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The Enormous Risks and Uncertain Benefits of an Israeli Strike Against Iran's Nuclear Facilities

Assaf Zoran argues that an attack on Iran's nuclear facilities may have the opposite result of prompting an escalation in Iran’s nuclear developments, a pattern previously observed in response to kinetic actions attributed to Israel.




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When Actions Speak Louder Than Words: Adversary Perceptions of Nuclear No-First-Use Pledges

Would the world be safer if the United States pledged to never use nuclear weapons first? Supporters say a credible pledge would strengthen crisis stability, decrease hostility, and bolster nonproliferation and arms control. But reactions to no-first-use pledges by the Soviet Union, China, and India suggest that adversaries perceive pledges as credible only when the political relationship between a state and its adversary is already relatively benign, or when the state’s military has no ability to engage in nuclear first use against the adversary. 




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Reducing Nuclear Dangers

Matthew Bunn argues that governments need help from scientists and engineers both in understanding the dangers that nuclear weapons continue to pose and in finding paths to reduce them.




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Is Nuclear Proliferation Back?

Joseph Nye considers lessons from his own work on preventing the spread of nuclear technology in the 1970s.




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Russia and the Global Nuclear Order

Russia's 2022 invasion of Ukraine illuminated the long profound shadow of nuclear weapons over international security. Russia's nuclear threats have rightfully garnered significant attention because of the unfathomable lethality of nuclear weapons. However, the use of such weapons in Ukraine is only one way—albeit the gravest— that Russia could challenge the global nuclear order. Russia's influence extends deep into the very fabric of this order—a system to which it is inextricably bound by Moscow's position in cornerstone institutions such as the Nuclear Non-Proliferation Treaty (NPT) and the International Atomic Energy Agency (IAEA). From withdrawing from key treaties to stymieing resolutions critical of misconduct, Moscow has demonstrated its ability to challenge the legitimacy, relevance, and interpretations of numerous standards and principles espoused by the West.




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VolitionRx Demonstrates NuQ® Blood Test Detects 95% of Pancreatic Cancers in Second Preliminary Study - Introduction to VolitionRx Nucleosomics� technology: Revolutionizing cancer diagnosis

VolitionRx�s Nucleosomics� diagnostic platform detects epigenetic changes to fragments of chromosomes, called nucleosomes, that circulate in the blood of cancer patients. Credit: VolitionRx.




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Nuclear waste tanker pilots futuristic aluminium sail

Adding blade-like sails to tankers could reduce their annual fuel consumption by up to 30 per cent, slashing the climate impact of the shipping industry




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Dietary Nucleic Acids and Their Role in Cancer Prevention

All living things have nucleic acids. When people eat food containing nucleic acids, they get incorporated into the body. According to research by associate




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Need Nuclear Power Plant?

NEED POWER PLANT? A PRAGMATIC APPROACH IS NEED OF THE HOUR

Electric power is a growing need in a developing...




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U.S. summer nuclear outages declined in 2024, returning to 2022 levels

Average U.S. nuclear capacity outages during the summer of 2024 (June 1 through August 31) decreased to about 2.6 gigawatts (GW) per day from 3.1 GW in 2023, similar to average summer daily outages in 2022. Outages this past summer were highest in mid-July and early August, averaging 3.1 GW per day and peaking at 5.7 GW on the last day of August. More recently, nuclear outages have exceeded the five-year average because of weather-related disruptions and refueling outages.




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Nuclear Weapons: Earth's Last Line of Defense Against Asteroids

NASA is on alert. The U.S. space agency is closely tracking two asteroids that would be making a close encounter with our planet. There is no need to be alarmed as the first asteroid is 130 feet in diameter and at




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A Small Sting, A Giant Setback! Rare Bees Derail Meta's Nuclear Data Center Dream

Meta's ambitious plans for an AI data center encountered an unexpected obstacle: a rare bee species. The Financial Times reported that this discovery disrupted Meta's discussions with a nuclear power plant operator in the US. Meta CEO Mark Zuckerberg mentioned during




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Polar and tropical regioisomeric decanuclear cuprofullerenes

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02261K, Research Article
Jing-Xuan Sun, Ting-Ting Zou, Yi-Chun Zhang, Yu-Li Liu, Li Dang, Shun-Ze Zhan, Hong Cai, Dan Li
Two polar and tropical coordinated decanuclear regioisomeric cuprofullerenes with CuI atoms coordinating on CC bonds of the two polar zones around pentagons and the tropical zone of the equator have been successfully assembled, respectively.
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A tetranuclear-cluster-based MOF with a low-polarity pore environment for efficient C2H6/C2H4 separation

Inorg. Chem. Front., 2024, 11,7947-7954
DOI: 10.1039/D4QI01685H, Research Article
Meng Feng, Jiantang Li, Xirong Wang, Jingyu Wang, Dongmei Wang, Banglin Chen
Benefitting from reticular chemistry, the newly developed MOF material ZJNU-400 establishes a low-polarity environment that enables reversed ethane adsorption and facilitates the efficient separation of C2H6/C2H4.
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Detection and Identification of Single Ribonucleotide Monophosphates using a Dual In-Plane Nanopore Sensor Made from a Thermoplastic via Replication

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01062G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Steven A. Soper, Chathurika Rathnayaka, Indu Chandrasoma, Junseo Choi, Katie Childers, Maximillian Chibuike, Khurshed Akabirov, Farhad Shiri, Adam R Hall, Collin J McKinney, Matthew David Verber, Sunggook Park
We report the generation of ~8 nm dual in-plane pores fabricated in a thermoplastic via nanoimprint lithography (NIL). These pores were connected in series with nanochannels, one of which served...
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Grind, shine and detect: mechanochemical synthesis of AIE-active polyaromatic amide and its application as molecular receptor of monovalent anions or nucleotides

RSC Adv., 2024, 14,13227-13236
DOI: 10.1039/D4RA02129K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jakub S. Cyniak, Artur Kasprzak
The mechanochemical synthesis of AIE-active amide, as well as the application of the title compound as molecular receptor of monovalent anions and nucleotides, are described.
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Formation of H-bonding networks in the solid state structure of a trinuclear cobalt(III/II/III) complex with N2O2 donor Schiff base ligand and glutaric acid as bridging co-ligand: synthesis, structure and DFT study

RSC Adv., 2024, 14,13200-13208
DOI: 10.1039/D3RA07697K, Paper
Open Access
Sovana Maity, Sudip Bhunia, Michael G. B. Drew, Rosa M. Gomila, Antonio Frontera, Shouvik Chattopadhyay
Formation of hydrogen bonding network in a trinuclear linear mixed-valence centrosymmetric cobalt(III)–cobalt(II)–cobalt(III) complex has been analyzed using DFT calculations.
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Catalytic copolymerization of carbon dioxide and cyclohexene oxide by a trinuclear cyclohexane-bridged tetradentate Schiff base chromium complex

Polym. Chem., 2024, 15,4519-4528
DOI: 10.1039/D4PY00956H, Paper
Jie Huang, Boxiong Shen
The development of catalytic systems is a central area of research in carbon dioxide (CO2) and epoxy copolymerization.
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Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01798F, Paper
Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, Rong Tian
Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options.
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Probing the role of ligation and exonuclease digestion towards non-specific amplification in bioanalytical RCA assays

Analyst, 2024, 149,5491-5503
DOI: 10.1039/D4AN00866A, Paper
Vandana Kuttappan Nair, Chandrika Sharma, Shrawan Kumar, Mrittika Sengupta, Souradyuti Ghosh
Comprehensive quantitative analysis of various ligation and digestion conditions to identify and minimize non-specific amplification in RCA bioanalytical methods.
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Densification of sodium and magnesium aluminosilicate glasses at ambient temperature: structural investigations by solid-state nuclear magnetic resonance and molecular dynamics simulations

Phys. Chem. Chem. Phys., 2024, 26,27348-27362
DOI: 10.1039/D4CP02431A, Paper
Millena Logrado, Yara Hellen Firmo Gomes, Tomiki Inoue, Shingo Nakane, Yoshinari Kato, Hiroki Yamazaki, Akihiro Yamada, Hellmut Eckert
Superposition of 17O triple-quantum magic-angle spinning NMR spectra of 20MgO–20Al2O3–60SiO2 (MAS**) and 20Na2O–20Al2O3–60SiO2 (NAS**) glasses prepared at ambient pressure (AP) and pressurized and decompressed at 25 GPa at room temperature (HP(25)).
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Oxidation of fine aluminum particles: thermally induced transformations in particle shells and kinetics of oxide nucleation

Phys. Chem. Chem. Phys., 2024, 26,27602-27616
DOI: 10.1039/D4CP03355H, Paper
Andrey V. Korshunov
A submicron aluminum particle during oxidation is a shrinking spherical segment due to the growth of a single γ-Al2O3 nucleus.
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Theoretical insight into photodeactivation mechanisms of adenine–uracil and adenine–thymine nucleobase pairs

Phys. Chem. Chem. Phys., 2024, 26,27807-27816
DOI: 10.1039/D4CP02817A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kinga Szkaradek, Robert W. Góra
Ab initio calculations elucidate plausible intramolecular photoinduced relaxation pathways involving ring puckering and an efficient intersystem crossing in A–U and A–T base pairs, potentially hindering electron-driven proton transfer detection.
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Dynamics of ionic liquids by means of nuclear magnetic resonance relaxation – overview of theoretical approaches

Phys. Chem. Chem. Phys., 2024, 26,27248-27259
DOI: 10.1039/D4CP03183K, Review Article
Danuta Kruk, Elzbieta Masiewicz, Roksana Markiewicz, Rajendra Kumar Singh
Nuclear magnetic resonance relaxometry probes the translational and rotational dynamics of ionic liquids. To take advantage of this unique experimental potential, appropriate theoretical models are needed.
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Protein misfolding and amyloid nucleation through liquid–liquid phase separation

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D3CS01065A, Review Article
Semanti Mukherjee, Manisha Poudyal, Kritika Dave, Pradeep Kadu, Samir K. Maji
Protein misfolding and amyloid aggregation, linked to neurodegenerative diseases, can result from liquid–liquid phase separation (LLPS) and a subsequent liquid-to-solid transition. This represents LLPS as a generic mechanism in amyloid nucleation.
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Directed nucleophilic aromatic substitution reaction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC04912H, Communication
Yasuyuki Nitta, Takashi Nishikata, Michinori Sumimoto, Yusei Nakashima
In this study, we discovered a directed nucleophilic aromatic substitution reaction, "directed SNAr (dSNAr)", in the reaction of ortho-iodobezamides and amine in the presence of pyridine. The reaction proceeded ortho-specifically...
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Endosomolytic Peptides Enable the Cellular Delivery of Peptide Nucleic Acids

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05214E, Communication
Open Access
JoLynn B. Giancola, Ronald T. Raines
Precision genetic medicine enlists antisense oligonucleotides (ASOs) to bind to nucleic acid targets important for human disease. Peptide nucleic acids (PNAs) have many desirable attributes as ASOs but lack cellular...
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Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent

Chem. Commun., 2024, 60,13440-13442
DOI: 10.1039/D4CC04672B, Communication
Hirotaka Murase, Mio Eto, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki
A novel oligonucleotide acetylating-reagent that induces a site-specific RNA acetylation through duplex formation has been developed.
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In silico investigation of the interaction between α-synuclein aggregates and organic supramolecular assemblies

Mol. Syst. Des. Eng., 2024, 9,1155-1166
DOI: 10.1039/D4ME00071D, Paper
Laura Le Bras, Yves L. Dory, Benoît Champagne
An α-synuclein aggregate with the PreNAC and NACore areas, responsible for the aggregation, highlighted.
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Adsorption of nucleotides and nucleic acids on goethite nanoparticle: mode, sites and relationship with phosphate and non-phosphate structure

Environ. Sci.: Nano, 2024, Accepted Manuscript
DOI: 10.1039/D3EN00891F, Paper
Huajun Feng, Shanshan Ma, Zaiming Chen, Yungui Li, Meizhen Wang, Yangcheng Ding
The impact of iron (hydr)oxide adsorption on nucleotides and nucleic acids (NNA) in the environment varies. However, there is a lack of quantitative reports on how iron (hydr)oxide adsorption changes...
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Effects of nucleating agents on the II–I transition of iPB-1

CrystEngComm, 2024, 26,1940-1951
DOI: 10.1039/D3CE01303K, Paper
Zhiqi Li, Jingqing Li, Shichun Jiang
For iPB-1, II–I transition is of industrial importance; whereas, the traditional solid–solid II–I transition mechanism encountered challenges. It is form I formation in amorphous phase that triggers II-I transition with crystal reorganizations.
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Solvent-polarity-controlled assembly of polynuclear titanium-calixarene complexes: constructing isolated {Ti7}, {Ti13}, {Ti24} and {Tb2Ti13} clusters

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D3CE01275A, Paper
Yanyan Wang, Ying Xiong, Wuping Liao
The assembly of polynuclear titanium-calixarene complexes is based on Ti4–C8A SBUs.
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Extended isomerism in heteronuclear metal-organic frameworks: synthetic strategies and crystal structures of lanthanide-cobalt-oxydiacetate systems

CrystEngComm, 2024, Accepted Manuscript
DOI: 10.1039/D4CE00168K, Paper
Fernando Igoa, Agustín López Cabrera, Javier Gonzalez-Platas, Leopoldo Suescun, Carlos Kremer, Julia Torres
Here, we present the synthesis and crystal structure of a series of heteronuclear metal-organic frameworks, which consists of cobalt(II) and lanthanide(III) ions or yttrium(III), connected by oxydiacetato (oda2-) as ligand....
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Nitro group and K+-based secondary building units for the self-assembly of 3D coordination polymers built on dinuclear dianionic helicate connectors

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D4CE00255E, Paper
Open Access
Raúl Mendoza-Báez, Alan Molina-Renteria, Juan Olguín
Two dinuclear dianionic helicates, K2[MII2(L)3] M = MnII (1) and NiII (2), based on 2-hydroxy-5-nitrobenzaldehyde, self-assemble into novel 3D coordination polymers due to nitro groups acting as secondary assembly instruction.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00358F, Paper
Open Access
Yuma Matsuura, Shinichiro Fuse
Various 2,5-disubstituted furans were synthesized via 5-substituted 2-halomethylfurans using microflow technology.
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Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00402G, Paper
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari
5-(Benzimidazol-2-yl)- and 5-(benzothiazol-2-yl)-pyrimidine bases-modified oligonucleotides were prepared by post-synthetic trifluoromethyl conversion and their fluorescence properties were measured.
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A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA

Org. Biomol. Chem., 2024, 22,2963-2967
DOI: 10.1039/D4OB00089G, Communication
Jiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji
A phosphamide nucleotide analog (dNTPγNH2) exhibited higher stability than dNTPs and can be recognized by DNA polymerases in PCR.
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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt

Org. Biomol. Chem., 2024, 22,2953-2957
DOI: 10.1039/D4OB00203B, Communication
Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
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Nuclear excitation by electron capture seen at long last

Breakthrough could lead to new type of energy source




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The worst accident in the world : Chernobyl, the end of the nuclear dream / Nigel Hawkes [and others] ; illustrations by Duncan Mil.

London : Pan Books Ltd : William Heinemann Ltd, 1986.




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Inside JET: The world's biggest nuclear fusion experiment | On Location

Inside these walls, scientists have been trying for decades to create an unlimited source of energy, nuclear fusion. Welcome to JET, the world's biggest nuclear fusion experiment. Scientists argue that fusion could replace coal gas and nuclear fission in the energy mix alongside renewable energy, which can prove to be unreliable. If we can learn to control it, nuclear fusion could change life as we know it. But that's a big if. This video was produced as part of Digital Society, a publishing partnership between WIRED and Vontobel where all content is editorially independent. Visit Vontobel Impact for more stories on how technology is shaping the future of society: https://www.vontobel.com/en-int/about-vontobel/impact/ With thanks to the CCFE: https://ccfe.ukaea.uk #WIRED #NuclearFusion #NuclearReactor




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Re:WIRED GREEN 2022: Alan Ahn on the Future of US Nuclear Power

Alan Ahn, senior resident fellow of the Climate and Energy program at Third Way, an organization that advocates for sustainable nuclear power, will take the stage to discuss the future of nuclear power in the United States and how recent events in Ukraine and Japan have changed people’s perceptions of nuclear energy as a clean solution.




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Re:WIRED GREEN 2022: Alan Ahn on the Future of US Nuclear Power

Alan Ahn, senior resident fellow of the Climate and Energy program at Third Way, an organization that advocates for sustainable nuclear power, will take the stage to discuss the future of nuclear power in the United States and how recent events in Ukraine and Japan have changed people’s perceptions of nuclear energy as a clean solution.




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MIT Professor Explains Nuclear Fusion in 5 Levels of Difficulty

Nuclear fusion underpins some of the most basic processes in our universe and holds the promise of virtually limitless, clean, carbon-free energy. Dr. Anne White, Professor of Nuclear Science and Engineering at The Massachusetts Institute of Technology, has been challenged to explain the nature of nuclear fusion to 5 different people; a child, a teen, a college student, a grad student, and an expert.




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Improvements in low-level radionuclide measurement capability through use of the Apex Q sample introduction system combined with ICP-MS/MS

J. Anal. At. Spectrom., 2024, 39,2929-2936
DOI: 10.1039/D4JA00216D, Paper
Ben Russell, Frankie Falksohn, Alexandre Tribolet, Hibaaq Mohamud, Olivia Pearson, Emma Braysher, Saskia Burke, Anu Bhaisare
Improvement in sensitivity and interface removal capability for radionuclide measurement using desolvating sample introduction combined with ICP-MS/MS.
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Advancing energy safety via stepwise nucleophilic substitution on tetrazine

J. Mater. Chem. A, 2024, 12,30548-30557
DOI: 10.1039/D4TA06039C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jatinder Singh, Richard J. Staples, Jean'ne M. Shreeve
This study presents a feasible approach to synthesizing hydrazine/nitroamine and amino/nitroamine substituted tetrazine derivatives.
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CERN, the world’s biggest nuclear research centre, turns 70; in search of funding for next project

The nuclear physics hub needs to finance the construction of the Future Circular Collider as its existing particle accelerator — famed for discovering the Higgs Boson — edges toward the end of its useful life




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India asks states away from coal to consider nuclear power

India has pledged to achieve net-zero by 2070 and has a target to generate 500 GW of renewable energy a year by 2030