There is provided a compound having an excellent controlling effect on pests represented by the formula (1): wherein, A1 represents —NR7—, etc., A2 represents a nitrogen atom, etc., A3 represents a nitrogen atom, etc., R1 represents a C1-C6 chain hydrocarbon group optionally substituted by one or more atoms or groups selected from Group X, etc., R2, R3 and R4 are the same or different and each represents a C1-C6 chain hydrocarbon group optionally substituted by one or more halogen atoms, etc., R5 and R6 are the same or different and each represents a C1-C6 chain hydrocarbon group optionally substituted by one or more atoms or groups selected from Group X, etc., R7 represents a C1-C6 chain hydrocarbon group optionally substituted by one or more atoms or groups selected from Group W, etc., n represents 0, 1 or 2, or an N-oxide thereof.

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Method of manufacturing a fused silica crucible, including manufacturing a plurality of carbon electrodes for melting a vitreous silica object to be melted by arc discharge by rubbing the surface of a carbon electrode of the electrodes with a vitreous silica of the same type as the vitreous silica object to be melted, by at least one of: inserting a front end of the carbon electrode into a storage tank storing powdered vitreous silica, by at least one of rotating and reciprocating in an axial direction the storage tank and the carbon electrode relative to each other; rubbing the surface of the carbon electrode by ejecting powdered vitreous silica from a nozzle onto the surface of the electrode; rubbing the surface of the electrode with a vitreous silica grinder; and rubbing the surface of the electrode against a rotating surface of a portion of a fused vitreous silica crucible.

A mounting flange for attaching an HVAC air diffuser terminal in an opening in a floor or other mounting surface. The mounting flange includes a trim ring and a flange clip. The flange clip is adjustably and movably received in a slot defined a side of the trim ring. A pawl on the flange clip engages with ratchets defined in a surface of the trim ring adjacent to the slot to maintain the flange clip in selected position relative the underside of a floor. The air diffuser terminal is secured in the floor opening between gripping surfaces on the flange clip and the trim ring. An optional screw operably connects the flange clip with the trim ring so that the diffuser may be securely tightened in the floor opening.

An adapter for front forks of a front loading commodity collection truck allows the truck to collect from rear load and side load style containers. An intermediate container is carried on the forks of the truck. An engagement apparatus is mounted on the intermediate container and is laterally extendible to engage the commercial container at curbside and draw the container to the intermediate container. The engagement apparatus will lift the commercial container and tip it over the intermediate container. Controls in the cab of the truck control operation of the adapter. The adapter can be removed easily from the forks when a front loading refuse container is encountered.

A semiconductor structure including a device configured to receive an input data-word. The device including a logic structure configured to generate an encrypted data-word by encrypting the input data-word through an encrypting operation. The device further including an eFuse storage device configured to store the encrypted data-word as eFuse data by blowing fuses in accordance with the encrypted data-word.

A coal nozzle assembly for a pulverized coal burner includes a diffuser. A flow conditioner also may be used with the assembly. The assembly conditions the coal/air flow before the coal/air flow is introduced to the furnace. The flow conditioner directs the coal into the diffuser where it is swirled to form a fuel rich outer ring disposed about an air rich inner portion before the fuel is delivered to the coal nozzle.

An adjustable air diffuser is disposed in an airflow channel into which a travelling wind is directed through an opening provided in a bumper face. The diffuser opens and closes the channel by movable louver blades driven by an actuator. An upper part of the diffuser is disposed to face a rear wall of the bumper face and is attached to a bumper beam extending along a vehicle width direction. A lower part of the diffuser is attached to a vehicle body structural member. The attachment structure includes a column that is disposed behind the adjustable air diffuser. A lower end of the column is attached to a lower end of the adjustable air diffuser. Weak portions are provided on the column such that the column breaks when the column interferes with another member behind the column.

A method of treatment of water in an aquatic environment. Water is first pumped from a reservoir to a first mixing station. An inert gas is introduced into the pumped water at the first mixing station to provide inert gas saturated water, which inert gas saturated water will displace undesired gasses in the water in the reservoir. The inert gas saturated water is then pumped to a sparging column such that the inert gas and undesired gasses will be released from the inert gas saturated water to provide depleted water.

A counterbalance mechanism for counterbalancing weight of a bottom-hinged door (such as a clamshell-type airstair door of an aircraft) includes an operator handle, a hoist rod pivotally connected at one end to the operator handle and at an opposite end thereof to the door near a bottom region thereof. A force accumulator assembly is provided which includes a force biasing member which accumulates and dissipates a bias force when opening and closing the door, respectively, to provide mechanical counterbalance to the weight of the door. A bellcrank assembly operatively connects the operator handle to the force accumulator. In such a manner, weight counterbalancing of the door is achieved.

A disposal method for entirely recycling solid refuse includes the following steps: sorting, crushing, drying, pressing with high pressure to shaped articles, producing charcoal from combustible refuse in high temperature and firing incombustible refuse in high temperature, at last cooling high temperature articles to obtain solid fuel with various shapes and bricks or board used for building. The method achieves entirely recycling house refuse, especial solid refuse. The method recycles solid refuse to obtain fuel and building material with economic value. The method is simple and its processing cost is low.

A two stage scrubber process for ethanol fermentation has a first stage using fusel oil to remove the hazardous air pollutants and recover the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage.

A fuselage panel made of composite material having a skin with an opening, at least part of the contour of which is reinforced by an integrated reinforcement made of composite material. The fuselage panel includes at least one liner made of composite material which is attached to and superposed on the reinforced skin portion and participates at least partially in defining the contour of the opening, the panel additionally including consolidating members, each passing at least partially through the liner and at least partially through the reinforced skin portion.

Positioning system of sectors of a device for producing an airplane fuselage in which a lamination mandrel comprises a plurality of sectors borne by a supporting structure and mobile along guides between: an expanded lamination position and a contracted disassembling position. Each guide comprises a fixed part borne by the supporting structure and a mobile part sliding along/with respect to the fixed part in a rectilinear direction H. Between a portion of each mobile part facing towards the respective sector and a stiffening structure of the sector a positioning device is provided which allows adjustment of the position of the sector with respect to the guide in two directions which lie in a plane RP perpendicular to the axis H of the guide.

A constraint system of sectors of a device for producing an airplane fuselage in which a lamination mandrel is adapted to receive and support a band of impregnated synthetic material. The lamination mandrel comprises a plurality of sectors angularly spaced about the axis and mobile between: an expanded lamination position and a contracted disassembling position. A constraint system is provided between each sector and the sectors adjacent thereto which guarantees a predetermined arrangement of the first sector with respect to the second sector adjacent thereto, preventing any translation along two directions which lie in an adjustment plane perpendicular to an axis RD which extends radially from the symmetry axis to the external surface.

A catamaran type vessel for use in a wastewater facility for servicing submerged air diffusers is disclosed. The vessel has spaced apart pontoon having an A-frame spanning between the upper decks of the pontoon and connecting the pontoons. A hook connected to a winch is secured to a cross header above the space between the pontoons. The hook is lowered into water and lifts an air header, to which the air diffusers are connected. An air diffuser is then pulled on the pontoons and serviced. The vessel is then propelled to a position to service other air diffusers in the pontoon.

Various systems and methods for implementing fuse-based integrity protection are described herein. A system for validating a read-only memory (ROM), the system comprising a ROM reader logic, implemented at least partly in hardware, to: access a read-only memory (ROM) having a plurality of permanently programmable electric couplings (PPECs), the PPECs having been programmed; survey a number of permanently altered PPECs in the set of PPECs to produce a counter value; read a binary representation of the counter value from PPEC values stored as a PPEC signature; and read a binary representation of the binary complement of the counter value from PPEC values in the PPEC signature; and a ROM validation logic, implemented at least partly, in hardware, to verify the integrity of the ROM using a combination of at least two of: the counter value, the binary representation of the counter value, and the binary representation of the binary complement of the counter value.

A compact CMOS anti-fuse memory cell. In one aspect, an apparatus includes an N− well and an anti-fuse cell formed on the N− well. The anti-fuse cell includes a lightly doped drain (LDD) region deposited in the N− well, an oxide layer deposited on the N− well and having an overlapping region that overlaps the LDD region, and a control gate deposited on the oxide layer, wherein a bit of the anti-fuse cell is programmed when a voltage difference between the control gate and the LDD region exceeds a voltage threshold of the oxide layer and forms a leakage path from the control gate to the LDD region, and wherein the leakage path is confined to occur in the overlapping region.

A array of electrically programmable fuse (eFuse) units includes at least one connecting switch connecting two adjacent eFuse units. Each eFuse unit includes an eFuse, a write switch for passing through a first portion of a write current, a read/write switch for passing through a second portion of the write current or a read current, and a common node. The eFuse, the write switch, the read/write switch, and the at least one connecting switch are connected to each other at the common node. By turning on and off the at least one connecting switch, the current is split among the eFuse units, so that the size of the write switch can be reduced, thus reducing the total area of the array.

A method directs fuel-oxidant premix into a reaction zone through a first total premix inlet flow area, and causes the premix to combust and form a stable flame projecting into a process chamber through an outlet from the reaction zone. At a time when the process chamber has a temperature at or above an auto-ignition temperature of the fuel, the flame is blown off to initiate diffuse combustion in the process chamber without a stable flame. The flame is blown off by directing the premix into the reaction zone through a second total premix inlet flow area greater than the first total premix inlet flow area.

A device includes an optical delivery fiber having a core having a first inside diameter joined to a capillary having an outer surface and a capillary tube having an inner surface. The capillary tube has a second inside diameter in the region of the joining to the optical delivery fiber. The second inside diameter is less than the first inside diameter of the delivery fiber.

This application claims a system for the distribution of waste water. The invention allows water to drain from a source into the invention, where the water is distributed and diffused through a collection of outlets. Thus a large amount of water can be distributed over a large area so that the environment can more easily absorb the water and the flow of water does not cause erosion. The preferred embodiment of the invention optionally may include one or more filters to remove substances from the water before distribution.

The original Bad Company frontman makes the clarification after some media outlets mistaken him for his fellow rocker who passed away from cardiac arrest on May 6.

PwC, Microsoft, KPMG & EY to help business turn profitable by next fiscal.

'Leathery and musky' is how the brand describes it and claims that the scent will stay for as long as four years. Each bag comes with a complimentary miniature bottle of FendiFrenesia, which can be used to refresh the bag's scent and can be worn as a traditional perfume.

SO, is it a smoking gun after all? Or is it just a damp water pistol?

The Voice by Andy Morffew (cc by)

Hello yes this is a bird ... or is it??? How people tweeted in the '70s, from Going To Maine

SALEM, Ore. (AP) — Oregon is renowned for its craft beer and increasingly for its high-grade marijuana, but the state is keeping the two apart — for now. In a new ruling, the Oregon Liquor Control Commission, which regulates both alcoholic products and recreational marijuana, says beer and other alcoholic drinks as of Jan. 1 […]

The new rules prohibit marijuana products featuring “a name, design or brand” that is similar to something you’d see in a candy or toy shop. But they aren’t as sweeping as the emergency ban swiftly approved in late 2018 that resulted in a backlash from businesses.

ABC North Coast resident arts reviewer, Jeanti St Clair looks at the Northern Rivers Portrait Prize.

Renowned sailor Jon Sanders blames a "huge, confused swell" for the sinking his yacht off the coast of WA.

At the end of the bitumen road and surrounded by parched grazing land, Ivanhoe, like many outback towns, is fighting for survival.

Bradley Edwards elects not to offer a detailed defence to three charges of murdering Sarah Spiers, Jane Rimmer and Ciara Glennon — crimes that became known as the Claremont serial killings.

'Brief Encounter' serves as a poignant little reminder of the volcano ready to erupt beneath the cover of a mediocre suburban life.

Ambulance paramedics left a woman with a history of mental illness alone in her home without electricity, hot water or lighting before she was found dead months later, in a move a coroner said was "difficult to understand."

A senior manager of a Melbourne aged care home initially refused to act on video footage of elder abuse for a month due to the Christmas break, the aged care royal commission hears.

A man who had a container of railway detonators in his bag on a train on the New South Wales south coast pleads guilty to possessing an explosive device in public.

The family of an elderly man posts a video of him crawling on his hands and knees to the toilet and claims he was discharged from an Adelaide hospital without proper treatment.

Letters released by the Independent Commissioner Against Corruption show he was refused $2 million to fund an evaluation of the Central Adelaide Local Health Network.

The details of a secret recording of a conversation between accused Adelaide wife killer Peter Dansie and his son are revealed in court.

Outside a pre-polling booth in Manly, Tony Abbott refused to elaborate on a previous statement he made about the Bob Hawke. Mr Abbott has been criticised by both sides of politics for politicising the late prime minister's death. May 17, 2019.

Allegations a female firefighter was grabbed by the neck by a male colleague, and another suffered burns after being "blocked" from leaving a house fire, spark an investigation at a regional SA fire station but the findings will not be made public.

Oliver Scales-Copeland, who is accused of stabbing two police officers at a service station north of Sydney yesterday, represents himself in court and becomes emotional when his bail application is refused.

A 33-year-old Victorian woman who was repeatedly denied breast screenings because of her age is urging other women to "follow their instincts" after being diagnosed with cancer.

Gold Coast Deputy Mayor Donna Gates refuses to comment on a ruling handed down by the Office of the Independent Assessor made public this week.

Three men with links to the Rebels bikie gang are refused bail after being charged with the murder of a Central Coast man who was beaten so severely he spent two months in a coma before dying.

MORNING BRIEFING: The serial sex offender who raped and killed Sydney woman Janine Balding will not be released for another two years, while the North Ryde RSL club cancels a conservative event on abortion over security fears.

A judge denies bail to an 18-year-old ride-share driver accused of getting into an argument with a group of passengers before ramming his car into two of them.