A method of making a compressible elastomeric spring including at least one compressible elastomeric pad enclosed by a pair of metal plates includes the steps of forming plates with a center aperture and a plurality of prongs positioned about a peripheral edge thereof, forming each end of the pad with an axial projection and abutting groove, aligning the plurality of prongs with each respective projection and respective groove and applying axial force to one end of the spring to frictionally interlock the plurality of prongs with such projection and groove. The method also provides for making a multi-tiered stack of pads separated by plates in the above described manner and pre-shortening the spring prior to installation into the conventional yoke. The above described method additionally improves axial straightness and lateral stability of the multi-tiered spring assembly.

A friction/elastomeric draft gear having a housing, a spring assembly arranged within the housing, and a friction clutch assembly having a wedge member and defining first sliding friction surface disposed at an angle θ relative to a longitudinal axis of the draft gear and a second friction surface disposed at an angle β relative to a longitudinal axis of the draft gear. The spring assembly is designed in combination with the angles θ and β of the first and second friction sliding surfaces relative to the longitudinal axis such that the draft gear consistently and repeatedly withstands between about 100 KJ and 130 KJ of energy imparted at less than three meganewtons over a range of travel of the wedge member in an inward axial direction relative to the draft gear housing not exceeding 120 mm.

Polymerization reactor systems providing real-time control of the average particle size of catalyst system components are disclosed. Methods for operating such polymerization reactor systems also are described.

A styrene monomer reclamation process and system is described. The styrene monomer reclamation process includes providing a waste plastic. The waste plastic includes styrenic polymers. The waste plastic is formed into polymer particles. At least a portion of the polymer particles are dissolved in a solvent to form a polymer stream. The dissolved polymer particles are depolymerized to form a styrene monomer stream.

There is provided a lithographic printing plate precursor that enables image recording using a laser and that provides an excellent scumming resistance and an excellent developability while maintaining a satisfactory printing durability. Also provided are a platemaking method, and a novel polymerizable monomer. A lithographic printing plate precursor has a support, and an image recording layer disposed thereon and containing a radical polymerization initiator and a polymerizable monomer that has a sulfonamide group and at least two ethylenically unsaturated groups; a lithographic printing plate platemaking method uses this lithographic printing plate precursor; and a polymerizable monomer has a sulfonamide group and at least two ethylenically unsaturated groups.

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.

Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

Materials and methods for treating and preventing American Foulbrood disease in honeybees, such as materials and methods for using phage lysin enzymes to lyse Paenibacillus larvae, are provided herein.

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

A method and apparatus for underwater pelletizing and subsequent drying of crystallizing polymers to crystallize the polymer pellets with out subsequent heating is shown in FIG. 5. High velocity air or other inert gas is injected into the water and pellet slurry line (120) toward the dryer near the pelletizer exit (102) at a flow rate from about 100 to about 175 m3/hour, or more. Such high-speed air movement forms a vapor mist with the water and significantly increases th speed of the pellets into and out of the dryer such that the polymer pellets leave the dryer with sufficient latent heat to cause self-crystallization within the pellets. A valve mechanism in the slurry line (150) after the gas injection further regulates the pellet residence time and a vibrating conveyor after the dryer helps the pellets to achieve the desired level of crystallinity and to avoid agglomeration.

The present invention is directed to an explosive composition comprised of heavy ANFO and expanded polymeric beads that have a density that is less than the density of the heavy ANFO. The expanded polymeric beads have a size that is determined or based on the size of ammonium nitrate prills used in the heavy ANFO portion of the composition. In one embodiment, the expanded polymeric beads that are utilized in the composition are at least 70% of the lower limit of the mesh size of the predominant ammonium nitrate prill mesh size. In another embodiment, the expanded polymeric beads are at least 70% of the a size that is related to the average mesh size of the ammonium nitrate prills.

Systems and methods for treating small elongated fibrous and particles of certain materials, e.g., PTFE materials in a suspension are presented. In some instances, high-intensity ultrasound (or acoustical energy) is applied to a sample of the material, through a fluid coupling medium or suspension, to achieve a material transformation in the sample. In various embodiments, fibrillation of particles of PTFE or similar materials is accomplished, or the formation of extended structures of these materials is caused or enhanced. Also, the ability to separate long fiber samples by ultrasonic or acoustic cavitation action is provided.

A candle with shimmering properties has (i) wax; and (ii) light reflective particles dispersed throughout the wax, in the form of a candle base mixture, such that upon lighting the candle base mixture with a flame, at least a portion of the candle base mixture melts from a solid state to a liquid state, forming a pool of molten liquid in which the liquid moves. The light reflective particles highlight the movement of the liquid, such that the movement of the liquid is visible to an observer. A wick may be mounted within the candle base mixture and a container may contain the candle base mixture. A fragrance and/or dye are optional ingredients of the candle.

An improved organic photoconductor drum having a protective overcoat layer and method to make the same is provided. The protective overcoat layer is prepared from a curable composition including a crosslinkable hole transport molecule containing four radical polymerizable functional groups in combination with a crosslinkable acrylate having at least 6 functional groups.

Substrates such as sheet metal components may be kept spaced apart from each other using a molded polymeric spacing device. The spacing device has a main body with a thickness corresponding to the desired minimum spacing between the substrates and, extending from the main body or a base connected to said main body, an attachment member capable of being inserted into an opening in one of the substrates, but resistant to being easily withdrawn from such opening. Noise and vibration that might otherwise be generated or propagated by closely proximate substrates are reduced through the use of such molded polymeric spacing devices, which may be integrally fashioned from a rubber.

This invention includes embodiments which disclose a hand-held tool implement or apparatus which includes among other things, a handle attached to a head with a scraper and a hammering surface thereon.

Silane-crosslinkable polymeric compositions comprising a polyolefin having hydrolyzable silane groups, an acidic silanol condensation catalyst, a phenolic antioxidant, and an ester-functionalized thioether. Such crosslinkable polymeric compositions can be employed in various articles of manufacture, such as in the wire and cable industry.

An example composite material composed of a metal or multilayered metal substrate onto which an elastomer or elastomeric mixture is positioned by electrophoretic disposition. The elastomer or elastomeric mixture forms a flexible non-rigid elastomeric coating, which imparts a soft touch tactile feeling to the metal base substrate.

A polymerizable liquid crystal compound represented by Chemical Formula 1: wherein in Chemical Formula 1, groups and variables are the same as defined in the detailed description.

Methods for producing alcohols and oligomers contemporaneously from a hydrocarbon feed containing mixed butenes using an acid based catalyst are provided. Additionally, methods for producing fuel compositions having alcohols and oligomers prepared from mixed olefins are also provided as embodiments of the present invention. In certain embodiments, the catalyst can include a dual phase catalyst system that includes a water soluble acid catalyst and a solid acid catalyst.

A method for removing glyphosate from a solution by contacting the solution with a polymeric particle including a moiety selected from the group consisting of ammonium, amine and combinations thereof, wherein the moiety is positively charged in the solution.

ACT for America, which the Southern Poverty Law Center has designated as an anti-muslim hate group, showed up on Saturday morning in cities nationwide, dubbing its protest a "March Against Sharia." Berkeley was spared, but the group appeared in nearby Santa Clara, and in Roseville, a suburb of Sacramento.…

AN EX-Barton Peveril student has been nominated for "Rookie of the Year" after playing football at an American college.

A VICTORY in the America’s Cup by Sir Ben Ainslie could generate as much as £140 million for the Hampshire economy.

THE Duke of Edinburgh has taken to the waters to watch Sir Ben Ainslie prepare in his bid to bring back the America's Cup to Britain for the first time in 165 years.

Sir Ben Ainslie has taken a major step towards winning the America's Cup.

HAMPSHIRE skills and technology are at the heart of the boat which hopes to bring the America's Cup to Britain for the first time in the competition's 166-year history.

Yet another go at the Founding Fathers? Well, to judge from historian and documentary filmmaker Tom Shachtman’s new book, “The Founding Fortunes,” Yes and No. Subtitled “How the Wealthy Paid for and Profited from America’s Revolution,” Shachtman’s analysis of the years 1763-1813 merits a yes because he does revisit some of the big names and battles of the day. But the answer is also no because “The Founding Fortunes” is not just another look at Colonial and post-Colonial politics and economics. Shachtman has a timely and provocative take on who in America supported the War for Independence, and why. Relying on hundreds of historical documents and contemporary scholarship, Shachtman’s out to dispel what he calls “myths” about some of the movers and shakers of the day. And to suggest, by comparison, the less-than-generous or suspect ambitions of some of the wealthy today who would influence current events under the heading of patriotism. It’s a complicated and complex story Shachtman

"Our best musicians in the jazz tradition were radical imaginers," Samora Pinderhughes says. A pianist and composer in his mid-20s, he has asserted his connection to that lineage with The Transformations Suite , an earnest and ambitious new work combining music, words and visuals. The piece, which took five years to chisel into shape, was inspired by African-American resistance and protest movements, as well as the oppression that many still endure. Pinderhughes now lives in Harlem, but he grew up in the Bay Area, in a family of academics and social activists. Shortly after releasing The Transformations Suite last fall, he brought the project to the Way Christian Center in Berkeley for a performance that was several things at once: a homecoming, an album-release concert, a rousing community gathering. Along with a group of smart young jazz musicians, the ensemble features spoken-word poetry by the accomplished actor Jeremie Harris and passages of soulful singing by Jehbreal Jackson.

Copyright 2020 NPR. To see more, visit https://www.npr.org.

The Bishop Gunn frontman has booked a concert in Arkansas as Governor Asa Hutchinson is relaxing lockdown restrictions in the state amid the ongoing Covid-19 crisis.

Weeks after COVID-19 shut down productions worldwide, Ryan Murphy admits that he has been contemplating between pushing production back by a year or changing theme.

Series creator Ryan Murphy reveals in a new interview that he has done writing the scripts for the new installment of the series, though the production has yet to start due to the Coronavirus pandemic.

The creator/host of the long-running modeling competition finds herself under fire after a clip from a past episode in which she confronted Dani Evans about the gap in her teeth came out online again.

Series creator Ryan Murphy reveals in a new interview that he has done writing the scripts for the new installment of the series, though the production has yet to start due to the Coronavirus pandemic.

The creator/host of the long-running modeling competition finds herself under fire after a clip from a past episode in which she confronted Dani Evans about the gap in her teeth came out online again.

On the 50th anniversary of the song topping the chart, Burton Cummings says it was their decision to not play their smash for the Nixon family. Continue reading…

Transatlantic dates to help mark orchestra's centenary.

Numerical Audio has announced availability of the MM-1 Mute Master app for iOS, a unique AUv3 effect plugin designed to create automated or generative arrangements by automatically mixing multiple tracks inside a DAW. MM-1 allows you to create modular style arrangements where individual tracks are brought in and out based on a set number of […]

The post Numerical Audio releases MM-1 Mute Master programmable mixer for iPad appeared first on rekkerd.org.

I believe immigrants make America great. My maternal grandparents were refugees from an area in Syria that later became Lebanon. In the early 1900s they escaped a drought, the collapse of the Ottoman Empire, and relentless poverty to pursue a better life in America. My grandfather, we called him “Jiddu,” which is Arabic for “my grandfather,” was employed in a shoe factory and spent his spare time hanging out on his friend’s vegetable farm. Neither of them achieved prominence. They lived their lives contributing to industrial America and raising their children. I could not communicate with my grandparents because of the language barrier. I was told that Sittu, my grandmother, learned to read the destination on the bus she needed to take, but other than that could not communicate in English. I wish I had been able to ask them about their lives in the old country and why they left. Like other immigrant groups, they took a risk in coming to America’s shores. I believe those risk-takers

A few years ago, I read George Packer’s “The Unwinding: An Inner History of the New America.” It was a haunting portrayal of the slow unraveling of the United States through the life stories of many individuals. Like so many others, I found the book to be fascinating. So, it was with great interest that I saw Packer had published a new book, this time focused on the late diplomat Richard Holbrooke. I recalled the name Holbrooke, but couldn’t say I knew a lot about him. Given how much I had enjoyed “The Unwinding,” I thought this book too would surely be worth a read. “Our Man: Richard Holbrooke and the End of the American Century” was an utterly engrossing portrait of not only the man, but also the decline of American power from Vietnam to Afghanistan. Through the person of Richard Holbrooke, we witness the follies and unforced errors that have haunted our foreign policy for the last forty years. We also witness the occasional triumphs – most notably Holbrooke’s masterful work in

Duke University Press, ISBN-13: 978-0822368687, English, 288 pages, 2019, USA

Eidsheim starts this book by introducing ‘the acousmatic question’ (“who’s this, who’s speaking?”) to discuss the dichotomy between a sound and its source before and →

A vehicle produced in Belvidere has topped a new list of cars with the most American content. Fiat Chrysler ’s Jeep Cherokee came in at number one on the list created by Cars.com . The website looked at which cars were manufactured in America, had the most American parts, and support the most American factory jobs. Four of the top ten cars on the list are made by foreign-based companies. But Cars.com’s executive director, Joe Wiesenfelder, said, these days, all manufacturers are global. “And even what you consider an American brand might import vehicles from across the border," he said. "Whereas what might at one time been considered an import brand is building the cars here in the U.S.” Wiesenfelder sees the list as a service for someone who’s looking at what car to buy. “If they’re interested in contributing to the U.S. economy," he said, "they might see that it’s on the American-Made Index and say, ‘well, that’s one more count in its favor.’” Two other cars produced in Illinois made

In 1963, President John F. Kennedy designated May as Older Americans Month. Since then, the population of older Americans has steadily increased. To be considered an older American, you have to be at least 60 years old. During the Kennedy Administration, there were about 17 million Americans over the age of 60. Now there are more than 68 million. In Illinois, more than 15% of the population is comprised of people who are at least 60 years old. By the year 2030, it's expected that 25% of Illinoisans will have that designation. Lifescape Community Services assists older adults in northwestern Illinois. Zach Satterlee is its fund development and marketing director. Satterlee, who is 26, says that treating all people with kindness and respect helps build a healthier population. "We need to realize that though people are older, or seniors, or at a certain age, that doesn't mean that they don't have tons of things to give to society." He continued, "We can all think of older adults in our

Will progressives and moderates feud as the country burns? Or will they unite to defeat President Trump and usher in a new era of reform?

Harpist Yolanda Kondonassis’ newest album “dreams, soars and levitates” through an intricately flowing compositional architecture with the inclusion of a newly commissioned harp concerto by Pulitzer Prize-winning composer Jennifer Higdon . “The idea was the interplay and the precociousness, and the childlike wonder,” Kondonassis elaborates on how Higdon encompassed her emotions in the composition. “She really impressed upon us that this is fluid and full of wonder, rather than the somnambulant kind of experience.” Kondonassis’ album “American Rapture” expands upon how North American compositions have developed through three generations and features the Rochester Philharmonic Orchestra, directed by Ward Stare. Listen to the full interview between Kondonassis, Stare and Of Note’s Katy Henriksen with the streaming link above.

This is Sample Size, our weekly new music feature with KOSU's Ryan LaCroix and LOOKatOKC music critic Matt Carney. Today, Matt plays new music from Hamilton Leithauser + Rostam , American Football , and LABRYS . Follow Matt & Ryan on Twitter at @mdotcarney & @KOSUryan .