Maltese judge quashes extradition to the US of Daniel Meli, ordering that his case be reheard by the magistrates’ court 

Not a second goes by without pundits and the media scrutinizing the U.S. election polls and tracking the candidates' performances. But polls aren't votes. What if the polls are all wrong?

CHIANG MAI - Police found an unregistered barking deer, a protected species, at the house of the fengshui consultant arrested for allegedly defrauding people of over 100 million baht.

The US Census Bureau processes data before publishing it in order to keep personal information private – but a new approach could maintain the same privacy while improving accuracy

Title: Are Cholesterol Tests Always Accurate?
Category: Diseases and Conditions
Created: 3/9/2022 12:00:00 AM
Last Editorial Review: 3/9/2022 12:00:00 AM

Sequence variation observed in populations of pathogens can be used for important public health and evolutionary genomic analyses, especially outbreak analysis and transmission reconstruction. Identifying this variation is typically achieved by aligning sequence reads to a reference genome, but this approach is susceptible to reference biases and requires careful filtering of called genotypes. There is a need for tools that can process this growing volume of bacterial genome data, providing rapid results, but that remain simple so they can be used without highly trained bioinformaticians, expensive data analysis, and long-term storage and processing of large files. Here we describe split k-mer analysis (SKA2), a method that supports both reference-free and reference-based mapping to quickly and accurately genotype populations of bacteria using sequencing reads or genome assemblies. SKA2 is highly accurate for closely related samples, and in outbreak simulations, we show superior variant recall compared with reference-based methods, with no false positives. SKA2 can also accurately map variants to a reference and be used with recombination detection methods to rapidly reconstruct vertical evolutionary history. SKA2 is many times faster than comparable methods and can be used to add new genomes to an existing call set, allowing sequential use without the need to reanalyze entire collections. With an inherent absence of reference bias, high accuracy, and a robust implementation, SKA2 has the potential to become the tool of choice for genotyping bacteria. SKA2 is implemented in Rust and is freely available as open-source software.

Background

Computer-aided detection (CAD) systems hold promise for improving tuberculosis (TB) detection on digital chest radiographs. However, data on their performance in exclusively paediatric populations are scarce.

Antifolates are important for chemotherapy in non–small cell lung cancer (NSCLC). They mainly rely on reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT) to enter cells. PCFT is supposed to be the dominant transporter of the two in tumors, as it operates optimally at acidic pH and has limited transport activity at physiological pH, whereas RFC operates optimally at neutral pH. In this study, we found RFC showed a slightly pH-dependent uptake of antifolates, with similar affinity values at pH 7.4 and 6.5. PCFT showed a highly pH-dependent uptake of antifolates, with an optimum pH of 6.0 for pemetrexed and 5.5 for methotrexate. The Michaelis-Menten constant (K_m) value of PCFT for pemetrexed at pH 7.4 was more than 10 times higher than that at pH 6.5. Interestingly, we found that antifolate accumulations mediated by PCFT at acidic pH were significantly affected by the efflux transporter, breast cancer resistance protein (BCRP). The highest pemetrexed concentration was observed at pH 7.0–7.4 after a 60-minute accumulation in PCFT-expressing cells, which was further evidenced by the cytotoxicity of pemetrexed, with the IC₅₀ value of pemetrexed at pH 7.4 being one-third of that at pH 6.5. In addition, the in vivo study indicated that increasing PCFT and RFC expression significantly enhanced the antitumor efficacy of pemetrexed despite the high expression of BCRP. These results suggest that both RFC and PCFT are important for antifolates accumulation in NSCLC, although there is an acidic microenvironment and high BCRP expression in tumors.

A grand jury has formally charged a 22-year-old man with capital murder and rape in the death of Nabra Hassanen, who was killed on her walk back to a Virginia mosque.

The Fairfax County Circuit Court indicted Darwin Martinez-Torres of Sterling, Virginia, on Monday on four counts of capital murder for killing Nabra, who was with friends while they had a meal before Ramadan services. Dozens of people had gathered outside the courthouse today, chanting “Justice for Nabra.”

Virginia law has specific conditions for pursuing the death penalty, but the Associated Press reported that the grand jury’s indictment described in graphic detail how Nabra’s killing was grounds for a death penalty against Martinez-Torres. The indictment appears to acknowledge for the first time that the 17-year-old Muslim teen was raped. Under state law, the combination of a rape charge with a premeditated murder charge means the death penalty can be pursued.

Police have said that Martinez-Torres, who is an undocumented immigrant, got into a confrontation on June 18 with a group of teens walking back to the All Dulles Area Muslim Society after grabbing a late meal. He is accused of returning later and beating Nabra with a baseball bat. Police said Nabra’s body was later discovered in a pond. A search warrant affidavit revealed that Martinez-Torres admitted to killing Nabra and had led authorities to where he dumped her body, AP reported.

Nabra’s parents and Muslim advocates have said that Nabra’s death was motivated by hate, but police has said that they will not treat the killing as a hate crime. Instead, police have said it was a road rage incident.

“The reason this guy he hit my daughter is because she’s Muslim,” Nabra’s father Mahmoud Hassanen told WAMU. “Why [didn’t he] hit the boy who bothered him?”

Nabra’s father added that he hoped for the death penalty, while her mother said she wanted Martinez-Torres to serve life in prison.

“I just want people to remember her, and don’t forget her,” Mahmoud told WAMU. “I think nobody can forget her too, for what she did in her life.”

A preliminary hearing for Martinez-Torres reportedly turned emotional on Friday, with Nabra’s parents both shouting at the suspect in court. Nabra’s mother Sawsan Gazzar apparently threw a shoe at Martinez-Torres during the proceedings.

READ MORE: D.C. memorial for slain Muslim teen was set on fire, officials say

The post Man accused of killing Muslim teen indicted on capital murder charges appeared first on PBS NewsHour.

A new way to store numbers in computers can dynamically prioritise accuracy or range, depending on need, allowing software to quickly switch between very large and small numbers

The US Census Bureau processes data before publishing it in order to keep personal information private – but a new approach could maintain the same privacy while improving accuracy

Adam Peaty roared back at those writing him off after cruising through his 50 metres breaststroke semi-final – but was later accused of being disrespectful towards Commonwealth Games competitors.

ALS, the most common form of motor neuron disease, can take a long time to diagnose, but a blood test could help doctors spot the condition sooner

From assembling delicate electronics to constructing safety-critical aerospace components, the margin for error has shrunk to almost nothing. To meet these rigorous standards, the manufacturing industry increasingly relies on robotic precision. Modern robotics, equipped with advanced sensors, grippers, and AI, allow manufacturers to complete intricate tasks with extraordinary accuracy. Technological Innovations Driving Robotic Precision Today’s […]

The post Robotic Precision in Manufacturing: Achieving High Accuracy for Complex Tasks appeared first on Chart Attack.

AI search engine embraces 2024 US election with live tracker and chatbot info hub.

A police officer from the Mexican border state of Tamaulipas faces a murder charge for his role in the killing of an underage teenager he allegedly mistook for a gunman. He and five other officers are also charged with planting evidence to cover up the incident.

The post Mexican Cops Accused of Killing Innocent Teen, Cover Up appeared first on Breitbart.

1. Bulldozer justice: SC lays down pan-India guidelines for demolition of properties, says Executive can’t become judge and accused, convicts have certain rights  The Hindu
2. "House Embodies Hope": Supreme Court Demolishes 'Bulldozer Justice' Idea  NDTV
3. Unconstitutional to demolish house without following due process merely because they are involved in a crime: SC  The Indian Express
4. Supreme Court on bulldozer action: ‘No demolition without following guidelines, 15-day notice’  Hindustan Times
5. Bulldozer justice: Executive can't become judge, demolish house of accused, SC says  The Times of India

ADELAIDE’S Mark Ricciuto has denied orchestrating a campaign to cut dollars from the contract of one of his star players.

Accumold, with over 40 years of experience in micromoulding technology, is set to participate at Compamed, taking place in Düsseldorf, Germany, from 11-14 November. The company will highlight its small and complex parts for medical device OEMs.

• Johnson & Johnson Innovative Medicines gives a peek inside its $43 billion gross-to-net bubble

• Optum Rx joins the private label biosimilar bandwagon

• Biosimilars boom for provider-administered drugs

• Fresh evidence of how copay accumulators hurt patients

There’s still time to request an invite to the inaugural Drug Channels Leadership Forum. Attendance will be highly limited. We have already begun extending invitations, so apply now to be considered. Click here to view the full agenda.

The US Census Bureau processes data before publishing it in order to keep personal information private – but a new approach could maintain the same privacy while improving accuracy

Dental caries also called 'dental cavities' or 'tooth decay,' can be debilitating. Modern dentistry has tried-and-tested solutions for treating caries without the need to remove the tooth altogether.

Karnataka Health Minister Dinesh Gundu Rao instructed district officials to ensure accurate reporting and auditing of medlinkdengue/medlink-related deaths.

Researchers from Cincinnati Children's Hospital and the University of Cincinnati College of Medicine have developed a novel approach to increase speed

medlinkAmyotrophic lateral sclerosis/medlink (ALS) is a medlinkneurodegenerative disease/medlink that affects neurons in the brain and spinal cord.

Wearables in Diabetes Management: Smartwatches and smart rings can accurately monitor blood glucose levels (BGLs) anywhere and anytime.

Accuray Announces Results for Third Quarter Fiscal 2010

medlinkWearable devices/medlink, including medlinksmartphones/medlink and smartwatches, lack essential sensors for accurate energy expenditure

Remote echocardiograms using robot arm technology are as precise as in-person exams by cardiologists, according to new research to be presented at this

Ice cream ingredients are essential for everyone who makes this creamy item whether with the help of a machine or with individual efforts. You must not forget that the powerful your additive the...

There was a lot of speculation around the death of the singer and investigations were conducted in order to understand if it was a murder, accident or a suicide case

1. "Legal Process Shouldn't Prejudge Guilt Of Accused": Supreme Court On Bulldozer Justice  NDTV
2. Supreme Court’s Big Ruling On Bulldozer Justice: 'Guilt Of An Accused Can't Be Prejudged'  News18
3. Bulldozer justice: Executive can't become judge, demolish house of accused, SC says  The Times of India
4. Unconstitutional to demolish house without following due process merely because they are involved in a crime: SC  The Indian Express
5. Supreme Court's key verdict on ‘bulldozer justice’ today | What happened in hearings  Hindustan Times

Delhi BJP calls for an inquiry into alleged collusion between AAP and power discoms, claiming undue financial benefits at citizens' expense.

Digital land records, mobile data apps to be used for data collection

Complaint lodged by LDF Wayanad Parliamentary Committee says Congress violated electoral rules and regulations