Crews finished repairing a break in the Transcanyon Pipeline that occurred north of Phantom Ranch earlier this week. https://www.nps.gov/grca/learn/news/pipeline-break-fixed.htm

Grand Canyon National Park is in the process of replacing a portion of the Transcanyon Pipeline (TCP) at Phantom Ranch. As part of the construction process, the TCP will be turned off to allow crews to connect the new portions of the pipeline to the existing pipeline. https://www.nps.gov/grca/learn/news/temporary-pipeline-shutdown.htm

The U.S. Department of the Interior today released the Final Environmental Impact Statement (FEIS) for a Long-Term Experimental and Management Plan (LTEMP) for Glen Canyon Dam operations. https://www.nps.gov/grca/learn/news/final-eis-glen-canyon-adaptive-management.htm

Beginning in mid-February the National Park Service will rehabilitate the pump houses at Indian Garden and the Black Bridge near Phantom Ranch. https://www.nps.gov/grca/learn/news/pumphouse-and-black-bridge-repairs.htm

Grand Canyon National Park’s North Rim will open as scheduled May 15 with limited visitor services despite major storm-caused breaks in the only pipeline that supplies its water. https://www.nps.gov/grca/learn/news/north-rim-water-hauling.htm

The Kaibab Suspension Bridge, also called the Black Bridge, will close to foot traffic while trail crews replace wood decking and tread boards. https://www.nps.gov/grca/learn/news/repairs-close-black-bridge.htm

Grand Canyon National Park implemented Level 2 water conservation measures on Wednesday, October 3, due to a series of breaks in the Transcanyon Waterline. This morning Water Utility staff at the park responded to another pipeline break. Additionally, attempts to pump water beyond Indian Garden yesterday failed. Park staff are currently assessing the situation and attempting to resolve the problem as quickly as possible. https://www.nps.gov/grca/learn/news/grand-canyon-nat-pk-prepares-for-potential-increase-in-water-conservation-methods.htm

In advance of a winter storm, Grand Canyon National Park will close Desert View Drive, on the South Rim at 7 p.m. (MST), Wed. Nov. 27, 2019. Additionally, the Arizona Department of Transportation (ADOT) took precautionary measures by closing state Route (SR) 67, the 43-mile highway, between Jacob Lake and the North Rim of Grand Canyon National Park on Tues. Nov. 26. https://www.nps.gov/grca/learn/news/grand-canyon-national-park-prepares-for-winter-storm-2019-11-26.htm

The Irish people are repaying a debt of gratitude to Native Americans suffering from COVID-19, 170 years after a tribe helped Ireland during the Great Famine.

The post Irish People Are Repaying Debt of Gratitude to Suffering Native Americans 170 Years After Potato Famine appeared first on Good News Network.

Portugal is aiming to leap out of their COVID-19 lockdown by launching a series of clean energy projects that could generate 5.5 billion Euro in investment.

The post Portugal Preparing Several Billion-dollar Clean Energy Projects for Post-Coronavirus Future appeared first on Good News Network.

Forest managers are seeking practical guidance on how to adapt their current practices and, if necessary, their management goals, in response to climate change. Science-management collaboration was initiated on national forests in eastern Washington where resource managers showed a keen interest in science-based options for adapting to climate change at a 2-day workshop. Scientists and managers reviewed current climate change science and identified resources vulnerable to expected climate change. Vulnerabilities related to vegetation and habitat management included potential reductions in forest biodiversity and low forest resilience to changing disturbance regimes. The vulnerabilities related to aquatic and infrastructure resources included changing water quality and quantity, the risk to roads and other facilities from changes to hydrologic regimes, and the potential loss of at-risk aquatic species and habitats. Managers then worked in facilitated groups to identify adaptations that could be implemented through management and planning to reduce the vulnerability of key resources to climate change. The identified adaptations were grouped under two major headings: Increasing Ecological Resiliency to Climate Change, and Increasing Social and Economic Resiliency to Climate Change. The information generated from the science-management collaborative represents an initial and important step in identifying and prioritizing tangible steps to address climate change in forest management. Next would be the development of detailed implementation strategies that address the identified management adaptations..

Sunderland are looking for a new club secretary with Brett Baker moving on this summer

The proposal by GEOBROADCAST SOLUTIONS to allow FM boosters to transmit geotargeted programming like ads and news separate from the primary station's programming has gained the support of … more

The Friends star said this is the longest time she's being away from Johnny McDaid since first meeting more than seven years ago

The Department of Arts, Heritage and the Gaeltacht oversees the conservation, preservation, protection and presentation of Ireland’s heritage and cultural assets. Our goals are to promote and protect Ireland’s heritage and culture, to advance the use of the Irish language,...

Today, the U.S. Environmental Protection Agency (EPA) announced a final rule that threatens to undermine the Mercury and Air Toxics Standards. The American Lung Association, Allergy & Asthma Network, Alliance of Nurses for Healthy Environments, American...

Have you been thinking of high-quality web design? Are you floundering with the things that you will put on your homepage? Are you second-guessing yourself? If this is the case then you have come to the right place. More often than not, experienced business owners and marketers struggle with nailing their homepage content. However, it is safe to say that there is no perfect formula for this! As your website is your company’s virtual front door, you have the right to choose how to represent yourself. In other words, there is an array of things that you can include on

The post 7 Things to Include on Your Website Homepage appeared first on Photoshop Lady.

It is a requirement that a visa applicant must fill in or complete his or her application form in a manner that all questions are answered, and no incorrect answers are given or provided. There is also a requirement that visa applicants must not provide incorrect information during interviews with the Minister for Immigration (‘Minister’), […]

The post Visa cancelled due to incorrect information given or provided to the Department of Home Affairs appeared first on Visa Australia - Immigration Lawyers & Registered Migration Agents.

By The EPA The U.S. Environmental Protection Agency (EPA) today launched a new online portal that will provide local leaders in the nation’s 40,000 communities with information and tools to increase resilience to climate change. Using a self-guided format, the … Continue reading →

This paper describes a dataset and protocols for evaluating continuous speech separation algorithms. Most prior studies on speech separation use pre-segmented signals of artificially mixed speech utterances which are mostly emph{fully} overlapped, and the algorithms are evaluated based on signal-to-distortion ratio or similar performance metrics. However, in natural conversations, a speech signal is continuous, containing both overlapped and overlap-free components. In addition, the signal-based metrics have very weak correlations with automatic speech recognition (ASR) accuracy. We think that not only does this make it hard to assess the practical relevance of the tested algorithms, it also hinders researchers from developing systems that can be readily applied to real scenarios. In this paper, we define continuous speech separation (CSS) as a task of generating a set of non-overlapped speech signals from a extit{continuous} audio stream that contains multiple utterances that are emph{partially} overlapped by a varying degree. A new real recorded dataset, called LibriCSS, is derived from LibriSpeech by concatenating the corpus utterances to simulate a conversation and capturing the audio replays with far-field microphones. A Kaldi-based ASR evaluation protocol is also established by using a well-trained multi-conditional acoustic model. By using this dataset, several aspects of a recently proposed speaker-independent CSS algorithm are investigated. The dataset and evaluation scripts are available to facilitate the research in this direction.

Several problems of artificial intelligence, such as predictive learning, formal concept analysis or inductive logic programming, can be viewed as a special case of half-space separation in abstract closure systems over finite ground sets. For the typical scenario that the closure system is given via a closure operator, we show that the half-space separation problem is NP-complete. As a first approach to overcome this negative result, we relax the problem to maximal closed set separation, give a greedy algorithm solving this problem with a linear number of closure operator calls, and show that this bound is sharp. For a second direction, we consider Kakutani closure systems and prove that they are algorithmically characterized by the greedy algorithm. As a first special case of the general problem setting, we consider Kakutani closure systems over graphs, generalize a fundamental characterization result based on the Pasch axiom to graph structured partitioning of finite sets, and give a sufficient condition for this kind of closures systems in terms of graph minors. For a second case, we then focus on closure systems over finite lattices, give an improved adaptation of the greedy algorithm for this special case, and present two applications concerning formal concept and subsumption lattices. We also report some experimental results to demonstrate the practical usefulness of our algorithm.

For $n$-vertex graphs with treewidth $k = O(n^{1/2-epsilon})$ and an arbitrary $epsilon>0$, we present a word-RAM algorithm to compute vertex separators using only $O(n)$ bits of working memory. As an application of our algorithm, we give an $O(1)$-approximation algorithm for tree decomposition. Our algorithm computes a tree decomposition in $c^k n (log log n) log^* n$ time using $O(n)$ bits for some constant $c > 0$.

We finally use the tree decomposition obtained by our algorithm to solve Vertex Cover, Independent Set, Dominating Set, MaxCut and $3$-Coloring by using $O(n)$ bits as long as the treewidth of the graph is smaller than $c' log n$ for some problem dependent constant $0 < c' < 1$.

There exist two notions of equivalence of behavior between states of a Labelled Markov Process (LMP): state bisimilarity and event bisimilarity. The first one can be considered as an appropriate generalization to continuous spaces of Larsen and Skou's probabilistic bisimilarity, while the second one is characterized by a natural logic. C. Zhou expressed state bisimilarity as the greatest fixed point of an operator $mathcal{O}$, and thus introduced an ordinal measure of the discrepancy between it and event bisimilarity. We call this ordinal the "Zhou ordinal" of $mathbb{S}$, $mathfrak{Z}(mathbb{S})$. When $mathfrak{Z}(mathbb{S})=0$, $mathbb{S}$ satisfies the Hennessy-Milner property. The second author proved the existence of an LMP $mathbb{S}$ with $mathfrak{Z}(mathbb{S}) geq 1$ and Zhou showed that there are LMPs having an infinite Zhou ordinal. In this paper we show that there are LMPs $mathbb{S}$ over separable metrizable spaces having arbitrary large countable $mathfrak{Z}(mathbb{S})$ and that it is consistent with the axioms of $mathit{ZFC}$ that there is such a process with an uncountable Zhou ordinal.

We study the problem of jointly designing a sparse sensor and actuator schedule for linear dynamical systems while guaranteeing a control/estimation performance that approximates the fully sensed/actuated setting. We further prove a separation principle, showing that the problem can be decomposed into finding sensor and actuator schedules separately. However, it is shown that this problem cannot be efficiently solved or approximated in polynomial, or even quasi-polynomial time for time-invariant sensor/actuator schedules; instead, we develop deterministic polynomial-time algorithms for a time-varying sensor/actuator schedule with guaranteed approximation bounds. Our main result is to provide a polynomial-time joint actuator and sensor schedule that on average selects only a constant number of sensors and actuators at each time step, irrespective of the dimension of the system. The key idea is to sparsify the controllability and observability Gramians while providing approximation guarantees for Hankel singular values. This idea is inspired by recent results in theoretical computer science literature on sparsification.

By Energy.Gov Annual reports analyzing the wind energy industry released today by the Energy Department show continued rapid growth in wind power installations in 2015, demonstrating market resilience and underscoring the vitality of the U.S. wind energy market on a … Continue reading →

At every level of America's food system, mandated closures and outbreaks of COVID-19 have interrupted the finely tuned network that normally gets food from farmers and food processors to restaurants, grocery stores and food banks.…

For parents of budding artists and creative types, it can often seem like the arts get short shrift in the K-12 curricula, especially at a time when STEM — short for science, technology, engineering and math — is the buzzword in education and the most visible casualties of school budget cuts are librarians and music teachers.…

The present invention relates to a compound of formula A, wherein R is alkyl. Compound A may be used as an intermediate in the preparation of O-desmethyl venlafaxine or a salt thereof, and the present invention provides such a preparation, as well as a process for preparing the compound of formula A.

A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

Disclosed is a method for producing graphene functionalized at its edge positions of graphite. Organic material having one or more functional groups is reacted with graphite in reaction medium comprising methanesulfonic acid and phosphorus pentoxide, or in reaction medium comprising trifluoromethanesulfonic acid, to produce graphene having organic material fuctionalized at edges. And then, high purity and large scaled graphene and film can be obtained by dispersing, centrifugal separating the functionalized graphene in a solvent and reducing, in particular heat treating the graphene. According to the present invention graphene can be produced inexpensively in a large amount with a minimum loss of graphite. (FIG. 1)

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine.

Provided herein are processes for preparing estolides and estolide base oils from fatty acid reactants utilizing catalysts. Further provided herein are processes for preparing carboxylic esters from at least one carboxylic acid reactant and at least one olefin.

Methods of separating renewable materials, such as lipids, from microorganisms, such as oleaginous yeasts, may include conditioning cell walls of the microorganisms to form, open or enlarge pores, and removing at least a portion of the renewable material through the pores. These methods may result in delipidated microorganisms with cell walls that are substantially intact and with mesopores. These delipidated microorganisms may be used to produce biofuels.

Methods and systems are provided that apply cavitation to a grain-based liquid medium processing stream of an oil separation process in order to achieve increased yields. Ultrasonic sources can be used in generating the cavitation. Typically, the oil processing system is a downstream process of an alcohol (such as ethanol) production facility utilizing a dry grind, a modified dry grind or a wet mill alcohol production process.

The invention relates to ceramide dimers which are constructed from two ceramide molecules which are crosslinked to each other via their lipophilic end. The ceramide molecules thereby have at least one hydrophilic group at their hydrophilic end for increasing the hydration shell of the dimer. The ceramide dimers according to the invention can be used as pharmaceutical preparation or as cosmetic preparation.

The present invention relates to a composition for cosmetics including a polyglycerol fatty acid ester, which is an ester of polyglycerol having an average degree of polymerization of 4 to 100 with a fatty acid having 2 to 18 carbon atoms, has a hydroxyl value equal to or less than 15 mgKOH/g, and has a specific gravity at 20° C. of 0.96 to 1.15; a cosmetic which includes the composition for cosmetics; a method for producing an oil-in-water emulsion cosmetic which includes mixing the composition for cosmetics; and a two-separate-layer-type cosmetic, which comprises the composition for cosmetics. The present invention relates to the composition for cosmetics which can be appropriately used in producing a cosmetic giving a highly excellent feel in using and having a very good texture, a cosmetic showing a very high stability over time as an emulsion, and a two-separate-layer-type cosmetic.

The present invention relates to a composition for cosmetics including a polyglycerol fatty acid ester, which is an ester of polyglycerol having an average degree of polymerization of 4 to 100 with a fatty acid having 2 to 18 carbon atoms, has a hydroxyl value equal to or less than 15 mgKOH/g, and has a specific gravity at 20° C. of 0.96 to 1.15; a cosmetic which includes the composition for cosmetics; a method for producing an oil-in-water emulsion cosmetic which includes mixing the composition for cosmetics; and a two-separate-layer-type cosmetic, which comprises the composition for cosmetics. The present invention relates to the composition for cosmetics which can be appropriately used in producing a cosmetic giving a highly excellent feel in using and having a very good texture, a cosmetic showing a very high stability over time as an emulsion, and a two-separate-layer-type cosmetic.

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.

Provided herein are processes of preparing sulfonated estolide compounds, and the removal of sulfonate residues from those compounds to provide desulfonated estolide base oils. Exemplary sulfonated estolide compounds include those selected from the formula: wherein z is an integer selected from 0 to 15; q is an integer selected from 0 to 15; x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected 0 to 20; n is equal to or greater than 0; R6 is selected from —OH, optionally substituted alkyl, and optionally substituted aryl; and R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said compounds is independently optionally substituted.

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C═N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).

The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.

Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.

The invention relates 6-acyl-(6H)-dibenz[c,e][1,2]oxaphosphorin-6-oxides of the formula ##STR1## wherein each of R1, R2 and R3 may be present one or more times and R1, R2 and R3 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms and wherein Ar represents an aromatic hydrocarbon group having from 6 to 10 carbon atoms.The invention further relates to a process for the preparation of the afore-mentioned compounds and polymerizable compositions containing them as an essential ingredient as a photo-initiator. Finally the invention relates to 6-alkoxy-(6H)-dibenz[c,e][1,2]oxaphosphorin of the formula II ##STR2## wherein each of R1 and R2 may be present once or more times and R1 and R2 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms, at least one R1 being, however, halogen and wherein R4 represents alkyl having from 1 to 6 carbon atoms.

The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucleotide thus obtained with formation of phosphotriester groups, blocking of free primary 5'--OH groups, elimination of a protective group from the terminal 5'--OH group, where appropriate single or multiple repetition of the abovementioned steps to introduce further nucleoside phosphate or oligonucleoside phosphate units, and cleavage of the nucleoside-carrier bond and, where appropriate, elimination of all protective groups present in the oligonucleoside phosphates. The phosphine derivative used is a compound of the general formula III ##STR1## in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R3 is a protective group which can be liberated by β-elimination.

Antivirally active compounds of formula (I), wherein R1 is hydrogen, hydroxy, mercapto or amino; R2 is hydrogen, hydroxy, fluoro, chloro or amino; R3 and R4 are independently selected from (II), (III), amino, hydroxy or an ether or ester residue thereof, or R3 together with R4 is (IV), wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R2 is amino and R3 and R4 are hydroxy, R1 is not hydroxy and in addition, when n=1, R1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatments of virus infections as well as use of compounds of formula (I) without the proviso for the manufacture of a medicament for treatment of AIDS. ##STR1##

Catalyst compositions comprising metallocene complexes having polymerisable olefinic groups substituent on an organic group containing a cyclopentadienyl nucleus may be used for the preparation of polyolefins. The catalyst compositions may be in the form of polymers comprising the metallocene complex and may be suitably supported on inorganic supports. Polymers having a broad range of density and melt indices as well as low hexane extractables and excellent powder morphology and flowability may be obtained by use of the catalyst compositions. Preferred metallocene complexes are zirconium complexes in which the polymerisable olefinic group is vinyl.

A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an alkyl lipid or alkyl lipid derivative.