A pneumatic tire includes first and second side members at first and second sides and a tread section between the first and second side members. The tread section has a tread pattern including a pair of main grooves extending linearly in a circumferential direction of the tire and a land section extending in the circumferential direction between the main grooves. The land section includes a sub groove extending in the circumferential direction without connecting to the main grooves, and a first sipe connecting between the sub groove and one of the main grooves. The sub groove includes a first groove section extending diagonally toward the first side at 0 to 30 degrees with respect to the circumferential direction and a second groove section connecting to the first groove section and extending diagonally toward the second side at 10 to 45 degrees with respect to the circumferential direction.

Side lug rows are provided at both side regions of a tread surface and are formed by a plurality of lugs defined by lug grooves opening to edges in the tread width direction, and a central block row aligned on the tire equator and formed by a plurality of blocks is disposed between positions at ¼ of the tread surface width from the tire equator. The tire has a directional tread pattern, with a designated rotation direction, formed by circumferential grooves and width direction grooves that define the blocks of the central block row and are narrow grooves with a narrower groove width than the lug grooves. The distance from the tire equator to the groove wall in each of the circumferential grooves defining the blocks is set to be larger at a leading edge of each block than at a trailing edge of each block.

The pneumatic tire 1 includes a belt layer 14 that includes a circumferential reinforcing layer 145 and a pair of cross belts 142, 143. Also, the pneumatic tire 1 includes at least three or more circumferential main grooves 21 to 23 in the tread portion having groove bottoms that are convex in the groove depth direction. Also, the curvature radius RA of the groove bottom of an arbitrary first circumferential main groove 21, 22 and the curvature radius RB of the groove bottom of an arbitrary second circumferential main groove 23 have the relationship RA

A pneumatic tire comprises a tread portion, at least two circumferentially and continuously extending longitudinal grooves being provided with the tread portion, a land portion divided between the longitudinal grooves, a plurality of lateral grooves being provided with the land portion, each lateral grooves with one end communicating with one of the longitudinal grooves and the other end extending toward a tire equator, the longitudinal groove with a groove wall to which lateral grooves are connected, in each section between lateral grooves adjacent to a circumferential direction of the tire, the groove wall having a protruded portion and a dent portion being formed the nearest side of the tire equator, the protruded portion inclined with respect to the circumferential direction of the tire so as to gradually reduce a width of the longitudinal groove toward at least one lateral groove.

A pneumatic tire unit comprises a front tire to be mounted on a leading side of a vehicle, and a rear tire to be mounted on a trailing side of the vehicle. A plurality of recesses is provided in at least one tire side portion of the front tire, and a plurality of protrusions is provided on at least one tire side portion of the rear tire. A negative pressure region that can be generated at a back surface side of the vehicle is reduced and, therefore, air resistance of the vehicle is reduced and fuel economy is enhanced.

A device for changing the rotational angle position of a pneumatic tire relative to a rim, on which the pneumatic tire is fitted to the rim, includes a manipulating device with a gripper adapted to be rotated by a positionable rotary drive mechanism and having radially adjustable gripper fingers with oppositely facing lift-off devices. Via the gripper it is possible to load a wheel into a clamping fixture, and following unseating of the tire beads from the clamped rim the pneumatic tire can be rotated relative to the rim through a computed angular difference.

There is described a machine (1) for regeneration of pneumatic tires (2) comprising a beading device (5) for axial locking of the pneumatic tire to be regenerated in the direction of the revolving axis of the pneumatic tire (2) which provides an untranslatable bead (6) and a translatable bead (7) in said direction, a work rasp (9) mounted on a spindle (25), inflation means (66) of the pneumatic tire and a discharge cochlea (77). Said machine further comprises a roughing miller (8) suitable to prepare the pneumatic tire to a subsequent finishing by means of the rasp (9), said miller (8) being mounted on the same spindle (25) of the rasp (9) and after it, and constituted of a monoblock (27) with discharge channels (28) for chips produced by inserts (29) with a curved profile (30) providing a plurality of planar blades (31) joined by discharge grooves (32) of the chips produced.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

A surgical tool assembly includes a pair of opposing jaws. Further, a viewing opening may be provided in at least one of the opposing jaws. The viewing opening may extend from an upper to a lower surface of the opposing jaw in which the viewing opening is provided. The viewing opening may include a material retainer provided proximate the lower surface of the opposing jaw in which the viewing opening is provided. The material retainer may include an inclined surface inclined towards a central axis of the viewing opening. A grasping insert may be molded onto a lower surface of the opposing jaw in which the viewing opening is provided and an elastomeric material of the grasping inserts may within the viewing opening, the material of the grasping inserts covering the inclined surface of the first material retainer.

Methods are provided for processing municipal human waste such that the processed material is is greater than 99% free of pathogenic organisms. The processed material can be used as an organic fertilizer or a “Class A” organic fertilizer. The methods include reducing the moisture content of human sludge free of polymeric flocculant to less than about 30% moisture and processing the sludge through an extruder under conditions having a minimum temperature of about 140° C., a residence time of about 30 seconds, and an atmospheric pressure differential of about 40 atmospheres. The methods are economical and have numerous advantages including reduced use of fossil fuel, fast processing time, and production of an odor free organic fertilizer free of many land use restrictions.

Provided is a steel cord for reinforcing a rubber article, which has an improved durability against so-called cuts, such as notches and perforations, which are generated in the case of treading on an obtusely or sharply pointed projection, without decreasing the strength in the axial direction of the cord, and without increasing the thickness in the radial direction, namely without increasing the weight of a tire, as well as a tire using the steel cord for reinforcing a rubber article as a reinforcing material, especially a construction vehicle tire. Also provided is a steel cord for reinforcing rubber articles with a multi-twisted structure formed by twisting a plurality of sheath strands formed by twisting a plurality of wires around a core strand formed by twisting a plurality of wires, and the core strand being constituted of an at least three-layer-twisted structure formed by twisting core filaments and sheath filaments. The lowest tensile breaking strength of filament bs and the tensile breaking strength of steel cord Bc satisfy the relationship represented by the following formula: bs/Bc×100≧0.65.

A steel cord for reinforcement of rubber articles, whose cord strength is enhanced by preventing occurrence of preceding break of the outermost layer filaments in the steel cord having a multi-twisted structure, and a pneumatic tire using it as a reinforcing material are provided. In a steel cord for reinforcement of rubber articles having a multi-twisted structure in which a plurality of strands are twisted together, which strands have a layered twisted structure in which a plurality of steel filaments are twisted together, dc/ds, which represents the ratio between dc, the diameter of outermost layer sheath filaments constituting the outermost layer sheath of a core strand, and ds, the diameter of outermost layer sheath filaments constituting the outermost layer sheath of sheath strands, is 1.05 to 1.25.

Without decreasing the strength in the axial direction of the cord, and without increasing the thickness in the radial direction, a steel cord for reinforcing a rubber article, which improves durability against cut, as well as a construction vehicle tire utilizing the steel cord for reinforcing a rubber article as a reinforcing material is provided. A steel cord for reinforcing a rubber article is formed by twisting a plurality of sheath strands 2 formed by twisting a plurality of wires around a core strand 1 formed by twisting a plurality of wires, wherein the core strand 1 is constituted of a 4-layer-twisted structure and the diameter of the steel cord is 5 mm or larger. The tire of the present invention is a tire which has a belt constituted with 6 belt plies with cords arrayed on the outer side in the radial direction of the tire at a crown part of the carcass, which are crossed between the laminated plies, and wherein the steel cords for reinforcing a rubber article are applied to the third belt layer and the fourth belt layer.

An excavation system employing a high-pressure pulsed air jet that may optionally be used in combination with a low-pressure high velocity blower for excavating improvised explosive devices or other buried objects. The excavation system may also be employed to operate a pneumatic tool such as a cut-off tool or a chisel. The high velocity blower may incorporate a bifurcated fan duct having two air outlets. The system may include a pressure control module for regulating the from a high-pressure air source to an evacuation valve. The evacuation valve employs first and second valves where the second valve controls the operation of the first valve.

A vibration isolator with a pneumatic spring that is effective only in vertical direction, the pneumatic spring including a working space in which a vertically effective actuator is disposed.

A decelerator apparatus for mounting at the end of a pneumatic or gravity-fed fruit harvesting or delivery tube. The decelerator comprises a housing with a moving decelerator body aligned with a fruit-receiving inlet connected to the delivery tube. The decelerator body, for example a padded rotating wheel, moves at a speed slower than the speed at which the fruit is delivered into the housing, includes multiple depressions or indentations for receiving and separating fruit, and further defines a compressive deceleration path that moves the fruit in a compressive but protective fit toward a housing exit, releasing the fruit after the fruit has been decelerated to the speed of the moving body.

An apparatus for preserving human or animal remains comprising a burial chamber further comprising a hermetically sealed interior containing gas or water vapor, wherein the gas creates a gas pressure within the hermetically sealed interior, and a vacuum pump, wherein the vacuum pump is in functional communication with the hermetically sealed interior, wherein the vacuum pump operates to evacuate the gas or the water vapor from the hermetically sealed interior, and wherein the vacuum pump is intermittently activated to reduce the gas pressure within the hermetically sealed interior for a desiccating duration.

A coffin for use in an alkaline hydrolysis processes described. The coffin comprises a dissolvable receptacle for a cadaver, the dissolvable receptacle being dissolvable in the alkaline hydrolysis process. A method of disposing of a cadaver is also described. The method includes the steps of placing the cadaver into a coffin comprising a dissolvable receptacle; placing the coffin in an alkaline hydrolysis unit; and adding water and a chemical into the alkaline hydrolysis unit with the cadaver, to break down the cadaver into a fluid component and a bone residue component and to dissolve the dissolvable receptacle of the coffin by alkaline hydrolysis.

A contaminated human remains pouch includes a sheet of material that is resistant to chemical and biological agents having a substantially rectangular shape having a first long side, a second long side, a first short side and second short side. Complimentary securing elements are fixed along an edge of the first long side and along an edge of the second long side. A folded portion in each corner of the material forms a first seam between adjacent portions of the first short side and a second seam between adjacent portions of the second short side. The complimentary securing elements on the edge of the first long side and the edge of the second long side define an opening when the folder portion in each corner is folded over, and the complimentary securing elements are configured to be mated together to substantially seal the contaminated human remains pouch from cross-contamination.

The present application provides a back mixing device for use with a pneumatically conveyed flow of solids having a varying flow rate. The back mixing device may include a nozzle, a chamber in communication with the nozzle, and an exit. The chamber may include an expanded area leading to a restriction such that the chamber creates a recirculation pattern in the flow of solids so as to smooth the varying flow rate though the back mixing device.

A human body radiation examining method and system are disclosed. In one aspect, the human body radiation examining method comprises: identifying a person to be examined. The method further comprises retrieving an accumulative radiation dose of the person according to identification result. The method further comprises obtaining a predicted single radiation scanning dose of a human body radiation examining device intended to perform a current radiation examination. The method further comprises calculating a sum value of the accumulative radiation dose of the person and the predicted single radiation scanning dose of the human body radiation examining device. The method further comprises determining whether to perform the current radiation examination on the person according to whether the sum value exceeds a dose limit. In some embodiments, the human body radiation examining system and method can improve the security of the human body radiation examination.

A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.

Audio File Edit | Remove Saturday marks 50 years since the first moon landing. Now, NASA is tapping a team from Stony Brook University to investigate how going to space impacts human health. The team is one of eight NASA has selected to help further exploration of our solar system with robots and astronauts. Timothy Glotch, a professor of geosciences at Stony Brook, leads the team. Professor Glotch, thank you for joining All Things Considered. What do you hope to find in your research? So the overall goal of the RISE2 team, which is the name of our team, is to help pave the way for humans to safely return to the moon and explore and get back safely to Earth. So as you mentioned one of our goals is to try and understand the health effects of exploration. We have a team of geochemists working with folks in the medical school at Stony Brook University to understand the reactivity of dust on the moon, and how if you breathe that in how that might lead to potential health effects. And how

This show, we bring you Umar bin Hassan of The Last Poets. Umar is a long-running and key member of the legendary group, and we talk to him about everything he’s seen. From his youthful adventures as a shoeshine boy to being forced out of his hometown on pain of death; from being a veritable prince of Harlem to his battles with drug addiction; from Gil Scott-Heron to Miles Davis — we travel through it all.

See http://theciphershow.com/episode/51/ for full show notes and comments.

The Unfinished has launched the Humankind 2020 promotion, a collection of limited edition charity synth soundsets. For those who don’t know, Humankind is a collection of synth soundsets (of 64 patches each), with 50% of the proceeds going to charity. This time around I have chosen The Trussell Trust, a wonderful charity who help provide […]

The post The Unfinished launches Humankind 2020, adding soundsets for RePro, U-No-LX and The Legend appeared first on rekkerd.org.

President Trump excoriated the administration of President Barack Obama as “human scum” who attempted to undermine him by “targeting” former national security adviser Michael Flynn. 

A criminal investigation is underway after the death of an inmate at the Arizona State Prison Complex in Yuma on Thursday.

“He is well-acquainted with the working culture of large global brands, which puts him at the right position to take charge of reinforcing Stovekraft’s position as the market leader in the FMCD (fast moving consumer durables) space,” chairman and MD Rajendra Gandhi said.

Molly Melching first went to Senegal in 1974 as an exchange student from the University of Illinois. But, instead of returning to the United States, she stayed on, eventually creating a nonprofit organization to educate and empower women and communities. That organization Tostan created and implemented educational programs focused on human rights, health, literacy, financial management and childhood development. It may be best known for leading thousands of communities in Africa to end female genital cutting and forced childhood marriage. WPSU's Anne Danahy talked with Melching about her work. Transcript Anne Danahy: Welcome to take note on WPSU, I'm Anne Danahy. Molly Melching first went to Senegal in 1974 as an exchange student from the University of Illinois. But instead of returning to the United States, she stayed, eventually creating a nonprofit organization to educate and empower women and communities. That organization, Tostan, created and implemented educational programs

Chhetri joins the brand's roster of global players like Antoine Griezmann, Romelu Lukaku, Luis Suarez and Sergio Aguero among others.

Campus Activewear is part of the Synergy Action Group that sells 100,000 pairs of shoes every day through more than 50,000, mostly third-party, outlets, according to Action Shoes’ website.

"Our business activity in Greater China has been around 85 percent below the prior year level since Chinese New Year on January 25," Adidas said in a statement.

“The Puma and First Mile programme has diverted about 40 tonnes of plastic waste from landfills and oceans, just for the products made for 2020. This roughly translates into 1,980,286 plastic bottles being reused,” said Stefan Seidel, head of corporate sustainability for Puma, in a press statement

Puma operates 365 owned stores in India, and over the past three years, has signed up cricketer Virat Kohli, boxer Mary Kom, footballer Sunil Chhetri and actress Sarah Ali Khan to endorse its products.

According to the company, Puma's collaboration with the Indian cricket captain saw a massive rise in sales in FY2019 with sales through One8 accounting for almost 10 per cent of its overall sales, and cementing the leadership position by a wider margin.

In a letter to the brand’s business partners, Bjorn Gulden, global CEO of Puma SE, announced Ganguly’s elevation in the company adding that that he will continue to work out of Puma’s India head office in Bengaluru.

Khan will be the face for Puma’s soon-to-be launched collection of low-intensity training apparel collection targeted at workouts such as yoga, barre, and pilates. The new line will be launched in April and retailed both online and offline.

Puma said it expected all markets to recover by the end of the year and for growth to return in 2021, noting that the crisis has made many people do more sports than before and has strengthened the trend towards more casual dressing.

People are doing what they can to stay healthy, but what about their pets? Dr. Phyllis Sill is a veterinarian at Roscoe Veterinary Clinic. She says if you want to keep your dogs safe, there are certain things you shouldn't do: " Don’t let your dog suddenly go on a long run or a long walk if it hasn’t been conditioned to do so," she said. "They are probably going to end up with lameness issues or injuries." She continued, "Don’t get a group of dogs together, they might fight." Sill said it is important to think about things your dog can eat or swallow, like chocolate or the sugar substitute xylitol. "Try to keep them up and away," she warned, "because if dogs get into sugar-free gum, it can kill them." The Roscoe Veterinary Clinic is considered an essential business; therefore it remains open amid Governor J.B. Pritzker's "stay-at-home" order. But, Sill said, even though they are open, they are only admitting patients with serious conditions. "We are looking at patients who have growths

Women composers and performers united to create art from the human condition with pianist Lara Downes’ latest album “Holes in the Sky,” named for a poem by Georgia O’Keeffe. In addition to representing women in music, “Holes in the Sky” also served to support human welfare efforts, including PLAN International to support impoverished children. “These are stories about the power of the expressive urge, the creative urge, to come forward,” Downes says about the potential of music. “It will come forward, despite anything else trying to constrain it.” Downes will represent women’s contributions to the past, present and future of American music by performing music from “Holes in the Sky” 3 p.m. Sunday, Sept. 15 at Crystal Bridges Museum of American Art as part of the Van Cliburn Concert Series . Listen to the full interview between Downes and Of Note’s Katy Henriksen with the streaming link above.

Jessie Beck, a biologist with Oikonos Ecosystem Knowledge, is our captain on today ’ s inflatable boat commute to A ñ o Nuevo Island.

Buried deep in Stanford Hospital is a network that’s a little more Jules Verne than Silicon Valley.

Have you ever wondered who invented the wheel? Who told the first joke? Who drank the first beer? Who was the first surgeon? Who sparked the first fire?

The New Yorker contributor Jenna Krajeski recently met with a woman who calls herself Esperanza. In her home country, Esperanza was coerced and threatened into prostitution, and later was trafficked into the United States, where she was subjected to appalling conditions. Esperanza eventually obtained legal help, and applied for something called a T visa. The T visa contains unusual provisions that recognize the unique circumstances of human-trafficking victims in seeking legal status. It has also been a crucial tool to obtaining victims’ coöperation in prosecuting traffickers. The Trump Administration claims to want to fight the problem of human trafficking, but Krajeski notes that its policies have done the opposite: T-visa applicants can now be deported if their applications are rejected. This dramatic change in policy sharply reduced the number of applications from victims seeking help. “If what [the Administration] cares about is putting traffickers in prison, which is what they say they care about, their prosecutions are going down and will go down further,” Martina Vandenberg, the president of the Human Trafficking Legal Center, says. “Trafficking victims under the circumstances can’t actually coöperate.”

Sarah Stillman joins Dorothy Wickenden to talk about how the deterrence policies of Republican and Democratic Presidents have failed, and what the Democratic candidates should be saying about how to deal with asylum seekers.

The earliest epidemics date back to Neolithic times, and, in the millennia since, viral outbreaks have repeatedly shaped the course of human history, influencing behavior and creating and destroying cultural norms. In the weeks since COVID-19 became a worldwide emergency, people are showing resilience, humor, and creative ways of communicating as governments and businesses struggle to respond. Robin Wright joins Dorothy Wickenden to discuss differing responses to infectious diseases across time and cultures, and the global political ramifications of COVID-19.