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Disputing Inaccurate Information on a Credit Report

The role of an SEO company is to improve the search engine visibility of their clients and drive more online traffic (and potential conversions) to their website. Although search engine results page (SERP) rankings aren’t the only measure of success, they are certainly an important indicator of positive growth. Here at SEO Advantage, one of […]

When Ferris teacher Mandy Manning received the National Teacher of the Year award earlier this month, she shook President Donald Trump's hand. Three times…

His statement arrives after a group of 467 former contestants of the game show penned an open letter to the show, demanding an apology from the show's producers for not censoring a controversial hand gesture in an episode.

The New York police officer accused of using a chokehold in an incident captured on video Sunday has been charged with strangulation. The officer, 39-year-old David Afanador, was suspended the same day the cellphone video appeared to show him choking a Black man on a Queens boardwalk. Now he's been arrested and charged with felony strangulation and attempted strangulation. Afanador pleaded not guilty and was released Thursday afternoon without bail. Queens District Attorney Melinda Katz noted that New York state had criminalized chokeholds just days earlier. "The ink from the pen Gov. Cuomo used to sign this legislation was barely dry before this officer allegedly employed the very tactic the new law was designed to prohibit," Katz said in a statement. "Police officers are entrusted to serve and protect — and the conduct alleged here cannot be tolerated." Afanador could face up to seven years in prison if convicted. Sunday's incident began when police responded to complaints about

She said the assault occurred when she traveled from Nashville to Los Angeles with Brooks, who was performing with soul singer Sam Moore at a Grammy Awards tribute in 2019.

A home repair show that helps Coloradans recover from shady contractors is accused of hiring just such a contractor for a project in Larkspur.

Lili Bernard claims he drugged and raped her repeatedly.

The ex-captain allegedly targeted Black people for decades.

“This is not the oath that I swore to uphold.”

He was trying to get the attention of a mascot.

Republicans are failing for a much more obvious reason, a more fundamental reason. They're failing because they haven't done much that is worth doing. They haven't tried very hard to improve your life. When the crisis came, they fled. They did nothing to defend you. They did nothing to defend the country. Continue reading →

Gauteng legislature secretary Linda Mwale has signed a sweetheart agreement with Nehawu to let 32 employees accused of defrauding the institution off the hook.

It was out of fear for his mental health and to avoid the perpetuation of an ongoing wrong that a judge ordered that one of the five men charged with the murder of soccer star Senzo Meyiwa be removed from solitary confinement.

The MK Party continued its campaign against accountability for corruption, with its deputy leader, John Hlophe, suggesting National Director of Public Prosecutions Shamila Batohi was "misleading the nation" about the Guptas' extradition.

Ivan Matic
Jan 1, 2008; 7:132-144
Research

Amelia C. Peterson
Nov 1, 2012; 11:1475-1488
Technological Innovation and Resources

Ludovic C. Gillet
Jun 1, 2012; 11:O111.016717-O111.016717
Research

Jesper V. Olsen
Dec 1, 2005; 4:2010-2021
Technology

Jürgen Cox
Sep 1, 2014; 13:2513-2526
Technological Innovation and Resources

Shao-En Ong
May 1, 2002; 1:376-386
Research

Accumulation of the microtubule-associated protein tau is associated with Alzheimer's disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser-262 and Ser-356 plays critical roles in tau accumulation and toxicity. Microtubule affinity–regulating kinase 4 (MARK4) phosphorylates tau at those sites, and a double de novo mutation in the linker region of MARK4, ΔG316E317D, is associated with an elevated risk of AD. However, it remains unclear how this mutation affects phosphorylation, aggregation, and accumulation of tau and tau-induced neurodegeneration. Here, we report that MARK4ΔG316E317D increases the abundance of highly phosphorylated, insoluble tau species and exacerbates neurodegeneration via Ser-262/356–dependent and –independent mechanisms. Using transgenic Drosophila expressing human MARK4 (MARK4wt) or a mutant version of MARK4 (MARK4ΔG316E317D), we found that coexpression of MARK4wt and MARK4ΔG316E317D increased total tau levels and enhanced tau-induced neurodegeneration and that MARK4ΔG316E317D had more potent effects than MARK4wt. Interestingly, the in vitro kinase activities of MARK4wt and MARK4ΔG316E317D were similar. When tau phosphorylation at Ser-262 and Ser-356 was blocked by alanine substitutions, MARK4wt did not promote tau accumulation or exacerbate neurodegeneration, whereas coexpression of MARK4ΔG316E317D did. Both MARK4wt and MARK4ΔG316E317D increased the levels of oligomeric forms of tau; however, only MARK4ΔG316E317D further increased the detergent insolubility of tau in vivo. Together, these findings suggest that MARK4ΔG316E317D increases tau levels and exacerbates tau toxicity via a novel gain-of-function mechanism and that modification in this region of MARK4 may affect disease pathogenesis.

Genta Kakiyama
Dec 1, 2020; 61:1629-1644
Research Articles

NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from benign nonalcoholic fatty liver (NAFL) to NASH remain unclear. This lack of knowledge leads to a decreased ability to find relevant animal models, predict disease progression, or develop clinical treatments. In the current study, we used multiple mouse models of NAFLD, human correlation data, and selective gene overexpression of steroidogenic acute regulatory protein (StarD1) in mice to elucidate a plausible mechanistic pathway for promoting the transition from NAFL to NASH. We show that oxysterol 7α-hydroxylase (CYP7B1) controls the levels of intracellular regulatory oxysterols generated by the "acidic/alternative" pathway of cholesterol metabolism. Specifically, we report data showing that an inability to upregulate CYP7B1, in the setting of insulin resistance, results in the accumulation of toxic intracellular cholesterol metabolites that promote inflammation and hepatocyte injury. This metabolic pathway, initiated and exacerbated by insulin resistance, offers insight into approaches for the treatment of NAFLD.

Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to quantify pRab10 levels for drug target engagement or patient stratification. To meet this challenge, we developed an high accuracy and sensitivity targeted mass spectrometry (MS)-based assay for determining Rab10-Thr73 phosphorylation stoichiometry in human samples. It uses synthetic stable isotope-labeled (SIL) analogues for both phosphorylated and nonphosphorylated tryptic peptides surrounding Rab10-Thr73 to directly derive the percentage of Rab10 phosphorylation from attomole amounts of the endogenous phosphopeptide. The SIL and the endogenous phosphopeptides are separately admitted into an Orbitrap analyzer with the appropriate injection times. We test the reproducibility of our assay by determining Rab10-Thr73 phosphorylation stoichiometry in neutrophils of LRRK2 mutation carriers before and after LRRK2 inhibition. Compared with healthy controls, the PD predisposing mutation carriers LRRK2 G2019S and VPS35 D620N display 1.9-fold and 3.7-fold increased pRab10 levels, respectively. Our generic MS-based assay further establishes the relevance of pRab10 as a prognostic PD marker and is a powerful tool for determining LRRK2 inhibitor efficacy and for stratifying PD patients for LRRK2 inhibitor treatment.

This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. Methods: A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. Results: In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype (n = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. Conclusion: PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC.

SURREY, British Columbia, Nov. 12, 2024 — Today, the Quantum Algorithms Institute (QAI) announced a partnership with Canadian companies, AbaQus and InvestDEFY Technologies, to solve common challenges in training machine learning […]

The post Quantum Algorithms Institute Drives Predictive Model Accuracy with Quantum Collaboration appeared first on HPCwire.

Onward State published a story this week that contained on-the-record comments from former Marquette players about Carolyn Kieger's coaching style.

Researchers say that the iconic painting's swirling sky lines up with Kolmogorov's theory of turbulence, suggesting that the artist was a careful observer of the world around him

Former Dawson City Mayor Bill Kendrick has filed his defence against the town's encroachment violation lawsuit.

CME Group, the world's leading derivatives marketplace, today announced its new CBL Australian Carbon Credit Unit (ACCU) futures have launched and are available for trading. A total of five...

Three Ga. high school seniors have been charged with aggravated sexual battery and consumption of alcohol by a minor stemming from an alleged sexual assault during a post-prom party.

A man has been arrested here in connection with the murder of a 50-year-old beautician in Rajasthan's Jodhpur whose body was chopped and buried in a pit by the accused, an official has said.

In this post, we will learn about the most important parameters for the analog simulators that affect the accuracy of the simulation results. We will also understand how each parameter limits the accuracy of the measurements for the DC and transient analyses.(read more)

A LAWYER for Britain’s Prince Andrew on Tuesday questioned whether Virginia Giuffre is legally entitled to pursue her civil lawsuit accusing the Duke of York of sexually abusing her when she was under

The Academic Staff Union of Universities on Tuesday raised an alarm over a plot to sabotage the interest of public universities in the country. ASUU’s National President, Prof Emmanuel Osodeke, at an event marking the 2024 ASUU’s Heroes Day in Abuja, also accused the World Bank and the International Monetary Fund of working relentlessly to

Ukraine abandoned its constitutional neutrality to pursue EU and NATO membership only in 2019, years after Russia annexed Crimea and backed pro-Russia separatists in Donbas. NATO considered Ukraine’s membership after Moscow invaded Georgia, starting a war in Europe.

London — A British soldier accused of passing sensitive information to Iran's Islamic Revolutionary Guard Corps pleaded guilty Monday to escaping from prison while awaiting trial. Daniel Abed Khalife is on trial at London's Woolwich Crown Court, accused of collecting sensitive information between May 2019 and January 2022. Khalife, who is no longer a member of the British armed forces, also denies leaving a fake bomb on a desk and absconding from his barracks in 2023. Prosecutors had also alleged Khalife escaped from London's Wandsworth prison in September 2023 by tying himself to the bottom of a delivery van, sparking a brief nationwide manhunt. The 23-year-old had originally pleaded not guilty to escaping from lawful custody but changed his plea to guilty Monday after having given evidence for several days earlier this month. Khalife is also charged with gathering information that might be useful to an enemy, namely Iran, obtaining information likely to be useful for terrorism and perpetrating a bomb hoax. He still denies those three charges and his trial continues.

Proceeding to the discovery phase means both parties must collect and exchange evidence.