Serum proteomics reveal APOE-ε4 -dependent and APOE-ε4 -independent protein signatures in Alzheimer’s disease  Nature.com

quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data  Nature.com

Proteomic signatures improve risk prediction for common and rare diseases  Nature.com

A multi-species benchmark for training and validating mass spectrometry proteomics machine learning models  Nature.com

Spatial proteomics identifies JAKi as treatment for a lethal skin disease  Nature.com

Proteomic scores and dietary patterns  Nature.com

Spatial proteomics of single cells and organelles on tissue slides using filter-aided expansion proteomics  Nature.com

Proteomic analysis of the combined effects of cannabigerol and 3- O -ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes  Nature.com

Artificial intelligence is powerful, but what about natural intelligence? This hour, TED speakers explore the intrinsic genius in animal language, insect behavior, plant anatomy and our immune system. Guests include neuroscientist Greg Gage, computational neuroscientist Frances Chance, social psychoneuroimmunologist Keely Muscatell and environmental researcher Karen Bakker.

We want to dedicate this episode to Bakker who passed away in August 2023, only a few months after giving her TED Talk. Her research and legacy continue to inspire.

TED Radio Hour+ subscribers now get access to bonus episodes, with more ideas from TED speakers and a behind the scenes look with our producers. A Plus subscription also lets you listen to regular episodes (like this one!) without sponsors. Sign-up at plus.npr.org/ted

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There are two sides to every coin — and sometimes our strengths become weaknesses. This hour, TED speakers explore the mixed blessings and volatile flip sides of mental health, parenting and AI. Guests include developmental psychologist Yuko Munakata, entrepreneur Andy Dunn and AI researcher Yejin Choi.

Original broadcast date: August 11, 2023

TED Radio Hour+ subscribers now get access to bonus episodes, with more ideas from TED speakers and a behind the scenes look with our producers. A Plus subscription also lets you listen to regular episodes (like this one!) without sponsors. Sign-up at plus.npr.org/ted.

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Artificial intelligence is powerful, but what about natural intelligence? This hour, TED speakers explore the intrinsic genius in animal language, insect behavior, plant anatomy and our immune system.

Guests include neuroscientist Greg Gage, computational neuroscientist Frances Chance, social psychoneuroimmunologist Keely Muscatell and environmental researcher Karen Bakker.

Original broadcast date: March 8, 2024

Learn more about sponsor message choices: podcastchoices.com/adchoices

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Posted by Gordon Fyodor Lyon on May 05

The beguiling, mist-covered forest of Los Cedros provides a vision of a future where the rights of the natural world are actively and effectively protected.

For the city’s LGBTQ community, Toronto’s outdoor spaces have been sites of both liberation and violence

In this excerpt, author Misty Pratt explores emerging research—and her own experience—that suggests remedies like park prescriptions may be as key to mental and physical health as diet, exercise, and sleep.

a great little store that we just visited for the first time today

New packaging options/flavor combinations were created to accommodate the needs/requests of convenience, warehouse, drug store and big box chains. 

Multipurpose Smart ID Card with PKI (Bio Digital Signature with Smart Card + e-ID + Credit Card)
Source: SG 17 Chairman
Study Questions: Q9/17

UPU-ITU mini workshop: Multipurpose Smart ID Card with PKI (Bio Digital Signature with Smart Card + e-ID + Credit Card)"
Source: TSB
Study Questions: Q9/17

PABCO Roofing’s entire Signature Cut line, including Paramount, Cascade, and Paramount Advantage, has earned UL 2218 Class 4 impact resistance, offering enhanced durability and aesthetic appeal.

Restore biodiversity in your community.

Location: Electronic Resource- 

Location: Electronic Resource- 

When Tina Berkett moved from New York City to Los Angeles in 2007, she immediately noticed the West Coast's creative spirit…

Maybe you shouldn't be surprised that Spokane's most notable distillery has an origin not unlike its host city…

For Tycho's Scott Hansen, it all comes back to water…

Karolina Pliskova joins star-studded Edgbaston line-up.

video screenshot via abc.net.au

Recently besieged by dry weather and Crazy Ants, Christmas Island's Red Crabs are Back, baby. Chariot pulled by cassowaries has posted about their 100 million march to the ocean (and incidental occupation of roads, school grounds, living rooms, toilet drains, and Metafilter threads).

When recordings like Forces of Nature: Live at Slugs' seemingly falls from yonder jazz sky, we must stop to thank those swinging stars above for our grand fortune. Because despite all our flaws--a broken politic, a poisoned planet, constant wartime bickering--we are a fortunate, if mostly undeserving, race of peculiarities... [ read more ]

In this 2016 conversation, Eleanor Wachtel speaks with the English poet about her poetry collection Falling Awake — and the enduring inspiration of the natural world.

Eleanor Wachtel spoke with the Scottish author about her novels, Autumn and Winter, in 2018.

Take a ‘virtual visit’ to a nature reserve named after one of Bermuda’s National Heroes with the video, photos and 360° panoramas below providing a visual journey of the Gladys Morrell Nature Reserve in Sandys. When announcing her as a National Hero back in 2015, the Government said, “Many will remember Gladys Morrell as one […]

Photo courtesy of Cheryl Smith. Bag found in Japan. 

Today's architecture is no longer about creating the best space just for humans, though of course that has to be a factor. It's also about preserving and living in harmony with the natural world. But being harmonious with nature presents a unique set of challenges. The Hidden Garden House by RAD+ar (Research Artistic Design + Architecture) is a showcase of creative and innovative solutions for just such a challenge.[...]

The post Russian Nature: Beautiful and Diverse appeared first on English Russia.

Check out some of NOVA’s best nature documentaries available for streaming.

By David Blackmon In the wake of the election of President Donald Trump to serve a second term in office, along with presumptive Republican majorities in both houses of Congress, many are now asking about what the future will hold for the oddly named Inflation Reduction Act. Trump made it repeatedly clear on the campaign […]

The post Biden’s Signature Climate ‘Boondoggle’ Might Be On Chopping Block After Trump Win appeared first on Liberty Unyielding.

The TV presenter says the previous Tory administration was "reckless" to scale back climate policy.

Representatives of 196 countries have been meeting in Cali, Colombia, as part of the COP biodiversity summit.

My father, the birder, is often excited to share his sightings with me — especially so this summer when he got back from a long-planned trip to South Africa. 153 species! I love how he finds joy and peace by connecting with the world through observing birds, interacting with fellow birders, and telling tales of his birding adventures. In so many wonderful ways, Dad’s daily routines and way of life are linked to nature and the birds he loves.

Towards just transition in Africa: Green financing for nature-based solutions and rural resilience 21 July 2022 — 9:30AM TO 1:00PM Anonymous (not verified) 30 June 2022 Libreville and online

This hybrid event in Libreville explores just transition policy and green financing for nature-based solutions, with a particular focus on the integration of job creation priorities in conservation and rural resilience.

Global climate policies towards a ‘just transition’ under the Paris Agreement should align with and support African states’ national sustainable development priorities – in particular, the need for decent and fair job creation, as well as resilient and sustainable land, environment, and ecosystem management policies.

Achieving green growth requires innovative and more accessible financing models, especially as wealthy nations’ financial pledges have fallen short. Ahead of the ‘African COP27’ set to take place in Egypt in November 2022, there is a need for transformational strategic thinking and context-specific action from African governments, civil society, businesses and financiers, in their green financing demands and national implementation plans.

Preservation of biodiversity and nature is not only critical in the global fight against climate change but is also vital for conservation-based economic development. Natural capital stocks, such as terrestrial and marine ecosystems and biodiversity, produce benefits that support societal and individual well-being and economic prosperity, such as clean air, fresh water, regulation of water flows and pollination of crops – while also acting as important carbon sinks. Financing environmental protection must go beyond compensation and contribute to creating fair social and economic conditions for incentivizing conservation.

At this hybrid event in Libreville, participants will discuss green financing for nature-based solutions, particularly the integration of plans for job creation in conservation and rural resilience within just transition planning.

This event is part of a series on Towards Just Transition: Connecting Green Financing and Sustainable Job Creation in Africa, supported by the Chatham House Sustainability Accelerator.

This event will be held in French and English with simultaneous interpretation.

This event will also be broadcast live on the Chatham House Africa Programme’s Facebook page.

Sean A Burnap
Dec 7, 2020; 0:RA120.002305v1-mcp.RA120.002305
Research

Tirsa L. E. van Westering
Dec 1, 2020; 19:2047-2067
Research

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and γ. AMPKα and β are encoded by two genes, the γ subunit by three genes, all of which are expressed in a tissue-specific manner. It is not fully understood, whether individual isoforms have different functions. Using RNA-Seq technology, we provide evidence that the loss of AMPKβ1 and AMPKβ2 lead to different gene expression profiles in human induced pluripotent stem cells (hiPSCs), indicating isoform-specific function. The knockout of AMPKβ2 was associated with a higher number of differentially regulated genes than the deletion of AMPKβ1, suggesting that AMPKβ2 has a more comprehensive impact on the transcriptome. Bioinformatics analysis identified cell differentiation as one biological function being specifically associated with AMPKβ2. Correspondingly, the two isoforms differentially affected lineage decision toward a cardiac cell fate. Although the lack of PRKAB1 impacted differentiation into cardiomyocytes only at late stages of cardiac maturation, the availability of PRKAB2 was indispensable for mesoderm specification as shown by gene expression analysis and histochemical staining for cardiac lineage markers such as cTnT, GATA4, and NKX2.5. Ultimately, the lack of AMPKβ1 impairs, whereas deficiency of AMPKβ2 abrogates differentiation into cardiomyocytes. Finally, we demonstrate that AMPK affects cellular physiology by engaging in the regulation of hiPSC transcription in an isoform-specific manner, providing the basis for further investigations elucidating the role of dedicated AMPK subunits in the modulation of gene expression.

Astrid M. Moerman
Dec 23, 2020; 0:jlr.RA120000974v1-jlr.RA120000974
Research Articles

Carotid atherosclerosis is a risk factor for ischemic stroke, one of the main causes of mortality and disability worldwide. The disease is characterized by plaques, heterogeneous deposits of lipids and necrotic debris in the vascular wall, which grow gradually and may remain asymptomatic for decades. However, at some point a plaque can evolve to a high-risk plaque phenotype, which may trigger a cerebrovascular event. Lipids play a key role in the development and progression of atherosclerosis, but the nature of their involvement is not fully understood. Using matrix-assisted laser desorption/ionization mass spectrometry imaging, we visualized the distribution of approximately 200 different lipid signals, originating of > 90 uniquely assigned species, in 106 tissue sections of 12 human carotid atherosclerotic plaques. We performed unsupervised classification of the mass spectrometry dataset, as well as a histology-directed multivariate analysis. These data allowed us to extract the spatial lipid patterns associated with morphological plaque features in advanced plaques from a symptomatic population, revealing spatial lipid patterns in atherosclerosis and their relation to histological tissue type. The abundances of sphingomyelin and oxidized cholesteryl ester species were elevated specifically in necrotic intima areas, while diacylglycerols and triacylglycerols were spatially correlated to areas containing the coagulation protein fibrin. These results demonstrate a clear co-localization between plaque features and specific lipid classes, as well as individual lipid species in high-risk atherosclerotic plaques.

Using a simple, environment friendly proteome extraction (TOP), we were able to optimize the analysis of clinical samples. Using our TOP method we analyzed a clinical cohort of microsatellite stable (MSS) and unstable (MSI-H) colorectal carcinoma (CRC). We identified a tumor cell specific, STAT1-centered, immune signature expressed by the MSI-H tumor cells. We then showed that long, but not short, exposure to Interferon- induces a similar signature in vitro. We identified 10 different temporal protein expression patterns, classifying the Interferon- protein temporal regulation in CRC. Our data sheds light on the changes that tumor cells undergo under long-term immunological pressure in vivo, the importance of STAT proteins in specific biological scenarios. The data generated could help find novel clinical biomarkers and therapeutic approaches.