Music experiences will be integrated across other devices like iPhone, Apple Watch, iPad and Mac

Apple’s Chinese suppliers have started test production in Northern Vietnam: report

While the WBJDF has been at loggerheads with the State government on multiple occasions, the WBJDA appears to be going soft on the administration

After restricting Delhi Daredevils to a modest 138/8, in spite of Quinton de Kock's timely fifty, RCB rode on Virat Kohli's calm aggression to a 6-wicket win.

The tougher scrutiny could dampen investment flows into the region.

The post Financial discipline focus for startups in Indonesia in 2020 appeared first on DealStreetAsia.

As the Jiomart platform takes off and increases in scale, there could be interesting possibilities that may emerge.

The post Guest Post | Implications and second-order effects of Jio-Facebook deal appeared first on DealStreetAsia.

"Covid-19 is redefining what uncertainty means," said Sequoia Capital India in its newsletter.

The post Founders grappling to make startups recession-proof: Sequoia Capital appeared first on DealStreetAsia.

Apple and Google’s tech standard is gaining momentum against go-it-alone systems

Scotland, Wales and Northern Ireland to retain ‘stay at home’ advice

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The Indian government's decision of starting the sale of liquor during lockdown to handle the states' economies, became a major topic of debate amongst people on social media. Some of them welcomed the decision and others criticised it by stating that

Modi started his tenure as the 16th Prime Minister of India after his swearing-in on May 30, 2019.

Pakistan said on Sunday that it has “fully complied” with the ICJ’s judgement in the Kulbhushan Jadhav case, days after India’s lead counsel asserted

Many companies, including Samsung, Panasonic, Sony, Whirlpool of India and BSH Home appliances, in the country are getting enquiries from people confined in their homes about such products.

The theme here is simple: whatever your dog is looking at might be pretty, but your dog is always prettier. Got it?

Princeton University has offered admission to 1,890 students, or 6.1 percent of the record 31,056 applicants for the Class of 2021, in what is the University's most selective admission process to date. Last year, the University's admission rate was 6.46 percent. The class size is expected to be 1,308 students for the Class of 2021.

Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

A webinar showcasing MPI's profiles of unauthorized immigrants in the 94 U.S. counties with the largest populations potentially eligible for DACA or DAPA, and the implications of the data for implementation of the DACA and DAPA programs.

Testimony of Marc R. Rosenblum, Deputy Director, U.S. Immigration Program, before the House Committee on Homeland Security Subcommittee on Oversight and Management Efficiency.

OM SportsLink ministers to young boys in Mamelodi, the largest township of Pretoria, South Africa, every Friday.

In October, 140 people take the Table Mountain Challenge in Cape Town and Franschhoek, South Africa, as part of the Freedom Climb.

OM Philippines hosts camps for children affected by recent trauma that facilitate emotional restoration through dance, songs, crafts, Bible stories and more.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

Erin Brown and William McCarter were Penn State’s 2020 nominees for the Truman Scholarship, which rewards students for commitments to public service.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

Royal Enfield has already cleared its BS4 inventory and is only selling BS6 compliant motorcycles starting 21st March, 2020.

In order to get this service, the customers need to update their Rapido Android app. All details here.

“The export without permission would have violated the law, thus, enforcement of such award would be violative of the public policy of India”, the SC said.