Petrini Custom Builders focused on creating a high-performance residential home, which included elevating design and performance using Atlas Roofing EnergyShield.

Challenges created by weather and the pandemic meant this project had to begin in January 2021 and be completed in a year, all while prioritizing energy efficiency. 

Using McElroy Metal roofing and wall panels, this storage facility became the brand's "flagship self-storage facility" thanks to its aesthetics.

This state-of-the-art 6,000-square-foot LEED Platinum Certified residence is built solely with sustainability, energy efficiency and comfort in mind.

Parallel Products is a leader in the sustainability industry naturally turned to upgrading its operations with solar roofing to reduce energy consumption.

Thanks to polyurethane foam and Polyglass silicone coating, this 1-million-square-foot warehouse in Texas took on the brunt of an EF2 tornado.

The Kia Forum, outside of Los Angeles, was under pressure to have its existing rooftop logo removed and replaced. Contractor Centimark, using GAF products, got the job done on time. Learn how in this GAF case study.

The work completed on a metal roof by R/J Group was quickly be put to the test as Hurricane Ian blew through only two weeks after completion.

This research was undertaken by Stuart Fordyce as part of an MSc in Integrated Service Improvement (Health and Social Care) at the University of Edinburgh. It considers the impact of a rapidly ageing population on a Scottish local authority and its attempt to shift the focus to a more contemporary service provision. The aim is to explore what factors are inhibiting the effectiveness of enablement. Using a case study approach the research explored whether: (i) enablement is wholly effective in addressing the increase in current service demands; (ii) the approach adopted by the local authority is undermined as services are now over extended and are attempting to address competing objectives, and; (iii) the paradigmatic change across the sector in the future will materialise if organisations cannot create the capacity and infrastructure to enable change to occur

Minerallac Company, an electrical construction hardware manufacturer, find Repeat Signage software a useful tool for keeping staff updated on events and information. Staff is their satellite office, 2000 miles away, now feel more connected since digital signage was utilised.

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also capable of inhibiting autophagic flux, demonstrating the ability of these compounds to engage with more than one target. In this study, we present two additional mechanisms by which tenovins are able to activate p53 and kill tumor cells in culture. These mechanisms are the inhibition of a key enzyme of the de novo pyrimidine synthesis pathway, dihydroorotate dehydrogenase (DHODH), and the blockage of uridine transport into cells. These findings hold a 3-fold significance: first, we demonstrate that tenovins, and perhaps other compounds that activate p53, may activate p53 by more than one mechanism; second, that work previously conducted with certain tenovins as SirT1 inhibitors should additionally be viewed through the lens of DHODH inhibition as this is a major contributor to the mechanism of action of the most widely used tenovins; and finally, that small changes in the structure of a small molecule can lead to a dramatic change in the target profile of the molecule even when the phenotypic readout remains static.

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ABSTRACTIntroduction: Nigeria has the highest number of children who have not received any vaccines in Africa. The training-of-trainers (TOT) model used to train program managers (PMs) and health care workers (HCWs) is ineffective for adult learning and limits immunization programs’ success. We incorporated adult learning principles (ALPs) in designing and delivering TOT for immunization PMs and HCWs to use data to engage communities for tailored immunization strategies.Methods: Our study was implemented in 3 local government areas (LGAs) of the Federal Capital Territory, Nigeria. A training curriculum was developed, integrating ALPs and technical and operational content based on best practices in delivering immunization training and the training needs assessment findings. State PMs (n=10), LGA PMs (n=30), and HCWs (n=42) were trained on the human-centered design for tailoring immunization programs (HCD-TIP) approaches using ALPs. We used interviews and surveys with purposively and conveniently sampled PMs and HCWs, respectively, and observations to assess participants’ satisfaction, knowledge and competence, behavior changes, and results. The interviews were analyzed thematically, and surveys were statistically.Results: There was a high level of satisfaction with the training among LGA PMs (100%), state PMs (91%), and HCWs (85%), with significant knowledge and competence improvements post-training (P<.001). The trained participants conducted 2 HCD sessions with 24 undervaccinated communities and co-designed 24 prototype solutions for testing. Results showed increased coverage of the pentavalent vaccine first dose (54%) and third dose (188%) across 12 participating communities. Improved community colaboration, communication skills, and data-driven approaches were the most cited behavior changes in practice.Conclusion: The application of ALPs in training, use of HCD-TIP approaches and tools, and supportive supervision enhanced PMs’ and HCWs’ capacity for tailored interventions. Countries should consider adopting a holistic approach that focuses on using these approaches in immunization programs to strengthen the health system for equitable vaccine coverage.

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Apr 22, 2024

For most of this century, the Arctic has been a place of peaceful cooperation in science and environmental protection, an approach built on a foundation of multiple agreements reached in the twentieth century. The Russian invasion of Ukraine and the geopolitical reverberations of the war have disrupted or outright halted most collaboration between Western and Russian scientists and conservationists.

Virginia Bioinformatics Institute Video Case Study

Manchester : Manchester University Press, [2017]

[Msida] : Malta Historical Society, Foundation for International Studies, University of Malta, 1991.

Efforts to document government support benefiting specific sectors or industries have paid scant attention to support given to the non-energy minerals sector. The issue of support for this sector is explored by way of a case study of Australia, a leading producer and exporter of minerals.

The Trentino co-operative model has gained wide acclaim for its positive economic and social impact upon the territory. Developing a strong understanding of why the model has been so effective is important in identifying those factors which other localities could utilise as potential criticalities.

The Trentino co-operative model has gained wide acclaim for its positive economic and social impact upon the territory. Developing a strong understanding of why the model has been so effective is important in identifying those factors which other localities could utilise as potential criticalities.

This case study is part of a design challenge in which I was asked to explore live streaming as a media format.

Many biologists are now routinely seeking to determine the three-dimensional structures of their proteins of choice, illustrating the importance of this knowledge, but also of the simplification and streamlining of structure-determination processes. Despite the fact that most software packages offer simple pipelines, for the non-expert navigating the outputs and understanding the key aspects can be daunting. Here, the structure determination of the type IV pili (TFP) protein PilA1 from Clostridioides difficile is used to illustrate the different steps involved, the key decision criteria and important considerations when using the most common pipelines and software. Molecular-replacement pipelines within CCP4i2 are presented to illustrate the more commonly used processes. Previous knowledge of the biology and structure of TFP pilins, particularly the presence of a long, N-terminal α-helix required for pilus formation, allowed informed decisions to be made during the structure-determination strategy. The PilA1 structure was finally successfully determined using ARCIMBOLDO and the ab initio MR strategy used is described.

Some Marine and Coastal have been altered over long periods of time, resulting in a loss of knowledge of their true healthy state, new research suggests. In this UK study, researchers used historical records, samples of sediment and present-day diving surveys to reconstruct the true history of shellfish beds on the east coast of Scotland.

Municipal solid waste (MSW) landfills, which consist of everyday consumer items, are potential long-term sources of emissions that could threaten the environment and human health if they are not managed carefully after closure. New research has presented a methodology to estimate future emission levels for closed MSW landfills and the impact of different aftercare strategies.

New research has compared the environmental impact of four alternative methods of water supply in Copenhagen. Results indicated that rain and stormwater harvesting is the most environmentally sound approach, whilst desalination currently has a large environmental impact, mainly due to electricity use. However, if freshwater extraction is included as an impact, the environmental credibility of desalination is improved.

Modern technologies have provided new ways for communities to engage with climate change. This study investigated the role of Internet-based tools in disseminating the findings of a climate change research project in Canada and provides insights on how best to use the Internet to communicate the outcomes of scientific research.

Municipal solid waste (MSW) landfills, which consist of everyday consumer items, are potential long-term sources of emissions that could threaten the environment and human health if they are not managed carefully after closure. New research has presented a methodology to estimate future emission levels for closed MSW landfills and the impact of different aftercare strategies.

A new study has examined how recent policy developments, such as the EU Habitats and Water Framework Directives, have resulted in wider and more integrated management of river estuaries, using the Severn Estuary in the UK as a case study.

The complexity of environmental issues and a lack of co-operation or shared objectives between parties involved in urban planning are preventing promotion of environmental sustainability, a new study suggests. The Finnish research, based on focus groups with 32 professionals in urban planning and environmental sustainability, suggests that the short-term economic goals of local authorities, the complexity of environmental sustainability, and a lack of co-operation between different decision-making groups in urban planning were creating barriers to achieving sustainability.

A case study in Greece suggests that farmers growing low-value crops such as maize and cotton will suffer most from policies which introduce charges for water. However, this impact can be mitigated if groundwater is priced based on the energy needed for pumping, shifting some of the burden to higher value crops.

A new model, named OUTOPIE could help design more effective agri-environmental schemes. The model links the farm, field and landscape levels to allow a more accurate assessment of the costs of enrolling specific fields in conservation schemes. Using the model, the researchers were able to assess the cost-effectiveness of different policies for the conservation of the Little Bustard bird (Tetrax tetrax) in France.

Tourists would be willing to pay for increased biodiversity and reduced clear-felling in forests, a recent Finnish case study suggests. In a survey of over 900 visitors to Lapland, most stated that they felt landscape quality and biodiversity were important, and that they would be happy to pay their share for preserving these qualities.

Moose avoid roads during day when human activity is highest, new research suggests. Monitoring moose movements in Sweden, researchers have found that the probability of moose being near roads drops after 06:00 and only rises again at approximately 18:00.

Cities located in biodiversity hotspots can provide valuable refuges for a wide range of plants, a recent study suggests. Of the 379 plant species and sub-species recorded in the city of Ioannina, Greece, 27 were of conservation interest. Town planners can ensure that cities play an important role in supporting regional biodiversity when designing future urban developments, the researchers say.

The non-restricted production and use of pharmaceuticals and personal care products (PPCPs) has led to their presence in effluents from treatment plants, which can pose a threat to aquatic organisms downstream. This study analysed the breakdown of six common chemicals in four Danish treatment plants. The findings shed new light on the factors affecting removal of PPCPs from waste, showing that the composition of waste is more important than the design of the treatment plant.