climb in interim profit, helped by a pickup in SA road construction activity.

In a recent high-profile case, Harvard College rescinded its offer to a school-shooting survivor after racist comments he’d written online surfaced. But how common is it for colleges to take back offers? And do students have any recourse?

At present we reward quantity, not quality. The door could be opening for that to change, argues Johan Fourie.

The 2016 National Teacher of the Year will represent Connecticut’s 5th district, becoming the first African-American woman from the state to serve in Congress.

Against all odds, 19-year-old Melisa from Albania joins Logos Hope.

A boy from an underprivileged community in Córdoba, Argentina, shows his excitement when he hears the gospel message.

There was positive rental growth in all provinces despite tenants feeling the pinch due to challenging economic conditions, according to the latest Payprop Rental Index.

Pedro Calado, vice-president of Madeira’s regional government, tells Sebastian Shehadi about the island's capacity for more upmarket tourism and its ongoing struggle to gain financial independence from Portugal. 

Ai-Da, the humanoid robot, sold the artwork "AI God" for a whopping $1.3 million at Sotheby's. Here's how it happened.

Joe Biden pledged a peaceful transfer of power Thursday after Donald Trump's decisive US election win, while the Republican showed his intent to ditch the outgoing president's policies by suggesting he would talk to Vladimir Putin.

The influencer and activist has been outspoken in her support for Israel and has been using her platform to combat antisemitism around the world. 

Cases of beer were wheeled into the Capitol after the House narrowly passed a health care bill on May 4, 2017, that would repeal and replace major parts of the Affordable Care Act. Every Democrat voted no, joined by 20 Republicans.

Thailand is targeting economic growth of 3.5% in 2025 after 2.7% growth seen this year, and the government will soon consider more stimulus measures and the rollout of phase two of its US$14 billion handout scheme, the finance minister said on Wednesday.

An IRGC commander discusses Iran's missile expansion strategy and its implications for Israel.

Toyota has teamed up with JAXA since 2019 to develop the manned lunar rover — which it dubbed the Lunar Cruiser — that they hope can be put on the moon in 2029.

Title: Pandemic Learning Can Strain Children's Eyes
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

MSNBC’s Chris Hayes called out Fox News for not showing the full context of Donald Trump’s “enemy within” comments during Vice President Kamala Harris’ interview on the network earlier Wednesday.

The anchor of All In opened his broadcast by calling attention to something that Harris herself did in the sit-down with Fox’s Bret Baier. The clip that the right-wing network showed to Harris as part of Baier’s question was of Trump during his all-female town hall event in Georgia—the one where Trump bizarrely argued he was the “father of IVF.”

In the clip that Fox aired directly to Harris during her interview, Trump wasn’t heard talking about how former House Speaker Nancy Pelosi or Rep. Adam Schiff are the “enemy within.” Instead, Fox made it so Harris had to react to him talking more mildly about “phony investigations.” The network omitted Trump’s line about “the enemy within.”

Read more at The Daily Beast.

Early reactions to Call Of Duty: Black Ops 6 multiplayer range from frothing dislike through omnimovement hype to our own Ed Thorn's dead-eyed appraisal that it's "a good one, I think. Not a bad one. If you like Call Of Duty, you will like this. If you don't like Call Of Duty, you will not like this." I feel like we need to emergency-deploy a supply crate of smelling salts, because the sheer OK-ness of Black Ops 6 appears to have tumbled Ed into a stupor.

Perhaps it would be a different story if he'd encountered some of the spawning issues and glitches people are talking about, with players joining games and materialising right into a hail of fire. The players in question include Black Ops 6's developers, who comically note in the latest Black Ops 6 patch notes that "Yes, we saw ourselves in a Killcam before selecting a Loadout too." The latest patch seeks to address this, naturally. As regards the campaign side of things, it also resets your safehouse currency to 5000, if you've had your single player funds stolen (or multiplied) by technical gremlins.

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