ine Help! I need to teach my course online and I’ve never done this before By blogs.ams.org Published On :: Mon, 16 Mar 2020 16:05:52 +0000 By: Yvonne Lai, University of Nebraska-Lincoln Ray Levy, Mathematical Association of America This is cross-posted in MathValues and Abbe Herzig has written a companion post. Additional resources and future meetings are also available here: https://tinyurl.com/OnlineTalkshop. In times of crisis we … Continue reading → Full Article Faculty Experiences Online Education
ine Surprise! Transitioning to online teaching By blogs.ams.org Published On :: Mon, 16 Mar 2020 19:17:51 +0000 By Abbe Herzig, AMS Director of Education Many of us are experiencing stress as schools, colleges and universities move instruction out of the classroom. Fortunately, even if distance learning is new to you, it isn’t new, and there is a … Continue reading → Full Article Classroom Practices Communication Faculty Experiences Mathematics Education Research Online Education Distance Learning education Mathematics Education
ine Online learning in the time of Coronavirus: Tips for students and the instructors who support them By blogs.ams.org Published On :: Mon, 30 Mar 2020 10:00:26 +0000 Abbe Herzig, AMS Director of Education In the midst of the upheaval due to the Coronavirus, students and faculty are transitioning to new virtual classrooms. Many of us haven’t chosen to learn or teach, but here we are, making the … Continue reading → Full Article Graduate Education Mathematics Education Research Online Education Student Experiences education Mathematics Education online learning
ine Case Study: A 43-Year-Old Man With Perineal Pain and Swelling By clinical.diabetesjournals.org Published On :: 2001-10-01 David J. MeierOct 1, 2001; 19:Case Studies Full Article
ine Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. We investigated hospital outcomes in patients with isolated or combined hyperglycemic crises. RESEARCH DESIGN AND METHODS We analyzed admissions data listing DKA or HHS at two academic hospitals. We determined 1) the frequency distributions of HHS, DKA, and combined DKA-HHS (DKA criteria plus elevated effective osmolality); 2) the relationship of markers of severity of illness and clinical comorbidities with 30-day all-cause mortality; and 3) the relationship of hospital complications associated with insulin therapy (hypoglycemia and hypokalemia) with mortality. RESULTS There were 1,211 patients who had a first admission with confirmed hyperglycemic crises criteria, 465 (38%) who had isolated DKA, 421 (35%) who had isolated HHS, and 325 (27%) who had combined features of DKA-HHS. After adjustment for age, sex, BMI, race, and Charlson Comorbidity Index score, subjects with combined DKA-HHS had higher in-hospital mortality compared with subjects with isolated hyperglycemic crises (adjusted odds ratio [aOR] 2.7; 95% CI 1.4, 4.9; P = 0.0019). In all groups, hypoglycemia (<40 mg/dL) during treatment was associated with a 4.8-fold increase in mortality (aOR 4.8; 95% CI 1.4, 16.8). Hypokalemia ≤3.5 mEq/L was frequent (55%). Severe hypokalemia (≤2.5 mEq/L) was associated with increased inpatient mortality (aOR 4.9; 95% CI 1.3, 18.8; P = 0.02). CONCLUSIONS Combined DKA-HHS is associated with higher mortality compared with isolated DKA or HHS. Severe hypokalemia and severe hypoglycemia are associated with higher hospital mortality in patients with hyperglycemic crises. Full Article
ine Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess whether initiation of insulin glargine (glargine), compared with initiation of NPH or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes. RESEARCH DESIGN AND METHODS This was a retrospective new-user cohort study of female Medicare beneficiaries aged ≥65 years initiating glargine (203,159), detemir (67,012), or NPH (47,388) from September 2006 to September 2015, with follow-up through May 2017. Weighted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for incidence of breast cancer according to ever use, cumulative duration of use, cumulative dose of insulin, length of follow-up time, and a combination of dose and length of follow-up time. RESULTS Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06) or detemir (HR 0.98; 95% CI 0.92–1.05). No increased risk was seen with glargine use compared with either NPH or detemir by duration of insulin use, length of follow-up, or cumulative dose of insulin. No increased risk of breast cancer was observed in medium- or high-dose glargine users compared with low-dose users. CONCLUSIONS Overall, glargine use was not associated with an increased risk of breast cancer compared with NPH or detemir in female Medicare beneficiaries. Full Article
ine New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 2) By care.diabetesjournals.org Published On :: 2014-12-01 Hannele Yki-JärvinenDec 1, 2014; 37:3235-3243Emerging Technologies and Therapeutics Full Article
ine New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Basal and Mealtime Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 1) By care.diabetesjournals.org Published On :: 2014-10-01 Matthew C. RiddleOct 1, 2014; 37:2755-2762Emerging Technologies and Therapeutics Full Article
ine Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis By care.diabetesjournals.org Published On :: 2014-04-01 Alison J. DunkleyApr 1, 2014; 37:922-933Current Concepts of Type 2 Diabetes Prevention Full Article
ine Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association By care.diabetesjournals.org Published On :: 2015-10-01 Richard A. InselOct 1, 2015; 38:1964-1974Scientific Statement Full Article
ine Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society By care.diabetesjournals.org Published On :: 2013-05-01 Elizabeth R. SeaquistMay 1, 2013; 36:1384-1395Scientific Statement Full Article
ine Latin American business leaders optimistic about region’s post-pandemic economy By www.upi.com Published On :: Wed, 06 May 2020 18:44:51 -0400 Despite worrying economic projections, business leaders in Latin America remain optimistic about post-pandemic economy. Full Article
ine Bank of England: British economy could decline 14 percent By www.upi.com Published On :: Thu, 07 May 2020 07:29:45 -0400 A Bank of England report said Thursday the British economy could fall as much as 14 percent this year, which would be its worst showing in more than 300 years. Full Article
ine Chinese exports up in April, Beijing’s data show By www.upi.com Published On :: Thu, 07 May 2020 12:45:49 -0400 China's exports rebounded in April, growing 3.5 percent, according to the latest data from Beijing's General Administration of Customs on Thursday. Full Article
ine Air Force, Marines train near China amid heightened tensions By www.upi.com Published On :: Wed, 06 May 2020 14:06:18 -0400 The Air Force and Marines have both reported engaging in training maneuvers in the East and South China Sea in recent weeks amid escalating tensions in the region. Full Article
ine Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association By care.diabetesjournals.org Published On :: 2015-10-01 Richard A. InselOct 1, 2015; 38:1964-1974Scientific Statement Full Article
ine Guideline Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes By care.diabetesjournals.org Published On :: 2013-08-01 Itamar RazAug 1, 2013; 36:S139-S144Diabetes Pathophysiology Full Article
ine Treatment of Type 2 Diabetes: From "Guidelines" to "Position Statements" and Back: Recommendations of the Israel National Diabetes Council By care.diabetesjournals.org Published On :: 2016-08-01 Ofri MosenzonAug 1, 2016; 39:S146-S153II. Diabetes Treatment Options Full Article
ine Association of Urine Haptoglobin With Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Transethnic Collaborative Work By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes. RESEARCH DESIGN AND METHODS We employed a transethnic approach with a cohort of Asian origin (Singapore) (N = 2,061) and a cohort of European origin (France) (N = 1,438) included in the study. We used survival analyses to study the association of urine haptoglobin with risk of all-cause and cause-specific mortality. RESULTS A total of 365 and 525 deaths were registered in the Singapore cohort (median follow-up 7.5 years [interquartile range 3.5–12.8]) and French SURDIAGENE cohort (median follow-up 6.8 years [interquartile range 4.3–10.5], respectively. Singapore participants with urine haptoglobin in quartiles 2 to 4 had higher risk for all-cause mortality compared with quartile 1 (unadjusted hazard ratio [HR] 1.47 [95% CI 1.02–2.11], 2.28 [1.62–3.21], and 4.64 [3.39–6.35], respectively). The association remained significant in quartile 4 after multiple adjustments (1.68 [1.15–2.45]). Similarly, participants in the French cohort with haptoglobin in quartile 4 had significantly higher hazards for all-cause mortality compared with quartile 1 (unadjusted HR 2.67 [2.09–3.42] and adjusted HR 1.49 [1.14–1.96]). In both cohorts, participants in quartile 4 had a higher risk of mortality attributable to cardiovascular disease and infection but not malignant tumor. CONCLUSIONS Urine haptoglobin predicts risk of mortality independent of traditional risk factors, suggesting that it may potentially be a novel biomarker for risk of mortality in patients with type 2 diabetes. Full Article
ine Explainer: Illegal Immigration in the United States By www.migrationpolicy.org Published On :: Wed, 13 Feb 2019 16:12:18 -0500 How has the size of the unauthorized population in the United States changed over time? How is illegal immigration changing, and where do unauthorized immigrants come from? This explainer answers basic questions about illegal immigration, the changing patterns from Mexico, and more. Full Article
ine ADA standard on treating biofilm in waterlines available for comment By www.ada.org Published On :: Fri, 17 Jan 2020 12:35:00 -0600 The American Dental Association Standards Committee on Dental Products has approved the document for circulation and comment. Full Article
ine February JADA examines connection between healthy eating habits, untreated caries By www.ada.org Published On :: Mon, 27 Jan 2020 08:00:00 -0600 Greater compliance with dietary guidelines may reduce the chance of untreated caries in adults, according to a study published in the February issue of The Journal of the American Dental Association. Full Article
ine Abstract deadline for smokeless tobacco summit at end of February By www.ada.org Published On :: Wed, 19 Feb 2020 09:31:00 -0600 The deadline for abstracts for the upcoming National Summit on Smokeless Tobacco Prevention is Feb. 29. Full Article
ine ADA releases coronavirus handout for dentists based on CDC guidelines By www.ada.org Published On :: Mon, 24 Feb 2020 11:53:00 -0600 The handout covers strategies for helping prevent the transmission of suspected respiratory disease in the dental health care setting and answers frequently asked questions related to the virus, based on guidelines from the Centers for Disease Control and Prevention. Full Article
ine FDI World Dental Congress abstract deadline in late March By www.ada.org Published On :: Tue, 25 Feb 2020 13:42:00 -0600 The deadline for submission of abstracts for the FDI World Dental Congress is March 25. Full Article
ine Oral medicine recognized as a dental specialty By www.ada.org Published On :: Wed, 04 Mar 2020 14:24:00 -0600 Oral medicine becomes the 11th dental specialty recognized by the National Commission on Recognition of Dental Specialties and Certifying Boards. The recognition comes after the National Commission on March 2 adopted a resolution based on an application from the American Academy of Oral Medicine to recognized oral medicine as a dental specialty. Full Article
ine Illinois orthodontist wins ADA Stanford Award for retainer research By www.ada.org Published On :: Fri, 06 Mar 2020 15:11:00 -0600 An Illinois orthodontist won the American Dental Association's 2019 John W. Stanford New Investigator Award for her research paper evaluating the effects of eight cleaning methods on copolyester polymer, a material commonly used in clear thermoplastic retainers. Full Article
ine ADA, other dental organizations ask Labor Department to help small businesses By www.ada.org Published On :: Thu, 19 Mar 2020 12:07:00 -0500 The ADA, along with a large group of other dental organizations, told the U.S. Department of Labor that they are concerned about provisions in HR 6201, the Families First Coronavirus Response Act as related to family and medical leave and paid sick leave. Full Article
ine ADA urges Congress to increase relief for small businesses, dentist owners By www.ada.org Published On :: Thu, 19 Mar 2020 14:51:00 -0500 As Congress works on a third legislation package in response to the coronavirus pandemic, the ADA is asking lawmakers to include provisions on how to assist dental practices and other small businesses facing economic burdens. Full Article
ine ADA, other organizations outline economic response needs to survive pandemic By www.ada.org Published On :: Fri, 20 Mar 2020 11:16:00 -0500 The ADA and nearly 100 other organizations are asking Congress and the White House to help businesses survive the coronavirus crisis by reducing their costs and increasing their cash flow as much as possible in the coming weeks. Full Article
ine HPI poll examines impact of COVID-19 on dental practices By www.ada.org Published On :: Wed, 01 Apr 2020 12:27:00 -0500 The ADA Health Policy Institute launched an ongoing biweekly poll the week of March 23 that shows 76% of dentists surveyed had closed their offices to all but emergency patients during the COVID-19 pandemic. Another 19% indicated their offices are closed completely. Full Article
ine JADA’s new CSA Corner highlights ACE Panel survey results on HPV vaccine By www.ada.org Published On :: Fri, 03 Apr 2020 14:06:00 -0500 Dentists’ comfort levels and perceived roles in discussing and administering the human papillomavirus vaccine appear to vary, according to the results of an American Dental Association Clinical Evaluators Panel survey published in The Journal of the American Dental Association. Full Article
ine ADA asks Treasury Department, Small Business Administration to clarify intent of interim rule By www.ada.org Published On :: Sun, 05 Apr 2020 11:09:00 -0500 The Association continues to wait for clear guidance from the U.S. Department of Treasury and Small Business Administration on the best way to help dentists considering applying for Paycheck Protection Program 7(a) loans and Economic Injury Disaster Loans. Full Article
ine Small Business Administration: Dentists can apply for both economic injury disaster and paycheck protection program loans By www.ada.org Published On :: Mon, 06 Apr 2020 13:28:00 -0500 Dentists can apply for both Economic Injury Disaster Loans and Paycheck Protection Program 7(a) loans, the Small Business Administration told the American Dental Association on April 6. Full Article
ine Webinar on Small Business Administration loans available online By www.ada.org Published On :: Fri, 10 Apr 2020 10:26:00 -0500 The ADA webinar, Small Business Administration Loans: Understanding the Options for Dentist Owners, is available online. Full Article
ine ADA asks Congress to increase funding, extend dates for Small Business Administration loans By www.ada.org Published On :: Mon, 13 Apr 2020 14:08:00 -0500 The ADA is urging Congress to continue supporting small businesses during the COVID-19 pandemic by increasing funding and streamlining the application process for Small Business Administration loans. Full Article
ine Index shows that dentists slowly but surely embracing electronic means of doing business By www.ada.org Published On :: Thu, 16 Apr 2020 10:26:00 -0500 Despite the ADA Council on Dental Benefits’ efforts, the practice of using automated electronic means for verifying eligibility and benefits, checking claim status or receiving and reconciling payment remains underutilized by many dental providers according to an index, said Dr. Randall Markarian, council chair. Full Article
ine Amalgam separator deadline remains intact By www.ada.org Published On :: Fri, 17 Apr 2020 10:04:00 -0500 The deadline for dental offices to install amalgam separators remains intact but the Environmental Protection Agency announced March 26 that it will be initiating “a new temporary enforcement discretion policy” during the COVID-19 pandemic. Full Article
ine ADA antibiotics guideline authors to discuss C. diff infections in dentistry during Peggy Lillis Foundation conference By www.ada.org Published On :: Fri, 17 Apr 2020 13:55:00 -0500 Two of the authors of the American Dental Association's antibiotics guideline will discuss C. diff infections and antibiotic stewardship in dentistry April 21 as part of a free, online conference organized by the Peggy Lillis Foundation. Full Article
ine Senate votes to expand small business aid By www.ada.org Published On :: Tue, 21 Apr 2020 16:20:00 -0500 The Senate passed new coronavirus relief legislation April 21 calling for much-needed funding for depleted federal loan programs that could help businesses nationwide, including dentists and dental practices, recover from the economic fallout of the pandemic. Full Article
ine American College of Emergency Physicians endorses ADA's antibiotics guideline By www.ada.org Published On :: Wed, 22 Apr 2020 14:18:00 -0500 The American College of Emergency Physicians has endorsed the American Dental Association's clinical practice guideline on the use of antibiotics for the management of pulpal- and periapical-related pain and swelling. Full Article
ine Agencies submit final rule extending ERISA deadlines during pandemic By www.ada.org Published On :: Thu, 30 Apr 2020 13:05:00 -0500 The U.S. Department of Labor said April 28 that it is extending the Employee Retirement Income Security Act of 1974 filing deadlines for certain notice and disclosure requirements in the wake of the COVID-19 pandemic. Full Article
ine Maine law eliminates insurance waiting periods for kids By www.ada.org Published On :: Mon, 04 May 2020 10:46:00 -0500 D 1975, An Act to Facilitate Dental Treatment for Children, enacted on March 17, enables children with private dental insurance to receive care without having to wait up to several months for coverage to start. Full Article
ine Venezuelan crude production continued to decline in December By www.upi.com Published On :: Thu, 17 Jan 2019 10:55:05 -0500 Venezuelan crude oil production continued its steady decline and hit a new low in December with just 1.15 million barrels per day produced. Full Article
ine Refineries, investors fear crude shortages over possible Venezuela sanctions By www.upi.com Published On :: Thu, 24 Jan 2019 10:54:11 -0500 An unexpected rise in U.S. crude inventories offset fears of potential risk to Venezuelan crude supply because of possible U.S. sanctions. Full Article
ine U.S. rural areas soon might be on front lines in COVID-19 pandemic By www.upi.com Published On :: Tue, 05 May 2020 18:42:18 -0400 The COVID-19 pandemic has left a path of destruction in urban centers throughout the northeastern United States, but the next outbreak hotspots could have even deadlier effects in rural areas. Full Article
ine 2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-30T13:26:58-07:00 OBJECTIVEIn 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM).RESEARCH DESIGN AND METHODSUp to September 2018, 1.4 million office BP measurements in 79,849 children and adolescents (aged 5–20 years) with T1DM have been documented in the DPV (Diabetes Prospective Follow-up) registry. BP values of the most recent year were aggregated, and BP values of 74,677 patients without antihypertensive medication were analyzed (median age 16 years and diabetes duration 5.3 years and 52.8% boys). BP values were classified according to AAP 2017 and the references of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2011) and the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents (fourth report) (2004).RESULTSOf the patients, 44.1%, 29.5%, and 26.5% were hypertensive according to AAP 2017, KiGGS, and fourth report, respectively. Differences in prevalence of HTN were strongly age dependent: <10 years, AAP 2017 31.4%, KiGGS 30.7%, fourth report 19.6%; 10 to <15 years, AAP 2017 30.9%, KiGGS 31.2%, fourth report 22.4%; and ≥15 years, AAP 2017 53.2%, KiGGS 28.4%, fourth report 30.0%. Among teenagers ≥15 years, 59.1% of boys but only 46.3% of girls were classified as hypertensive by AAP 2017 but only 21.1%/26% of boys and 36.7%/34.4% of girls by KiGGS/fourth report, respectively.CONCLUSIONSClassification of BP as hypertension depends strongly on the normative data used. Use of AAP 2017 results in a significant increase in HTN in teenagers ≥15 years with T1DM, particularly in boys. AAP 2017 enhances the awareness of elevated BP in children, particularly in patients with increased risk for cardiovascular disease. Full Article
ine Erratum. Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach. Diabetes Care 2020;43:852-859 By care.diabetesjournals.org Published On :: 2020-04-15T14:26:52-07:00 Full Article
ine Clinical and Public Health Implications of 2019 Endocrine Society Guidelines for Diagnosis of Diabetes in Older Adults By care.diabetesjournals.org Published On :: 2020-04-23T12:17:35-07:00 OBJECTIVEScreening for diabetes is typically done using hemoglobin A1c (HbA1c) or fasting plasma glucose (FPG). The 2019 Endocrine Society guidelines recommend further testing using an oral glucose tolerance test (OGTT) in older adults with prediabetic HbA1c or FPG. We evaluated the impact of this recommendation on diabetes prevalence, eligibility for glucose-lowering treatment, and estimated cost of implementation in a nationally representative sample.RESEARCH DESIGN AND METHODSWe included 2,236 adults aged ≥65 years without known diabetes from the 2005–2016 National Health and Nutrition Examination Survey. Diabetes was defined using: 1) the Endocrine Society approach (HbA1c ≥6.5%, FPG ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL among those with HbA1c 5.7–6.4% or FPG 100–125 mg/dL); and 2) a standard approach (HbA1c ≥6.5% or FPG ≥126 mg/dL). Treatment eligibility was defined using HbA1c cut points (≥7 to ≥9%). OGTT screening costs were estimated using Medicare fee schedules.RESULTSDiabetes prevalence was 15.7% (~5.0 million) using the Endocrine Society’s approach and 7.3% (~2.3 million) using the standard approach. Treatment eligibility ranged from 5.4 to 0.06% and 11.8–1.3% for diabetes cases identified through the Endocrine Society or standard approach, respectively. By definition, diabetes identified exclusively through the Endocrine Society approach had HbA11c <6.5% and would not be recommended for glucose-lowering treatment. Screening all older adults with prediabetic HbA1c/FPG (~18.3 million) with OGTT could cost between $737 million and $1.7 billion.CONCLUSIONSAdopting the 2019 Endocrine Society guidelines would substantially increase the number of older adults classified as having diabetes, require significant financial resources, but likely offer limited benefits. Full Article
ine Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).RESEARCH DESIGN AND METHODSIn this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.RESULTSChange in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.CONCLUSIONSThis phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs. Full Article