The superior colliculus receives a direct projection from retinal ganglion cells. In primates, it remains unknown if the same ganglion cells also supply the lateral geniculate nucleus. To address this issue, a double-label experiment was performed in two male macaques. The animals fixated a target while injection sites were scouted in the superior colliculus by recording and stimulating with a tetrode. Once suitable sites were identified, cholera toxin subunit B-Alexa Fluor 488 was injected via an adjacent micropipette. In a subsequent acute experiment, cholera toxin subunit B-Alexa Fluor 555 was injected into the lateral geniculate nucleus at matching retinotopic locations. After a brief survival period, ganglion cells were examined in retinal flatmounts. The percentage of double-labeled cells varied locally, depending on the relative efficiency of retrograde transport by each tracer and the precision of retinotopic overlap of injection sites in each target nucleus. In counting boxes with extensive overlap, 76–98% of ganglion cells projecting to the superior colliculus were double labeled. Cells projecting to the superior colliculus constituted 4.0–6.7% of the labeled ganglion cell population. In one particularly large zone, there were 5,746 cells labeled only by CTB-AF555, 561cells double labeled by CTB-AF555 and CTB-AF488, but no cell labeled only by CTB-AF488. These data indicate that retinal input to the macaque superior colliculus arises from a collateral axonal branch supplied by ~5% of the ganglion cells that project to the lateral geniculate nucleus. Surprisingly, there exist no ganglion cells that project exclusively to the SC.

The technology, enabled by thorium atoms, could keep time more accurately than atomic clocks and enable new discoveries about gravity, gravitational waves and dark matter

The grassroots organization, Nihon Hidankyo, was lauded for "demonstrating through witness testimony that nuclear weapons must never be used again"

The final 3D atlas of the sky will help scientists study dark matter and dark energy, which make up 96 percent of the universe but remain mysterious

Stefano Terlizzi joined the Ken and Mary Alice Lindquist Department of Nuclear Engineering as the John and Jean M. Brennan Clean Energy Early Career Professor on July 22. In this Q&A, Terlizzi talks about his research background and interests, why he chose Penn State and more.

This week SA Money Report tries to understand eThekwini's surprising plan for nuclear power, and whether the ANC's RET faction has a hand in things.

India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge.

India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge.

NASA’s Power to Explore Challenge calls on U.S. students to submit ideas for moon missions powered by radioisotope systems. The contest encourages kindergarten through Year 12 students to envision a mission, detail objectives, and apply their unique “power” to achieve mission success. Entries are due by January 31, 2025, and grand prize winners will tour NASA’s Glenn Research Center, gaining insight into the technology and science of space exploration.

[Namibian] Russian company Rosatom and South African AllWeld Nuclear and Industrial are joining forces to promote the sustainable development of nuclear energy in Africa.

BAKU, Azerbaijan — The head of the United Nations' nuclear watchdog said Tuesday he's hopeful that meetings this week with Iranian officials, including the country's new president, can lead to a breakthrough in monitoring the country's nuclear program, a longstanding issue that has gained new urgency as Israel has twice struck Iran amid rising tensions in the Middle East. Rafael Mariano Grossi, director general of the International Atomic Energy Agency, will travel to Iran on Wednesday to meet for the first time with President Masoud Pezeshkian, who was elected in July. Grossi said he hopes to build on positive discussions he had with Iranian Foreign Minister Abbas Araghchi during the U.N. General Assembly in September. "We have a problem that we need to solve," Grossi said in an interview at the U.N. climate conference in Azerbaijan. "That is this gap, this lack of confidence, which we should not allow to grow into a self-fulfilling prophecy of using nuclear facilities as targets." He added: "There has been a bit of a dire straits dynamic with Iran that we want to go beyond." Iran is rapidly advancing its atomic program while increasing stockpiles of uranium enriched to near weapons-grade levels, all in defiance of international demands, according to the IAEA. Iran says its program is for energy purposes, not to build weapons. Grossi's visit comes as Israel and Iran have traded missile attacks in recent months after more than a year of war in Gaza, which is governed by Hamas, a group supported by Iran. Grossi noted that international law prohibits the attack of nuclear facilities and "it's obvious that is something that can have radiological consequences." The Biden administration said last month that it had won assurances from Israel that it would not attack nuclear or oil sites. A 2015 nuclear agreement between Iran and world powers put limits on Iran's nuclear program, which the West fears could be used to make nuclear weapons. The deal included the lifting of economic sanctions on Iran. But that deal collapsed after Donald Trump's administration in 2018 pulled the United States from it. That led Iran to abandon all limits put on its program and enrich uranium to up to 60% purity. When asked if the IAEA feared Iran may be developing a bomb, Grossi said he didn't "have any information that would sustain that." He added that inspectors' job was not to "judge intentions," but rather verify that what Iran says about its nuclear program was true. Trump's reelection last week raises questions about whether and how the incoming administration and Iran may engage. Grossi said he had worked with the first Trump administration, which he said engaged in "seamless, professional work," and looked forward to looking with Trump's second administration. "Circumstances have changed in that the problem has grown bigger than it was," said Grossi. "The problem of not finding a solution."

Solar power is now priced competitively with traditional forms of energy, which makes new nuclear power plants financially unviable.

North Korea conducted its fourth hydrogen bomb test last week, and reactions from around the world have ranged from outrage and alarm to dismissiveness.

The warnings from the United Nations and from anti-nuclear activists are increasingly ominous: the world is closer to a nuclear war—by design or by accident—more than ever before. The current conflicts—and the intense war of words—between nuclear and non-nuclear states—Russia vs. Ukraine, Israel vs. Palestine and North Korea vs. South Korea—are adding fuel to a […]

In recent years, the rhetoric, strategy and practice of nuclear deterrence has grown riskier, more urgent, more dangerous, less stable, and increasingly in the hands of deficient leaders and policymakers. Playing Nuclear Games The ten States that have manufactured and test detonated nuclear weapons since 1945, each have received and/or provided assistance to other States […]

The United Nations Secretary General António Guterres congratulated grassroots Japanese organization Nihon Hidankyo on being awarded the 2024 Nobel Peace Prize. “The atomic bomb survivors from Hiroshima and Nagasaki, also known as the hibakusha, are selfless, soul-bearing witnesses of the horrific human cost of nuclear weapons,” he said in a statement. “While their numbers grow smaller each […]

Satellite images show China working on nuclear reactor for new warship

India’s federal power minister on Tuesday asked the states that are away from coal resources to consider setting up nuclear-based power plants, besides identifying and listing the power utilities to meet investments to support growing power demand.

The Indian government in its federal budget this year had proposed to partner with private players to develop small nuclear reactors to increase the amount of electricity from sources that do not produce carbon dioxide emissions.

States should consider setting up nuclear power plants at the sites where coal-based thermal power plants have completed their life, Manohar Lal, the country’s power minister, told states as per a government statement.

India’s stringent nuclear compensation laws have hampered talks with foreign power plant builders such as General Electric GE.N and Westinghouse.

The country, which currently has about 8 gigawatts of nuclear capacity, aims to increase it to 20 GW by 2032.

The minister also asked the states to identify and list their power utilities in the country’s stock exchange to meet increasing investment demand in the power sector as well as improve the transmission system to add more renewable capacity.

India has pledged to achieve a net zero carbon emission target by 2070 and has a target of 500 GW of renewable energy by 2030.

Two important barriers to a stable, powerful fusion reaction have been leapt by an experiment in a small tokamak reactor, but we don’t yet know if the technique will work in larger devices

Concern over the risks of enabling nuclear weapons development is usually focused on nuclear fission reactors, but the potential harm from more advanced fusion reactors has been underappreciated

Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds

Smashing gold nuclei together at high speeds billions of times has resulted in 16 particles of antihyperhydrogen-4, a very exotic and heavy form of antimatter

These stunning photographs are all shortlisted for the Sony World Photography Awards 2024

Pregnane X receptor (PXR) belongs to the nuclear receptor superfamily that plays a crucial role in hepatic physiologic and pathologic conditions. Phase separation is a process in which biomacromolecules aggregate and condense into a dense phase as liquid condensates and coexist with a dilute phase, contributing to various cellular and biologic functions. Until now, whether PXR could undergo phase separation remains unclear. This study aimed to investigate whether PXR undergoes phase separation. Analysis of the intrinsically disordered regions (IDRs) using algorithm tools indicated a low propensity of PXR to undergo phase separation. Experimental assays such as hyperosmotic stress, agonist treatment, and optoDroplets assay demonstrated the absence of phase separation for PXR. OptoDroplets assay revealed the inability of the fusion protein of Cry2 with PXR to form condensates upon blue light stimulation. Moreover, phase separation of PXR did not occur even though the mRNA and protein expression levels of PXR target, cytochrome P450 3A4, changed after sorbitol treatment. In conclusion, for the first time, these findings suggested that exogenous PXR does not undergo phase separation following activation or under hyperosmotic stress in nucleus of cells.

The diagnostic work-up of patients with fever of unknown origin (FUO) begins with a thorough history and physical examination, complete blood count with differential, chest x-ray, urinalysis and culture, electrolyte panel, liver enzymes, erythrocyte sedimentation rate, and C-reactive protein level. Additional imaging procedures, including nuclear medicine tests, are generally used as second-line procedures, with ¹⁸F-FDG PET and PET/CT assuming increasingly important roles in the diagnostic work-up. The Society of Nuclear Medicine and Molecular Imaging, the Infectious Diseases Society of America, and the American College of Nuclear Medicine convened an autonomous expert work group to comprehensively review the published literature for nuclear imaging in adults and children with FUO and establish appropriate use criteria (AUC). This process was performed in accordance with the Protecting Access to Medicare Act of 2014, which requires that all referring physicians consult AUC by using a clinical decision support mechanism before ordering advanced diagnostic imaging services. The complete findings and discussions of the work group were published on January 8, 2023, and are available at https://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=15666. The AUC in the final document are intended to assist referring health care providers in appropriate use of nuclear medicine imaging procedures in patients with FUO. The work group noted limitations in the current literature on nuclear medicine imaging for FUO, with the need for well-designed prospective multicenter investigations. Consensus findings from published data and expert opinions were used to create recommendations in common clinical scenarios for adults and children. Included in the complete document is a discussion of inflammation of unknown origin (IUO), a recently described entity. In view of the fact that the criteria for FUO and IUO are similar (except for fever > 38.3°C [100.9°F]) and that the most common etiologies of these 2 entities are similar, it is the expert opinion of the work group that the recommendations for nuclear medicine imaging of FUO are also applicable to IUO. These recommendations are included in the full guidance document. This summary reviews rationale, methodology, and main findings and refers the reader to the complete AUC document.

The role of gastrin-releasing peptide receptor (GRPR) in various diseases, including cancer, has been extensively studied and has emerged as a promising therapeutic target. In this study, we successfully achieved the use of [²¹²Pb]Pb-DOTAM-GRPR1, comprising the α-particle generator, ²¹²Pb, combined with a GRPR-targeting peptide, GRPR1, in a prostate cancer model. Methods: Pharmacokinetics, toxicity, radiation dosimetry, and efficacy were assessed in GRPR-positive prostate tumor–bearing mice after intravenous administration of [²¹²Pb]Pb-DOTAM-GRPR1 (where DOTAM is 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane). Results: Preclinical studies have shown tumor targeting of up to 5 percent injected dose per gram over 24 h, and optimization of the drug formulation and quantity has led to minimized oxidation and off-target binding, respectively. Particularly, an increase in peptide amount from 28 to 280 ng was shown to reduce off-target uptake, especially at the level of the pancreas, by about 30%. Furthermore, dosimetry studies confirmed the kidney as the dose-limiting organ, and toxicity studies revealed that a nontoxic dose of up to 1,665 kBq could be injected into mice. Efficacy studies indicated a median survival time of 9 wk in the control group, which received only a buffer solution, compared with 19 wk in the group that received 4 injections of 370 kBq at 3-wk intervals. Conclusion: Taken together, these combined data demonstrate the safety, tolerability, and efficacy of [²¹²Pb]Pb-DOTAM-GRPR1, thus warranting further exploration in clinical trials.

α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Various factors, including posttranslational modifications (PTMs), can influence the propensity of α-Syn to misfold and aggregate. PTMs are biochemical modifications of a protein that occur during or after translation and are typically mediated by enzymes. PTMs modulate several characteristics of proteins including their structure, activity, localization, and stability. α-Syn undergoes various posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, glycation, O-GlcNAcylation, nitration, oxidation, polyamination, arginylation, and truncation. Different PTMs of a protein can physically interact with one another or work together to influence a particular physiological or pathological feature in a process known as PTMs crosstalk. The development of detection techniques for the cooccurrence of PTMs in recent years has uncovered previously unappreciated mechanisms of their crosstalk. This has led to the emergence of evidence supporting an association between α-Syn PTMs crosstalk and synucleinopathies. In this review, we provide a comprehensive evaluation of α-Syn PTMs, their impact on misfolding and pathogenicity, the pharmacological means of targeting them, and their potential as biomarkers of disease. We also highlight the importance of the crosstalk between these PTMs in α-Syn function and aggregation. Insight into these PTMS and the complexities of their crosstalk can improve our understanding of the pathogenesis of synucleinopathies and identify novel targets of therapeutic potential.

α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focusing on more recent knowledge. In particular, we review the genetic evidence linking AS to familial and sporadic PD, including a number of recently identified point mutations in the SNCA gene. We briefly go over the relevant neuropathological findings, stressing the evidence indicating a correlation between aberrant AS deposition and nervous system dysfunction. We analyze the structural characteristics of the protein, in relation to both its physiologic and pathological conformations, with particular emphasis on posttranslational modifications, aggregation properties, and secreted forms. We review the interrelationship of AS with various cellular compartments and functions, with particular focus on the synapse and protein degradation systems. We finally go over the recent exciting data indicating that AS can provide the basis for novel robust biomarkers in the field of synucleinopathies, while at the same time results from the first clinical trials specifically targeting AS are being reported.

The Euclid space telescope's massive “cosmic atlas” promises to shed light on fundamental questions in physics and cosmology

The first ever full-scale demonstration of a nuclear reactor designed to passively cool itself in an emergency was a success, showing that it should be possible to build nuclear plants without the risk of dangerous meltdown

A new design for a nuclear battery that generates electricity from the radioactive decay of americium is unprecedentedly efficient

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

Scientists in New Mexico conducted several experiments and learned that asteroids can be deflected from Earth using explosions of nuclear warheads above the space rock's surface.

The California-based Middlebury Institute of International Studies published research this week that showed China has constructed a prototype nuclear reactor that could fit aboard a large surface vessel - a sign that China is making progress toward building a nuclear-powered aircraft carrier.

The post Report: China Builds ‘Prototype’ Nuclear Reactor for Aircraft Carrier appeared first on Breitbart.

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 23rd, 2024. It’s the end of another week, and …

Continue reading "SwitchArcade Round-Up: ‘Thermonuclear’, ‘Magnus Trilogy’, Plus Today’s Other New Releases and Sales"

The outcome of the 2024 U.S. presidential election could reshape policies from health care at home to nuclear proliferation abroad

Dec 5, 2023

David W. Kearn argues that deployment of nuclear weapons cannot rectify a perceived imbalance in conventional forces in the western Pacific.

The Indian civil nuclear bureaucracy understands it is "essential" to advance cooperation with the U.S., but claims progress is stymied by the inability of U.S. firms to share sensitive technical information pending the authorizations required under U.S. licensing regulations.

Nov 26, 2020

• Elbe Group Discusses Strategic Stability, Hybrid Warfare and Terrorism.
• Mowatt-Larssen’s Book Details Lessons He Learned While Tracking Al-Qaida’s WMD Programs.
• Experts on New START Extension and Other Nuclear Priorities of Biden Presidency.
• Kazakhstan’s Last HEU Eliminated.
• William Potter Joins Russian Academy of Sciences.
• COVID, Nuclear Security On Agenda of IAEA’s 64th General Conference.
• Mayak Aims to Process Entire range of SNF.
• Atomguard Reports Foiling Unauthorized Access.
• Allison: US Vital Interest in Prevention of Nuclear Terrorism Will Continue to Guide Its North Korea Policy.
• Learning from COVID-19 to Prepare for Nuclear Attack.
• Hecker, Kassianova Encourage Young US and RF Professionals to Explore Lessons of Nuclear Accidents.
• Experts Weigh in on 75th Anniversary of Hiroshima Bombing.
• A New Look at IAEA’s Nuclear Security Recommendations.
• Azerbaijan Has Threatened to Strike Armenia’s NPP With Missiles.
• IAEA Notified of 189 Incidents Of Material Being Out Of Regulatory Control in 2019.
• Russia To Retrieve More Radioactive Debris from Bottom of Ocean.
• Researchers Propose Fast Way to Detect Weapons Grade Materials.
• Keeping Nuclear Power Plants Out of Reach of Terrorists During the Coronavirus Pandemic.
• Bunn, Tobey and Roth Testify on Prevention of Nuclear Theft, Call for Cooperation With Russia.
• Budapest Memorandum Parsed.
• IAEA Holds A Ministerial on Nuclear Security.
• Assessing Progress on Nuclear Security.
• 12^th GUMO Officer On Trial for Embezzlement.
• Lukashenko: Pompeo Alerted Me to Nuclear Materials at Border.
• US and Russia Reported HEU and Plutonium to IAEA.
• IAEA Bank Receives LEU.
• GICNT Hosted 8 Multilateral Activities in 2019.

Dec 10, 2021

• U.S.-Russia Elbe Group Maintains Focus on Threat of Nuclear Terrorism.
• Former Chernobyl Plant Manager Bryukhanov Dies.
• Matthew Bunn on Threat to Nuclear and Radiological Transports.
• On 9/11 Anniversary Russian Officials Call for Resumption of U.S.-Russian CT Cooperation.
• Experts Weigh in on 9/11 Anniversary.
• U.S. and Norway Agree to Eliminate All of Norway’s HEU.
• Two Soviet Nuclear Submarine Reactors Located.
• Russian Security Council: Terrorists Remain Interested in NBC.
• IAEA Adopts Resolutions on Nuclear Security, NS Center Planned.
• Allison on Risk of Mega-terrorist Attack After U.S. Withdrawal From Afghanistan.
• Arbatov Warns of Enduring Threat of Nuclear Terrorism to Russia in His New Volume.
• Russia’s New Security Strategy Drops References to CT Partnership With U.S.
• NNSA’s Non-Proliferation Budget to Decrease in ’22, Provides for US and Russian Visits.
• Should U.S.-Russian Interaction in Cyberspace Involve CT? 
• Russia’s NPP Operator Conducts Emergency Preparedness Exercise.
• Putin and Biden Discuss Terrorist Threat Emanating from Afghanistan, but No Deal.
• U.S. Experts on Ensuring Access to Neutrons While Reducing Nuclear Terrorism Risks.
• Beebe Weighs in on U.S.-Russian CT Interaction.
• Duo Detained for Alleged Attempt to Sell Americium-241.
• 12th GUMO Guard’s Sentence Upheld.
• NDAA-Mandated Group to Identify Nuclear Terrorism Risks.
• Belfer’s MTA Hosts Conference on Lessons of Fukushima and Chernobyl.
• Russia Withdraws from Uranium Hexafluoride Transportation Deal with U.S.
• Bell: U.S. Needs to Convince Russia on Contending With Nuclear Terrorism Threat.
• U.S. and Canada Complete Repatriation of HEU Material.
• Siegfried Hecker Outlines his Vision of Future for Nuclear Security Cooperation.
• Hackers Breach U.S. Nuclear Agency.
• Tobey on Assassinations of Nuclear Scientists and Terrorists.
• Rosatom Has Checked Nuclear Sites, Following a Tip on Terrorism from U.S.

Jun 21, 2022

Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy).  Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here.

Mar 15, 2024

Europe after the Russo-Ukrainian War must develop a new security structure to defend against any Russian aggression. The safest option is a non-offensive, confidence-building defense. This option includes proposals such as the “spider in the web” strategy and the “porcupine” strategy to provide for European security in a region threatened by Russian expansion—without relying on the threat of nuclear war.

Mar 14, 2024

David Kearn argues that the idea that the first use of nuclear weapons since 1945 would be by the United States in the defense of Taiwan against a conventional Chinese invasion would have significant, negative, and long-lasting, diplomatic ramifications. It is difficult to fathom the myriad potential consequences, but U.S. nuclear weapon use would almost certainly shatter the non-proliferation regime as a functioning entity, incentivize states (including China) to acquire or improve their existing nuclear arsenal, and damage America's standing globally.

Mar 15, 2024

On March 13, President Vladimir Putin granted an interview, in which he again delved into the conditions under which he says he would initiate the use of nuclear weapons. His remarks were so ambiguous that it caused mainstream Western media organizations—which tend to agree on what to emphasize in news out of the Kremlin—to put divergent headlines on the news stories that they ran about this particular interview. “Putin, in Pre-Election Messaging, Is Less Strident on Nuclear War. The Russian leader struck a softer tone about nuclear weapons in an interview with state television,” was the NYT’s headline. In contrast, the FT’s headline was “Russia ‘prepared’ for nuclear war, warns Vladimir Putin. President resumes bullish rhetoric over use of atomic arsenal if west threatens Moscow’s sovereignty,” while CBS News ran with “Putin again threatens to use nuclear weapons, claims Russia's arsenal ‘much more’ advanced than America's” and WSJ led with “Putin Rattles Nuclear Saber Ahead of Presidential Elections; Raising specter of nuclear confrontation.” So, which is it? Has Putin just struck a softer tone about nuclear weapons or has he rattled his nuclear saber yet again? The answer is both.

Apr 1, 2024

Report by Trevor Findlay about recent politics surrounding the Iranian Nuclear Program.

Apr 17, 2024

Mariana Budjeryn presents "Russia's Invasion of Ukraine and Its Impact on the Global Nuclear Order" at the DOE/NNSA Administrator's Strategy Forum