Sweden’s Johnie Berntsson led the Bermuda Gold Cup round robin stage with six wins, followed by USA’s Chris Poole and Australia’s Cole Tapper. A spokesperson said, “Sweden’s Johnie Berntsson, 2023 defending champion of the Bermuda Gold Cup and three-time winner of the event, completed the round robin stage of this year’s Bermuda Gold Cup event […]

The Ministry of Tourism, Culture, and Sport celebrates Jada Pearman, saying her “recent performance with the Paul Taylor Dance Company at New York’s David H. Koch Theatre has brought pride to Bermuda.” A Government spokesperson said, “Jada debuted in Dedicated to You, a solo choreographed by Robert Battle, honouring the legacy of dance icon Carolyn […]

When I was an undergraduate at university many years ago, my deep enjoyment and love for the works of William Shakespeare blossomed. I had the privilege of taking a Shakespearean class and then during one summer in my undergraduate years, I was able to travel through Europe inexpensively on a bike and a Europass to see the great sites. A memory I remember most is going to Stratford-upon-Avon and watching a William Shakespeare play. I don’t know where my passion and love for his plays comes from but it has been a deep part of my life. His writings have also taught me many things.

When I was in England many years ago for the first time, I was standing in the back of the audience watching the play ‘As You Like It’ that was performed not too far from the ... Read More »

The post What Shakespeare Can Teach Us About Enlightenment: All the world’s a stage appeared first on Enlightenment Podcast.

Alright, today we're going to cover some common questions you may have
about the Stage Shredded Status DVD's before
they sell out...

==> Click here to learn how this transformation went down...


If you've seen the video but have some questions before ordering:

Question: Is SSS a documentary of Vince Delmonte's transformation or is there an actual program included?

Answer: Yes, SSS includes an entire program (covered on 3 of the 8 disks) and it was filmed with former NFL lineman and NPC level bodybuilder Ryan Watson! They are both pretty jacked up in this workout so it's pretty motivating too!

What Vince is going to do for anyone who orders is send you the printable workout sheets of the Stage Shredded Status workout program! Just email him your receipt to the help desk for proof of purchase!

You'll love this program because it relies on a variance of rep ranges to target, specifically, the Type 11a & Type 1a muscle fibers which create the training effect of
hypertrophy and strength-endurance. The combos generate a lot of lactate to boost growth hormone levels to assist in fat loss. You don't do super heavy loads because heavy lifting does not involve enough mechanical stress to promote fat loss.
Plus, you would not normally lift super heavy when you get leaner because your joints have less fluid and fat to protect them from the bigger forces.

Question: What if I have more than 50 lbs to lose?

Answer: Heck, Vince had 30 lbs to lose so you're programming
is going to be no different than his. The only difference is that you have an extra 8-10 weeks to travel. Let's go!

==> Get 6-Pack Abs By Summertime!



Question: Is SSS for a complete beginner?

Answer: If Vince only cared about selling his DVD's I would say yes but if you have less than one year experience in his crazy fitness world, you'll probably find his approach a little too hardcore for now. Sit this one up unless you're absolutely intrigued to see how this goes down.

The weight training program is far too advanced and you would be better off learning the nutritional principles in No Nonsense Muscle Building, which focuses on a balanced approach to eating. You need to master a balanced
approach before implementing some of the more advanced things they did.

Question: I noticed you had an ENTIRE cupboard full of supplements.
Am I supposed to take all of those?!?!

Answer: When it comes to supplementation, that's a personal choice.

In the DVD's Vince explains WHY he takes what he takes and encourages you to just sit back and consider it an educational experience. Then, as you choose, start to add one new supplement a month and measure
the response. There are SO MANY supplements he's interested in trying himself but he likes to add one new thing at a time so he will get there when he gets there.

Question: What if I only have 10 lbs of fat to lose?

Answer: Again, the same principles apply and you'll learn how Vince adjusted his cardio intensity and frequency as he gets closer to the show to ensure he does not lose muscle the last few weeks.

You'll see EXACTLY how he changed his diet from phase to phase (He changed it three times throughout the 16 weeks) and you'll see some creative ways to switch around your macros and food sources
that assist with fat loss, WITHOUT dropping your calories.

==> Get 6-Pack Abs By Summertime!

Question: Is Ben Pakulski in any of the DVD's?

Answer: YES! The first 2 DVDs start off in Toronto when Vince is looking pretty bulky and they get 2 hours of coaching on the gym floor with Ben & Intentions! If you bought MI40 then you already have this footage but it's worth reviewing and owning it on hardcopy. I know that every time I watch this footage, I re learn something new and then BOOM, I have a better workout!

If you don't have this footage, heck, the first 2 hours is worth 3x the price of the DVDs because Ben bills $150 an hour! This is the kind of information that propelled him into the ranks of the top ten bodybuilders in the world this past month!

Question: How long are the DVDs on sale?

Answer: It depends... we have about 550 left in stock now and the $50 off sale ends Sunday night or whenever he sells out... Whatever comes first.

Trust that helps and THANK YOU for your interest in Vince's work. This is, by far, the best fat loss resource he's ever released. Grab it while you can!

Here is the $50 Off Discount link to get your DVDs shipped right now!

Get 6-Pack Abs By Summertime!


P.S. Vince ships all over the world!

Poor Mayor Pete just can't seem to catch a break on the internet. The presidential candidate from South Bend, Indiana tweeted a photo of himself walking down a hallway on Saturday with the caption, "On my way back to Iowa. It's phase 4. Let's do this." The tweet has been catching a fair amount of flack for appearing to be staged. 

Here are some of Twitter's most amusing reaction memes and tweets!

European stock indexes traded lower in Wednesday's premarket session, with the US Consumer Price Index (CPI) report firmly on investors' radar ahead of its release at 2:30 pm CET. Analysts anticipate ...

European stock indexes traded lower in Tuesday's premarket session, with the US Consumer Price Index (CPI) report firmly on investors' radar ahead of its release at 2:30 pm CET. Analysts anticipate in...

Sinwar, who topped Israel's most-wanted list, was a key figure believed to have been behind the 7 October attacks.

Legendary Christian writer C.S. Lewis gave us an analogy to help explain otherwise inexplicable moments such as this. Tolerance, Lewis once wrote, “parodies love as flippancy parodies merriment.” In a […]

The post Biden Asked If He'll Get a Hostage Deal by the End of His Term, and His Response Is Telling appeared first on The Western Journal.

The rare feat of winning both the Two Oceans and Soweto marathons has marked Onalenna Khonkhobe’s breakthrough season, establishing him as one of South Africa’s rising road-running stars.

Visual Abstract

Felicia Grasso
Dec 1, 2020; 19:1986-1996
Research

Juntuo Zhou
Nov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384
Research

Coronavirus disease 2019 (COVID-19) is a highly contagious infection and threating the human lives in the world. The elevation of cytokines in blood is crucial to induce cytokine storm and immunosuppression in the transition of severity in COVID-19 patients. However, the comprehensive changes of serum proteins in COVID-19 patients throughout the SARS-CoV-2 infection is unknown. In this work, we developed a high-density antibody microarray and performed an in-depth proteomics analysis of serum samples collected from early COVID-19 (n = 15) and influenza (n = 13) patients. We identified a large set of differentially expressed proteins (n = 132) that participate in a landscape of inflammation and immune signaling related to the SARS-CoV-2 infection. Furthermore, the significant correlations of neutrophil and lymphocyte with the CCL2 and CXCL10 mediated cytokine signaling pathways was identified. These information are valuable for the understanding of COVID-19 pathogenesis, identification of biomarkers and development of the optimal anti-inflammation therapy.

Plasmodium, the malaria parasite, undergoes a complex life cycle alternating between a vertebrate host and a mosquito vector of the genus Anopheles. In red blood cells of the vertebrate host, Plasmodium multiplies asexually or differentiates into gamete precursors, the male and female gametocytes, responsible for parasite transmission. Sexual stage maturation occurs in the midgut of the mosquito vector, where male and female gametes egress from the host erythrocytes to fuse and form a zygote. Gamete egress entails the successive rupture of two membranes surrounding the parasite, the parasitophorous vacuole membrane and the erythrocyte plasma membrane. In this study, we used the rodent model parasite Plasmodium berghei to design a label-free quantitative proteomic approach aimed at identifying gender-related proteins differentially released/secreted by purified mature gametocytes when activated to form gametes. We compared the abundance of molecules secreted by wild type gametocytes of both genders with that of a transgenic line defective in male gamete maturation and egress. This enabled us to provide a comprehensive data set of egress-related molecules and their gender specificity. Using specific antibodies, we validated eleven candidate molecules, predicted as either gender-specific or common to both male and female gametocytes. All of them localize to punctuate, vesicle-like structures that relocate to cell periphery upon activation, but only three of them localize to the gametocyte-specific secretory vesicles named osmiophilic bodies. Our results confirm that the egress process involves a tightly coordinated secretory apparatus that includes different types of vesicles and may put the basis for functional studies aimed at designing novel transmission-blocking molecules.

The choice for adjuvant chemotherapy in stage II colorectal cancer (CRC) is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high-risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectrometry imaging could identify patients at risk. We report here the N-glycosylation signatures of the different cell populations in a group of stage II CRC tissue samples. The cancer cells, compared to normal epithelial cells, have increased levels of sialylation and high-mannose glycans, as well as decreased levels of fucosylation and highly branched N-glycans. When looking at the interface between cancer and its microenvironment, it seems that the cancer N-glycosylation signature spreads into the surrounding stroma at the invasive front of the tumor. This finding was more outspoken in patients with a worse outcome within this sample group.

Paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, is a parasitic infection of ruminant livestock which has seen a rapid rise in prevalence throughout Western Europe in recent years. Following ingestion of metacercariae (parasite cysts) by the mammalian host, newly-excysted juveniles (NEJs) emerge and invade the duodenal submucosa which causes significant pathology in heavy infections. The immature larvae then migrate upwards, along the gastrointestinal tract, and enter the rumen where they mature and begin to produce eggs. Despite their emergence, and sporadic outbreaks of acute disease, we know little about the molecular mechanisms used by C. daubneyi to establish infection, acquire nutrients and to avoid the host immune response. Here, transcriptome analysis of four intra-mammalian life-cycle stages, integrated with secretome analysis of the NEJ and adult parasites (responsible for acute and chronic disease respectively), revealed how the expression and secretion of selected families of virulence factors and immunomodulators are regulated in accordance with fluke development and migration. Our data show that whilst a family of cathepsins B with varying S2 sub-site residues (indicating distinct substrate specificities) are differentially secreted by NEJs and adult flukes, cathepsins L and F are secreted in low abundance by NEJs only. We found that C. daubneyi has an expanded family of aspartic peptidases, which is up-regulated in adult worms, although they are underrepresented in the secretome. The most abundant proteins in adult fluke secretions were helminth defence molecules (HDMs) that likely establish an immune environment permissive to fluke survival and/or neutralise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopolysaccharide in the microbiome-rich rumen. The distinct collection of molecules secreted by C. daubneyi allowed the development of the first coproantigen-based ELISA for paramphistomosis which, importantly, did not recognise antigens from other helminths commonly found as co-infections with rumen fluke.

The histopathological subtype of lung adenocarcinoma (LUAD) is closely associated with prognosis. Micropapillary or solid predominant LUAD tends to relapse after surgery at an early stage, whereas lepidic pattern shows a favorable outcome. However, the molecular mechanism underlying this phenomenon remains unknown. Here, we recruited 31 lepidic predominant LUADs (LR: low-risk subtype group) and 28 micropapillary or solid predominant LUADs (HR: high-risk subtype group). Tissues of these cases were obtained and label-free quantitative proteomic and bioinformatic analyses were performed. Additionally, prognostic impact of targeted proteins was validated using The Cancer Genome Atlas databases (n=492) and tissue microarrays composed of early-stage LUADs (n=228). A total of 192 differentially expressed proteins were identified between tumor tissues of LR and HR and three clusters were identified via hierarchical clustering excluding eight proteins. Cluster 1 (65 proteins) showed a sequential decrease in expression from normal tissues to tumor tissues of LR and then to HR and was predominantly enriched in pathways such as tyrosine metabolism and ECM-receptor interaction, and increased matched mRNA expression of 18 proteins from this cluster predicted favorable prognosis. Cluster 2 (70 proteins) demonstrated a sequential increase in expression from normal tissues to tumor tissues of LR and then to HR and was mainly enriched in pathways such as extracellular organization, DNA replication and cell cycle, and high matched mRNA expression of 25 proteins indicated poor prognosis. Cluster 3 (49 proteins) showed high expression only in LR, with high matched mRNA expression of 20 proteins in this cluster indicating favorable prognosis. Furthermore, high expression of ERO1A and FEN1 at protein level predicted poor prognosis in early-stage LUAD, supporting the mRNA results. In conclusion, we discovered key differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage LUAD. Some of these proteins could serve as potential biomarkers in prognostic evaluation.

SpaceX successful launched a South Korean communication satellite from Kennedy Space Center in Florida on Monday afternoon.

For the first time ever, the Food and Agriculture Organization of the United Nations (FAO) will be hosting two back-to-back conferences looking at the challenges and solutions for sustainable livestock [...]

The 1898 Wilmington massacre left dozens of Black North Carolinians dead. Conspirators also forced the city's multiracial government to resign at gunpoint

Tampico, Mexico :: Logos Hope's international crewmembers perform their onboard theatre show entirely in Spanish for the first time.

Penn State Centre Stage will produce Stephen Sondheim's "Sweeney Todd: The Demon Barber of Fleet Street,” with book and lyrics by Hugh Wheeler, music directed by Anne Van Steenwinkel, Nov. 12–22, at the Playhouse Theatre on the University Park campus.

ICTSI said it will use all legal channels to make sure that a Maersk subsidiary, "is not successful in holding the Durban port, and indeed the South African economy hostage to their interests".

In this week's episode of SA Money Report, we delve into Eskom's latest plunge into darkness.

OMNIvision works behind the scenes at TeenStreet, OM’s international youth congress, providing top quality video for thousands of teens.

DOVER, DE – After a difficult year for Delaware small businesses, the Division of Small Business is re-starting EDGE Grants, an innovative, competitive program to provide young Delaware companies with funds to help them expand their business. EDGE (Encouraging Development, Growth and Expansion) grows Delaware’s economy by providing funding to promising early-stage businesses to level […]

DOVER, DE (March 1, 2022) – Young Delaware companies in need of funding to help expand their business can now apply to compete for an Encouraging Development, Growth and Expansion (EDGE) Grant from the Division of Small Business. The division will be accepting EDGE Grant applications until March 31 from promising early-stage businesses throughout Delaware. […]

Zomato witnesses approximately 400,000 cancelled orders monthly which prompted it to launch the initiative.

I am trying to understand the Linting process. I know that mainly JasperGold is the tool for this purpose. Though I think JasperGold is more suited for later stages of the design. As a RTL Design Engineer, I want to make sure that if another tool has the capability of doing Linting earlier in the flow. for example, does Xcelium, Genus or Confomal support linting. I have seen some contradicting information online regarding this topic, though I can't find anything related to Linting on any of these tools.

Thanks

It has become challenging to ensure that the designs are complete, correct, and adhere to necessary coding rules before handing them off for RTL verification and implementation. RTL Designer Signoff Solution from Cadence helps the user identify RTL bugs at a very early development stage, saving a lot of effort and cost for the design and verification team. Our reputed customers have confirmed that using RTL signoff for their design IP helped save up to 4 weeks and reduce the late-stage RTL changes by up to 80%.(read more)

Tel Aviv, Israel — Israeli protesters expressed concern for the hostages in Gaza on Saturday, after Qatar said it was pausing as a key mediator for a cease-fire that would help bring the captives home. Thousands of people rallied in Tel Aviv holding signs reading "400," the number of days since the hostages were taken when Hamas militants attacked southern Israel on October 7, 2023. Efforts to broker a truce in the ensuing war between Hamas and Israel have proven fruitless, and on Saturday Qatar put its mediation on hold until the two sides showed "willingness and seriousness" in talks. Protester Ruti Lior said she was unsure how much sway Qatar had, but was still "very, very worried" by their decision to pull back from negotiations. "This is further proof for me that there really is no seriousness, and these deals are being sabotaged," the 62-year-old psychotherapist told AFP. Saturday's rally featured an installation of masks representing Netanyahu along with signs bearing the word "Guilty." Other placards read "Hostage deal now" and "Drop your weapon, stop the war." "How many more tears must fall and how much more blood must be shed before someone does what needs to be done and brings our children home?" Niva Wenkert, mother of hostage Omer Wenkert, was quoted as saying in a statement released by campaign group Hostage and Missing Families Forum. In the October 7, 2023, attack, Hamas militants killed 1,200 people and captured about 250 hostages, sparking the war in Gaza. Israel says it believes Hamas is still holding 101 hostages, including 35 the military says are dead. Hamas has been designated a terror group by the United States, the U.K. and other Western countries. Israel’s counteroffensive in Gaza has killed more than 43,000 people, according to the territory's health ministry, which does not distinguish between combatants and civilians in its count. Israelis have been protesting weekly to pressure their government to do more to secure the captives' release. Qatar, which has hosted Hamas's political leadership since 2012 with U.S. blessing, has been involved in months of protracted diplomacy aimed at ending the war in Gaza. But the talks, also mediated by Cairo and Washington, have repeatedly hit snags since a one-week truce in November 2023 -- the only one so far -- with both sides trading blame for the impasse. 

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Former Meta COO Sheryl Sandberg delivers an emotional address on her post-October 7 transformation, urging Jewish leaders to combat rising antisemitism and campus bias.

Sullivan laid the blame squarely on Hamas, clarifying that the issue was that the group simply didn’t want to make a deal under any terms.

KARACHI: The Federal Board of Revenue’s (FBR) decision to fix the minimum retail price (MRP) of tea at Rs1,200 per kg for levying sales tax would make the commodity more expensive, warned traders on Tuesday.

Pakistan Tea Association (PTA) Chairman Mohammad Altaf said the MRP at the import stage would have an adverse impact of Rs150-300 per kg on imported tea prices.

The flat MRP also ignores global tea prices hovering between 0.50 cents to over $3 per kg. Tea is imported in different packaging, with bulk shipments typically weighing more than 5kgs and around/approximately 80kgs. An 18 per cent general sales tax is already charged based on the imported tea.

He said before fixing the MRP for sales tax purposes, it is crucial to consider that the definition of “manufacturer” in Section 2(16) of the Sales Tax Act 1990, includes activities such as blending, mixing, processing, and packaging, as clarified in Circular No. 3(11) ST-L&P/2013-94433-R dated July 17, 2019. Based on this, tea imported for these processes qualifies as “raw material”.

Tea sellers warn FBR move will incentivise arrival of low-quality product via illegal channels

“According to judicial interpretations (e.g., CTO v. Rajasthan Taxchem Ltd., 2007) and definitions in Advanced Law Lexicon, “raw material” includes ingredients necessary for manufacturing. Tea used in blending and packaging clearly falls under this category, he added.

Accordingly, sales tax should be based on the import value, as per Subsection 46(f) of Section 2 of the Sales Tax Act, 1990, rather than the minimum retail price, Altaf said.

Tea retail prices vary significantly due to numerous factors, including the company, method of sale (open or packaged), product quality, and regional differences. The PTA chief said that the flat MRP rate per kg also does not reflect the prices charged by most traders, manufacturers, and sellers.

The imposition of a flat rate per kg would have severe negative consequences for a large portion of the tea trade, which may result in reduced business activity and ultimately lead to a loss of revenue for the national exchequer via misusing several exemptions.

Two-thirds of Pakista­nis purchase tea at Rs700-950 per kg, reflecting socio-economic and regional price variations.

He said that MRP cannot be applied at the import stage as the tea has to follow various value-addition procedures before it is made shelf-ready. “This MRP disrupts the supply chain and eradicates the role of wholesalers and distributors who play a vital role in the business, while MRP at the import stage also eradicates the basic right of commercial imports,” the PTA chief observed.

Tea is a part of our daily diet, a staple food item, not a drink.

Most people in rural and urban areas consume tea as per their earnings. Further fixing of MRP will incentivise unscrupulous elements to exploit the situation, and thus, import of low-priced teas will find its way through illegal channels, Altaf feared.

Published in Dawn, November 13th, 2024

This year could bring up to 25 named tropical storms in the Atlantic Ocean due to a shift to La Niña conditions, says the US National Oceanic and Atmospheric Administration

Title: What Are the 4 Stages of Congestive Heart Failure?
Category: Diseases and Conditions
Created: 6/24/2020 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

ABSTRACTIntroduction:Since the health information system (HIS) in public health care services in Serbia was introduced in 2009, it has gradually expanded. However, it is unclear how well the HIS components have developed and the whole system’s stage of maturity.Method:In June–September 2021, a maturity assessment of the Serbian HIS was conducted for the first time using the HIS Stages of Continuous Improvement (SOCI) toolkit. The toolkit measures HIS status across 5 HIS domains: leadership and governance, management and workforce, information and communication technology (ICT), standards and interoperability, and data quality and use. The domains were further divided into 13 components and 39 subcomponents whose maturity stage was assessed on a 5-point Likert scale, indicating the level of development: (1) emerging/ad hoc; (2) repeatable; (3) defined; (4) managed; and (5) optimized. The toolkit was applied in a working group of 32 professionals and experts who were engaged in developing the new national eHealth strategy and action plan.Results:The overall maturity score of the Serbian HIS was 1.6, which indicates a low level. The highest baseline score (2) was given to the standards and interoperability domain, and the lowest (1.1) was given to ICT infrastructure. The remaining 3 domains (leadership and governance, Management and Workforce, and Data Quality and Use) were similarly rated (1.7, 1.7, and 1.6, respectively).Conclusion:A baseline assessment of the maturity level of Serbian HIS indicates that the majority of components are between the emerging/ad hoc stage and repeatable, which represent isolated, ad hoc efforts, with some basic processes in place and existing and accessible policies. This exercise provided an opportunity to address identified weaknesses in the upcoming national eHealth strategy.

BACKGROUND AND PURPOSE:

Reocclusion after treatment is a concern in endovascular therapy for isolated intracranial atherothrombotic stroke-related large-vessel occlusion (AT-LVO). However, the optimal endovascular therapy technique for AT-LVO has not yet been investigated. This study evaluated the optimal endovascular therapy technique for AT-LVO in a real-world setting.

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.

Stage III nonsmall cell lung cancer (NSCLC) represents a wide range of tumour (T1 to T4) and nodal (N0 to N3) components, requiring variable management and a multidisciplinary approach. Recent advancements in minimally invasive techniques, molecular biology and novel drug discoveries have accelerated the refinement of stage III NSCLC management. The latest developments in staging include the forthcoming update of the nodal component in the 9th TNM (tumour–node–metastasis) edition, which emphasises the critical role for endobronchial ultrasonography in mediastinal staging. Recent treatment developments include the use of immunotherapy and targeted molecular therapy in both the neoadjuvant and adjuvant setting, either in combination with other modalities or used alone as consolidation. Surgical and radiotherapy advancements have further enhanced patient outcomes. These developments have significantly improved the prognosis for patients with stage III NSCLC. Fast-changing recommendations have also brought about a challenge, with clinicians facing a number of options to choose from. Therefore, a multimodal approach by a multidisciplinary team has become even more crucial in managing stage III NSCLC.

Sir Andy Murray will swap Centre Court for the stage next summer as he embarks on a tour discussing his illustrious tennis career.

Israeli President Isaac Herzog says hostages are "going through hell in the dungeons of Gaza" during meeting with President Biden at White House.

Screaming girls. Sudden riches. Your face on the cover of Smash Hits magazine. Life in a Nineties boyband sounds like a dream, but one survivor of the maelstrom likens it more to being in the military. Jessie Thompson goes behind the scenes of revealing new BBC documentary ‘Boybands Forever’

His early personnel choices indicate his incoming administration would be willing to use sticks as well as carrots to deal with Russia.

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC From the outside, one might assume all biotech venture capital (VC) firms are more similar than different. However, once you look under the

The post A Primer on Early-Stage Biotech VC appeared first on LifeSciVC.

Edmunds.com�s roundup of new vehicles at the 2014 LA Auto Show