The alarming rise of anti-Semitism in this country and other parts of the world is completely unacceptable, a letter to the editor says.

Allison Bosse scored 23 points to lift the Bulldogs over Mooresville, 51-42, in Tuesday's sectional opener.

Superintendent of Public Instruction Jennifer McCormick announced Thursday that schools will stay closed for the rest of the academic year.

While a return to full, in-person classes is unlikely, IU President Michael McRobbie outlined five possibilities for the fall semester.

As colleges look to the fall semester, they're faced with the uncertainty of what it will look like. But plans are underway.

An Indiana University student is suing the school, looking for a partial reimbursement on tuition and fees paid for the spring semester.

Governo pretende divulgar os dados atrasados em maio, segundo afirmou à BBC News Brasil secretário do Trabalho do Ministério da Economia, Bruno Dalcolmo.

Passagem da Terra pela trilha de resquícios do cometa Halley traz espetáculo de chuva de meteoros todos os anos; países da América do Sul estão entre os melhores posicionados para assistir a esse show noturno.

Investigamos centenas de histórias enganosas durante a pandemia. Isso nos deu uma ideia sobre quem está por trás da desinformação - e o que os motiva. Aqui estão sete tipos de pessoas que iniciam e espalham falsidades.

Em Lund, gramados de parque receberam fezes para que odor espantasse frequentadores, evitando aglomerações.

Mulheres que doaram os filhos décadas atrás relatam angústia e tristeza em busca de respostas sobre paradeiros das crianças.

An Indiana University student is suing the school, looking for a partial reimbursement on tuition and fees paid for the spring semester.

Starsky Robotics has begun testing unmanned, remotely operated trucks on highways. The vehicles are being pitched as a solution for the industry's massive driver shortage.

In a string of tweets, the actor apologized for retweeting an anti-Semitic meme.

The presidential election is closer than you think, but thus far the celebrities are staying pretty far away.

In the wake of Soleimani's death, a group of 60 American ethicists, including some notable Catholic theologians, released a statement stating that "the drone killing of Iranian General Qassem Soleimani on January 3rd by the United States was not morally justified…"

The Fiat-Chrysler Windsor Assembly Plant looks to be on track for a May 19 reopening according to union leadership.

Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. Kindlin-2 is widely expressed in multiple cell types, except those from the hematopoietic lineage. A previous study has reported that the Drosophila Fit1 protein (an ortholog of kindlin-2) prevents abnormal spindle assembly; however, the mechanism remains unknown. Here, we show that kindlin-2 maintains spindle integrity in mitotic human cells. The human neuroblastoma SH-SY5Y cell line expresses only kindlin-2, and we found that when SH-SY5Y cells are depleted of kindlin-2, they exhibit pronounced spindle abnormalities and delayed mitosis. Of note, acetylation of α-tubulin, which maintains microtubule flexibility and stability, was diminished in the kindlin-2–depleted cells. Mechanistically, we found that kindlin-2 maintains α-tubulin acetylation by inhibiting the microtubule-associated deacetylase histone deacetylase 6 (HDAC6) via a signaling pathway involving AKT Ser/Thr kinase (AKT)/glycogen synthase kinase 3β (GSK3β) or paxillin. We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, leading to spindle abnormalities not only in the SH-SY5Y cell line, but also cell lines derived from colon and breast tissues. The findings of our study highlight that kindlin-2 regulates mitotic spindle assembly and that this process is perturbed in cancer cells in a hypoxic environment.

M. Mahmood Hussain
Jan 1, 2003; 44:22-32
Reviews

Prótese auditiva ancorada em osso não emite um som como o aparelho convencional. Seu diferencial é vibrar o osso da cabeça.

The post SUS vai oferecer aparelho de última geração para tipo de perda auditiva até então sem tratamento appeared first on Saúde Próspera.

Aos primeiros sinais de visão embaçada, as hipóteses mais frequentes sempre são miopia, astigmatismo, hipermetropia. Mas esses sintomas podem indicar outra doença ocular chamada ceratocone - uma deformidade progressiva da córnea, que assume o formato...

The post Visão embaçada e distorcida nem sempre é miopia: fique atento aos sinais do ceratocone appeared first on Saúde Próspera.