Gov. Erik Greitens has resigned and the board doesn't have enough governor-appointed members to form a quorum. Important tasks have been piling up.

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

Low-intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for noninvasive brain stimulation (NIBS). TUS delivered in a theta (5 Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30–60 min, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity; depotentiation is the reversal of long-term potentiation (LTP) by a subsequent protocol with no effect alone. Metaplasticity can enhance plasticity induction and clinical efficacy of NIBS protocols. In our study, we compared four NIBS protocol combinations to investigate metaplasticity on tbTUS in humans of either sex. We delivered four interventions: (1) sham continuous theta burst stimulation with 150 pulses (cTBS150) followed by real tbTUS (tbTUS only), (2) real cTBS150 followed by sham tbTUS (cTBS only), (3) real cTBS150 followed by real tbTUS (metaplasticity), and (4) real tbTUS followed by real cTBS150 (depotentiation). We measured motor-evoked potential amplitude, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation (ICF), and short-interval intracortical facilitation before and up to 90 min after plasticity intervention. Plasticity effects lasted at least 60 min longer when tbTUS was primed with cTBS150 compared with tbTUS alone. Plasticity was abolished when cTBS150 was delivered after tbTUS. cTBS150 alone had no significant effect. No changes in M1 intracortical circuits were observed. Plasticity induction by tbTUS can be modified in manners consistent with homeostatic metaplasticity and depotentiation. This substantiates evidence that tbTUS induces LTP-like processes and suggests that metaplasticity can be harnessed in the therapeutic development of TUS.

While President Kennedy may be one of the best known gravesites in Arlington, there are many other notable Americans buried in these sacred grounds (Ryan Reed and Molly Roberts). Read more at http://smithsonian.com/arlington

See how geometric designs are inspiring new ways to make stretchy materials. (Video by Ahmad Rafsanjani and Damiano Pasini/McGill University)

Recently digitized footage shows the 5th Div. cemetery dedication on Iwo Jima with band, gun salute and officers speaking. In the final scene, tow Marines kneel over the temporary resting place of 3/13 PFC Ernest T. Langbeen. (U.S. Marine Corps History Division and Moving Image Research Collections, University of South Carolina)

Unexplored iron-rich magma could help power current and future technologies

The long-term loan is the latest agreement Yemen has made with a museum in order to protect its cultural heritage amid ongoing civil war

While expectations are high for some special sightings, experts warn that comets are notoriously fickle and unpredictable

Experts say that the trove of silver currency is official treasure and includes coins from England and Ireland

While the annual shower usually makes for a sleepy showing, it has been known to produce fantastic outbursts in the past

Comet Tsuchinshan-ATLAS should be visible to the naked eye as it passes Earth on its way out of our solar system

While the Orionids, peaking early Sunday and Monday, might be hard to see because of the waning gibbous moon, these zippy meteors can produce long "trains" that last up to several minutes

Prior to the new research, scientists had traced the source of just 6 percent of the known meteorites that fell on our planet

Geologists suggest the catastrophic impact of "S2" delivered key nutrients to the oceans, prompting microorganisms to thrive

In a rare technique among mammals, the bats burn proteins from blood, rather than carbs or fat, to power their pursuits of prey, according to a new study

Sławomir and Szymon Milewski were searching for a Roman road when they stumbled upon the cache of coins, which is worth more than $120,000

In the late 19th century, city officials turned the final resting place for 10,000 souls into what's now Greenwich Village’s James J. Walker Park

A new book charts the history of pet cemeteries and honors the universal experience of grieving an animal companion

The Société de transport de Montréal (STM) has established a non-urgent text line for transit users to signal security issues in the Metro network.

The insect eggshell is a multifunctional structure with several important roles, including generating an entry point for sperm via the micropyle before oviposition, serving as an oviposition substrate attachment surface, and functioning as a protective layer during embryo development. Eggshell proteins play major roles in eggshell tanning and hardening following oviposition and provide molecular cues that define dorsal–ventral axis formation. Precise eggshell formation during ovarian follicle maturation is critical for normal embryo development and the synthesis of a defective eggshell often gives rise to inviable embryos. Therefore, simple and accurate methods for identifying eggshell proteins will facilitate our understanding of the molecular pathways regulating eggshell formation and the mechanisms underlying normal embryo development. This protocol describes how to isolate and enrich eggshells from mature oocytes of Aedes aegypti mosquitoes and how to extract their eggshell proteins for liquid chromatography with tandem mass spectrometry (LC–MS/MS) proteomic analysis. Although this methodology was developed for studying mosquito eggshells, it may be applicable to eggs from a variety of insects. Mosquitoes are ideal model organisms for this study as their ovarian follicle development and eggshell formation are meticulously regulated by blood feeding and their follicles develop synchronously throughout oogenesis in a time-dependent manner.

After more than a century of searching, scientists have discovered a gene in snails that may control asymmetries inside many animals

Stephanie Yuill spent five weeks visiting First World War sites across Europe on a bike she bought from the grocery store. 

Dave Campbell of Thunder Bay, Ont., is resting his legs after taking the ride of his life through the Western Cape of South Africa in the 800-kilometre bikepacking 'Rhino Run.' Here are some of the photos he shared from his six-day expedition at the end of October.

Chair Rick Petrella and trustees Dan Dignard, Bill Chopp and Mark Watson of the Brant Haldimand Norfolk Catholic District School Board were to Italy between July 8 and 15 to buy $100,000 in custom artwork for two new high schools. It's among trips by Ontario school boards that have come under scrutiny for the way public money is spent.

Several firearms, body armour, diamonds and fentanyl shaped like dog treats were among the items seized in a recent bust, say Metro Vancouver Transit Police.

Hired in July by the Seattle Kraken as an assistant coach after two seasons with their AHL affiliate, Jessica Campbell is starting to get to know the team, schedule demands and managing "the vigorous push through it all." It's also about managing the attention as a trailblazer.

Bob Iaccino, Path Trading Partners

Curventa and RuRoc Adapt Original Design for Formula One Pit Crew Safety Wear

Sharing Information Between Design and Production Eliminates Budget Overruns That Erode Customers’ Profits

3D mechanical design and design analysis software speed time to market, grow revenues; 3D PartStream.NET boosts company's online catalog sales

Texas

Find out the latest news and updates on the CME Group Metals market, including the continued growth we are seeing with our Precious Metals products.

Get all the latest updates on COMEX Copper options including a new all-time high trading record and the strong growth of RFQs.

OMer Richard Sharp teaches practical and relevant methods of sharing the Gospel with Portuguese young people at a youth camp.

Larry Shover, Efficient Advisors

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Dan Deming, KKM Financial

Bob Iaccino, Path Trading Partners

Larry Shover, Efficient Advisors

Todd Colvin, Ambrosino Brothers

At Battle High School in Columbia, Mo., students in geometry class have swapped their compasses and protractors for hammers and hard hats. And they're doing it for a good cause.

A newly discovered protein naturally houses an unusual binding site that can differentiate between rare earth elements, and researchers at Penn State have made it even better. Rare earth elements are key components used in everything from modern tech to gasoline production. The protein, called LanD, enriches neodymium and praseodymium over other similar rare earth elements and has the potential to revolutionize industrial mining, researchers said.

A Kenyan court ruled on Friday that Facebook's parent company Meta could be sued in the East African nation over the dismissal of dozens of content moderators by a contractor.

In the 1980s, OM organised large summer campaigns with the huge task of covering every town and village in France with Christian literature.

Jack Kaye, associate director for research at NASA, is the speaker for the Department of Meteorology and Atmospheric Science’s colloquium scheduled for 3:30 p.m. on Wednesday, Nov. 13, in 112 Walker Building on the University Park campus. He will give the talk “Integration of Vantage Points, Programs, and Approaches for Space-Based Earth Remote Sensing.”

Fast-rising methane emissions could undermine efforts to limit global warming by mid-century, prompting scientists and policymakers to urge aggressive action to curb output of the potent greenhouse gas.

OnePlus seems to be preparing to launch the OnePlus Ace 5 and Ace 5 Pro in China. The Chinese tech brand is yet to make an official announcement, but rumours about the duo continue to surface on the Web. As per a new leak, the OnePlus Ace 5 will run on the Snapdragon 8 Gen 3 chipset. The upcoming Ace 5 smartphones are also said to feature a metal middle frame.