Retail giants like Yoox Net-a-Porter Group and Brooks Brothers quickly pivoted to offer life-saving services.

Monique Lynch is a 29-year-old who believes her purpose is to improve the lives of those around her, especially the downtrodden and persons living with mental health issues. This angel-on-earth in the eyes of many is a Jill of several trades as...

“Don’t use social media to impress people, use it to impact people.” – Dave Willis This is the strategy used by The Distinguished’s 2020 Social Media Personality of the Year, Dr Terri-Karelle Reid, who has, in some aspect, impacted the...

[Edinburgh] : [publisher not identified], [1890]

Mathias Colomb Cree Nation is wondering why the federal government ignored their community's proposal for an emergency COVID-19 response space in favour of a Calgary company's. 

The post Using SOLIDWORKS for New Creative Purposes appeared first on SOLIDWORKS Education Blog.

A group of 16 people from a church in USA sees lives changed during their short-term outreach in Kiel, Germany.

A welder's life is renewed in Kaharlyk, Ukraine through a new business opportunity with OM.

Smaller classes could help bridge the gap between home and school, writes former teacher Marc Vincenti.

“How about defining student and teacher performance based on what parents and citizens actually want for their children—all of the goals, not just one,” suggests Donald B. Gratz.

On view from October 4-25, 2019 Free opening reception on Friday, October 4, at 5 p.m. Wilmington, Del. (September 25, 2019) – Art with Purpose, an exhibition of photographs and paintings by Leah Beach, will be on view in the Mezzanine Gallery from October 4-25, 2019. The artist will host a free opening reception on […]

The nationwide lockdown suspended the operation of international flights and such people were had to prolong their stay in India. They were concerned that the extra stay due to lockdown may make them a resident of India for tax purposes under section 6 of the Act.

The FCA recently published a discussion paper on transforming culture in financial services. The paper is a collection of short essays by industry leaders, professional bodies and culture experts and is aimed at helping firms to develop and emb...

dsPIC33CK64MC105 General Purpose Plug-In Module (PIM) Information Sheet

ABSTRACT

In the absence of a vaccine, multidrug-resistant Neisseria gonorrhoeae has emerged as a major human health threat, and new approaches to treat gonorrhea are urgently needed. N. gonorrhoeae pili are posttranslationally modified by a glycan that terminates in a galactose. The terminal galactose is critical for initial contact with the human cervical mucosa via an interaction with the I-domain of complement receptor 3 (CR3). We have now identified the I-domain galactose-binding epitope and characterized its galactose-specific lectin activity. Using surface plasmon resonance and cellular infection assays, we found that a peptide mimic of this galactose-binding region competitively inhibited the N. gonorrhoeae-CR3 interaction. A compound library was screened for potential drugs that could similarly prohibit the N. gonorrhoeae-CR3 interaction and be repurposed as novel host-targeted therapeutics for multidrug-resistant gonococcal infections in women. Two drugs, methyldopa and carbamazepine, prevented and cured cervical cell infection by multidrug-resistant gonococci by blocking the gonococcal-CR3 I-domain interaction.

IMPORTANCE Novel therapies that avert the problem of Neisseria gonorrhoeae with acquired antibiotic resistance are urgently needed. Gonococcal infection of the human cervix is initiated by an interaction between a galactose modification made to its surface appendages, pili, and the I-domain region of (host) complement receptor 3 (CR3). By targeting this crucial gonococcal–I-domain interaction, it may be possible to prevent cervical infection in females. To this end, we identified the I-domain galactose-binding epitope of CR3 and characterized its galactose lectin activity. Moreover, we identified two drugs, carbamazepine and methyldopa, as effective host-targeted therapies for gonorrhea treatment. At doses below those currently used for their respective existing indications, both carbamazepine and methyldopa were more effective than ceftriaxone in curing cervical infection ex vivo. This host-targeted approach would not be subject to N. gonorrhoeae drug resistance mechanisms. Thus, our data suggest a long-term solution to the growing problem of multidrug-resistant N. gonorrhoeae infections.

What film critics have to say about this week's new releases.

Two men have been charged after a £3 million cocaine haul was uncovered in a purpose-built smuggling lorry in Dover.

Tottenham have granted the NHS access to their stadium to carry out coronavirus testing.

Dayne Beams worries the coronavirus pandemic will further contribute to mental health issues in the AFL and wider society but is finding peace outside the game.

Jorge Flores-Rojas, 44, an undocumented Mexican national, was sentenced to 24 years in prison by Chief Judge Robert J. Conrad, Jr. in Charlotte, N.C., for two counts of sex trafficking of minors and one count of interstate transportation of an adult for purposes of commercial sex. Flores-Rojas pled guilty to the charges on Oct. 7, 2008.

Charles Kizer, 53, from Memphis, Tenn., was sentenced late Friday by U.S. District Judge Samuel H. Mays, Jr. to 10 years in prison for violating the Mann Act.

Attorney General Eric Holder announced today that the Obama administration, as part of successfully concluding negotiations on the E.U.-U.S. Data Protection and Privacy Agreement (DPPA), would seek to work with Congress to enact legislation that would provide E.U. citizens with the right to seek redress in U.S. courts if personal data shared with U.S. authorities by their home countries for law enforcement purposes under the proposed agreement is subsequently intentionally or willfully disclosed, to the same extent that U.S. citizens could seek judicial redress in U.S. courts for such disclosures of their own law enforcement information under the Privacy Act

This blog was written by Rene Russo, CEO of Xilio Therapeutics, as part of the From The Trenches feature of LifeSciVC. In an environment where senior leaders are tasked with defining agile strategies in uncertain times, there are many perspectives

The post Long-Range Planning (LRP): Reframed Leaders Require Purpose appeared first on LifeSciVC.

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Apr 29, 2020

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 

Executive Summary Across the globe, multilateralism appears in crisis. Skepticism of the benefits of a multilateral order grounded in underlying liberal principles is manifesting throughout the Western world. The United States, the system’s imperfect cornerstone, scorns a growing number of multilateral institutions and norms each day. Within Europe, Brexit and discord over the European Union’s…

Instead of trashing these old treads, they have been made into a inter-looping work of art in the same station.

Thousands of pairs of unwanted eyewear are collected and transformed into a unique, twinkling facade for an Istanbul museum.

It is modern in appearance yet traditional in operations

You will find your ikigai at the intersection of what you are good at and what you love doing.

This new California-based company is run by two entrepreneurial moms who understand the value of local production, quality fabrics, and reducing one's environmental impact.

Featuring an interlocking system that's inspired by traditional Japanese joinery, this desk also has a swappable, modular system for organizing your stuff.

Think you need to be an engineer and spend a bundle to create a mini-hydropower generator? Think again.

Not sure if you really want to live in a tiny house? This tiny home builder is making these cabins from salvaged materials, which visitors can test out at an eco-retreat in Maryland.

A fading fairytale village will become Switzerland's first 'scattered hotel' thanks to a foundation committed to saving it.