Europe’s biggest activist investor shakes up management teams to unlock hidden value

She is fair, light-eyed and the perfect clothes horse. But on days when regular modelling assignments dry up, she doesn't mind changing 50 outfits and being photographed in a small studio against a plain white backdrop. Front, side, and back and you are done, says Anushree, 24, a Mumbai model.

Archives, Room Use Only - QC517.V92 1927

Archives, Room Use Only - UG582.H4 G78 1920z

The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for machine-learning-based docking of main-chain fragments to the sequence and for their sequence-independent connection using a dedicated library of protein fragments. The combined use of these new methods noticeably increases sequence coverage and reduces fragmentation of the protein models automatically built with ARP/wARP.

The phase problem remains a major barrier to overcome in protein structure solution by X-ray crystallography. In recent years, new molecular-replacement approaches using ab initio models and ideal secondary-structure components have greatly contributed to the solution of novel structures in the absence of clear homologues in the PDB or experimental phasing information. This has been particularly successful for highly α-helical structures, and especially coiled-coils, in which the relatively rigid α-helices provide very useful molecular-replacement fragments. This has been seen within the program AMPLE, which uses clustered and truncated ensembles of numerous ab initio models in structure solution, and is already accomplished for α-helical and coiled-coil structures. Here, an expansion in the scope of coiled-coil structure solution by AMPLE is reported, which has been achieved through general improvements in the pipeline, the removal of tNCS correction in molecular replacement and two improved methods for ab initio modelling. Of the latter improvements, enforcing the modelling of elongated helices overcame the bias towards globular folds and provided a rapid method (equivalent to the time requirements of the existing modelling procedures in AMPLE) for enhanced solution. Further, the modelling of two-, three- and four-helical oligomeric coiled-coils, and the use of full/partial oligomers in molecular replacement, provided additional success in difficult and lower resolution cases. Together, these approaches have enabled the solution of a number of parallel/antiparallel dimeric, trimeric and tetrameric coiled-coils at resolutions as low as 3.3 Å, and have thus overcome previous limitations in AMPLE and provided a new functionality in coiled-coil structure solution at lower resolutions. These new approaches have been incorporated into a new release of AMPLE in which automated elongated monomer and oligomer modelling may be activated by selecting `coiled-coil' mode.

Molybdenum oxides and sulfides on various low-cost high-surface-area supports are excellent catalysts for several industrially relevant reactions. The surface layer structure of these materials is, however, difficult to characterize due to small and disordered MoOx domains. Here, it is shown how X-ray total scattering can be applied to gain insights into the structure through differential pair distribution function (d-PDF) analysis, where the scattering signal from the support material is subtracted to obtain structural information on the supported structure. MoOx catalysts supported on alumina nanoparticles and on zeolites are investigated, and it is shown that the structure of the hydrated molybdenum oxide layer is closely related to that of disordered and polydisperse polyoxometalates. By analysing the PDFs with a large number of automatically generated cluster structures, which are constructed in an iterative manner from known polyoxometalate clusters, information is derived on the structural motifs in supported MoOx.

When it comes to brain size, Homo sapiens generally get the most credit. But to find the baby mammals with the proportionally largest brains on […]

The post Weddell seals have big-brained pups appeared first on Smithsonian Insider.

NFL Commissioner Roger Goodell talks during a press conference at the Hilton Hotel on Sept. 19, 2014 in New York City. Goodell spoke about the NFL's failure to address domestic violence, sexual assault and drug abuse in the league.; Credit: Elsa/Getty Images

Update 1:04 p.m. Goodell: 'Same mistakes can never be repeated'

Commissioner Roger Goodell says the NFL wants to implement new personal conduct policies by the Super Bowl. At a news conference Friday, Goodell made his first public statements in more than a week about the rash of NFL players involved in domestic violence. He did not announce any specific changes, but said he has not considered resigning.

"Unfortunately, over the past several weeks, we have seen all too much of the NFL doing wrong," he said. "That starts with me."

The league has faced increasing criticism that it has not acted quickly or emphatically enough concerning the domestic abuse cases.

The commissioner reiterated that he botched the handling of the Ray Rice case.

"The same mistakes can never be repeated," he said.

Goodell now oversees all personal conduct cases, deciding guilt and penalties.

He said he believes he has the support of the NFL's owners, his bosses.

"That has been clear to me," he said.

The Indianapolis Colts' Darius Butler was among those who tweeted criticism of the press conference:

Colts tweet 1

Colts tweet 2

The commissioner and some NFL teams have been heavily criticized for lenient or delayed punishment of Rice, Adrian Peterson and other players involved in recent domestic violence cases. Less than three weeks into the season, five such cases have made headlines, the others involving Greg Hardy, Ray McDonald and Jonathan Dwyer.

Vikings star running back Peterson, Carolina defensive end Hardy and Arizona running back Dwyer are on a special commissioner's exemption list and are being paid while they go through the legal process. McDonald, a defensive end for San Francisco, continues to practice and play while being investigated on suspicion of domestic violence.

As these cases have come to light, such groups as the National Organization of Women and league partners and sponsors have come down hard on the NFL to be more responsive in dealing with them. Congress also is watching to see how the NFL reacts.

In response to the criticism, the NFL announced it is partnering with a domestic violence hotline and a sexual violence resource center.

Goodell also said in a memo to the clubs late Thursday that within the next 30 days, all NFL and team personnel will participate in education sessions on domestic violence and sexual assault. The memo said the league will work with the union in providing the "information and tools to understand and recognize domestic violence and sexual assault."

The league will provide financial, operational and promotional support to the National Domestic Violence Hotline and the National Sexual Violence Resource Center.

12:07 p.m. Roger Goodell to break silence on domestic abuse and the NFL

Roger Goodell will make his first public statements in more than a week about the rash of NFL players involved in domestic violence when he holds a news conference Friday.

The NFL commissioner will address the league's personal conduct policy. The league has faced increasing criticism it has not acted quickly or emphatically enough concerning the domestic abuse cases.

His last public appearance was at a high school in North Carolina on Sept. 10.

The commissioner and some NFL teams have been heavily criticized for lenient or delayed punishment of Ray Rice, Adrian Peterson and other players involved in recent domestic violence cases. Less than three weeks into the season, five such cases have made headlines, the others involving Greg Hardy, Ray McDonald and Jonathan Dwyer.

Vikings star running back Peterson, Carolina defensive end Hardy and Arizona running back Dwyer are on a special commissioner's exemption list and are being paid while they go through the legal process. McDonald, a defensive end for San Francisco, continues to practice and play while being investigated on suspicion of domestic violence.

As these cases have come to light, such groups as the National Organization of Women and league partners and sponsors have come down hard on the NFL to be more responsive in dealing with them. Congress also is watching to see how the NFL reacts.

In response to the criticism, the NFL announced it is partnering with a domestic violence hotline and a sexual violence resource center.

Goodell also said in a memo to the clubs late Thursday that within the next 30 days, all NFL and team personnel will participate in education sessions on domestic violence and sexual assault. The memo said the league will work with the union in providing the "information and tools to understand and recognize domestic violence and sexual assault."

The league will provide financial, operational and promotional support to the National Domestic Violence Hotline and the National Sexual Violence Resource Center.

"These commitments will enable both the hotline and NSVRC to help more people affected by domestic violence and sexual assault," Goodell said in the memo.

The National Domestic Violence Hotline provides domestic violence victims and survivors access to a national network of resources and shelters. It is available 24 hours a day, seven days a week in 170 languages. Goodell noted that the hotline received 84 percent more calls from Sept. 8-15, and the organization said more than 50 percent of those calls went unanswered because of lack of staff.

"The hotline will add 25 full-time advocates over the next few weeks that will result in an additional 750 calls a day being answered," he said.

NSVRC supports sexual violence coalitions across the United States. The NFL's initial support will be directed toward state coalitions to provide additional resources to sexual assault hotlines.

This story has been updated.

Building Information Modelling (BIM) can enhance the design of a building, reduce costs and save energy. However, little research has been carried out on its impact on sustainable practices. A US survey illustrates that many practitioners do not see sustainability as a primary application, suggesting that more effort is needed to encourage the integration of ‘green’ design and construction into BIM.

Integrated environmental modelling (IEM) is an organised approach to streamlining the movement of scientific information from its research sources to its application in problem solving, according to a study that envisions a global-scale IEM community. The researchers present a roadmap for the future of IEM, describing issues that could be addressed to develop its potential even further, such as how best to integrate diverse stakeholder perspectives and appropriate guidelines for ‘problem statements’.

A new model, named OUTOPIE could help design more effective agri-environmental schemes. The model links the farm, field and landscape levels to allow a more accurate assessment of the costs of enrolling specific fields in conservation schemes. Using the model, the researchers were able to assess the cost-effectiveness of different policies for the conservation of the Little Bustard bird (Tetrax tetrax) in France.

The effects of climate change on the distribution of species can be predicted more accurately by considering the genetic differences between different groups of the same species, a new study suggests. The researchers found that a computer model which incorporated genetic information on different groups of a US tree species was up to 12 times more accurate in predicting tree locations than a non-genetically informed model.

The emissions of two perfluoroalkyl acids (PFAAs) into the Danube River Basin have been estimated in a test of four different hypotheses regarding the factors affecting those emissions. The results were used to simulate water concentrations for comparison with measured data. The researchers found that incorporating wastewater treatment information and wealth distribution alongside population data can improve the accuracy of emissions estimates.

Chemicals that persist in the environment can harm humans and wildlife. This study describes a computer modelling-based approach to predict which chemical compounds are likely to be persistent. The models were correctly able to predict persistence for 11 of 12 chemicals tested and could provide a cost-effective alternative to laboratory testing.

A new tool used to investigate exhaust emissions of marine vessels has been developed and applied to shipping in the Baltic Sea.

Increased insulation in homes could reduce ventilation and lead to greater exposure to indoor air pollution, a new study suggests. This, in turn, could affect health. The researchers modelled exposure to fine particles, which indicated that insulating half the homes in Greece by 2020 could lead to a 6% increase in adverse health effects. Sources of indoor air pollution should be reduced as far as possible and, failing that, sufficient airing is key, they recommend.

Models that predict how nitrogen from the air is deposited in the sea could be useful in predicting algal blooms. Based on the knowledge that excess nitrogen increases algal growth rates, researchers simulated nitrogen deposition in the North Sea and suggested that, using predicted weather data, it might be possible to adapt this approach to predict algal blooms.

A recent study develops a framework for implementing IAMs using the Lombardy region of Italy as a case study. Researchers have run an uncertainty and sensitivity analysis with an environmental model, specifically with an Integrated Assessment Model (IAM) for air quality, demonstrating how model components are sources of uncertainty in the output of an integrated assessment. Policy responses should therefore consider uncertainty and sensitivity when developing measures to improve air quality.

Microsoft faces strong competition on both desktop and mobile fronts. What can the new CEO do to ensure the company's success?

Video: Get green tips from Arianna Huffington and Nancy O'Dell.

Some of the nation's most recognized brands are joining the Department of Energy's Workplace Charging Challenge.

It can be expensive and challenging to recycle unwanted electronics, as many organizations charge a fee or have limited operating hours. Luckily, Dell offers a

Dell's 'Plant a Tree for Me' Program Offsets Your Carbon Footprint

Dell Studio Hybrid: 70% More Efficient Than Typical Desktops

Dell Headquarters Powered by 100% Green Energy

Compostable and locally sourced bamboo computer cushions push Dell’s corporate initiatives to new levels.

Dell has partnered with experts at The Conservation Fund and Carbonfund.org to replant formerly forested areas in need of restoration, with a goal of half a mil

See how JM Family reduces data center power consumption by 17 percent and saves $150,000 annually by going green. When JM Family's growth increased its computin

Randell to take up role on 1 April.

Monica Deller, an Amazon Bestselling author, hopes to bring more awareness to the issue of human trafficking and is compiling stories for a new book series on human trafficking and related subjects.

Konstanze Alex, Dell's director B2B influencer relations and content co-creation, offers insights from the company's success using influencer marketing for B2B.

Mister Rooster Brand…geared towards 2 to 6 years old and their families.

Ms. Pinching has been endorsed by Marquis Who's Who as a leader in education

Monica Deller, an Amazon Bestselling author, hopes to bring more awareness to the issue of human trafficking and is compiling stories for a new book series on human trafficking and related subjects.

Mr. Blaisdell has been endorsed by Marquis Who's Who as a leader in the film industry

Another look at 3D modelling suitable for IE10 and IE11 without using 'transform-style: preserve-3d;'

3D modelling with 360 º animation suitable for IE10 and IE11 without using 'transform-style: preserve-3d;'

3D modelling with 360 º animation using 'transform-style: preserve-3d;' so NOT for IE10 or IE11

In the information overload age, the user needs to find... more

The idea of the organization and companies as phenomena to... more

The research is developed around the contemporary debate on LGBT... more

Scott Rendell struck against former club Woking to earn Eastleigh a point as they extended their unbeaten run to eight matches.

Scott Rendall admitted his confidence is sky high after his fine goalscoring continued with a match winning hat-trick.

Damit das Spielen detailreich und ohne Ruckeln abläuft, benötigen Konsolenzocker einen leistungsstarken Gaming-Fernseher mit guter Auflösung. Erfahren Sie hier, worauf beim Kauf eines guten Gaming-TV zu achten ist.

Laptop mit Touchscreens sind die perfekte Mischung aus den Vorzügen eines Notebooks und den intuitiven Bedienmöglichkeiten eines Tablets.

Immer mehr Smartphone-Nutzer lieben riesige Displays – große Handys sind im Trend, denn sie können auch ein Tablet ersetzen und sind somit deutlich vielseitiger als kleinere Modelle. Was ein Phablet kann und mit welchen Geräten Sie richtig liegen, erfahren Sie hier.

¿Es legal que la empresa de los hermanos del Secretario de Hacienda de Medellín se beneficie con nombramientos del municipio?