Weekends through autumn, join jewelers, silversmiths, weavers, potters and more during Desert View Watchtower's Cultural Demonstrator Series. https://www.nps.gov/grca/learn/news/watchtower-cultural-demonstrators.htm

Models, kits and methods useful in the demonstration of sialendoscopy devices and techniques are described. An exemplary demonstration apparatus comprises a support structure, an insert structure contacting the support structure, and a duct structure contacting the insert structure. The insert structure has a top surface defining a first opening and a bottom surface defining a second opening, and defines a channel with a first end in communication with the first opening and a second end in communication with the second opening. The duct structure comprises an elongate tubular member and has a first end in fluid communication with the first opening of the insert member, a second end, and defines a lumen extending from the first end to the second end. A portion of the duct structure is releasably disposed within the channel defined by the insert structure.

Starring in the skit for 'The Tonight Show Starring Jimmy Fallon', The Rolling Stones frontman gets onboard to support a non-profit providing for children in need during the coronavirus pandemic.

Businesses in the region are being encouraged to find out more about the importance of the growing digital economy at a free event taking place at Coventry University in January.

Sharing the reasons for the slowdown in the shoe industry, shoe manufacturer Pradeep Kumar said: "The main cause is the flood that most part of the country is facing. Due to sluggish sales, we are also short of funds."

Salon chains and wellness providers look to spur sales and attract new clients.

In Berlin, Stuttgart, Frankfurt, München und Köln gab es am Samstag erneut Proteste gegen die Einschränkungen wegen der Corona-Epidemie. Vor dem Reichstag nahm die Polizei 30 Personen vorläufig fest. Unter den Teilnehmern war auch Vegankoch Attila Hildmann.

Spring became an Alaska Airlines pilot during the golden age of aviation in the 1960s: a time when intuition and a dash of fearlessness helped steer the manual control systems.

As usual, May Day demonstrators took to the streets on Friday. Only this time, they drove in cars and practiced safe distancing while pushing for immigrant and workers' rights as well as a proposed tax on large corporations.

Goedemorgen! In Duitsland zijn er demonstraties tegen de coronamaatregelen in het land, en Jandino Asporaat organiseert een benefiet.

Het wordt een overwegend zonnige dag. Met 20 tot lokaal 26 graden wordt het nog een stuk warmer dan in de afgelopen dagen. De noordoostenwind is zwak tot matig.

Ga je vandaag de weg op? Hier vind je het overzicht van de werkzaamheden. Check hier de aangepaste dienstregeling voor het spoor.

Wat kun je vandaag verwachten?

Het is in Rusland de Dag van de Overwinning. Het is 75 jaar geleden dat het Rode Leger nazi-Duitsland versloeg. Vanwege de coronacrisis zijn er dit jaar geen militaire parade of veteranen op het Rode Plein. Wel vliegen er gevechtsvliegtuigen over Moskou. In Duitsland zijn in diverse steden demonstraties tegen de coronamaatregelen van de regering. Er worden duizenden deelnemers verwacht. Cabaretier Jandino Asporaat organiseert vanavond de live benefietshow Samen één Koninkrijk. De show, waarmee geld wordt ingezameld voor inwoners van Curaçao, Aruba en Sint-Maarten, is direct na het NOS Journaal van 20.00 uur te volgen op NPO 1.

Wat heb je gemist?

Verpleeghuizen hebben sinds begin maart al geprobeerd hun personeel te laten testen op het coronavirus, maar werden geweigerd door laboratoria, terwijl die soms voldoende testcapaciteit hadden. Zelfs toen half maart bezoek aan verpleeghuizen werd verboden vanwege besmettingsgevaar, werd het personeel niet getest.

De tests werden geweigerd omdat onduidelijk was waar in Nederland er beschikbare capaciteit was. Het grootste laboratorium van Nederland, Star-shl, had naar eigen zeggen wel capaciteit, maar weigerde aanvankelijk verpleeghuizen, omdat het RIVM dit voorschreef. "Marktwerking leidde de afgelopen tien jaar tot een wildgroei aan laboratoria", schrijft Trouw, dat samen met Argos en De Groene Amsterdammer het journalistieke onderzoeksplatform Investico inschakelde om het nieuws over de tests te achterhalen. "Waar voorheen één of twee labs per regio waren, zijn er nu landelijk ruim honderd. Volgens GGD'ers en arts-microbiologen is het overzicht zoek."

Ander nieuws uit de nacht

Entertainer Roy Horn (Siegfried & Roy) overleden in Las Vegas: Horn (75), die overleed aan het coronavirus, werd wereldberoemd met de extravagante leeuwen- en tijgershows die hij jarenlang met partner Siegfried Fischbacher maakte. Rapper Tekashi 6ix9ine maakt grootse comeback na vervroegde vrijlating: toen bekend werd dat 6ix9ine zou gaan getuigen in een zaak over bendegeweld, werd hij het lachertje van de rapscene. Maar online werd de hype steeds groter naarmate zijn comeback naderde. KNVB-plan voor oefenwedstrijden in augustus biedt FC Utrecht hoop: de bekerfinale tussen Feyenoord en FC Utrecht is door de coronapandemie van de agenda gehaald. Utrecht hoopt alsnog op doorgang: de bekerwinnaar verdient een ticket voor Europees voetbal.

En dan nog even dit:

In Nederland is een vulkaan ontdekt. Het gaat om een 150 miljoen jaar oude uitgedoofde vulkaan. Hij ligt 100 kilometer ten noordwesten van Texel, en is bij toeval door de Geologische Dienst Nederland gevonden. De nieuwe vulkaan is Mulciber genoemd, naar de Romeinse God van vuur en vulkanen.

De diep begraven Mulciber werd herkend aan afwijkingen in de structuur van de ondergrond en het aardmagnetisch veld op die plek. De vulkaan is de tweede van Nederland. Vijftig jaar geleden werd de eerste gevonden, in de Waddenzee.

Fijne dag!

As family and friends of Joyce Clarke demand to know why the young woman was shot dead by police, a tragic picture of her early life blighted by drugs and mental illness is beginning to emerge.

Massive wins for Geelong and Brisbane over North Melbourne and Gold Coast respectively have them closing in on a top two finish, while the Bombers are completely dismantled by the Bulldogs.

Whatever you think of Doom Eternal right now, id and Bethesda are determined to spice it up going forward. They’ve hinted at what’s coming next for the hellish shooter, starting with a preview of the game’s first free update. The simply titled Update...

Well, this one hits the sweet spot of topics I keep trying to demonstrate: both a Streisand Effect and Masnick's Impossibility Theorem. As you may have heard, a group of Republican political consultants and strategists, who very much dislike Donald Trump, put together an effort called The Lincoln Project, which is a PAC to campaign against Trump and Trumpian politics. They recently released an anti-Trump campaign ad about his terrible handling of the COVID-19 pandemic, called Mourning in America, which is a reference to Ronald Reagan's famous Morning in America campaign ad for the 1984 Presidential election. The new ad is, well, pretty powerful:

And while it's unlikely to convince Trump fans deep into their delusions, it certainly got under the President's skin. He went on one of his famous late night Twitter temper tantrums about the ad, and later lashed out at the Lincoln Project when talking to reporters. He was super, super mad.

And what did that do? Well, first it got the ad a ton of views. Earlier this week, one of the Lincoln Project's founders, Rick Wilson, noted that the ad had already received 15 million views across various platforms in the day or so since the ad had been released. Also, it resulted in the Lincoln Project getting a giant boost in funding:

The Lincoln Project, which is run by Republican operatives who oppose President Donald Trump, raised $1 million after the president ripped the group on Twitter this week – marking it the super PAC’s biggest day of fundraising yet.

Reed Galen, a member of the Lincoln Project’s advisory committee, told CNBC that the total came after the president’s Tuesday morning Twitter tirade in reaction to an ad titled “Mourning in America,” which unloads on Trump’s response to the coronavirus pandemic. It recently aired on Fox News, which Trump often watches and praises. Galen said it was the Lincoln Project’s best single-day fundraising haul

Not only that, but it has opened up more opportunity for the Lincoln Project team to get their word out. With so much interest in the ad, it opened up opportunities for the project members to get their message in various mainstream media sources. Reed Galen wrote a piece for NBC:

What we accomplished this week was not something to be celebrated. No commercial should have the power to derail the leader of the free world.

And another Lincoln Project founder, George Conway (who, of course, is the husband of Trump senior advisor Kellyanne Conway), wrote something similar for the Washington Post:

It may strike you as deranged that a sitting president facing a pandemic has busied himself attacking journalists, political opponents, television news hosts and late-night comedians — even deriding a former president who merely boasted that “the ‘Ratings’ of my News Conferences etc.” were driving “the Lamestream Media . . . CRAZY,” and floated bogus miracle cures, including suggesting that scientists consider injecting humans with household disinfectants such as Clorox.

If so, you’re not alone. Tens of thousands of mental-health professionals, testing the bounds of professional ethics, have warned for years about Trump’s unfitness for office.

Some people listened; many, including myself, did not, until it was too late.

That's the kind of media exposure you can't buy, but which you get when you have a President who appears wholly unfamiliar with the Streisand Effect.

And that then takes us to the Impossibility Theorem, regarding the impossibility of doing content moderation at scale well. After Trump's ongoing tirade, Facebook slapped a "Partly False" warning label on the video when posted on Facebook. While the whole situation is ridiculous, it's at least mildly amusing, considering how frequently clueless Trumpkins insist that Facebook censors "conservative" (by which they mean Trumpian) viewpoints. Also, somewhat ironic in all of this: the only reason that Facebook now places such fact check labels on things is because anti-Trump people yelled at how Facebook needed to do more fact checking of political content on its site. So, now you get this.

Part of the issue is that Politifact judged one line in the ad as "false." That line was that Trump "bailed out Wall St. but not Main St." Politifact says that since the CARES Act Paycheck Protection Program has given potentially forgivable loans to some small businesses, and because the bill was done by Congress, not the President, that line is "false." And yet, because angry (usually anti-Trump) people demanded that Facebook do more useless fact checking, the end result is that the video now gets a "false" label.

Of course, this shows both the impossibility of doing content moderation well and the silliness of betting big on fact checking with a full "true or false" claim. One could argue that that line has misleading elements, but is true in most cases. Tons of small businesses are shuttering. Many businesses have been unable to get PPP loans, and under the current terms of the loans, they're useless for many (especially if they have no work for people to do, since the loans have to be mostly used on payroll over the next couple months). But does that make the entire ad "false"? Of course not.

And Rick Wilson is super mad about this. He's right to be mad about Politifact's designation, though it's really a condemnation of the religious focus on "true or false" in fact checking, rather than in focusing on what is misleading or not:

But the ad doesn’t actually claim that small businesses received zero help. Rather, it makes the point that Main Street America is still seriously struggling as the economic fallout from the coronavirus pandemic continues.

But Wilson is also mad at Facebook:

Speaking exclusively to Mediaite, Wilson called the decision “the typical fuckery we’ve come to expect from both the Trump camp and their tame Facebook allies.”

“Facebook is perfectly content to allow content from QAnon lunatics, anti-vaxxers, alt-righters, and every form of Trump/Russian — but I repeat myself — disinformation,” he pointed out. “This is a sign of just how powerfully ‘Mourning In America’ shook Donald Trump and his allies. Their attempt to censor our ad isn’t a setback for us; it’s a declaration of an information war we will win.”

Separately, the Lincoln Project also sent out an email to supporters, again blaming Facebook:

... it's no secret that Facebook has stood by and done little to nothing as lie after lie — from the Liar-In-Chief himself — runs wild on their platform.

(Oh, and let's also not forget the conspiracy theories, foreign disinformation campaigns and negligence that got Mark Zuckerberg questioned by the United States Congress.)

But, this? This is an entirely different and dangerous kind of collusion.

And what is Facebook's excuse for playing favorites with its recently-transferred former employees in the Trump campaign?

They say a "fact-checker" labeled our claim that "Donald Trump helped bailout Wall Street, not Main Street" was untrue.

....Really?

The email goes on to justify the "main street" line with a bunch of links, and then again argues that Facebook is "censoring the truth" to help Trump:

Is that "Partly False?" Of course not.

We told the truth about Donald Trump...

He lost his damn mind over it on Twitter...

Attacked us in front of Air Force One...

Then sent his spin machine to discredit us...

And now his allies at Facebook are doing his damage control by censoring the truth he doesn't like.

I get the frustration -- and I find it at least a bit ironic that the whole "fact checking" system was a response to anti-Trump folks mad at Facebook for allowing pro-Trump nonsense to spread -- but this is just another example of the Impossibility Theorem. There is no "good" solution here. We live in a time where everyone's trying to discredit everyone they disagree with, and many of these things depend on your perspective or your interpretation of a broad statement, like whether or not Trump is helping "main street."

We can agree that it's silly that Facebook has put this label on the video, but also recognize that it's not "Trump's allies at Facebook" working to "censor the truth he doesn't like." That's just absurd (especially given the reason the fact checking set up was put together in the first place).

But, hey, outrage and claims of censorship feed into the narrative (and feed into the Streisand Effect), so perhaps it all is just designed to work together.

"Stoppt Gates", "Legt den Maulkorb ab", "Widerstand": In mehreren deutschen Städten haben Bürger gegen die Corona-Beschränkungen protestiert. Auf Abstandsregeln nahmen nicht alle Rücksicht.

George Gascón pushed L.A. County Dist. Atty. Jackie Lacey into a runoff. His challenge is to show how his progressive policies can keep us safer.

"Never in my wildest dreams did I think it would be my brother until I saw everything the next day and saw his name," said Rosemary Gomez, 38. “I was like, ‘No, it can’t be him, it can’t be him.' Then his (estranged) wife called me. She was in a state of shock."

Christi Gibson June 28, 2017 DES MOINES- With health insurance premiums on the rise and deductibles skyrocketing, not to mention the majority of insurance companies in Iowa abandoning the Affordable Care Act (Obamacare), Iowans are growing increasingly concerned about healthcare for themselves and their family members. The impending vote on […]

You would walk into a quiet house, In a quiet neighbourhood and, Take a young girl, Into the woods, And rape her, Leaving a father disfigured, You would, Take a husband, In the middle of the night, And break his legs, And electrocute him, Because he will not salute your Blown up image, You would, […]

OBJECTIVE

A recent publication questioned the integrity of insulin purchased from U.S. retail pharmacies. We sought to independently validate the method used, isotope dilution solid-phase extraction (SPE) liquid chromatography mass spectrometry (LC-MS), and expand analysis to two U.S. Pharmacopeia (USP) methods (high-performance LC with ultraviolet detection and LC-MS).

London : J. & A. Churchill, 1887.

London : Smith, Elder, 1887.

London : James Nisbet & Co., MDCCCLXXX [1880]

The European repo market has held up well amid the initial volatility created by the economic slowdown caused by COVID-19,...

The post European Repo Demonstrates Its Resilience appeared first on OpenMarkets.

Most therapeutic products used in children have not been studied in that population. There is a need for special incentives and market protection (pediatric exclusivity) to compensate drug sponsors for studying these products in children.

Of 189 products studied under pediatric exclusivity, 173 (92%) received new labeling information. Pediatric efficacy was not established for 78 (42%), including 81% of oncology drugs. Probability of demonstrating efficacy was related to therapeutic area and year exclusivity was granted. (Read the full article)

Visitors to the Delaware State Fair can learn how to cook Japanese foods, carve a chicken, eat healthy on a budget and make a watermelon banana split – all in one place, at the Department of Agriculture’s Education Building. Starting Friday, July 19, DDA and its partners will offer a lineup of free food and cooking demonstrations every day of the fair.

Answers To Indian Rupee Demonetization Of Rs 500, 1000 currency Notes

There’s nothing like the heat of a DAC demo to stress new technology and the engineers behind it! Such was the case at DAC 2018 at the new locale of Moscone Center West, San Francisco. Cadence and AMIQ were two of several vendors who announced ...(read more)

Offshore Renewable Energy (ORE) Catapult and consultancy firm Frazer-Nash, both based in the UK, will perform a live demonstration of their marine hydrokinetics (MHK) energy project risk assessment tool during the International Tidal Energy Summit pre-conference risk and reliability workshop in London on Nov. 23.
 

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Several hundred demonstrators have gathered in the Swiss capital, Bern, St Gallen and Zurich to protest against a government-imposed coronavirus...

God’s love for sinners is a well-documented historical fact. Its verification doesn’t hinge on the consensus of theologians, nor does its validation rest on something we feel. The apostle John points us to the cross as the consummate and undeniable proof of divine love.

ADB has approved a $100 million loan for a demonstration project that will help clean up the Xin’an River in Anhui Province in the PRC. The project will also pilot an innovative financing mechanism to reduce rural pollution...

NEW YORK AUTO SHOW – March 23, 2016 – HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, will join leading global automakers at the 2016 New York Auto Show...

ABSTRACT

Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and epidemiologic studies that show an association of secretor status with infection caused by several genotypes. The fucosyltransferase 2 gene (FUT2) affects HBGA expression in intestinal epithelial cells; secretors express a functional FUT2 enzyme, while nonsecretors lack this enzyme and are highly resistant to infection and gastroenteritis caused by many HuNoV strains. These epidemiologic associations are confirmed by infections in stem cell-derived human intestinal enteroid (HIE) cultures. GII.4 HuNoV does not replicate in HIE cultures derived from nonsecretor individuals, while HIEs from secretors are permissive to infection. However, whether FUT2 expression alone is critical for infection remains unproven, since routinely used secretor-positive transformed cell lines are resistant to HuNoV replication. To evaluate the role of FUT2 in HuNoV replication, we used CRISPR or overexpression to genetically manipulate FUT2 gene function to produce isogenic HIE lines with or without FUT2 expression. We show that FUT2 expression alone affects both HuNoV binding to the HIE cell surface and susceptibility to HuNoV infection. These findings indicate that initial binding to a molecule(s) glycosylated by FUT2 is critical for HuNoV infection and that the HuNoV receptor is present in nonsecretor HIEs. In addition to HuNoV studies, these isogenic HIE lines will be useful tools to study other enteric microbes where infection and/or disease outcome is associated with secretor status.

IMPORTANCE Several studies have demonstrated that secretor status is associated with susceptibility to human norovirus (HuNoV) infection; however, previous reports found that FUT2 expression is not sufficient to allow infection with HuNoV in a variety of continuous laboratory cell lines. Which cellular factor(s) regulates susceptibility to HuNoV infection remains unknown. We used genetic manipulation of HIE cultures to show that secretor status determined by FUT2 gene expression is necessary and sufficient to support HuNoV replication based on analyses of isogenic lines that lack or express FUT2. Fucosylation of HBGAs is critical for initial binding and for modification of another putative receptor(s) in HIEs needed for virus uptake or uncoating and necessary for successful infection by GI.1 and several GII HuNoV strains.

For most of Doom Eternal‘s demonic foes, the best they can expect is to make a nice corpse. A particularly pleasing splash of gore on the Doom Slayer’s boot. But for those lucky few that manage to take down our man in green, a special reward will soon be in store. Doom Eternal’s first major […]

Qubits are often stabilised by being supercooled, which makes quantum computer chips hard to scale up. Now they have been operated at above -272°C for the first time

Robots that can control puppets could one day learn to manipulate complex physical objects like clothing and flexible sheets