PURPOSE

We aimed to evaluate the efficacy and safety of use of the Fasting Algorithm for Singaporeans with Type 2 Diabetes (FAST) during Ramadan.

PURPOSE

Most real-world studies on anticoagulants have been based on health insurance databases or performed in secondary care. The aim of this study was to compare safety and effectiveness between patients treated with vitamin K antagonists (VKAs) and patients treated with direct oral anticoagulants (DOACs) in a general practice setting.

Purpose:

KEYNOTE-158 (ClinicalTrials.gov identifier: NCT02628067) investigated the efficacy and safety of pembrolizumab across multiple cancers. We present results from patients with previously treated advanced well-differentiated neuroendocrine tumors (NET).

Purpose:

In the phase III DUO trial, duvelisib, an oral dual PI3K-, inhibitor, demonstrated significantly improved efficacy versus ofatumumab [median (m) progression-free survival (PFS), 13.3 vs. 9.9 months (HR, 0.52; P < 0.0001); overall response rate [ORR], 74% vs. 45% (P < 0.0001)], with a manageable safety profile in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). We report results from patients with progressive disease (PD) after ofatumumab who crossed over to duvelisib in the DUO trial.

Nacubactam is a novel β-lactamase inhibitor with dual mechanisms of action as an inhibitor of serine β-lactamases (classes A and C and some class D) and an inhibitor of penicillin binding protein 2 in Enterobacteriaceae. The safety, tolerability, and pharmacokinetics of intravenous nacubactam were evaluated in single- and multiple-ascending-dose, placebo-controlled studies. Healthy participants received single ascending doses of nacubactam of 50 to 8,000 mg, multiple ascending doses of nacubactam of 1,000 to 4,000 mg every 8 h (q8h) for up to 7 days, or nacubactam of 2,000 mg plus meropenem of 2,000 mg q8h for 6 days after a 3-day lead-in period. Nacubactam was generally well tolerated, with the most frequently reported adverse events (AEs) being mild to moderate complications associated with intravenous access and headache. There was no apparent relationship between drug dose and the pattern, incidence, or severity of AEs. No clinically relevant dose-related trends were observed in laboratory safety test results. No serious AEs, dose-limiting AEs, or deaths were reported. After single or multiple doses, nacubactam pharmacokinetics appeared linear, and exposure increased in an approximately dose-proportional manner across the dose range investigated. Nacubactam was excreted largely unchanged into urine. Coadministration of nacubactam with meropenem did not significantly alter the pharmacokinetics of either drug. These findings support the continued clinical development of nacubactam and demonstrate the suitability of meropenem as a potential β-lactam partner for nacubactam. (The studies described in this paper have been registered at ClinicalTrials.gov under NCT02134834 [single ascending dose study] and NCT02972255 [multiple ascending dose study].)

BACKGROUND AND PURPOSE:

Flow-diverter treatment for previously stented aneurysms has been reported to be less effective and prone to complications. In this study, we evaluated the effectiveness and safety of flow diverters for recurrent aneurysms after stent-assisted coiling.

Clothes that light up by themselves could be a high-tech replacement to high-visibility gear worn by cyclists and construction workers

The UK government has pledged to make smart motorways safer by rolling out a radar detection system within the next three years, but New Scientist can reveal that just 7 per cent of the roads are protected by the measure today

Israel exports ready-to-eat fully cooked and not shelf-stable poultry products to the United States. And those exports may continue, according to a report by the USDA’s Food Safety and Inspection Service. That’s because Israel has passed its latest foreign equivalency audit by the United States. The audit did not turn up any deficiencies that might... Continue Reading

While NBA teams are slowly gearing up to return to training facilities this week, the league has reportedly issued a memo prohibiting those with elevated temperatures from participating.  

Shoppers will have to get used to "supermarket-style" queuing and till screens as well as innovations such as video-conferencing advice from ­assistants when high-street stores start to reopen after the end of the lockdown.

A man has told how he pulled his young daughter to safety before a "horrific" crash that left his husband trapped between two vehicles in north London.

Companies around the country are figuring out how to safely reopen office during the pandemic. The new normal might involve smartphone apps and badges to track employees.

Sara Cherry, a microbiologist at the University of Pennsylvania, feels safer at work than almost anywhere else. That’s because she works inside a biosafety level 3 laboratory on the Penn campus in Philadelphia, where she is the scientific director of the High-Throughput Screening Core.

• Alex Wurz calls measures to deal with coronavirus ‘immaculate’
  
• ‘F1 can be pioneer’ for other sports to follow, says GPDA chief

The Grand Prix Drivers’ Association is confident the precautions being taken by Formula One mean the sport stands every chance of resuming as planned in Austria on 5 July.

Alex Wurz, chairman of the GPDA, will reassure his members that Formula One has put the safety of everyone involved at the forefront of its plans to return to racing after attending a meeting with F1 and the FIA on Friday.

Devices that buzz when someone comes too close and wearables that tell you how long you've spent in the company of someone with covid-19, how tech is trying to break us out of lockdown

Major pork plant closed after hundreds of workers contract coronavirus, while speeding up of poultry production lines raises concerns over standards

• Coronavirus – latest updates
• See all our coronavirus coverage

The US government is accelerating controversial regulatory rollbacks to speed up production at meat plants, as companies express growing alarm at the impact of Covid-19 on their operations.

Last week Smithfield shut down one of the largest pork plants in the country after hundreds of employees contracted the coronavirus. The plant in South Dakota – whose output represents 4–5% of US pork production – is reported to be the largest single-source coronavirus hotspot in the US, with more than 600 cases. In response, the company said it was “critical” for the meat industry to “continue to operate unabated”.

Now it has emerged that as a wave of plants announce closures, US meat plants are being granted permission to increase the speed of their production lines. This comes despite warnings that the waivers for higher speeds on slaughter and processing lines will compromise food safety.

Third of workers at factory in Tipperary test positive, while McDonald’s supplier forced to temporarily halt production

An outbreak of Covid-19 among workers in a meat factory in Tipperary has raised fears that the virus is spreading through abattoirs and meat-processing plants in Ireland.

Sinn Féin’s spokesperson on agriculture, Brian Stanley, told the Irish parliament last night that 120 workers at the Rosderra Meats plant in Roscrea had tested positive for the virus. He also said that of 350 workers at the plant, up to 140 were off sick last week. Rosderra is the largest pork-processing company in Ireland.

Royal Life Saving Society Australia is warning parents to limit distractions and be vigilant with water safety, as new data shows one-year-olds are at the greatest risk of drowning compared to any other age group.

A new union-released report accuses Qantas of downplaying the risks of coronavirus before an outbreak at Adelaide Airport — but the airline has denied any wrongdoing.

Coby Persin, whose YouTube channel is known for prank videos with a touch of social commentary, tricked teenage girls he met online to meet him in person.

The Department announced the arrest of a former trooper with the Texas Department of Public Safety who is charged with depriving multiple Latino motorists of their civil rights. According to the four count indictment returned by a federal Grand Jury in Corpus Christi, Texas, on April 8, 2009, Michael Anthony Higgins violated federal law by willfully stealing money from Latino motorists that he had stopped on the highway while working as a trooper.

Atlantic States Cast Iron Pipe Co. a Phillipsburg, N.J.-based division of McWane Inc. of Alabama was sentenced today to pay a fine of $8 million for violations of environmental and worker safety laws as well as obstructing the federal investigation of its conduct.

Christopher Neil Gauntt, the former supervisor of the Fort Gibson Water Treatment Plant in Fort Gibson, Okla., pleaded guilty today in U.S. District Court in Muskogee, Okla., to falsifying a monthly operating report that certified the safety of drinking water from the facility.

Panagiotis Lekkas, the captain of the cargo ship, M/V Theotokos, was sentenced today in federal court in New Orleans to 10 months confinement.

“Eradicating youth violence is a priority of this administration and a priority of both these agencies," said Attorney General Holder and Education Secretary Duncan.

The new directive is part of a larger Justice Department initiative to create better communication and coordination to fight crime and promote justice in Indian Country.

The jury returned guilty verdicts on all four counts of the indictment that charged Michael Anthony Higgins with violating federal law by willfully stealing money from motorists that he had stopped on the highway while working as a trooper.

Medical device manufacturer Guidant LLC, a wholly-owned subsidiary of Boston Scientific Corporation, was charged today with criminal violations of the Federal Food, Drug, and Cosmetic Act related to safety problems with some of its implantable defibrillators.

Guidant LLC pleaded guilty today in St. Paul, Minn., before U.S. District Court Judge Donovan W. Frank to criminal violations of the Federal Food, Drug and Cosmetic Act.

Hundreds of American Indian and Alaskan Native communities will receive almost $127 million to enhance law enforcement, bolster justice systems, prevent youth substance abuse, serve sexual assault and elder victims, and support other efforts to combat crime.

Guidant LLC, a wholly-owned subsidiary of Boston Scientific Corporation, was formally convicted and sentenced today in St. Paul, Minn., for criminal violations relating to its interactions with the Food and Drug Administration (FDA).

The Department of Justice announced today that it is accepting applications from Native American and Alaska Native tribal communities for funding to improve public safety in Indian country via the Fiscal Year (FY) 2011 Coordinated Tribal Assistance Solicitation (CTAS).

“Our law enforcement officers put themselves in harm’s way every day to ensure the safety and security of the American people in cities and communities across the country, and we need to do everything we can to protect them,” Attorney General Holder said.

"As we have seen repeatedly – most clearly on September 11th and in the aftermath of Hurricane Katrina – in times of crisis and emergency, law enforcement officers and first responders must be able to communicate quickly, across all jurisdictions. And as national security and public safety threats have continued to grow and to evolve, the need to bring public safety communications into the 21st century has never been greater."

The Department of Justice today announced grants to nearly 150 American Indian and Alaskan Native nations providing $118.4 million to enhance law enforcement practices, and sustain crime prevention and intervention efforts in eight purpose areas.

"This marks the third time that this extraordinary group of leaders, researchers, front-line practitioners, and federal partners has come together to exchange insights, to share expertise, and to strengthen the essential work that has become not just our shared priority – but our common cause," said Attorney General Holder.

Columbus Manufacturing Inc., a wholly owned subsidiary of Columbus Foods LLC, has agreed to pay a penalty and make significant upgrades to settle Clean Air Act violations.

The Department of Justice announced today the filing of a consent decree with the Louisiana Department of Public Safety and Corrections (LDPSC) that resolves allegations of sexual harassment of an office administrator in violation of Title VII of the Civil Rights Act of 1964, as amended (Title VII).

After a seven week trial in federal court in Camden, N.J., multiple defendants were convicted on various felony counts of creating false records, trafficking in illegally possessed oysters, obstructing the Food and Drug Administration’s regulation of public health and safety, and conspiring to commit those crimes.

Sheila Birnbaum, Special Master of the September 11th Victim Compensation Fund (VCF), released the following statement on the final rule by the National Institute for Occupational Safety and Health (NIOSH) to include certain cancers into the World Trade Center Health Program.

Attorney General Eric Holder and the Department of Justice’s Bureau of Justice Assistance Director Denise E. O’Donnell today announced more than $11 million in awards to address neighborhood-level crime in 15 locations nationwide.

A 22-count federal indictment was unsealed today in federal court in New Orleans charging Connie M. Knight, 46, with impersonating a federal employee for the purpose of enticing people to pay her for fraudulent hazardous waste safety training.

U.S. Department of Justice Acting Associate Attorney General Tony West today addressed tribal leaders, law enforcement officers, lawyers and judges, policy experts and health and social services providers, and representatives from federal, state, local and tribal governments following a week of public safety events at the 13th National Indian Nations Conference in Agua Caliente, Calif.

Vice President Joe Biden and Attorney General Eric Holder today awarded the Public Safety Officer Medal of Valor to 18 public safety officers who exhibited exceptional courage in saving and protecting others and whose heroic actions were above and beyond the call of duty.

The Bureau of Justice Assistance awarded $1 million to the National Crime Prevention Council to support the development of a National Public Education Campaign on the subject of responsible gun ownership and safe gun storage.

"I recognize, as you do, that there’s no single prescription for addressing these challenges and confronting their underlying causes. But I also know that those whose lives have been impacted by gun violence – the victims and the survivors – are depending on us," said Attorney General Holder.

The Department of Justice and the Council of State Governments (CSG) highlight 17 states that have cut corrections costs while reducing recidivism and improving public safety. With funding from the Justice Department’s Bureau of Justice Assistance (BJA), staff from the CSG Justice Center – in partnership with the Pew Center on the States – worked with lawmakers, policymakers, and a wide range of justice system professionals and stakeholders from each state to identify crime and corrections trends and formulate strategies that would save money and improve safety.