THOSE last times.... we all of us have memories our minds keep running back to in these social distancing times. The last time we gathered, last time we swam together, the last drive to a beach. One of mine is the post-swim hot tub at the Scottish Winter Swimming Championships in the chilly waters of Loch Tay – around 30 of us crammed in there, many in fancy dress, some in swim make-up, a great, crowded bath of joy.

GUS MACKAY was full of good intentions when he agreed to become Cricket Scotland’s new chief executive last October.

Singjay Tashina McKenzie has found herself with a lot of downtime since government- mandated lockdowns and curfews have curtailed nightlife and affected recording studios due to the COVID-19 pandemic.

The ingenuity of Scotland’s independent food sector, and its determination to keep feeding us in these testing circumstances, is remarkable. Restaurants and cafés have gone down the takeaway route, small artisan suppliers who lost overnight all their catering customers have rapidly reconfigured their business around home delivery. Farmers who previously struggled to attract supermarket shoppers have never been so busy. Farmer’s markets have adapted to sell delivered or collected vegetable b

MARC Mazoyer is getting ready for the week ahead. He’s made soup, and a loaf of bread, and roasted a chicken and he’s thinking about what he’ll do with the food over the next few days. Some of the chicken can go into a dahl, and maybe a risotto, and he might make some quesadillas with it too. And the leftovers can go into a caesar salad. This is how Marc keeps physically well. But it’s how he keeps mentally well too.

From surf towns in Portugal to small communities in Zambia, God is using sports to break down barriers and bring people together in fellowship with Him.

LOCKDOWN may start easing soon, but it seems likely to be a long time yet before any of us find ourselves in an actual physical pub. It’s not of course the booze we’re missing – we can get plenty of that – but the company, the conviviality, the atmosphere, the feeling that, in the late hours, almost anything might kick off. So, for those who cry inside every time they walk past their closed-down local, or wake-up having dreamed of standing with a pint at the bar, here’s a few ways you

The 'Total Physical Response' method to learning vocabulary is beneficial for students, especially English-language learners, to break down and analyze the roots and endings of vocabulary words.

Marc Tucker's most-read blog posts in 2017.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Through contemporary worship, the OM team seeks to create an atmosphere of worship in which the younger generation in Japan can experience God.

The professionalism of physicians can have an impact on patient care and satisfaction and physician career success and is increasingly emphasized in residency training programs.

This study was an examination of the perspectives of families of pediatric patients and of pediatrics residents on the attributes of professionalism in physicians. Important overlaps were found between the attributes of professionalism prioritized by patient families and resident physicians. (Read the full article)

Previous evaluations of local reactions after the fifth diphtheria-tetanus-acellular pertussis (DTaP) vaccine in children 4 to 6 years of age have revealed that vaccination in the thigh is associated with a lower risk of local reactions compared with vaccination in the arm.

Among children 12 to 35 months of age, injection of DTaP vaccine in the thigh is associated with a lower risk of local reactions compared with vaccination in the arm. (Read the full article)

In parts of sub-Saharan Africa, sexual assault incidence among adolescents is as high as 24%, resulting in serious physical and mental health problems. In the United States, empowerment and self-defense training have been shown to decrease incidence of sexual assault.

This study evaluated an empowerment and self-defense training intervention for adolescent girls in the African context. This intervention proved highly effective at preventing sexual assault and should be replicable in other countries in sub-Saharan Africa and around the world. (Read the full article)

Preterm birth has been associated with increased risk of venous thromboembolism (VTE) in infancy, but the longer-term risk is unknown.

In a large national cohort, low gestational age at birth was associated with increased risk of VTE in infancy, early childhood, and young adulthood. These findings call for better awareness of the long-term risk of VTE among preterm birth survivors. (Read the full article)

Exposure to second-hand tobacco smoke during pregnancy and infancy has been linked to development of asthma, rhinitis, and eczema in young children. It is unclear whether these risks persist into adolescence.

Exposure to second-hand smoke in utero or during infancy influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages. (Read the full article)

"We can do better," Germany coach Silvia Neid concluded after her side joined France and Sweden in making it to the quarter-finals of the Olympic tournament in unspectacular fashion.

A master’s degree thesis defense is difficult enough under normal circumstances, but due to COVID-19, integrated masters/bachelors student Sabrina Carrozzi defended her thesis on Zoom.

Penn State senior Abigail Cowser was recently named one of 10 American Society of Civil Engineers "2020 New Faces of Civil Engineering - College Edition."

A studio course for architecture and landscape architecture students in the Stuckeman School prepares students for the collaborative design process they will take part in once they begin careers in their respective fields by blurring the boundaries between the disciplines in the college setting.

Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US-FDA and is currently being evaluated in phase 3 clinical trials in patients with acute bacterial skin and skin structure infections (ABSSSIs) and in patients with Staphylococcus aureus bacteremia. In this study, the activity of ceftobiprole and comparators was evaluated against more than 7,300 clinical isolates collected in the United States from 2016 through 2018 from patients with skin and skin structure infections. The major species/pathogen groups were S. aureus (53%), Enterobacterales (23%), Pseudomonas aeruginosa (7%), β-hemolytic streptococci (6%), Enterococcus spp. (4%), and coagulase-negative staphylococci (2%). Ceftobiprole was highly active against S. aureus (MIC_50/90, 0.5/1 mg/L; 99.7% susceptible by EUCAST criteria; 42% methicillin-resistant S. aureus [lsqb]MRSA[rsqb]). Ceftobiprole also exhibited potent activity against other Gram-positive cocci. The overall susceptibility of Enterobacterales to ceftobiprole was 84.8% (>99.0% susceptible for isolate subsets that exhibited a non-extended-spectrum β-lactamase [lsqb]ESBL[rsqb]-phenotype). A total of 74.4% of P. aeruginosa, 100% of β-hemolytic streptococci and coagulase-negative staphylococci, and 99.6% of Enterococcus faecalis isolates were inhibited by ceftobiprole at ≤4 mg/L. As expected, ceftobiprole was largely inactive against Enterobacterales that contained ESBL genes and Enterococcus faecium. Overall, ceftobiprole was highly active against most clinical isolates from the major Gram-positive and Gram-negative skin and skin structure pathogen groups collected at U.S. medical centers participating in the SENTRY Antimicrobial Surveillance Program during 2016–2018. The broad-spectrum activity of ceftobiprole, including potent activity against MRSA, supports its further evaluation for the potential ABSSSI indication.

Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California serogroup, circulates in the eastern and midwestern United States. While LACV infection is often asymptomatic, dozens of cases of encephalitis are reported yearly. Unfortunately, no antivirals have been approved to treat LACV infection. Here, we developed a method to rapidly test potential antivirals against LACV infection. From this screen, we identified several potential antiviral molecules, including known antivirals. Additionally, we identified many novel antivirals that exhibited antiviral activity without affecting cellular viability. Valinomycin, a potassium ionophore, was among our top targets. We found that valinomycin exhibited potent anti-LACV activity in multiple cell types in a dose-dependent manner. Valinomycin did not affect particle stability or infectivity, suggesting that it may preclude virus replication by altering cellular potassium ions, a known determinant of LACV entry. We extended these results to other ionophores and found that the antiviral activity of valinomycin extended to other viral families including bunyaviruses (Rift Valley fever virus, Keystone virus), enteroviruses (Coxsackievirus, rhinovirus), flavirivuses (Zika), and coronaviruses (HCoV-229E and MERS-CoV). In all viral infections, we observed significant reductions in virus titer in valinomycin-treated cells. In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.

Importance No antivirals are approved for the treatment of bunyavirus infection. The ability to rapidly screen compounds and identify novel antivirals is one means to accelerate drug discovery for viruses with no approved treatments. We used this approach to screen hundreds of compounds against La Crosse virus, an emerging bunyavirus that causes significant disease, including encephalitis. We identified several known and previously unidentified antivirals. We focused on a potassium ionophore, valinomycin, due to its promising in vitro antiviral activity. We demonstrate that valinomycin, as well as a selection of other ionophores, exhibits activity against La Crosse virus as well as several other distantly related bunyaviruses. We finally observe that valinomycin has activity against a wide array of human viral pathogens, suggesting that disrupting potassium ion homeostasis with valinomycin may be a potent host pathway to target to quell virus infection.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

France beat Croatia to earn a final tournament debut, as they joined Serbia, Romania and Poland in qualifying for UEFA Futsal EURO 2018 via the play-offs.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Philip M. Farrell
Jan 1, 2001; 107:1-13
ARTICLES

Penn State Harrisburg faculty share their experiences – the challenges, triumphs and innovations – as they are adapting lesson plans and teaching processes during this time of social distancing.

Penn State Extension is extending its free online courses offer through May 10.

The WireGuard protocol is intended to be the future of VPNs, promising better speeds and security. We tested NordVPN's implementation, and WireGuard appears set to deliver on its promises.

Penn State Health has opened two regional clinics to care for patients with confirmed or suspected COVID-19 who have health care needs that are serious enough to warrant a face-to-face appointment.

Penn State faculty are going beyond using traditional video in their courses by incorporating virtual-reality immersive experiences. They are discovering how those experiences help enhance active learning and focus students' attention on critical lessons in their courses.

UEFA European Championships have a habit of kick-starting careers and UEFA EURO 2016 has been no different – we pick out eight players whose lives may never be the same again.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Concern for their students and adapting to remote teaching are only a few of the stressors that teachers are facing during the coronavirus pandemic. In response, the Pennsylvania State Education Association (PSEA) has partnered with Sebrina Doyle, a graduate fellow in the College of Education, to offer mindfulness-based stress reduction training via Zoom to their members – to help alleviate feelings of helplessness, fear and anxiety. Doyle offered the hour-long webinar two days this month to approximately 700 PSEA members.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

"At the end of the class, over tea and mini-cakes, we take time to get to know them, to help them with administrative tasks or to discuss Bible stories," shares Louise.

Holders Lyon, former winners Arsenal and Wolfsburg, plus past finalists Barcelona, Paris and Fortuna all progressed.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Chelsea, Hertha, Montpellier, Midtjylland, PAOK, Sigma, Dinamo Zagreb and Dynamo Kyiv are into the play-offs.

Ajax, Atlético, Barcelona, Hoffenheim, Liverpool, Manchester United, Porto and Real Madrid topped their groups to reach the last 16.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

Two adults were significantly impacted by learning to read and write in recent adult literacy classes run by OM in Bangladesh.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Belgium, England, France, Germany, Iceland, Poland, Portugal, Serbia and Spain have won their groups to join Russia in the finals, with the eight play-off teams now also confirmed.

An OMer in Kazakhstan tells of a Kazakh friend and believer who, finding herself pregnant again before she is ready, wrestles with cultural norms.

OM Chile's newly-created sports ministry experiences God's faithfulness in its first football game.

In an effort to strengthen relationships with local churches, OM Chile recently held a dinner for local pastors that featured international flavours and testimonies.

Investigations result in discovery and correction of issues impacting consumers The Delaware Department of Insurance’s Market Conduct Examinations resulted in the receipt of nearly $700,000 in fines during 2019 from more than a dozen companies found to violate the Insurance Code or other related regulations. The fines are contributed to the General Fund, providing funding […]

Consumers won nearly 90% of arbitration cases in 2019 The Delaware Department of Insurance announced that its arbitration services program earned residents $839,466 in awards during 2019. Considering overlap from the previous year, 354 settlements occurred, and 144 cases were heard. Residents prevailed in about 90% of all cases. In total, the Department opened 502 […]