Title: Is Dairy Due for a 'Heart Health Makeover'?
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Age Can Impair a Man's Odds for Fatherhood: Study
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Title: America's Love Affair With Sleeping Pills May Be Waning
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Background

Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function.

Purpose Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise.Methods A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a series of auditory tests including otoacoustic emissions test, pure-tone audiometry, and tympanometry on the experimental and control groups.Results In the right ear, there were notable differences from 1000 Hz – 10,000 Hz and in the left ear from 6000 Hz – 10,000 Hz, with higher hearing thresholds in the experimental group of dental hygienists. While 56% of the univariate tests conducted on how many days were worked per week showed statistical significance, the regression line slope indicated those that worked more days had better hearing statuses. The variables for years in practice for dental hygienists, how many of those years were full-time employment, and how many years the dental hygienist had used an ultrasonic scaling device, also had many significant univariate tests for the experimental group only. These variables were more likely to serve as proxies representing true noise exposure. The paired t-test between the groups demonstrated statistically significant differences between the experimental and control group at 9000 Hz in both ears.Conclusion While results from this study demonstrated various qualitative differences in hearing status of the control group (non-dental hygienists) and experimental group (dental hygienists), age was found to be the most critical variable. Furthermore, this data demonstrated differences in hearing status based on various frequencies between dental hygienists and age-matched controls that should be further explored with a larger population.

During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 knockout pro-B cells can generate T lineage cells in vitro using the OP9-DL4 feeder system and in vivo after injection into sublethally irradiated Rag1^–/– mice. These T lineage-like cells lose their B lineage transcript profile and gain a T-cell lineage profile. Single-cell RNA-seq experiments showed that as YY1 knockout pro-B cells transition into T lineage cells in vitro, various cell clusters adopt transcript profiles representing a multiplicity of hematopoietic lineages, indicating unusual lineage plasticity. In addition, YY1 KO pro-B cells in vivo can give rise to other hematopoietic lineages in vivo. Evaluation of RNA-seq, scRNA-seq, ChIP-seq, and scATAC-seq data indicates that YY1 controls numerous chromatin-modifying proteins leading to increased accessibility of alternative lineage genes in YY1 knockout pro-B cells. Given the ubiquitous nature of YY1 and its dual activation and repression functions, YY1 may regulate commitment in multiple cell lineages.

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

Background

Quality of life is impaired in patients with sarcoidosis. The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health-related quality of life in patients with sarcoidosis, comprising subdomains of General Health Status (GHS), Lung, Medication, Skin and Eyes. The aim of this study was to enhance the validation of the KSQ, incorporating longitudinal validation and known-groups validity in a cohort with mild sarcoidosis.

Background

The real-world consequences of a Philips Respironics recall for positive airway pressure (PAP) devices distributed between 2009 and 2021 are unknown.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS), with a putative autoimmune origin and complex pathogenesis. Modification of the natural history of MS by reducing relapses and slowing disability accumulation was first attained in the 1990 s with the development of the first-generation disease-modifying therapies. Glatiramer acetate (GA), a copolymer of L-alanine, L-lysine, L-glutamic acid, and L-tyrosine, was discovered due to its ability to suppress the animal model of MS, experimental autoimmune encephalomyelitis. Extensive clinical trials and long-term assessments established the efficacy and the safety of GA. Furthermore, studies of the therapeutic processes induced by GA in animal models and in MS patients indicate that GA affects various levels of the innate and the adaptive immune response, generating deviation from proinflammatory to anti-inflammatory pathways. This includes competition for binding to antigen presenting cells; driving dendritic cells, monocytes, and B-cells toward anti-inflammatory responses; and stimulating T-helper 2 and T-regulatory cells. The immune cells stimulated by GA reach the CNS and secrete in situ anti-inflammatory cytokines alleviating the pathological processes. Furthermore, cumulative findings reveal that in addition to its immunomodulatory effect, GA promotes neuroprotective repair processes such as neurotrophic factors secretion, remyelination, and neurogenesis. This review aims to provide an overview of MS pathology diagnosis and treatment as well as the diverse mechanism of action of GA.

The leak caught national intelligence officials by surprise and led to an embarrassing Air Force Inspector General investigation.

HUNDREDS of travellers’ holiday plans are in disarray after all Tigerair flights in and out of Bali were cancelled again today and early tomorrow.

"I hear journalists are wondering if I’ve put my name in for the Scottish Parliament. Big news re 2026 coming in the next hour…watch this space."

Family business Graham’s Family Dairy has secured a multinational listing

The plane is hailed as 'one of the most advanced aircraft available on the market'

Josh has a decently sized angry cat burrito. Kelley butters the wolf in Rune Factory. Chris wonders if people have phones. But we all agree the new trend in game graphics should be soulshading.

The post RPG Cast – Episode 628: “Air Conditioning for Your Feet” appeared first on RPGamer.

Kelley gets bored and cleans her bathroom. Memories of the Virtual Boy make Josh's eyes hurt. Robert can't stop singing about Albuquerque. Chris, meanwhile, decides to make his own farming sim with coffee shops and old people.

The post RPG Cast – Episode 719: “Good morning, everybody. Hairball!” appeared first on RPGamer.

Richard Branson’s Virgin Group has swapped out its envoy on Virgin Australia’s board, putting in Warwick Negus.

More than a billion passengers flew with budget airlines last year, helping lift total passengers to 3.7 billion.

Tigerair has been forced to suddenly halt services to Bali after Jakarta unexpectedly cancelled a flight agreement.

More than 170 Australian travellers remained stranded in Bali last night following the Indonesian ban on Tiger­air.

Nintendo and The Pokémon Company in September filed a patent infringement lawsuit against Palworld developer Pocketpair. 

At the time Nintendo did not share which patents Palworld infringed on, however, Pocketpair has now revealed what patents Nintendo are claiming were infringed on.

"As announced on September 19, 2024, The Pokémon Company and Nintendo Co Ltd (hereinafter referred to as the Plaintiffs) have filed a patent infringement lawsuit against us," said Pocketpair. "We have received inquiries from various media outlets regarding the status of the lawsuit, and we would like to report the details and current status of this case as follows.

"The Plaintiffs claim that Palworld, released by us on January 19, 2024, infringes upon the following three patents held by the Plaintiffs, and are seeking an injunction against the game and compensation for a portion of the damages incurred between the date of registration of the patents and the date of filing of this lawsuit."

Nintendo and The Pokémon Company are each seeking an injunction and damages of five million yen plus late payment damages.

Pocketpair added, "We will continue to assert our position in this case through future legal proceedings. Please note that we will refrain from responding individually to inquiries regarding this case. If any matters arise that require public notice, we will announce them on our website, etc."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463022/nintendo-and-the-pokemon-company-seeking-injunction-and-damages-from-pocketpair/

Billionaire Bill Ackman spent days after the ABC presidential debate promoting false claims that a network “whistleblower” had allegedly uncovered collusion between ABC and Kamala Harris’ campaign. Now, a month and multiple denials later, he sees the claims differently.

“It seems pretty clear that the alleged @abc whistleblower debate story claiming that @KamalaHarris was given questions in advance and other advantages was a fake,” Ackman posted on X alongside a blog post by Megyn Kelly discussing the dubious claims.

What Ackman, CEO of Pershing Square Capital Management, did not acknowledge, however, is that he was one of falsehood’s early boosters. After an X account named “Black Insurrectionist” claimed it had been in touch with a whistleblower who alleged the Harris campaign had been given debate topics ahead of the showdown with Donald Trump and had demanded Trump—and Trump alone—be fact-checked.

Read more at The Daily Beast.

Donald Trump praised Fox News chief political anchor Bret Baier for a “great job” in his interview with Democratic 2024 presidential hopeful Kamala Harris on Wednesday night, claiming Baier had “showed how totally incompetent Kamala is” while himself demanding she undergo a cognitive ability test.

Trump joined his campaign in calling the interview a total disaster for Harris. During the interview, Harris and Baier engaged in multiple back-and-forths; at one point, on the topic of immigration, Harris clapped back at Baier as he interrupted her: “May I finish responding to you?”

Immediately after the interview aired, the campaign—notably advisers Stephen Miller and Steven Cheung—took to X to decry Harris’ responses.

Read more at The Daily Beast.

Early reactions to Call Of Duty: Black Ops 6 multiplayer range from frothing dislike through omnimovement hype to our own Ed Thorn's dead-eyed appraisal that it's "a good one, I think. Not a bad one. If you like Call Of Duty, you will like this. If you don't like Call Of Duty, you will not like this." I feel like we need to emergency-deploy a supply crate of smelling salts, because the sheer OK-ness of Black Ops 6 appears to have tumbled Ed into a stupor.

Perhaps it would be a different story if he'd encountered some of the spawning issues and glitches people are talking about, with players joining games and materialising right into a hail of fire. The players in question include Black Ops 6's developers, who comically note in the latest Black Ops 6 patch notes that "Yes, we saw ourselves in a Killcam before selecting a Loadout too." The latest patch seeks to address this, naturally. As regards the campaign side of things, it also resets your safehouse currency to 5000, if you've had your single player funds stolen (or multiplied) by technical gremlins.

Read more

Palworld developers Pocketpair have finally revealed which patents Nintendo and the Pokémon Company are suing them about. It looks like they're focusing on the act of throwing capsular items to catch or release monsters, together with the usage of monsters as mounts.

If you've somehow yet to encounter Palworld, it's a bestselling survival game that takes hefty - some would say, scandalous - inspiration from Pokémon, with players poaching Pokésque critters using magic spheres, and deploying them as soldiers and minions.

Read more

Here’s a Steam quote for you: ‘The Rise Of The Golden Idol is the best game I’ve ever played where I spent most of my time staring at the screen going “well what chuffing well is it, then?!” Fiendish but fair, this detective puzzler demands a heady mix of observation, deduction, and logic, but rewards you with a progressively engaging story, and steadily more infuriatingly brilliant puzzles. Despite teaching you everything you need to know in the tutorial, it still manages to introduce new wrinkles and twists on the formula with each fresh chapter. My verdict? Imagine me lying my floor, massaging my temple with one hand and giving a fat thumbs up with the other.

Read more

A new procedure turns an alloy of nickel and titanium into a material as strong as steel but 20 times stretchier – and one application could be building planes with shape-shifting wings

The 2024 Nobel prize in physics has gone to John Hopfield and Geoffrey Hinton for discoveries that enabled machine learning and are key to the development of artificial intelligence models like ChatGPT

A yachtsman who went missing at sea with his six-year-old daughter has revealed details of their ordeal.

Online group Girls Who Chase has created a global community of women who head into severe weather to record images, report damage and help scientists understand the impact of storms to be better prepared

Local officials are beginning to certify the results of this year's presidential election in a process that, so far, has been playing out quietly, in stark contrast to the tumultuous certification period four years ago that followed then-President Donald Trump's loss.

Meanwhile, the firm has announced LGA1700 upgrade kits for its existing AiO series.

This stunning new image from the NASA/ESA Hubble Space Telescope is one of the best ever views of a galaxy duo called MCG+05-31-045.

The post Hubble Spots Pair of Interacting Galaxies in Coma Cluster appeared first on Sci.News: Breaking Science News.

The 2024 Nobel prize in physiology or medicine has gone to Victor Ambros and Gary Ruvkun for their discovery that tiny pieces of RNA called microRNAs play a key role in controlling genes

Systems that can harvest water from moisture in the atmosphere could offer a valuable water source in the wake of disasters

Filters on commercial flights seem to stop peanut particles from circulating around aircraft, making the risk of a serious allergic reaction from inhaling the allergens very low

Blood tests have shown that about 7 per cent of workers on dairy farms that had H5N1 outbreaks had antibodies against the disease

A new study by the Centers for Disease Control and Prevention found that some dairy farm employees showed signs of infection, even when they didn’t report feeling sick. The CDC concluded that more bird flu testing of dairy farm employees is required. According to Dr. Nirav Shah, the CDC’s principal... Continue Reading

Myah Saakwa-Mante, a 20-year-old British university student, was caught at Los Angeles International Airport and arrested after allegedly attempting to smuggle T-shirts soaked with methamphetamine.

The New Zealand Commerce Commission has outlined its key areas of interest in relation to the proposed Fairfax-APN deal.

New Zealand’s competition watchdog has cited areas of overlap from a Fairfax-APN merger.

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