Paul Levitz

After more than four decades of dominance, free-market capitalism is facing a challenge. Its rival, the rather blandly named Modern Monetary Theory, promises to return economic planning to a less ideological footing. It’s also keen to strike a blow against the “surplus fetish” that many economists now blame for declining public services and growing inequality.

There's growing consensus among weather forecasting models that Australia could be in for a wet winter. But what do farmers think?

New COVID-19 testing clinics have opened in Warrnambool and Ballarat as the Victorian Government continues its push to surpass 200,000 tests by May 11.

The magpie and the kookaburra are two of Australia's favourite birds and, although they're not endangered yet, concerns for their wellbeing and survival are beginning to grow.

It's hoped a new house using a shared-ownership model will give people with disabilities a chance at home ownership and semi-independent living, but it comes with a $300,000 price tag per person.

A vintage FJ Holden panel van is commemorating the daring feats of newsreel crews in the 1940s and 50s when news was served at the movies.

Leaks from one of Adani's most significant contractors for its Carmichael coal mine, engineering firm GHD, show it has been rocked by internal dissent and management has been bombarded with complaints and questions about its work on the mine.

The Sutherlands hope that telling their story will help transgender parents be accepted to the point where, one day, "no-one bats an eyelid".

What can retailers learn from the lockdown and could it be the death-knell of the store, asks Tania Oakey, a retail expert at software vendor Cegid?

He also gave an update on the “The Nikki Project.”

Riley Curry and more young stars steal the spotlight.

The 25-year-old wins again at British Fashion Awards.

She doesn't want to be linked with "misogyny and violence."

New study shows almost no improvement in diversity.

The hip hop stars landed a major fashion campaign.

The mega-hit competition series gets a fresh spin.

The 26-year-old makes a shocking announcement.

Jillian Mercado is the face of the pop icon's online store.

Rihanna, Jourdan Dunn, Beyoncé, and more grace the top spot.

"This is also my love letter."

The actress' newest project hits YouTube this fall.

The couple shows off swanky Atlanta estate.

Five different business models for mobile fare payment apps are examined, as the world of apps used by transit agencies in the United States and Canada continues to steadily grow. The TRB Transit Cooperative Research Program's TCRP Synthesis 148: Business Models for Mobile Fare Apps documents current practices and experiences of transit agencies that offer mobile fare payment applications to transit riders. The report includes case examples from six cities: Santa Monica, Denver, Austin, Chicago, Dallas, ...

Barriers, berms, buildings, and natural terrain may affect the propagation of aircraft noise by shielding or reflecting sound energy. If terrain and manmade structures obstruct the line‐of‐sight between the source and the receiver, then sound energy will be attenuated at the receiver. This attenuation increases with the terrain and structures’ size and proximity to either the source or the receiver. If gaps exist in the terrain or structures, then the potential benefits of acoustical shielding will be su...

EPA announces the availability of the All-Ages Lead Model (AALM), Version 2 software with updated supporting documentation (External Review Draft). The AALM Model is scheduled to undergo an independent peer review by EPA's Science Advisory Board in October 2019. For more information related to scheduling and peer reviewers for this new tool, please visit the SAB AALM Project website. [Federal Register Notice Sep 24, 2019]

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Australia bit barn outfit NEXTDC adds classic film reference to usual mix of resilience, connectivity and security

Australian serial entrepreneur Bevan Slattery has revealed that he told the architects of a data centre he funded to make it resemble the sets used in classic submarine flick The Hunt for Red October.…

Индийский инсайдер Судханшу Амбхоре (Sudhanshu Ambhore)‏ продолжает публиковать подробности о новом смартфоне Realme X3 SuperZoom.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.

Amazon is taking up to $100 off the Apple Watch Series 5 this week, with prices starting at $299.99 for the 40mm GPS models. Only the Gold Aluminum Case with Pink Sport Band is available at this price. If you order today, the Apple Watch should arrive sometime next week.

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The Apple Watch Series 5 was released in September 2019 with a new OLED screen that supports an always-on feature, which represents the biggest change to the Series 5 models. The newest Apple Watch is available in 40mm and 44mm sizes, and it has the overall same design as the Series 4 models.

At the International Supercomputing Conference in Frankfurt, The Weather Company, an IBM Business, today announced a plan to help improve weather prediction globally via a new collaboration with the University Corporation for Atmospheric Research (UCAR) and the National Center for Atmospheric Research (NCAR), a federally funded research and development center for the atmosphere and Earth’s geospace systems.

• Con vigencia de 10 años, Banorte e IBM firman alianza estratégica que permitirá establecer las bases de un nuevo modelo de banca enfocado al cliente, y mejorar sustancialmente sus índices de eficiencia para alcanzar niveles cercanos al 40%, así como retornos sobre capital superiores al 20%. El acuerdo incluye servicios de consultoría y de tecnología, investigación y desarrollo. • “Estamos plenamente satisfechos con el acuerdo logrado, pues este suma el mejor talento humano, tanto de IBM, como de Banorte Ixe, y está en línea con nuestra búsqueda de herramientas tecnológicas para servir a nuestros clientes de manera individualizada”: Alejandro Valenzuela.

Seguridad, aplicaciones estratégicas y analítica móvil son clave para que las organizaciones inteligentes mejoren sus resultados

La inteligencia artificial (IA) promete transformar tanto el futuro del trabajo como la función de Recursos Humanos (RRHH). Alineado con esta premisa, IBM (NYSE: IBM) anunció hoy IBM Talent & Transformation, una nueva unidad destinada a ayudar a las organizaciones y a sus empleados a tener éxito en la era de la inteligencia artificial y la automatización.

Enfrenta IBM Desafíos de Big Data con Modelo Innovador de Servidor Abierto