Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.

Materials and methods of making low-sintering-temperature glass waste forms that sequester radioactive iodine in a strong and durable structure. First, the iodine is captured by an adsorbant, which forms an iodine-loaded material, e.g., AgI, AgI-zeolite, AgI-mordenite, Ag-silica aerogel, ZnI2, CuI, or Bi5O7I. Next, particles of the iodine-loaded material are mixed with powdered frits of low-sintering-temperature glasses (comprising various oxides of Si, B, Bi, Pb, and Zn), and then sintered at a relatively low temperature, ranging from 425° C. to 550° C. The sintering converts the mixed powders into a solid block of a glassy waste form, having low iodine leaching rates. The vitrified glassy waste form can contain as much as 60 wt % AgI. A preferred glass, having a sintering temperature of 500° C. (below the silver iodide sublimation temperature of 500° C.) was identified that contains oxides of boron, bismuth, and zinc, while containing essentially no lead or silicon.

Materials and methods of synthesizing mixed-layered bismuth oxy-iodine materials, which can be synthesized in the presence of aqueous radioactive iodine species found in caustic solutions (e.g. NaOH or KOH). This technology provides a one-step process for both iodine sequestration and storage from nuclear fuel cycles. It results in materials that will be durable for repository conditions much like those found in Waste Isolation Pilot Plant (WIPP) and estimated for Yucca Mountain (YMP). By controlled reactant concentrations, optimized compositions of these mixed-layered bismuth oxy-iodine inorganic materials are produced that have both a high iodine weight percentage and a low solubility in groundwater environments.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

The disclosure relates to anti-glial maturation factor beta (“GMF-B”) monoclonal antibodies (mAbs) and fragments thereof, as well as hybridoma lines that secrete antibodies or fragments. Therapeutic and diagnostic uses of such antibodies, including treatment and detection of cancer and dementia, and methods and kits for detecting cells or samples expressing GMF-B, including soluble GMF-B, are also encompassed.

The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance gene; a host cell and a plant cell having the recombinant vector transfected thereinto; a transformant transformed by the insect-resistance gene and a method for producing the same; a protein recovered thereby; and an insect-resistant agent comprising them as active ingredients. In accordance with the present invention, the insect-resistant protein is derived from a plant.

The invention provides intermediates of the formula: as well as a method of their preparation by reacting a thiol having at least two hydroxyl groups with a mono-unsaturated organic compound in the presence of a base catalyst. A polymerizable urethane acrylate oligomer or urethane methacrylate oligomer is formed by reacting a polyisocyanate with the intermediate. The polymerizable urethane acrylate oligomer or urethane methacrylate is blended with a polymerization initiator to form a composition which is useful in such applications as adhesives.

A vibratory compactor having a first compacting element having a variable vibratory mechanism that sets a modifiable compaction effort, a second compacting element, a first sensor configured to measure a first surface compactability associated with the first compacting element, a second sensor configured to measure a second surface compactability associated with the second compacting element and a control system. The control system is configured to receive the first surface compactability, receive the second surface compactability, determine a target compaction effort for the first compacting element based on the first surface compactability and the second surface compactability, and modify the variable vibratory mechanism to set the compaction effort at the target compaction effort.

Certain example implementations of the disclosed technology include a light emitting device. The light emitting device may include an enclosure with four sides and a top edge surface associated with each of the four sides. The enclosure may be capable of mounting on a grid frame of a suspended ceiling such that a portion of the top edge surfaces contacts a portion of the grid frame. The light emitting device may further include a light modifying element characterized by a substrate with four or more edges, a back surface disposed on the top edge surface of each of the four sides of the enclosure, and a front surface. In certain example embodiments the substrate may further comprise two or more edge trusses. A periphery of the light-emitting front surface may be capable of contacting the grid frame after the light emitting device is mounted to the grid frame.

Methods and apparatus for switching between a live video decoding and a recorded playback in a digital video and recording system. A received video data stream is transmitted to a first-in first-out video decoder buffer without first looping the video data stream through a playback buffer. The video data stream is transmitted from the video decoder buffer to a video decoder. If a “pause” command is received, the video data stream is transmitted to a first-in first-out playback buffer, while continuing to transmit the video data stream to the video decoder buffer. Transmission of the video data stream to the video decoder buffer is halted when the video decoder buffer fills up. The last byte of the video data stream that was transmitted to the video decoder buffer is marked. If a “play” command is received, the video data stored in the video decoder buffer is transmitted to the video decoder. The video data stored in the playback buffer is transmitted to the video decoder buffer starting at a point immediately after the data element that was marked previously.

A driver performance mapping system for a vehicle system is disclosed. The system may include a GPS receiver generating GPS data indicative of a current location of the vehicle. In addition, the system may also have a radar device generating current gap data indicative of a current gap distance from the vehicle to a lead vehicle. Further, the system may include an electronic controller configured to generate learned gap data based on the current gap data and stored gap data, and then assign the learned gap data with the GPS data.

A computer-implemented fan control method includes measuring a temperature within a computer system and dynamically selecting a fan speed step in response to the temperature received, wherein the fan speed step is selected from a fan speed table defining a finite number of fan speed steps each having an associated fan speed. A fan is operated at the dynamically selected fan speed step, wherein the fan is positioned to drive air through the computer system where the temperature is being measured. The fan output variation is measured over a prescribed time interval and the fan speed table is automatically modified to change the fan speeds associated with each fan speed step, wherein the fan speeds are changed as a function of the measured fan output variation while continuing to drive the fan.

This invention relates to the field of preparation technology of optical pH sensor by co-intercalated fluorescein and 1-heptanesulfonic acid sodium into layered double hydroxide. The sensor is composed by conductive materials and the surface LDH films by co-interacted FLU and HES. The synthesis method is: first: synthesis of LDH colloid suspension, subsequently, the FLU and HES co-intercalated LDH colloid solution was prepared following the ion-exchange method, then the thin film of FLU-HES/LDH was spreaded on the surface of the conductive material by electrophoretic deposition, and the oriental pH sensor was synthesized. The advantages of the present invention is: first, the LDH matrix provides chromophore molecules with a confined and stable environment; the novel electrophoretic deposition strategy in this work provides a method for precise control of thickness (ranging from nanometers to micrometers), and the oriental pH sensor show good pH responsive.

Compositions and methods for inhibiting and controlling the growth of microbes are disclosed. The composition comprises at least one chemically-modified peptide with antimicrobial activity and at least one carrier. The method comprises of administering an amount, effective for the prevention, inhibition and termination of microbial growth for industrial, pharmaceutical, household and personal care use.

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.

Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab')2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.

Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes an LNT1 polypeptide.

This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs.

The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

A system for radioisotope production uses fast-neutron-caused fission of depleted or naturally occurring uranium targets in an irradiation chamber. Fast fission can be enhanced by having neutrons encountering the target undergo scattering or reflection to increase each neutron's probability of causing fission (n, f) reactions in U-238. The U-238 can be deployed as one or more layers sandwiched between layers of neutron-reflecting material, or as rods surrounded by neutron-reflecting material. The gaseous fission products can be withdrawn from the irradiation chamber on a continuous basis, and the radioactive iodine isotopes (including I-131) extracted.

Nonconjugated conductive polymers absorb radioactive iodine, therefore are useful for protection against nuclear radiation. These polymers have at least one double bond per repeat unit. The ratio of the number of double bonds to the total number of bonds along the polymer chain is less than half. Examples of nonconjugated conductive polymers include: cis-1,4-polyisoprene (natural rubber), trans-1,4-polyisoprene (gutta percha), polybutadiene, polydimethyl butadiene, poly(b-pinene), styrene butadiene rubber (SBR), polyalloocimene, polynorbornene and many others. Through interaction with iodine atoms the double bonds in the nonconjugated polymers transform into radical cations leading to a dark color. The iodine atoms remain (immobile) bound to the polymer chain through the charge-transfer interaction, these polymers are very inexpensive and can be easily processed into any shape, structure and size. Therefore, these are useful for protection against nuclear radiation including radioactive iodine. These polymers when used as a thick cover can provide safe storage of nuclear waste materials including spent fuel rods.

A method for scanning and decoding encoded symbols comprises processing low resolution image data from a full field of view and/or high resolution image data from one or more windowed segments of the field of view to provide imaging that is easily adaptable to different types of symbols and varying environmental conditions. The scanning method can be switched between the low resolution mode and the high resolution mode automatically based on whether the low resolution data is sufficiently accurate to decode the symbol.

A system and method for assessing a health and functionality of a locomotive friction modifying system wherein the locomotive has a friction modifying applicator associated with a wheel of the locomotive for applying a friction modifying agent to a rail on which the wheel is traversing. The system and method comprise a sensor detecting a predetermined operational condition of the locomotive. The system and method also comprise a controller associated with the sensor and responsive to input from the sensor determining a per unit creep of an axle of the locomotive. The controller also determines a tractive effort of the axle of the locomotive and determines a friction modifying applicator state for the applicator associated with the axle. The controller further compares the determined per unit creep of the axle, the tractive effort of the axle and the state of the friction modifying applicator associated with the axle to a predetermined value indicative of the health and functionality of the locomotive friction modifying system. The controller provides an indication of the health and functionality of the locomotive friction modifying system.

A system and method for controlling an application of a friction modifying agent to an area of contact between a railway wheel and a railway rail over which the wheel is traversing to selectively modify the coefficient of friction at the contact area. A sensor is used for detecting a parameter relating to the operation of the railway train. A controller is responsive to the sensor for selecting one or more of a plurality of friction modifying agents and controls the application of the agent to the rail as a function of the parameter. An applicator is responsive to the controller and applies the friction modifying agent to the area of contact between the railway wheel and rail. A second application of the agent may be predicated upon the effectiveness of a first application of the agent. The selection of the appropriate agent may include a consideration of a current location of the railway vehicle.

A friction management system for a traveling crane applies a liquid or solid friction modifier (FM) in precisely controlled quantities to the crane wheels or rail to improve performance and safety during movement of the crane. The friction modifier is applied by a nozzle mounted on a crane truck, which nozzle is opened and closed by a valve. The duration of the valve opening per second, which controls the friction modifier application rate, is approximately proportional to the average current draw, which is detected by current sensors connected to the truck motors.

In one example, a modified electrical device includes a body and at least one connector on the body to make power and control connections with an active cover plate. A system includes an active cover plate comprising low voltage circuitry and a first interface and a modified electrical device. The modified electrical device includes high voltage circuitry and a second interface to connect to the first interface to supply low voltage to the active cover plate. A method for controlling a flow of power through a modified electrical device is also provided.

A system and method for modifying a gas turbine engine in the field to drill a series of cooling holes in a turbine rotor disk made of a superalloy. A portable field repair system includes a stand configured to receive, support, and position a turbine rotor disk, a drill having a self-feeding spindle and configured to automatically drill a predetermined depth through a superalloy and to automatically stop upon completion, a drill guide configured to coordinate the drill with a plurality of radial axes associated with a precise hole pattern to be cut and a drill mount configured to mechanically couple the drill to the drill guide and to position the drill during the modification of the gas turbine engine turbine rotor disk.

A communication apparatus with a multiple-input and multiple-output (MIMO) channel, includes a minimum mean square error (MMSE) detector configured to estimate quadrature amplitude modulation (QAM) symbols based on signals received through the MIMO channel. The apparatus further includes a QAM demodulator configured to demodulate the estimated QAM symbols, and estimate a first posterior probability of each of encoded bits of the estimated QAM symbols, and a first module configured to remove a first prior probability of each of the encoded bits from the first posterior probability to generate soft estimates of the encoded bits. The apparatus further includes a channel decoder configured to decode the encoded bits based on the soft estimates, and generate an improved posterior probability of each of the encoded bits, and a second module configured to generate a second prior probability of each of the encoded bits based on the improved posterior probability.

A method and apparatus prioritizing video information during coding and decoding. Video information is received and an element of the video information, such as a visual object, video object layer, video object plane or keyregion, is identified. A priority is assigned to the identified element and the video information is encoded into a bitstream, such as a visual bitstream encoded using the MPEG-4 standard, including an indication of the priority of the element. The priority information can then be used when decoding the bitstream to reconstruct the video information.

In a wireless network, plural downlink signals from plural base stations are transmitted to a terminal. The plural downlink signals all carry the same information to the terminal. The terminal provides feedback on the downlink channels. The feedback provides information on the taps of the channels. The amount of information fed back is constrained. Based on the feedback, transmission parameters of the downlink signals are adjusted. The process of transmitting, providing feedback, and adjusting the parameters continue so that the energy of the downlink signal is enhanced at the terminal location and suppressed elsewhere. Beam forming can be used to further suppress the energy signature at locations other than the terminal location.

A decoder receives a bitstream containing quantized coefficients representative of blocks of video representative of a plurality of pixels and decodes the bitstream using context adaptive binary arithmetic coding that includes at least two decoding modes, the first mode decoding the bitstream based upon a probability estimate which is based upon at least one of spatially and temporally adjacent syntax element values to a current syntax element being decoded, the second mode decoding the bitstream not based upon a probability estimate based upon other syntax elements to the current syntax element being decoded. The coding decodes the current syntax element using the first mode if the current syntax element is intra-coded and selecting between sets probable modes with different probabilities. The coding decodes the current syntax element using the second mode if the current syntax element is intra-coded and if selecting among one of the second set of probable modes.

A method includes extracting a first vector used to code a specific block belonging to a coded field picture arranged chronologically adjacent to a field picture to be coded and to a block to be coded, generating a second vector by scaling the first vector based on a temporal distance between the field picture and a second picture specified by a reference index and referenced for the block and included in the field picture and a temporal distance between a first picture pointed by the first vector and the coded field picture arranged chronologically adjacent to the field picture, and correcting the second vector based on a parity of the field picture, a parity of the first picture, a parity of the second picture and a parity of the coded field picture and forming the corrected second vector.

Various methods and systems for efficiently performing the blind decoding of downlink signals is described. Several forms of arranging possible CCE combinations are examined and investigated. Based on PDCCH size estimation/information, CCE concatenations that are most likely (of of limited sets) can be arrived at. Tree-based concatenations are also devised using largest CCE ordering to align smaller CCE sizes to similar boundaries. By such ordering, the search space for all possible CCE ordering and sizes can be reduced to an efficient tree. Set mapping between possible lnposelstartCCElnposelend/REs are also described using a first set to secondary and tertiary sets. Various other ordering and sorting schemes are also detailed that enable a blind decode of a PDCCH channel to be efficiently performed.

Sequential write operations to a unit of compressed memory, known as a compression tile, are examined to see if the same compression tile is being written. If the same compression tile is being written, the sequential write operations are coalesced into a single write operation and the entire compression tile is overwritten with the new data. Coalescing multiple write operations into a single write operation improves performance, because it avoids the read-modify-write operations that would otherwise be needed.

A method to inexpensively and efficiently produce conductive materials on the surface of which a nano-level fine structure is formed includes surface modification including immersing a stable anode electrode and a workpiece as a cathode electrode, the workpiece including a conductive material with a work surface, in an electrolytic solution, then applying a voltage not less than a first voltage and less than a second voltage between the stable anode electrode and the workpiece as the cathode electrode immersed in the electrolytic solution, thereby modifying the work surface, the first voltage being a voltage corresponding to a current value that is ½ of the sum of a first maximum current value appearing first in a positive voltage region and a first minimum current value appearing first in the positive voltage region with respect to voltage-current characteristics of a surface modification treatment system, the second voltage exhibiting a complete-state plasma.

Methods and apparatus for applying pulsed DC power to a plasma processing chamber are disclosed. In some implementations, frequency of the applied power is varied to achieve desired processing effects such as deposition rate, arc rate, and film characteristics. In addition, a method and apparatus are disclosed that utilize a relatively high potential during a reverse-potential portion of a particular cycle to mitigate possible nodule formation on the target. The relative durations of the reverse-potential portion, a sputtering portion, and a recovery portion of the cycle are adjustable to effectuate desired processing effects.

The present invention relates to a packing box for accommodation of plate bodies, which comprises a backplane, and a side plate vertically arranged at the periphery of the backplane, the plate body including a main body, and a PCB plate connected through a flexible sheet to the edge of the main body, a positioning member being further arranged in the space enclosed by the backplane and the side plate for preventing the PCB plate from moving relative to the main body. The positioning member of the present invention can prevent the PCB plate from moving relative to the main body of the plate body, playing a role in protecting the circuit on the flexible sheet and having low costs.

An apparatus having a frame; a shuttle member, adapted to receive and hold a needle blank, and movably mounted to the frame; a clamp member detachably mounted on the frame for supplying needle blanks to the shuttle member; a transfer mechanism mounted on the frame for facilitating the transfer of the needle blanks from the clamp member to the shuttle member; a press mechanism for imparting first flat surfaces to first opposing sides of the needle blanks held by the shuttle member; a mandrel mounted on the frame for imparting an arcuate profile to the needle blanks; a transport mechanism for transporting the needle blanks from the shuttle member to the mandrel; and a needle side press for imparting second flat surfaces to second opposing sides of the needle blanks. A method of forming a curved, rectangular bodied needle from substantially round-elongated needle blanks is also disclosed and comprises the steps of: transferring needle blanks from a clamp to a holding shuttle having die surfaces on needle engaging faces thereof; flat pressing first opposing sides of the needle blanks between die surfaces; transporting the needle blanks from the shuttle onto a rotatable mandrel; curving the needle blanks between the rotatable mandrel and a reciprocable belt; rotating the needle blanks about the mandrel and adjacent side press dies and depositing the needle blanks therebetween; and side pressing second opposing sides of the needle blanks between side press dies.

An apparatus for forming at least one curved, rectangular bodied surgical needle which comprises frame means, flat press means associated with said frame means for imparting first flat surfaces to opposite sides of at least a portion of at least one needle blank, curving means associated with said frame means for imparting an arcuate profile to at least a portion of the at least one needle blank and side press means mounted on said frame portion for imparting second flat surfaces to opposite sides of the needle blank, wherein said second flat surfaces are imparted substantially perpendicular to said first flat surfaces. There is also disclosed a method of forming a curved rectangular bodied needle from a substantially round-elongated needle blank comprising the steps of flat pressing opposite sides of the needle blanks between a pair of flat press dies, drawing the needle blanks from at least one of said flat press dies onto a rotatable mandrel, curving the needle blanks between said rotatable mandrel and a reciprocable belt, rotating the needle blanks adjacent side press dies and depositing the needle blanks therebetween and side pressing opposite sides of the needle blanks between said side press dies, on sides of the needle blanks substantially perpendicular to the flat pressed sides. A surgical needle is also disclosed having a tapered distal portion, a rectangular central portion and a bored proximal portion formed according to the apparatus and method described above. The tapered distal portion of the needle has a generally circular cross-section, the rectangular central portion is generally square and the bored proximal portion also has a generally circular cross-section.

An apparatus for forming at least one curved, rectangular bodied surgical needle which comprises frame means, flat press means associated with said frame means for imparting first flat surfaces to opposite sides of at least a portion of at least one needle blank, curving means associated with said frame means for imparting an arcuate profile to at least a portion of the at least one needle blank and side press means mounted on said frame portion for imparting second flat surfaces to opposite sides of the needle blank, wherein said second flat surfaces are imparted substantially perpendicular to said first flat surfaces. There is also disclosed a method of forming a curved rectangular bodied needle from a substantially round-elongated needle blank comprising the steps of flat pressing opposite sides of the needle blanks between a pair of flat press dies, drawing the needle blanks from at least one of said flat press dies onto a rotatable mandrel, curving the needle blanks between said rotatable mandrel and a reciprocable belt, rotating the needle blanks adjacent side press dies and depositing the needle blanks therebetween and side pressing opposite sides of the needle blanks between said side press dies, on sides of the needle blanks substantially perpendicular to the flat pressed sides. A surgical needle is also disclosed having a tapered distal portion, a rectangular central portion and a bored proximal portion formed according to the apparatus and method described above. The tapered distal portion of the needle has a generally circular cross-section, the rectangular central portion is generally square and the bored proximal portion also has a generally circular cross-section.

There is disclosed an apparatus for forming curved and rectangular bodied needle blanks from a length of needle stock which includes a generally cylindrical inner mandrel having a plurality of longitudinal channels formed in an outer surface thereof, the mandrel being dimensioned and configured for insertion within the length of needle stock. The apparatus also includes a plurality of broaches insertable into the longitudinal channels such that an edge of each broach projects radially outwardly of the mandrel to form a plurality of inner grooves on an inner surface of the length of needle stock. There is also provided structure for forming outer grooves in an outer surface of the length of needle stock to form a substantially grooved length of needle stock, cutters for cutting the grooved length of needle stock to form rings of curved rectangular bodied needle blanks interconnected by web portions and structure for dividing the rings at the web portions to form a plurality of curved rectangular bodied needle blanks. There is also disclosed a method of forming needle blanks from a length of needle stock having a longitudinal cavity therethrough and defining a longitudinal axis by forming at least two inner grooves in an inner surface of the length of needle stock and substantially parallel to the longitudinal axis, forming a number of outer grooves, equal to the number of inner grooves, in an outer surface of the length of needle stock and in substantial radial alignment with the at least two inner grooves to form a grooved length of needle stock and sectioning the grooved length of needle stock to form individual needle blanks.

There is disclosed an apparatus for forming curved and rectangular bodied needle blanks from a length of needle stock which includes a generally cylindrical inner mandrel having a plurality of longitudinal channels formed in an outer surface thereof, the mandrel being dimensioned and configured for insertion within the length of needle stock. The apparatus also includes a plurality of broaches insertable into the longitudinal channels such that an edge of each broach projects radially outwardly of the mandrel to form a plurality of inner grooves on an inner surface of the length of needle stock. There is also provided structure for forming outer grooves in an outer surface of the length of the needle stock to form a substantially grooved length of needle stock, cutters for cutting the grooved length of needle stock to form rings of curved rectangular bodied needle blanks interconnected by web portions and structure for dividing the rings at the web portions to form a plurality of curved rectangular bodied needle blanks. There is also disclosed a method of forming needle blanks from a length of needle stock having a longitudinal cavity therethrough and defining a longitudinal axis by forming at least two inner grooves in an inner surface of the length of needle stock and substantially parallel to the longitudinal axis, forming a number of outer grooves, equal to the number of inner grooves, in an outer surface of the length of needle stock and in substantial radial alignment with the at least two inner grooves to form a grooved length of needle stock and sectioning the grooved length of needle stock to form individual needle blanks.

Channel-bodied surgical needles and surgical incision members are disclosed having a generally U-shaped cross-sectional body portion and a penetrating tip portion formed on at least one end thereof. Preferably, penetrating tip portions are formed at both ends of the channel-bodied portion. The surgical needle and/or surgical incision member may additionally includes apparatus engagement structure formed adjacent either end of the body portion and engagable with a suitable surgical suturing apparatus. The channel-bodied surgical needle and/or surgical incision member may additionally include securement structure for attachment of a length of suture material thereto. There is also disclosed apparatus for forming a channel-shaped body portion and the suture attachment structure. Additionally, methods for suturing tissue sections, particularly vascular tissue sections, with the channel-bodied surgical needle and the channel-bodied surgical incision members, are disclosed. Also, methods for forming the channel-bodied surgical needle and channel-bodied surgical incision member are disclosed.

A system that encodes a sequence of integers using a variable-length compression technique is described. During operation, the system scans the sequence of integers and observes the sizes of the integers to determine a threshold value K from the observed sizes. For a given integer which is N bits in length, if N−K is greater than or equal to zero, the system generates a tag for the encoded integer which comprises a sequence of N−K zeros followed by a one, and generates a set of remaining bits for the encoded integer as a sequence of the N bits which make up the integer. Otherwise, if N−K is less than zero, the system generates a tag for the encoded integer as a single one, and generates a set of remaining bits for the encoded integer by padding the N bits which make up the integer with zeros so that the set of remaining bits is K bits in length.

Processes for preparation of macroporous membranes having unusually high equilibrium protein binding capacities are described. Membranes include a self-supporting porous membrane substrate and a grafted polymeric film on the pore surfaces of the substrate. A polymeric film may be grafted to the porous membrane substrate using surface-initiated polymerization. The grafted polymer chains within the polymeric film can act as molecular ‘brushes’ or ‘tentacles’ in solution and can contain one or more capture chemistries for biomolecules. Membranes can be used in the separation and purification of biomolecules such as proteins, nucleic acids, virus or virus-like particles, endotoxins, and the like.