https://www.bestbuy.com/site/apple-ipad-latest-model-with-wi-fi-128gb-space-gray/5985613.p?skuId=5985613

I'm thinking about it, but I am uniformed about the current ipads.

Airpods are $139.99

On a hillside meadow in rural Vermont, local architecture firm Birdseye has completed Bank Barn, a new residence that, from afar, might look like any another agricultural building. But it is actually a modern farmhouse strategically engineered to meet future net-zero energy targets. The architects drew inspiration from the regional farm structures built into the banks of hills to create the gabled dwelling, which is clad in weathered cedar and topped with a durable metal roof. An intensive energy consultation and modeling informed all parts of the design. The resulting project features an electricity-based energy system that is expected to[...]

Perched atop a hill in Aosta Valley’s highest municipality in northwest Italy is the newly completed House in Chamois, a modern, prefabricated home by Torino-based design and build firm Leap Factory. As with all “Leap Houses,” the home’s entire design and construction process was managed by the Leap Factory team and was constructed with a modular system built of natural, recyclable materials to allow for maximum flexibility. All of the components provided by Leap Factory for the House in Chamois were also designed and produced in Italy. [...]

Chapel Hill-based firm Arielle Condoret Schechter is known for its commitment to building sustainable homes that don't sacrifice elegance or comfort. The company's latest work includes the spacious Haw River House, which was built with several efficient features to create a net-zero energy home that is seamlessly linked with its natural surroundings.[...]

Kevin Howard is the president of the Enfield Outing Club. (No, they’re not dedicated to shooting British military rifles; they’re located in picturesque Enfield, New Hampshire.) He recently sent out a notice to members of the gun club, explaining why … Read more

That's Sports Illustrated swimsuit model Chrissy Teigen having a rather... unfortunate encounter with some peppers. That final photo? The result of some of her Instagram and Twitter followers telling her that milk would help neutralize the burning - which by all accounts it did!

On this month’s episode of the Arsenal Women Arsecast, Tim is joined by author, broadcaster and journalist Dr. Carrie Dunn, Carrie is an expert and academic on all things women’s sport and is the author of two books about the Lionesses- Roar of the Lionesses (2016) and Pride of the Lionesses (2019)- which you can by here https://www.pitchpublishing.co.uk/shop/pride-lionesses – or from your local bookstore if they are still delivering- they would probably appreciate the business right now!

Tim talks to Carrie about role modelling in women’s football, players in the women’s game are called upon to be role models, especially for young girls and to help increase participation in the sport. Many players see this as a privilege and an important responsibility- but to what extent is it fair? Is this just invisible labour we blithely place on female athletes?

Then Tim talks to Gunners defender Louise Quinn, who is a patron for lots of initiatives geared towards increasing participation in sport for young girls. Louise talks about why she believes in the power of role modelling and about her female role models when she was growing up. Tim also talks to Louise about how her and her teammates are handling training in times of quarantine and social distancing in response to the COVID-19 pandemic.

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Back by popular demand is our minimal and modern 2020 free printable calendar! This gorgeous free 2020 calendar is clean, simple, and perfect to help you plan your busy life. Free 2020 Printable Calendar Per your requests, we’ve even upgraded this year’s free printable 2020 calendar with options for a Sunday or Monday start calendars! […]

The post 2020 Free Printable Calendar: Minimal & Modern appeared first on Dear Crissy.

Last week I received a very long email with instructions for Zeder. This year millions of Jews around the world will log into Zoom, and try to continue a 2000-year tradition of not changing the tradition. We will recall plagues of past like infestation of locusts and raining frogs and we’ll silently scoff that Egypt […]

The post It’s time for Seder, which is Zeder, in our modern-day-plague ravaged Passover appeared first on Penelope Trunk Careers.

As COVID-19 spreads worldwide, leaders are relying on mathematical models to make public health and economic decisions. A new model developed by Princeton and Carnegie Mellon researchers improves tracking of epidemics by accounting for mutations in diseases. Now, the researchers are working to apply their model to allow leaders to evaluate the effects of countermeasures to epidemics before they deploy them.

This is a frightening thought but I may be the most photographed person in all of China In my first few days here I kept catching people taking pictures of me on the sly and when I looked at them I noticed them waving but thought they wanted me to

We develop a multi-risk SIR model (MR-SIR) where infection, hospitalization and fatality rates vary between groups—in particular between the “young”, “the middle-aged” and the “old”. Our MR-SIR model enables a tractable quantitative analysis of optimal policy similar to those already developed in the context of the homogeneous-agent SIR models. For baseline parameter values for the COVID-19 pandemic applied to the US, we find that optimal policies differentially targeting risk/age groups significantly outperform optimal uniform policies and most of the gains can be realized by having stricter lockdown policies on the oldest group. For example, for the same economic cost (24.3% decline in GDP), optimal semi–targeted or fully-targeted policies reduce mortality from 1.83% to 0.71% (thus, saving 2.7 million lives) relative to optimal uniform policies. Intuitively, a strict and long lockdown for the most vulnerable group both reduces infections and enables less strict lockdowns for the lower-risk groups. We also study the impacts of social distancing, the matching technology, the expected arrival time of a vaccine, and testing with or without tracing on optimal policies. Overall, targeted policies that are combined with measures that reduce interactions between groups and increase testing and isolation of the infected can minimize both economic losses and deaths in our model.

But many questions remain about the true origin of the Homo sapiens species.

New findings bolster the argument that the two groups of early humans had a lot of behavioral similarities.

NBA Commissioner Adam Silver said teams will not play for at least 30 days and will not gather in groups through this weekend in wake of coronavirus outbreak.

Model-car building is one of the old-school hobbies enjoying a resurgence during the pandemic lockdown. Haven't done that in a while? Here's where to find a kit and what to look for.

A model predicts COVID-19 deaths in the U.S. will drop to zero by June. Another suggests without a vaccine, the coronavirus will be with us for years.

Looking through Sunday's Image section, reader Katherine Wertheim of Ventura felt something was missing.

After he retired, Tidwell pleaded guilty to taking hundreds of guns from evidence lockers

A decade in the making, Tyra Banks' modeling utopia, ModelLand, 'will emulate a fantasy version of the modeling world.' The park opens in Santa Monica in May.

Along with Henry Segerstrom and Donald Bren, he helped make the OC more cosmopolitan.

Tesla's stock price sank Thursday after Consumer Reports blasted the reliability of the company's new Model 3 sedan and dropped it from a list of recommended vehicles.

Three years after he promised to sell an all-electric Model 3 mass-market sedan for $35,000 before incentives, Elon Musk may finally be coming through.

Buyers who order the new lower-cost "standard-range" $35,000 Tesla Model 3 electric car and expect to receive it in two to four weeks might be in for a surprise.

Panasonic is freezing plans to expand its role as Tesla's electric car battery supplier, a move that raises new questions about demand for Tesla's Model 3 — and the company's future.

The Tesla Model 3 remained the bestselling electric car in the United States last month by far, according to estimates from website Inside EVs.

Elon Musk's growth story is looking more like a fable as Tesla Inc. enters survival mode.

Tesla's sales of its Model 3 perked up in the U.S. in May, according to estimates from the website InsideEVs, after a round of price cuts.

Dodge offers two outrageous muscle cars — Hellcat iterations of its Charger and Challenger — that capture the magic of the 1960s horsepower wars.

Peer-to-peer car sharing seems strange but turns out to be easy, if a bit expensive.

Compartir el coche de persona a persona parece extraño, pero es fácil, aunque un poco caro

A tribute to Tony- and Emmy-winner Shirley Knight, an exemplar of Method who learned from the best of the Actor Studio stars.

To portray his on-screen hype man, Dave "Lil Dicky" Burd turned to his real-life hype man: Davionte "GaTa" Ganter.

CAR TAX changes and grants for those purchasing brand new fully electric vehicles means there's "never been a better time" to switch, according to an EV expert.

TODAY has seen a small Call of Duty Modern Warfare rollout on servers, bringing with it some interesting playlist changes on PS4 and Xbox One.

YOUNG Princess Elizabeth's night out celebrating VE Day on the streets of London helped turn her into a Queen like no other.

Look inside this 1950s modern home at 6474 Meridian St.

A Texas woman wanted to control her Tesla Model 3. So she implanted part of the vehicle's valet key in her arm.

Portrait Lighting is a powerful photography tool available on newer iPhone models cameras. Apple aimed to bring studio-quality effects to the camera app by analyzing light on a subject in real-time while in portrait mode, and the result is the portrait lighting mode feature. There are five different studio-like effects to choose from, in the ... Read More

I interviewed four business leaders in late 2019 to get their perspectives on the biggest obstacles and opportunities organizations are facing. Craig Lemasters was the president and CEO of Assurant Solutions. Under his leadership, Assurant Solutions doubled in size to $4B, underwent a digital transformation to expand an offering of risk management solutions in the […]

The following article, ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion, was first published on 100PercentFedUp.com.

Transcripts of House Intelligence Committee interviews have been cleared for release, and Adam Schiff is reportedly in panic mode. Unfortunately for Schiff, top law enforcement and intel officials said they saw no evidence of collusion between the Trump campaign and Russia in the transcripts. Republicans sought and got approval for the release of the transcripts […]

Continue reading: ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion ...

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

1 April 2020

Invitation Only Research Event

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles

The DOCK-D (dedicator of cytokinesis D) family proteins are atypical guanine nucleotide exchange factors that regulate Rho GTPase activity. The family consists of Zizimin1 (DOCK9), Zizimin2 (DOCK11), and Zizimin3 (DOCK10). Functions of the DOCK-D family proteins are presently not well-explored, and the role of the DOCK-D family in neuroinflammation is unknown. In this study, we generated three mouse lines in which DOCK9 (DOCK9−/−), DOCK10 (DOCK10−/−), or DOCK11 (DOCK11−/−) had been deleted and examined the phenotypic effects of these gene deletions in MOG35–55 peptide-induced experimental autoimmune encephalomyelitis, an animal model of the neuroinflammatory disorder multiple sclerosis. We found that all the gene knockout lines were healthy and viable. The only phenotype observed under normal conditions was a slightly smaller proportion of B cells in splenocytes in DOCK10−/− mice than in the other mouse lines. We also found that the migration ability of macrophages is impaired in DOCK10−/− and DOCK11−/− mice and that the severity of experimental autoimmune encephalomyelitis was ameliorated only in DOCK10−/− mice. No apparent phenotype was observed for DOCK9−/− mice. Further investigations indicated that lipopolysaccharide stimulation up-regulates DOCK10 expression in microglia and that microglial migration is decreased in DOCK10−/− mice. Up-regulation of C–C motif chemokine ligand 2 (CCL2) expression induced by activation of Toll-like receptor 4 or 9 signaling was reduced in DOCK10−/− astrocytes compared with WT astrocytes. Taken together, our findings suggest that DOCK10 plays a role in innate immunity and neuroinflammation and might represent a potential therapeutic target for managing multiple sclerosis.