A review by piltdown_man (179399). A good story, well told

Компания Meizu вчера, кроме флагманских смартфонов, представила ещё свои обновлённые накладные Bluetooth-наушники Meizu HD60.

With Internet marketing and Search engine optimization, crucial components to owning a company site, most web designers are adding SEO to their arsenal of capabilities. The concern is that most of these designers neglect to understand the whole picture of… Continue Reading →

What expression does — did — your mom use all the time? What skill did you learn from her?  What does (or did) she encourage you to do? These are great questions for any mom and child, whether the kid is 5 or 50. And if you click here, you can print out a very […]

These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!)

I am amazed at what gritty realism the Wall Street Journal will publish from Peggy Noonan. Life has been famously cruel to some good people the past few decades. The past few years it seemed the progressive left and the Democratic Party, confident in what they called the coalition of the ascendant, were looking at the old American working class, especially the white working class, and saying: “Here’s your disability check, now go take your opioids and get lost while we transform our country. By the way, we have friends on Wall Street.” From the right and Republicans it was: “Take your piece of the dole, we are importing an entire new people from other countries to take your place,...

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BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

Platform: Android, Flash, Unity — Ichima Coffeedo created a new game, and it's great! This game is a remake as their other recent installments, the original Room 7 Indigo Blue can't be played anymore. The graphics have been remarkably upgraded, pleasant tune was added and... Tagged as: android, browser, escape, flash, free, game, ichima, japanese, playthis, puzzle, rating-g, unity

After the bumper here, the review will get into spoiler territory. I will say that if you are a Sonic fan this movie will give you a sense of pride as it is far better than it should have had any right in being. Taking the franchise’s lore and resetting it to tell its own story, but retaining the strong characterization and quip heavy personalities of Sonic and Robotnik that makes their rivalry such a strong one. It also keeps the first entry simple with the hedgehog and doctor being the only two characters from the universe being in the film. This makes the story stronger since it can develop those two far more and not have to worry about any other kind of side character fan service for now.

Hey, at least now Sonic fans can brag to Mario ones that Mario may still be the king of games, but Sonic blew the plumber’s cinematic pieces out of the water. Not that that was a high bar I suppose. Then again, having better quality games than Sonic these days isn’t one either (the author quips while using a quote from Sonic Forces for his review’s headline).

In the video game Sonic the Hedgehog, timing is everything. While at the heart of the game is a fast paced platformer, its foundation has always been learning the layout of a level and timing your actions appropriately. In a twist, the timing of this film and its release had quite a bit of impact on my view of it.

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A great many people only experience science fiction by what my mother and millions of others referred to as "monster movies". From Frankenstein to Aliens and beyond, the unknown and the unexplored are often our undoing. Bleak Horizons, edited by Tarl Hoch, is a wonderful collection of 15 stories that mix SF and Horror with various levels of anthropomorphic settings and characters. And, full disclosure, one of those stories is mine. Happily, the mix includes more than just blood thirsty monsters and end of the universe scenarios.

Overall my favorite stories in this anthology are Hardwire, Pentangle, and The Ouroboros Plate. My least favorites are 4/13/2060 and Not Like Us. Below is a short review of all the pieces. I think you should snag a copy, if only to read my favorites and have a taste for this genre. However, I also really enjoyed Carmen Miranda's Ghost Is Haunting Space Station 3 so you have every right to question my taste.

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Linda McMahon is running for the US Senate in Connecticut. For twenty (20) years, she ran World Wrestling Entertainment (WWE) with her husband, Vince McMahon. A few years ago, a documentary film examined the WWE's celebration of violence against women. Her campaign doesn't want Connecticut voters to see that film. Watch these excerpts from the film to see why. Continue reading →

A year ago this month the U.S. Department of Justice announced that the banking giant JPMorgan Chase would avoid criminal charges by agreeing to pay $13 billion to settle claims that it had routinely overstated the quality of mortgages it … Continue reading →

Accountants CPA Hartford Connecticut LLC:  This transcript may contain errors. The Willis Report:  And tonight’s stunning accusation against Intuit, the maker of Turbotax, the popular tax preparation software.  Two whistleblowers claim that Intuit knew that criminals used its tax software … Continue reading →

The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP). Ask yourselves how American labor can compete against Vietnamese workers earning on average $0.56 per hour. Continue reading →

Democratic presidential candidate Bernie Sanders (I-VT) on Tuesday unveiled a plan to address income inequality by taxing Wall Street speculation and using the money to eliminate college tuition. Continue reading →

An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading →

The evidence is adding up that this election is a SHAM! Exit polls do not add up on the Democratic side and regularly predict better results for Bernie than the voting machines are telling us! The mainstream media won't even come close to touching this, and in fact they're even attacking Lee Camp for bringing it up. Don't miss this segment of Redacted Tonight! Continue reading →

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading →

This is the natural progression, this is the natural endgame of the Bill Clinton Democratic Party when he decided to change the Democratic Party from a party of workers and blue-collar people to a party of Silicon Valley and Wall Street. And Democrats have to acknowledge that. And if they don't, they ain't going nowhere. Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

Tucker Carlson: Elizabeth Warren's enemies on Wall Street and Big Tech are not really her enemies. Elizabeth Warren is really just this season's Hillary Clinton -- faithful party robot, stalwart defender of the prerogatives of the establishment. Continue reading →

Three portraits from yesterday's Blackpool Pride Festival in Blackpool, all of which were shot with the Fujifilm X-T1 and 90mm f/2 (my new favourite lens). As always, it was a great event, with lots of great characters.

While pretty much everyone enjoyed the Blackpool Pride Festival there were a handful of slightly less cheerful folk.

В новом интервью с SiriusXM "Trunk Nation" у легендарного гитариста Tony Iommi спросили, доволен ли он тем, как прошёл прощальный тур BLACK SABBATH "The End", на что он ответил:

«Было здорово иметь возможность отправиться в последний тур. Честно говоря, я чувствовал себя неважно [из-за] этого, потому что в основном это был мой выбор, моя вина, потому что турне для меня в некоторой степени было в физическом плане не самой лучшей идеей. Я имею в виду, что приходилось возвращаться в часа утра после концерта — ты отыграл концерт, а потом летишь обратно в отель — это было много возвращений поздними ночами. Я находился в таких же условиях, как когда мне было 20. Несмотря на то, что мы путешествовали [на] лучших [условиях] — у нас был собственный самолет, у нас были потрясающие отели, и нас разместили в Нью-Йорке или Лос-Анджелесе на 10 дней, или где-то ещё, это было вот так. Выходили из отеля, летели на самолёте, давали концерт, возвращались, но к тому времени, как мы заканчивали, возвращались в отель и ложились спать, уже было три-четыре часа. А для меня это было трудно, и мой доктор сказал мне попробовать немного успокоиться. И в то время это казалось правильным.

Особенно после всего, что случилось с Ронни [Джеймсом Дио], мне очень понравился тот период [с HEAVEN & HELL], когда мы были снова с Дио, мы очень сблизились с этой группой, и это была отличная группа. А потом мы решили заново собрать SABBATH с Ozz'ом [Ozzy Osbourne'ом], и это было круто для завершения карьеры. Но я думаю, что если бы Ронни был жив, я бы, наверное, делал что-нибудь с ним сейчас».

Iommi также ответил на вопрос, возможны ли разовые выступления группы:

«Думаю, это было бы неплохо, ну если мы сможем это сделать. Сложность в том, по крайней мере с SABBATH, что это всё серьёзное предприятие, ты не можешь просто взять и отыграть, так как нужны техники, полная линейка оборудования и всё такое. И это должен быть год или полтора тура... Я не против чего-то такого, я просто хотел бы всё сделать иначе». #Black_Sabbath #BlackSabbath #HardRock #Hard_Rock #HeavyMetal #Heavy_Metal

NCIS and NCIS: New Orleans aired new episodes last night. You can find ratings and links to watch the episodes below, along...

NCIS: Los Angeles aired the twelfth episode of season eight last night. “Kulinda” pulled in 10.35 million viewers at 8:00pm, earning a...

We are hunkered down here at the fabulous high-tech AustenBlog World Headquarters, and maintaining proper social distancing. Dorothy has been basically locked in her garret watching the North and South series on repeat, occasionally emerging to make another pot of tea and mumbling something that sounds like, “Save us, Richard Armitage.” The Editrix is herself…

Undone by Blood #3 is now due out June 10.

The post EXCLUSIVE: More meta revenge in UNDONE BY BLOOD #3 appeared first on The Beat.

IBM today announced it is now offering ThinkData Works’ open data solution on IBM’s platform-as-a-service, Bluemix, to give application developers access to clean, open data from all levels of government in Canada.

Kerry Stokes skips hotel quarantine for the comforts of home while Seven West Media skips covering the story.

Clive Palmer spends big on newspaper ads promoting his purchase of the drug hydroxychloroquine.

IBM and Telestream announced today at IBC 2017 a game-changing solution for high-speed capture and production of live, broadcast quality video from remote locations for faster production turnaround. Telestream Vantage powered by Aspera combines Aspera’s FASPStream high-speed streaming technology and Telestream Lightspeed Live Capture media processing platform to enable production teams to work on live video feeds from remote locations in near real time.

IBM and AOS, - a Colombian company specializing in providing business solutions- today announced they are collaborating to create a solution to enhance efficiency in the logistics and transport industry throughout the country, built on IBM Blockchain and Watson IoT on the IBM Cloud.

Walmart, JD.com, IBM, and Tsinghua University National Engineering Laboratory for E-Commerce Technologies announced today they will work together in a Blockchain Food Safety Alliance that will kick off with a collaboration designed to enhance food tracking, traceability and safety in China, to achieve greater transparency across the food supply chain.

IBM and MIT today announced that IBM plans to make a 10-year, $240 million investment to create the MIT–IBM Watson AI Lab in partnership with MIT. The lab will carry out fundamental artificial intelligence (AI) research and seek to propel scientific breakthroughs that unlock the potential of AI. The collaboration aims to advance AI hardware, software and algorithms related to deep learning and other areas, increase AI’s impact on industries, such as health care and cybersecurity, and explore the economic and ethical implications of AI on society. IBM’s $240 million investment in the lab will support research by IBM and MIT scientists.

The U.S. Chamber Foundation’s Corporate Citizenship Center and IBM today issued a new report that explores how efforts by businesses to be a positive force in communities – commonly referred to as corporate social responsibility (CSR) – influences public perception of those companies.

1-800-Flowers.com, Inc. (NASDAQ: FLWS) Gifts When you Need, an online gift concierge for the leading provider of floral and gourmet gifts, may help shoppers uncover the perfect gift for Moms this year. Data from thousands of customers using GWYN powered by IBM Watson (NYSE: IBM) gives insight on hot gifts picks for Mother’s Day.

Bank of Montreal (BMO), CaixaBank, Commerzbank and Erste Group have joined an initiative launched by UBS and IBM in 2016 to build a new global trade platform based on blockchain technology. This new platform, called Batavia, is built to be openly accessed by organisations of all sizes anywhere in the world, and can support trade finance for transactions across all modes of trade, whether goods are being transported by air, land or sea.