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An adolescent with disabling abdominal pain




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David Oliver: What the plan for social care omitted




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Nigeria's 2023 elections: Security, economic and foreign policy imperatives

Nigeria's 2023 elections: Security, economic and foreign policy imperatives 5 December 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 23 November 2022 Chatham House and Online

Bola Ahmed Tinubu, presidential candidate for the All-Progressives Congress, discusses his vision and recently-unveiled manifesto for ‘renewing hope’ in Nigeria.

Nigeria is scheduled to hold presidential and national assembly elections on 25 February 2023 as well as governorship and other subnational elections on 11 March 2023.

The elections will end President Muhammadu Buhari’s two terms in office since his election in 2015 and will mark the first time that he is not engaging in a presidential poll since Nigeria’s transition to civilian rule in 1999 – an important marker in Nigeria’s trajectory of democratic consolidation.

Nigeria’s recently enacted Electoral Act has contributed to improved hope around the election process, reflected in the addition of 12.29 million new voters in Nigeria’s voter registration exercise across the federation’s 36 states and 1,491 constituencies.

Yet Nigeria stands at a critical juncture, having suffered from two recessions in the past six years, unprecedented levels of food insecurity, persistent fuel scarcity and high levels of crude oil theft.

Civic fatigue also remains an important challenge and President Muhammadu Buhari’s three main policy pillars of security, economy and corruption continue to be defining issues for citizens.

At this event, Bola Ahmed Tinubu, presidential candidate for the All-Progressives Congress, discusses his vision and recently unveiled manifesto for ‘renewing hope’ in Nigeria including his policy proposals for economic reform and revival and how to deliver secure and inclusive job opportunities for Nigerian citizens.

Download a transcript

This event is a members and Africa programme event and is part of a series of events and outputs examining Nigeria’s 2023 elections and political developments.

As with all Chatham House member events, questions from members drive the conversation.




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Development of 18F-Fluoromisonidazole Hypoxia PET/CT Diagnostic Interpretation Criteria and Validation of Interreader Reliability, Reproducibility, and Performance

Tumor hypoxia, an integral biomarker to guide radiotherapy, can be imaged with 18F-fluoromisonidazole (18F-FMISO) hypoxia PET. One major obstacle to its broader application is the lack of standardized interpretation criteria. We sought to develop and validate practical interpretation criteria and a dedicated training protocol for nuclear medicine physicians to interpret 18F-FMISO hypoxia PET. Methods: We randomly selected 123 patients with human papillomavirus–positive oropharyngeal cancer enrolled in a phase II trial who underwent 123 18F-FDG PET/CT and 134 18F-FMISO PET/CT scans. Four independent nuclear medicine physicians with no 18F-FMISO experience read the scans. Interpretation by a fifth nuclear medicine physician with over 2 decades of 18F-FMISO experience was the reference standard. Performance was evaluated after initial instruction and subsequent dedicated training. Scans were considered positive for hypoxia by visual assessment if 18F-FMISO uptake was greater than floor-of-mouth uptake. Additionally, SUVmax was determined to evaluate whether quantitative assessment using tumor-to-background ratios could be helpful to define hypoxia positivity. Results: Visual assessment produced a mean sensitivity and specificity of 77.3% and 80.9%, with fair interreader agreement ( = 0.34), after initial instruction. After dedicated training, mean sensitivity and specificity improved to 97.6% and 86.9%, with almost perfect agreement ( = 0.86). Quantitative assessment with an estimated best SUVmax ratio threshold of more than 1.2 to define hypoxia positivity produced a mean sensitivity and specificity of 56.8% and 95.9%, respectively, with substantial interreader agreement ( = 0.66), after initial instruction. After dedicated training, mean sensitivity improved to 89.6% whereas mean specificity remained high at 95.3%, with near-perfect interreader agreement ( = 0.86). Conclusion: Nuclear medicine physicians without 18F-FMISO hypoxia PET reading experience demonstrate much improved interreader agreement with dedicated training using specific interpretation criteria.




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Turkey Is on the Road to a Severe Economic Crisis

Turkey Is on the Road to a Severe Economic Crisis Expert comment sysadmin 12 July 2018

The deteriorating state of the economy is President Erdoğan’s Achilles’ heel and the biggest threat to his currently unrivalled leadership.

A special one lira coin minted for the presidential inauguration of Recep Tayyip Erdogan. Photo: Getty Images.

Fifteen days after Turkey’s parliamentary and presidential elections, Turkish President Recep Tayyip Erdoğan appointed a new government under radically enhanced executive powers granted by the constitution. He chose 16 loyalists and partisan figures to ensure that he remains front and centre in decision-making and policy formation.

Most notably, Erdoğan sacrificed the former deputy prime minister and ex-Merrill Lynch chief economist Mehmet Şimşek in favour of his inexperienced son-in-law Berat Albayrak as finance and treasury minister to manage the fragile economy. Whether he has the competence to placate jittery financial markets and foreign investors is debatable.

Erdoğan will prioritize short-term growth at all costs to the detriment of macroeconomic and financial stability. That entails foregoing interest rate hikes needed to contain runaway double-digit inflation and to support a plummeting lira that depreciated nearly 20 per cent this year. It also means loosening the purse strings, flooding the markets with cheap credit and sponsoring rampant construction and mega-infrastructure projects.

True to his promise, he has appropriated to himself, by presidential decree, the right to hire the central bank governor, deputies and monetary policy committee members for a four-year term. This completes the politicization of the once-respected and independent central bank and is in line with his unorthodox monetary views that higher interest rates equates with higher inflation.

Erdoğan associates progress with gleaming high-rise buildings, gargantuan infrastructure show-pieces and elevated growth rates. He is spiking the fuel to boost the speed of the sputtering mid-sized Audi-style Turkish economy to achieve superior Ferrari growth rates. As any mechanic knows, these tactics are unsustainable in the long term. Eventually, the engine will burn out.

He does not seem to appreciate that Turkey’s growth model requires an overhaul to join the league of rich economies. It is too reliant on consumer spending and government-sponsored infrastructure and construction projects funded by speculative financial flows rather than on sustained private investment and exports.

Net result: the corporate sector’s foreign-exchange liabilities have climbed to a record $328 billion as of the end of 2017. When netted against foreign-exchange assets, it is still a worrying $214 billion. Its US dollar and euro debt pile has more than doubled since 2008, 80 per cent of which is held by domestic banks. Given these acute balance-of-payments conditions, it is not farfetched that Turkey may impose capital controls in the short-to-medium term to restrict the outflow of foreign assets. At $50 billion, the current account deficit – defined as the sum of the trade balance and financial flows – is not even covered by the central bank’s net international reserves at nearly $45 billion.

Unsurprisingly, some major Turkish companies are negotiating with their bondholders to restructure their sizeable foreign loan obligations as lira devaluation increases the financial burden. Should a significant number of Turkish corporates default on their foreign obligations, this would reverberate across the Turkish economy, cause mass consumer panic, shake the confidence of international financial markets and potentially lead to a crisis within the Turkish financial system and to a deep and prolonged economic recession.

Revealingly, Erdoğan’s nationalist allies, the Nationalist Movement Party (MHP), refused to join his government. Perhaps Devlet Bahçeli, the MHP leader, learned the lessons of the 2001 financial crisis as a member of a three-party government. So he is opting to project influence from the outside, rather than risk being tainted with responsibility for an economic downturn.

Turkey’s president is doubling down on his singular approach to governance irrespective of the fallout. Notwithstanding his current political dominance, the deteriorating state of the economy is his Achilles’ heel and the biggest threat to his currently unrivalled leadership.




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A Credit-fuelled Economic Recovery Stores Up Trouble for Turkey

A Credit-fuelled Economic Recovery Stores Up Trouble for Turkey Expert comment sysadmin 17 February 2020

Turkey is repeating the mistakes that led to the 2018 lira crisis and another freefall for the currency may not be far off.

Headquarters of the Central Bank of the Republic of Turkey. Photo: Getty Images.

Since the 2018 economic crisis, when the value of the lira plummeted and borrowing costs soared, Turkey’s economy has achieved a miraculous ‘V-shaped’ economic recovery from a recession lasting three quarters to a return back to quarterly growth above 1 per cent in the first three months of 2019.

But this quick turnaround has been built on vast amounts of cheap credit used to re-stimulate a consumption and construction boom. This so-called ‘triple C’ economy generated a rapid growth spurt akin to a modestly able professional sprinter injected with steroids.

This has made the currency vulnerable. The lira has steadily depreciated by 11 per cent against the US dollar since the beginning of 2019 and crossed the rate of 6 lira versus the US dollar on 7 February. And there are further warning signs on the horizon.

Credit bonanza

Statistics reveal that Turkish domestic credit grew by around 13 per cent on average throughout 2019. The credit bonanza is still ongoing. Mortgage-backed home sales jumped by a record high of 600 per cent last December alone and the 2019 budget deficit catapulted by 70 per cent due to higher government spending.

Turkey’s central bank fuelled this credit expansion by cutting interest rates aggressively to below inflation and, since the start of this year, purchasing lira-denominated bonds equivalent to around one-third of total acquisitions last year to push yields lower.

Equally, it has linked bank lending to reserve requirements – the money that banks have to keep at the central bank – to boost borrowings via state and private banks. Banks with a ‘real’ loan growth (including inflation) of between 5 and 15 per cent enjoy a 2 per cent reserve ratio on most lira deposits, which authorities adjusted from an earlier band of 10-20 per cent that did not consider double-digit inflation.

Cumulatively, bond purchases (effectively quantitative easing) and reserve management policies have also contributed to eased credit conditions.

Commercial banks have also reduced deposit rates on lira accounts to less than inflation to encourage consumption over saving. Together with low lending rates, the boost to the economy has flowed via mortgages, credit card loans, vehicle leasing transactions and general business borrowings.

Accordingly, stimulus is at the forefront of the government’s economic approach, as it was in 2017 and 2018. It does not seem to be implementing structural change to re-orient growth away from consumption towards productivity.

In addition, governance is, again, a central issue. President Recep Tayyip Erdogan’s near total monopolization of policymaking means he guides all domestic and external policies. He forced out the previous central bank governor, Murat Cetinkaya, in July 2019 because he did not share the president’s desire for an accelerated pace of interest rate reductions.

New challenges

Despite the similarities, the expected future financial turbulence will be materially different from its 2018 predecessor in four crucial respects.

Firstly, foreign investors will only be marginally involved. Turkey has shut out foreign investors since 2018 from lira-denominated assets by restricting lira swap arrangements. Unsurprisingly, the non-resident holdings of lira bonds has plummeted from 20 per cent in 2018 to less than 10 per cent today.

Secondly, the Turkish government has recently introduced indirect domestic capital controls by constraining most commercial transactions to the lira rather than to the US dollar or euro to reduce foreign currency demand in light of short-term external debt obligations of $191 billion.

Thirdly, the Turkish state banks are intervening quite regularly to soften Lira volatility, thereby transitioning from a ‘free float’ to a ‘managed float’. So far, they have spent over $37 billion over the last two years in a futile effort to buttress the lira. This level of involvement in currency markets cannot be maintained.

Fourthly, the Turkish state is being far more interventionist in the Turkish stock exchange and bond markets to keep asset prices elevated. Government-controlled local funds have participated in the Borsa Istanbul and state banks in sovereign debt to sustain rallies or reverse a bear market.

All these measures have one running idea: exclude foreign investors and no crisis will recur. Yet, when the credit boom heads to a downturn sooner or later, Turks will probably escalate lira conversions to US dollars; 51 per cent of all Turkish bank deposits are already dollar-denominated and the figure is still rising.

If Turkey’s limited foreign reserves cannot satisfy the domestic dollar demand, the government may have to impose comprehensive capital controls and allow for a double digit depreciation in the value of the lira to from its current level, with significant repercussions on Turkey’s political stability and economic climate.

To avoid this scenario, it needs to restore fiscal and monetary prudence, deal the with the foreign debt overhang in the private sector and focus on productivity-improving economic and institutional reforms to gain the confidence of global financial markets and Turks alike.




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ISC Opens Nominations for 2025 Jack Dongarra Early Career Award in HPC

Oct. 16, 2024 — The ISC High Performance Jack Dongarra Early Career Award and Lecture Series is an annual event that honors the remarkable contributions of Professor Jack Dongarra to […]

The post ISC Opens Nominations for 2025 Jack Dongarra Early Career Award in HPC appeared first on HPCwire.





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USS Wyoming submarine conducts two-missile Trident II test flight

The U.S. Navy conducted a two-missile test flight of unarmed life-extended Trident II-D5LE missiles from the USS Wyoming in the Eastern Test Range off the coast of Cape Canaveral, Fla, the Navy announced.




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Dominatrices Are Showing People How to Have Rough Sex Safely

Research shows rough sex is becoming more common. Dominatrices are helping the general public catch up.

 





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Cyprus signs NASA's Artemis Accords, becoming 46th nation to commit to safe space exploration

The Mediterranean island nation of Cyprus signed the U.S.-led Artemis Accords on Wednesday, becoming the 46th signatory to the agreement that establishes principles for the safe exploration of space.




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Will the end of economic growth come by design — or disaster? | Gaya Herrington

What if solving poverty, caring for nature and fostering well-being were the ultimate goals of the economy, instead of growth for its own sake? Environmentalist and economist Gaya Herrington proposes a shift in thinking from "never enough" to "enough for each," asking us to contemplate whether the end of exponential growth on a finite planet will come by design — or disaster.




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North Dakota, Wyoming Move Away From Smarter Balanced Tests

North Dakota and Wyoming state superintendents said this week that they will soon hire new testing vendors.




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Wyoming's Native Students More Likely to Face Suspension

Although Native American students make up a small percentage of Wyoming's student population, they are suspended more than their non-minority peers.




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Wyoming, Idaho Laws Expand K-12 Computer Science Education

All districts in Wyoming will be required to provide K-12 computer science instruction, and Idaho high schools will offer at least one high school CS course.




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Budget Cuts Lead Wyoming to Scale Back Relationship With Accrediting Agency

AdvancED, the national accreditation company, has for the last two years operated Wyoming's entire accreditation process but the state will now do the work on its own.




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Wyoming




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Wyoming




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Wyoming

State of the States: Education highlights from latest governor's address before the legislature.




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Wyoming

Half of the 48 school districts in Wyoming have fewer than 300 students. But they’re linked together, thanks to the state’s investment in a video and high-speed Internet connection that ties schools to the state university and community colleges, where students have access to classes that might not




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Wyoming Adopts New Science Standards

Wyoming's new science benchmarks are similar to the Next Generation Science Standards.




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Wyoming

Unlike many other states, Wyoming finds itself in a healthy financial position, thanks to its mineral and energy wealth.




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Wyoming




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Educational Opportunities and Performance in Wyoming

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Nation Gets a 'C' on School Finance, Even as Economic Downturn Takes Hold

Wyoming once again takes the top spot in Quality Counts' annual ranking of the states on school finance, while 22 states receive grades between C-minus and D-minus.




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Educational Opportunities and Performance in Wyoming

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Wyoming Schools Chief on the Coronavirus Challenge

"In communities most devastated by COVID-19, academic achievement is pretty far down on the priority list—this is the reality," says Wyoming state chief Jillian Balow.




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Wyoming teacher honored for student support amid pandemic




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Training Bias Out of Teachers: Research Shows Little Promise So Far

After a summer of protests over racial injustice, school districts are embracing anti-bias programs. The problem is: Few studies show they work.




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Teacher Activism Played Prominent Role in Southern Governors' Races

Governors' races in Kentucky and Mississippi took center stage, testing the political muscle of teacher activists and yielding possible policy implications for everything from public employee pensions to teacher pay.




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Wyoming teacher honored for student support amid pandemic




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Incoming California Governor to Seek Nearly $2 Billion in Early-Childhood Funding

Democrat Gavin Newsom, who takes office Jan. 7, plans to expand full-day kindergarten and child-care offerings in the state, according to media reports.




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Nation Gets a 'C' on School Finance, Even as Economic Downturn Takes Hold

Wyoming once again takes the top spot in Quality Counts' annual ranking of the states on school finance, while 22 states receive grades between C-minus and D-minus.




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College Football Playoff Rankings, Version Two, dominated by Big Ten

How did the Miami and Georgia losses impact the CFP rankings in their second release?




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Big Ten dominates latest College Football Playoff rankings

The Big Ten dominated the latest edition of the College Football Playoff (CFP) rankings, with the conference claiming four of the top five slots in the new standings revealed Tuesday night.




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Teacher Activism Played Prominent Role in Southern Governors' Races

Governors' races in Kentucky and Mississippi took center stage, testing the political muscle of teacher activists and yielding possible policy implications for everything from public employee pensions to teacher pay.




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Are Schools Prepared to Respond to Sex Abuse? Latest Probe Reveals Shortcomings

A federal investigation of Chicago's failures to respond to sexual violence in schools raises troubling questions for school districts nationwide.




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Notre Dame WBB puts up highlight-reel performance in dominating Purdue

Dazzling first with a relentless hawking defense that helped force 22 turnovers, then adding an almost frantic-paced offensive assault, the 2-0 No. 6-ranked Irish overwhelmed Purdue (1-1), 102-58, at Mackey Arena in West Lafayette, Ind. Dynamo guard Hannah Hidalgo was slapping, diving and picking pockets all night, making life miserable for any Boilermaker stuck bringing the ball up the floor. ► Snap Counts: Here's who played for Notre Dame football against Florida St.




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South Carolina Women’s Basketball continues domination at Ally Tipoff

Players and coaches said they had a good time playing in the Queen City.




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No. 4 Texas Women’s Basketball Dominates SEMO in Home Opener

The No. 4 Texas Longhorns kicked off their season with a 119-47 win over Southeast Missouri State (SEMO) on Sunday at Moody Center. This victory marked Texas' 13th consecutive home opener win, establishing a strong start to the 2024-2




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LSU women's basketball dominates Charleston Southern as Aneesah Morrow shines for Tigers

LSU women's basketball bucked a bit of a slow start to blowout Charleston Southern Tuesday morning.




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2024 NSW Premier’s History Awards – Call for nominations

Wednesday 14 February 2024
Call for nominations.




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Genomic Analysis of Reactive Astrogliosis

Jennifer L. Zamanian
May 2, 2012; 32:6391-6410
Neurobiology of Disease




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Transcriptomic Correlates of State Modulation in GABAergic Interneurons: A Cross-Species Analysis

GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical, and functional properties. In mouse visual cortex, they also differ in their modulation with an animal’s behavioral state, and this state modulation can be predicted from the first principal component (PC) of the gene expression matrix. Here, we ask whether this link between transcriptome and state-dependent processing generalizes across species. To this end, we analysed seven single-cell and single-nucleus RNA sequencing datasets from mouse, human, songbird, and turtle forebrains. Despite homology at the level of cell types, we found clear differences between transcriptomic PCs, with greater dissimilarities between evolutionarily distant species. These dissimilarities arise from two factors: divergence in gene expression within homologous cell types and divergence in cell-type abundance. We also compare the expression of cholinergic receptors, which are thought to causally link transcriptome and state modulation. Several cholinergic receptors predictive of state modulation in mouse interneurons are differentially expressed between species. Circuit modelling and mathematical analyses suggest conditions under which these expression differences could translate into functional differences.




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Upcoming launch of FAO's State of Food and Agriculture 2020

On 26 November 2020, 15:00 - 16:30 (CET), FAO will launch the 2020 edition of the State of Food and Agriculture (SOFA).

This year's edition of this flagship publication presents [...]




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Coming July 27: There's More to That from Smithsonian magazine and PRX

Smithsonian magazine covers history, science and culture in the way only it can — through a lens on the world that is insightful and grounded in richly reported stories. On There's More to That, meet the magazine's journalists and hear how they discover the forces behind the biggest issues of our time. 




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Academy Award Nominee Kathleen Turner Discusses Political Journalist Molly Ivins

More on Kathleen Turner and her show at Arena Stage: http://j.mp/T0IkkZ Before taking the stage in "Red Hot Patriot: The Kick-Ass Wit of Molly Ivins," Academy Award nominee Kathleen Turner discusses the woman who inspired the show.




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Superhero Comic Book and Movie Storytelling

Watch a course video excerpt from Rise of the Superheroes: The legendary Stan Lee, creator of the Avengers, Spiderman and Iron Man, has partnered with the Smithsonian National Museum of American History to launch the first global online course about superheroes to fans around the world.




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Biomimicry and Butterflies: How Nature is Inspiring Design and Innovation

More on biomimicry: http://j.mp/RI3OOB Scientists believe the iridescent wings of the morphos butterfly could be used in technology to benefit humans.