sa Swift satellite alerts astronomers to cosmic accident in constellation Draco By insider.si.edu Published On :: Wed, 24 Aug 2011 18:03:04 +0000 Two studies appearing in the Aug. 25 issue of the journal Nature provide new insights into a cosmic accident that has been streaming X-rays toward Earth since late March. NASA's Swift satellite first alerted astronomers to intense and unusual high-energy flares from the new source in the constellation Draco. The post Swift satellite alerts astronomers to cosmic accident in constellation Draco appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Smithsonian Astrophysical Observatory
sa Our galaxy might hold thousands of ticking “time bombs” By insider.si.edu Published On :: Tue, 06 Sep 2011 17:22:02 +0000 New research shows that some old stars might be held up by their rapid spins, and when they slow down, they explode as supernovae. Thousands of these "time bombs" could be scattered throughout our Galaxy. The post Our galaxy might hold thousands of ticking “time bombs” appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Smithsonian Astrophysical Observatory supernova
sa New dinosaur species named from hatchling fossil donated to National Museum of Natural History By insider.si.edu Published On :: Fri, 16 Sep 2011 12:12:25 +0000 The fossil represents the youngest nodosaur ever discovered, and the only known specimen of a new genus and species of dinosaur that lived approximately 110 million years ago during the Early Cretaceous Era. The post New dinosaur species named from hatchling fossil donated to National Museum of Natural History appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Science & Nature Chesapeake Bay dinosaurs fossils National Museum of Natural History new acquisitions new species
sa Ability to raft with flotsam and use non-reef habitats helps tropical fish journey to new places, study finds By insider.si.edu Published On :: Tue, 20 Sep 2011 18:44:36 +0000 Depending on where the fish disperse from, the use of ‘stepping stones', flotsam or simply being an adult can help in the journey to find a new home. The post Ability to raft with flotsam and use non-reef habitats helps tropical fish journey to new places, study finds appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature biodiversity conservation conservation biology endangered species fishes Tropical Research Institute
sa Crab pulsar dazzles astronomers with its gamma-ray beams By insider.si.edu Published On :: Thu, 06 Oct 2011 18:37:00 +0000 The same object that dazzled skygazers in 1054 C.E. continues to dazzle astronomers today by pumping out radiation at higher energies than anyone expected. The post Crab pulsar dazzles astronomers with its gamma-ray beams appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Smithsonian Astrophysical Observatory supernova
sa Suitor’s gentle massage soothes aggressive, cannibalistic female spiders, researchers find By insider.si.edu Published On :: Fri, 14 Oct 2011 13:11:11 +0000 A new study by a team of scientists from the Smithsonian’s National Museum of Natural History, the National University of Singapore and the Slovenian Academy of Sciences and Arts have unlocked the secret to mate binding in orb web spiders, and revealed just how it calms the cannibalistic female spider. The post Suitor’s gentle massage soothes aggressive, cannibalistic female spiders, researchers find appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature insects National Museum of Natural History spiders
sa Rising seas, development are altering prehistoric artifacts in the Chesapeake’s tidal zone By insider.si.edu Published On :: Mon, 09 Jan 2012 13:22:36 +0000 As a coastal archaeologist and expert in prehistoric and historic settlement sites in the Chesapeake Bay region, Darrin Lowery of the Smithsonian’s National Museum of Natural History and University of Deleware, is carefully watching the effects of coastal erosion and rising sea levels on coastal archaeological sites. The post Rising seas, development are altering prehistoric artifacts in the Chesapeake’s tidal zone appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Marine Science Science & Nature archaeology Chesapeake Bay climate change National Museum of Natural History
sa 190-million-year-old dinosaur nesting site discovered in South Africa By insider.si.edu Published On :: Fri, 27 Jan 2012 14:39:08 +0000 An excavation at a site in South Africa has unearthed the 190-million-year-old dinosaur nesting site of the prosauropod dinosaur Massospondylus–revealing significant clues about the evolution of complex reproductive behavior in early dinosaurs. The post 190-million-year-old dinosaur nesting site discovered in South Africa appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Research News Science & Nature dinosaurs National Museum of Natural History prehistoric
sa $35-million donation will build new dinosaur hall at National Museum of Natural History By insider.si.edu Published On :: Thu, 03 May 2012 16:58:22 +0000 The National Museum of Natural History will construct a new dinosaur exhibition hall made possible by a $35 million donation from David H. Koch, executive vice president of Koch Industries and philanthropist. The post $35-million donation will build new dinosaur hall at National Museum of Natural History appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Science & Nature dinosaurs exhibitions National Museum of Natural History
sa New mapping of Mars shows Medusae Fossae Formation older than once thought By insider.si.edu Published On :: Fri, 25 May 2012 11:54:04 +0000 Recent geologic mapping of the Medusae Fossae Formation on Mars—an intensely eroded deposit near the northern edge of the cratered highlands—has revealed a wider distribution of its western component than was previously recognized. The post New mapping of Mars shows Medusae Fossae Formation older than once thought appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics geology National Air and Space Museum planets
sa Fungal fidelity: some ants have been eating the same meal for 5 million years! By insider.si.edu Published On :: Wed, 30 May 2012 12:49:40 +0000 Scientists have discovered an incredible story of fungal fidelity among certain species of ants. The post Fungal fidelity: some ants have been eating the same meal for 5 million years! appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature ants Ecuador fungi insects National Museum of Natural History prehistoric South America
sa Save your local fishing hole By insider.si.edu Published On :: Wed, 06 Jun 2012 13:34:52 +0000 Last summer and this spring Boy Scout Arthur Carlton-Jones (shown here), working in conjunction with researchers at the Smithsonian Environmental Research Center in Edgewater, Md., […] The post Save your local fishing hole appeared first on Smithsonian Insider. Full Article Marine Science Science & Nature Spotlight conservation conservation biology fishes invasive species Smithsonian Environmental Research Center
sa Aircraft bird-strike reports can save lives. New video shows how to report, collect and ship evidence By insider.si.edu Published On :: Tue, 19 Jun 2012 13:23:11 +0000 A new video to help aviators identify the cause of bird strikes has been posted on YouTube by the U.S. Department of Agriculture's Wildlife Services Airport Wildlife Hazard Program and the Smithsonian's National Museum of Natural History. The post Aircraft bird-strike reports can save lives. New video shows how to report, collect and ship evidence appeared first on Smithsonian Insider. Full Article Animals Science & Nature aeronautics aviation bird strikes birds Feather Identification Lab National Museum of Natural History
sa Melting snow likely created fan deposits inside Martian craters, geologists say By insider.si.edu Published On :: Thu, 28 Jun 2012 22:47:50 +0000 Accumulations of drifting snow are the most plausible explanation for the presence of a number of puzzling alluvial fan deposits found inside large impact craters on Mars The post Melting snow likely created fan deposits inside Martian craters, geologists say appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics Center for Earth and Planetary Studies National Air and Space Museum rocks & minerals
sa New count reveals scrub-jay on Santa Cruz Island is among rarest bird species in the U.S. By insider.si.edu Published On :: Wed, 14 Nov 2012 14:19:22 +0000 Smithsonian Conservation Biology Institute scientists and collaborators have found that the island scrub-jay’s population on Santa Cruz Island—its only habitat—is significantly smaller than previously believed […] The post New count reveals scrub-jay on Santa Cruz Island is among rarest bird species in the U.S. appeared first on Smithsonian Insider. Full Article Animals Science & Nature biodiversity birds conservation conservation biology endangered species extinction Migratory Bird Center new species Smithsonian's National Zoo
sa NASA funds Smithsonian Astrophysical Observatory instrument to track North American air pollution By insider.si.edu Published On :: Wed, 28 Nov 2012 15:50:33 +0000 The Smithsonian Astrophysical Observatory has been awarded a NASA project to build the Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument. TEMPO will measure North American air pollution, from Mexico City to the Canadian tar/oil sands, and from the Atlantic to the Pacific, hourly and at high spatial resolution. The post NASA funds Smithsonian Astrophysical Observatory instrument to track North American air pollution appeared first on Smithsonian Insider. Full Article Science & Nature Space astronomy astrophysics carbon dioxide Center for Astrophysics | Harvard & Smithsonian climate change conservation biology pollution Smithsonian Astrophysical Observatory
sa Panama’s slime molds get attention from Arkansas University grad student By insider.si.edu Published On :: Thu, 13 Dec 2012 17:45:54 +0000 This past summer, Laura Walker became the first scientist to collect slime molds from soils at the Barro Colorado Nature Monument in Panama, a reserve administered by the Smithsonain since 1946. The post Panama’s slime molds get attention from Arkansas University grad student appeared first on Smithsonian Insider. Full Article Animals Science & Nature Center for Tropical Forest Science conservation biology fungi
sa NASA’s IRIS spacecraft scheduled to launch in April By insider.si.edu Published On :: Wed, 23 Jan 2013 16:42:37 +0000 NASA's next Small Explorer (SMEX) mission to study the little-understood lower levels of the sun's atmosphere has been fully integrated and final testing is underway. The post NASA’s IRIS spacecraft scheduled to launch in April appeared first on Smithsonian Insider. Full Article Science & Nature Space technology
sa New study proves the remora’s sucker disc is in fact a highly modified dorsal fin / Q&A with taxonomist David Johnson By insider.si.edu Published On :: Fri, 08 Feb 2013 12:54:10 +0000 The remora's sucker disc is "one of the most remarkable and most highly modified skeletal structures among vertebrates." The post New study proves the remora’s sucker disc is in fact a highly modified dorsal fin / Q&A with taxonomist David Johnson appeared first on Smithsonian Insider. Full Article Animals Marine Science Q & A fishes National Museum of Natural History new species osteology
sa T. rex to rule Dinosaur Hall in Washington, D.C. By insider.si.edu Published On :: Mon, 01 Jul 2013 13:25:17 +0000 The National Museum of Natural History announced this summer that it has reached a 50-year loan agreement with the U.S. Army Corps of Engineers to […] The post T. rex to rule Dinosaur Hall in Washington, D.C. appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Science & Nature Spotlight dinosaurs exhibitions fossils National Museum of Natural History osteology prehistoric
sa NASA launches IRIS carrying Smithsonian-built telescope By insider.si.edu Published On :: Wed, 03 Jul 2013 11:27:13 +0000 NASA’s Interface Region Imaging Spectrograph (IRIS) spacecraft launched at 10:27 p.m. EDT Wednesday, June 26 from Vandenberg Air Force Base, Calif. Its primary goal is […] The post NASA launches IRIS carrying Smithsonian-built telescope appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Smithsonian Astrophysical Observatory
sa NASA’s Chandra sees eclipsing planet in X-rays for first time By insider.si.edu Published On :: Wed, 14 Aug 2013 12:42:19 +0000 For the first time since exoplanets, or planets around stars other than the sun, were discovered almost 20 years ago, X-ray observations have detected an […] The post NASA’s Chandra sees eclipsing planet in X-rays for first time appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Chandra X-Ray Observatory Smithsonian Astrophysical Observatory
sa Sagittarius A: Center of the Milky Way By insider.si.edu Published On :: Thu, 05 Sep 2013 16:44:31 +0000 The center of the Milky Way galaxy, with The supermassive black hole Sagittarius A–at center–is revealed in this image. Astronomers have used NASA’s Chandra X-ray Observatory to […] The post Sagittarius A: Center of the Milky Way appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space Spotlight astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Chandra X-Ray Observatory Milky Way Smithsonian Astrophysical Observatory
sa T-rex to rule Dinosaur Hall By insider.si.edu Published On :: Fri, 18 Oct 2013 15:38:24 +0000 This image is a close-up of the skull of the Tyrannosaurus rex skeleton known as the Wankel T. rex which was installed in front […] The post T-rex to rule Dinosaur Hall appeared first on Smithsonian Insider. Full Article Research News Science & Nature Spotlight dinosaurs
sa Sprawl threatens water quality, climate protection, and land conservation in Massachusetts By insider.si.edu Published On :: Thu, 12 Dec 2013 16:44:29 +0000 A groundbreaking study by Harvard University’s Harvard Forest and the Smithsonian Conservation Biology Institute reveals that, if left unchecked, recent trends in the loss of […] The post Sprawl threatens water quality, climate protection, and land conservation in Massachusetts appeared first on Smithsonian Insider. Full Article Research News Science & Nature agriculture conservation biology
sa Algae assassin found responsible for whale mass grave in Chile By insider.si.edu Published On :: Tue, 25 Feb 2014 23:10:28 +0000 It has all the hallmarks of a paleontological crime scene: a massive graveyard along a remote desert highway containing the fossil bones of at least […] The post Algae assassin found responsible for whale mass grave in Chile appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Marine Science Research News Science & Nature endangered species fossils mammals National Museum of Natural History South America whales
sa One Scary Chicken—New species of large, feathered dinosaur discovered By insider.si.edu Published On :: Wed, 19 Mar 2014 21:01:21 +0000 Finding a fossil is the first step, recognizing it for what it truly is, is the real challenge. While closely studying three fossil skeletons from […] The post One Scary Chicken—New species of large, feathered dinosaur discovered appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Research News Science & Nature birds dinosaurs exhibitions extinction fossils National Museum of Natural History new acquisitions new species prehistoric
sa Ancient species of assassin fly discovered by Smithsonian scientist By insider.si.edu Published On :: Mon, 21 Apr 2014 19:35:17 +0000 National Museum of Natural History scientist Torsten Dikow discovered and named a new species of assassin fly, Burmapogon bruckschi, after studying the first two specimens […] The post Ancient species of assassin fly discovered by Smithsonian scientist appeared first on Smithsonian Insider. Full Article Research News Science & Nature insects National Museum of Natural History new species
sa Global warming will open Arctic to invasive species, Smithsonian scientists say By insider.si.edu Published On :: Wed, 28 May 2014 10:10:50 +0000 For the first time in roughly 2 million years, melting Arctic sea ice is connecting the north Pacific and north Atlantic oceans. The newly opened […] The post Global warming will open Arctic to invasive species, Smithsonian scientists say appeared first on Smithsonian Insider. Full Article Marine Science Research News Science & Nature carbon dioxide climate change conservation conservation biology invasive species mammals Smithsonian Environmental Research Center
sa Commercial shipping lanes changed in Panama to save humpback whales By insider.si.edu Published On :: Wed, 28 May 2014 19:07:39 +0000 The Republic of Panama’s proposal to implement four Traffic Separation Schemes for commercial vessels entering and exiting the Panama Canal and ports was approved unanimously […] The post Commercial shipping lanes changed in Panama to save humpback whales appeared first on Smithsonian Insider. Full Article Marine Science Research News Science & Nature Colombia conservation conservation biology Ecuador endangered species South America Tropical Research Institute whales
sa Chandra X-ray Observatory Celebrates 15th Anniversary By insider.si.edu Published On :: Tue, 22 Jul 2014 14:59:39 +0000 Fifteen years ago, NASA’s Chandra X-ray Observatory was launched into space aboard the Space Shuttle Columbia. Since its deployment on July 23, 1999, Chandra has […] The post Chandra X-ray Observatory Celebrates 15th Anniversary appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space Spotlight astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian Chandra X-Ray Observatory Smithsonian Astrophysical Observatory supernova
sa Maybe it’s safer riding a rhino. Genet expert poses new ideas on the mammal’s hitchhiking behavior By insider.si.edu Published On :: Tue, 23 Sep 2014 02:18:55 +0000 When some of the world’s largest mammals come your way, most animals steer clear. Not the genet. The small cat-like carnivore was captured on film […] The post Maybe it’s safer riding a rhino. Genet expert poses new ideas on the mammal’s hitchhiking behavior appeared first on Smithsonian Insider. Full Article Q & A Research News Science & Nature camera traps mammals
sa Satellite tracking helps with curlew conservation By insider.si.edu Published On :: Fri, 15 May 2015 11:05:18 +0000 Ever heard the joke about flying in from Mexico, and boy, are my arms tired? Try telling that to the blackpoll warbler. Researchers recently tracked […] The post Satellite tracking helps with curlew conservation appeared first on Smithsonian Insider. Full Article Animals Marine Science Q & A Research News Science & Nature birds climate change conservation conservation biology endangered species Migratory Bird Center migratory birds Smithsonian Conservation Biology Institute Smithsonian's National Zoo technology
sa Is Tattoo Ink Safe? By insider.si.edu Published On :: Fri, 16 Oct 2015 14:47:25 +0000 Tattoos really are more than skin deep—and that raises questions about their safety. Many people enjoy the aesthetic beauty of tattoos. But the brightly colored […] The post Is Tattoo Ink Safe? appeared first on Smithsonian Insider. Full Article Anthropology Research News National Museum of Natural History
sa National Zoo Opens New Home for Appalachian Salamanders By insider.si.edu Published On :: Mon, 19 Oct 2015 18:23:20 +0000 Salamanders are typically elusive animals and adept at hiding, but National Zoo visitors will have a chance to see a variety of different amphibian species […] The post National Zoo Opens New Home for Appalachian Salamanders appeared first on Smithsonian Insider. Full Article Animals Research News amphibian biodiversity carbon dioxide climate change conservation conservation biology endangered species Smithsonian's National Zoo
sa Killer Insect profile: The Assassin Fly By insider.si.edu Published On :: Mon, 30 Nov 2015 21:00:18 +0000 Stealthy. Aggressive. Lethal. Assassin flies are predators that hunt and feed on other insects. They are the third most diverse group of flies, with more […] The post Killer Insect profile: The Assassin Fly appeared first on Smithsonian Insider. Full Article Animals Science & Nature biodiversity conservation biology insects National Museum of Natural History spiders
sa Research shows same growth rate for farming, non-farming societies By insider.si.edu Published On :: Tue, 22 Dec 2015 13:37:10 +0000 Prehistoric human populations of hunter-gatherers in a region of North America grew at the same rate as farming societies in Europe, according to a new […] The post Research shows same growth rate for farming, non-farming societies appeared first on Smithsonian Insider. Full Article Anthropology Dinosaurs & Fossils Research News Science & Nature Spotlight agriculture astronomy astrophysics Center for Astrophysics | Harvard & Smithsonian
sa New horse-sized tyrannosaur with big brain reveals how “T. rex” became top predator By insider.si.edu Published On :: Mon, 14 Mar 2016 19:00:27 +0000 Pop quiz! Name the first five dinosaurs that come to mind. Chances are good that one you named was Tyrannosaurs rex, a popular favorite perhaps best […] The post New horse-sized tyrannosaur with big brain reveals how “T. rex” became top predator appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Research News Science & Nature extinction fossils National Museum of Natural History
sa In face of mass extinctions, Smithsonian’s Global Genome Initiative quietly saves world’s DNA By insider.si.edu Published On :: Tue, 05 Apr 2016 18:55:29 +0000 It is rare but not entirely uncommon to see a manatee swimming in the Atlantic waters of Maryland and Virginia. This one was dead, however, […] The post In face of mass extinctions, Smithsonian’s Global Genome Initiative quietly saves world’s DNA appeared first on Smithsonian Insider. Full Article Research News Science & Nature amphibian biodiversity climate change conservation conservation biology endangered species extinction National Museum of Natural History spiders
sa Cownose Rays Aquitted: Not Guilty of Decimating Chesapeake Oysters By insider.si.edu Published On :: Mon, 11 Apr 2016 18:43:08 +0000 Ten years ago, cownose rays in the Atlantic got a bad rap when this species (Rhinoptera bonasus) was accused of excessively eating up scallops in […] The post Cownose Rays Aquitted: Not Guilty of Decimating Chesapeake Oysters appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Chesapeake Bay Smithsonian Environmental Research Center
sa Sacred shrew mummies reveal species distribution in ancient Egypt By insider.si.edu Published On :: Fri, 22 Apr 2016 14:32:15 +0000 Nocturnal, solitary and fiercely territorial the adult Egyptian pigmy shrew—one of the smallest mammals on earth—weighs just 7 grams. French zoologist Isidore Geoffroy Saint-Hilaire first […] The post Sacred shrew mummies reveal species distribution in ancient Egypt appeared first on Smithsonian Insider. Full Article Animals Anthropology Science & Nature archaeology biodiversity mammals National Museum of Natural History
sa Study shows how birds dive safely at high speeds By insider.si.edu Published On :: Thu, 06 Oct 2016 10:37:44 +0000 To surprise their prey, some species of seabirds dive into the water at speeds greater than 50 miles per hour. A human diver entering the […] The post Study shows how birds dive safely at high speeds appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature birds National Museum of Natural History
sa ISO: a boring Martian landing spot for NASA’s InSight probe By insider.si.edu Published On :: Wed, 08 Feb 2017 14:27:13 +0000 NASA’s InSight probe, scheduled to land on the surface of Mars in November 2018, will be boring. Boring a hole, that is. It will drill […] The post ISO: a boring Martian landing spot for NASA’s InSight probe appeared first on Smithsonian Insider. Full Article Research News Science & Nature Space astronomy astrophysics geology National Air and Space Museum planets rocks & minerals
sa What does candied, microwaved sperm have to do with saving endangered species? By insider.si.edu Published On :: Mon, 06 Nov 2017 19:22:17 +0000 Today’s cutting-edge laboratories rely on ultra-cold refrigeration to keep delicate cells like sperm viable for use in the future. But a new technique using microwaves […] The post What does candied, microwaved sperm have to do with saving endangered species? appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature Smithsonian Conservation Biology Institute Smithsonian's National Zoo
sa Using genetics to help save world’s most trafficked mammal: the pangolin By insider.si.edu Published On :: Sun, 24 Dec 2017 07:12:38 +0000 One of Earth’s most evolutionarily unique species is also the world’s most trafficked mammal: pangolins, or “scaly anteaters.” A new study from the Smithsonian Conservation […] The post Using genetics to help save world’s most trafficked mammal: the pangolin appeared first on Smithsonian Insider. Full Article Animals Science & Nature Smithsonian Conservation Biology Institute Smithsonian's National Zoo
sa Protecting Puerto Rico’s heritage from another disaster By insider.si.edu Published On :: Wed, 09 May 2018 14:27:33 +0000 When a natural disaster strikes, it devastates lives and homes, and can even destroy a culture’s identity and history. After a disaster, humanitarian response is […] The post Protecting Puerto Rico’s heritage from another disaster appeared first on Smithsonian Insider. Full Article Art History & Culture Science & Nature
sa Smithsonian scientists become shark detectives to track species in the Chesapeake Bay By insider.si.edu Published On :: Thu, 13 Sep 2018 15:54:37 +0000 When many people think of the Chesapeake Bay, one of the first creatures that comes to mind is the iconic blue crab. But parts of […] The post Smithsonian scientists become shark detectives to track species in the Chesapeake Bay appeared first on Smithsonian Insider. Full Article Animals Marine Science Science & Nature Chesapeake Bay Smithsonian Environmental Research Center
sa Use GPO to Import Safe Senders & Auto Download External Email Content By www.bleepingcomputer.com Published On :: 2020-04-28T01:51:44-05:00 Full Article
sa Structure–function study of AKR4C14, an aldo-keto reductase from Thai jasmine rice (Oryza sativa L. ssp. indica cv. KDML105) By scripts.iucr.org Published On :: 2020-04-23 Aldo-keto reductases (AKRs) are NADPH/NADP+-dependent oxidoreductase enzymes that metabolize an aldehyde/ketone to the corresponding alcohol. AKR4C14 from rice exhibits a much higher efficiency in metabolizing malondialdehyde (MDA) than do the Arabidopsis enzymes AKR4C8 and AKR4C9, despite sharing greater than 60% amino-acid sequence identity. This study confirms the role of rice AKR4C14 in the detoxification of methylglyoxal and MDA, and demonstrates that the endogenous contents of both aldehydes in transgenic Arabidopsis ectopically expressing AKR4C14 are significantly lower than their levels in the wild type. The apo structure of indica rice AKR4C14 was also determined in the absence of the cofactor, revealing the stabilized open conformation. This is the first crystal structure in AKR subfamily 4C from rice to be observed in the apo form (without bound NADP+). The refined AKR4C14 structure reveals a stabilized open conformation of loop B, suggesting the initial phase prior to cofactor binding. Based on the X-ray crystal structure, the substrate- and cofactor-binding pockets of AKR4C14 are formed by loops A, B, C and β1α1. Moreover, the residues Ser211 and Asn220 on loop B are proposed as the hinge residues that are responsible for conformational alteration while the cofactor binds. The open conformation of loop B is proposed to involve Phe216 pointing out from the cofactor-binding site and the opening of the safety belt. Structural comparison with other AKRs in subfamily 4C emphasizes the role of the substrate-channel wall, consisting of Trp24, Trp115, Tyr206, Phe216, Leu291 and Phe295, in substrate discrimination. In particular, Leu291 could contribute greatly to substrate selectivity, explaining the preference of AKR4C14 for its straight-chain aldehyde substrate. Full Article text
sa Canonical nucleators are dispensable for stress granule assembly in intestinal progenitors [RESEARCH ARTICLE] By jcs.biologists.org Published On :: 2020-04-07T06:45:08-07:00 Kasun Buddika, Ishara S. Ariyapala, Mary A. Hazuga, Derek Riffert, and Nicholas S. SokolStressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Extensively characterized in cultured cells, the existence of such structures in stressed adult stem cell pools remain poorly characterized. Here we report that Drosophila orthologs of mammalian SG components AGO1, ATX2, CAPRIN, eIF4E, FMRP, G3BP, LIN-28, PABP, and TIAR are enriched in adult intestinal progenitor cells where they accumulate in small cytoplasmic messenger ribonucleoprotein complexes (mRNPs). Treatment with sodium arsenite or rapamycin reorganized these mRNPs into large cytoplasmic granules. Formation of these intestinal progenitor stress granules (IPSGs) depended on polysome disassembly, led to translational downregulation, and was reversible. While canonical SG nucleators ATX2 and G3BP were sufficient for IPSG formation in the absence of stress, neither of them, nor TIAR, either individually or collectively, were required for stress-induced IPSG formation. This work therefore finds that IPSGs do not assemble via a canonical mechanism, raising the possibility that other stem cell populations employ a similar stress-response mechanism. Full Article