Social media users alleged bias against former President Donald Trump when a Google search on Election Day for “where to vote” returned an interactive map to find a person’s polling station when including the word “Harris” but not “Trump.” The reason is because “Harris” is a county in Texas, whereas “Trump” is not a location.

The post Google’s ‘Where to Vote’ Search Result Reflects Quirk of Candidate Surname, Not Bias appeared first on FactCheck.org.

The post Friday Girls From Russian Province appeared first on English Russia.

It All Started with Hexie-lust!

Getting Hooked on Crochet

Original Crochet-Along, Frida's Flowers

Bored with making 6 identical flowers - Colors calling us!

Designing Our Afghans

Entering at the San Juan County Fair

We are taking this opportunity to say Thank You! We can’t express how much we appreciate you being a part of RSS Ground family. We hope our unique tools will continue to be useful to you for years to come. We usually never do this, but this time we would like to show our token […]

The post Happy Thanksgiving and Black Friday Deal appeared first on RSSground.com.

Pile ups and loop outs...This week's Friday Fails has it all!
( Comments: 46 )

Ride, eat, party, sleep, repeat.
( Comments: 49 )

We've pulled together an eclectic mix of mountain bike-related gift ideas for all the riders on your list.
( Photos: 12, Comments: 49 )

As Florida’s seagrass beds die off, manatees are starving. Can the seagrass–and the manatees–make a comeback?

The most popular US state for British tourists has plenty more to offer than Disney – experts Susan Veness and Simon Veness share eight destinations for a fun-packed city break

Having lived in London for four years, American Kassondra Cloos thought a trip see her adopted city as imagined by the Wizarding World of Harry Potter in Orlando would be fairly pointless – but instead she finds a home from home that’s suited to even grown-up kids

Over 100,000 passengers passed through the airport on 27 October

Over a dozen flights cancelled or delayed between Bali and Australia

Dados enviados pela Voyager 2 em 1986 mostravam que as luas de Urano eram completamente diferente do resto do Sistema Solar

“This bill makes American liquefied natural gas accessible and cost-effective to regional allies."

The post Florida Lawmakers Want Accessible Liquefied Natural gas appeared first on Shark Tank.

The FEMA official who was just fired for telling workers to avoid homes impacted by the hurricanes in Florida if they had Trump signs says that it was not “isolated” and that FEMA workers were instructed to do it in the Carolinas too. (X) The American people must get justice. Indict and convict. So, apparently this …

Yale medical school’s chief psychiatry resident told a TV host that people should avoid their Trump-voting relatives on Thanksgiving and Christmas. While on MSNBC with host Joy Reid, Amanda Calhoun said if you have relatives who voted for Trump, “it’s completely fine to not be around those people and to tell them why.” Calhoun suggested […]

The post Yale psychiatrist says you should avoid your Trump-voting relatives during the holidays appeared first on Liberty Unyielding.

The vice-president failed to make the case that she would be different from her boss, President Joe Biden.

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

velocityconf: New #velocityconf CA program preview is up: http://t.co/rKjf91RXdD @ariyahidayat on End-to-End JS Quality Analysis.

Ergatta's Black Friday deals are live now, giving shoppers a chance to save up to $850 on its smart rowers, including free shipping.

The best early Black Friday MacBook deals include all-time low prices on the latest MacBook Air models.

Black Friday is weeks away, but Amazon already has several great deals you can find now. Here are the best Amazon early Black Friday deals.

Too much fluoride can make your teeth brown, but getting a little bit is a dentist's dream. Here's the complete history of fluoridated water.

Kenya's candidate for the top job at the African Union said on Saturday that if US president-elect Donald Trump does not want to work with Africa, the continent has "other friends".

There is a reason Joe Rogan became the world's largest podcaster. He doesn't take his audience -- or his guests -- for granted. He wants MEANINGFUL conversations.

The post Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet appeared first on Clash Daily.

Spend enough time talking with entrepreneurs, product people, designers, and anyone charged with proving something, and you’ll bump into questions about validation. “How do you validate if it’s going to work?”“How do you know if people will buy it to not?”“How do you validate product market fit?”“How do you validate if a feature is worth… keep reading

The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday.

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability. Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2. Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ∼3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog. The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain. These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.

In their comment (1) on our publication (2), the authors make two points: (i) they raise concerns about the possible effect of residual NONOate in our study, and (ii) they promote nitrosylcobalamin (NOCbl) supplied by their own company. Both points lack merit for the following reasons. The authors make the astonishing claim that the spectra of nitric oxide (NO•) and cobalamins overlap. Unlike NO•, cobalamin absorbs in the visible region, permitting unequivocal spectral assignment of NOCbl as reported (3). We demonstrated that whereas NOCbl is highly unstable in solution, it is stabilized by the B12 trafficking protein CblC. So even if present, residual NONOate (which is unstable at neutral pH and is removed during the work-up (3)) could not account for the observed difference.The authors then misrepresent our synthetic method, claiming that anaerobic conditions were used to generate nitrocobalamin (NO2Cbl), which results in the transient formation of NOCbl. We synthesized NO2Cbl aerobically using nitrite as described (4); NOCbl is not an intermediate in this ligand exchange reaction. The aerobic instability of NOCbl has been rigorously described by inorganic chemists (3, 5) and raises obvious questions about its purported biological effects as exemplified by the authors' own 2003 JBC publication, which was later withdrawn.As to promoting NOCbl from their company, the authors refer to a synthetic route from a mixture of NO• gas and aquocobalamin. The authors' method (6) has been described as “dubious” by chemists (5). Whereas DEAE NONOate used in our method is widely known as an NO• donor,...

After a thorough read of this paper (1), we wish to clarify that the authors' anaerobic method of synthesis for the production of nitrocobalamin results in the transient formation of nitrosylcobalamin, an unstable intermediate upon exposure to air. We concur that the authors' method results in the production of nitrocobalamin based on the UV-visible data as shown. The authors' adapted anaerobic method consists of mixing hydroxocobalamin hydrochloride with diethylamine NONOate diethylammonium salt in aqueous solution. Of concern, the UV spectrum of nitric oxide overlaps that of all cobalamin species under anaerobic conditions, making any assignments of the binding of nitric oxide to hydroxocobalamin suspect (2). Additionally, the use of acetone to precipitate the authors' product causes precipitation of diethylamine NONOate, resulting in an impure product. As a result, its utility for drawing experimental conclusions is faulty.The product from the authors' anaerobic synthetic method has not been assessed for purity, and the synthetic method itself has not been validated using a stability-indicating method as required by the International Conference on Harmonization (ICH) (ICH Q2B, Validation of Analytical Procedures) methodology, which is a hallmark for analytical characterization. Our nitrosylcobalamin synthesis involves reacting nitric oxide gas with hydroxocobalamin acetate as a heterogeneous mixture in a non-electron-donating solvent followed by rotary evaporation. Our nitrosylcobalamin product is stable in air, releases nitric oxide gas in situ (3), and meets ICH stability guidelines (4). Additionally, our nitrosylcobalamin product demonstrates biological activity, which has not been observed for nitrocobalamin (3, 5).