ba DNA on 100-year-old bat from France may help fight deadly fungus in North America By insider.si.edu Published On :: Tue, 24 Oct 2017 15:26:01 +0000 A bat specimen collected in France at the end of World War I, since housed in the collections of the Smithsonian’s National Museum of Natural […] The post DNA on 100-year-old bat from France may help fight deadly fungus in North America appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature bats National Museum of Natural History Smithsonian Conservation Biology Institute
ba Earth’s oceans are losing their breath. Here’s the global scope By insider.si.edu Published On :: Thu, 04 Jan 2018 19:01:17 +0000 In the past 50 years, the amount of water in the open ocean with zero oxygen has increased more than fourfold. In coastal water bodies, […] The post Earth’s oceans are losing their breath. Here’s the global scope appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature climate change Smithsonian Environmental Research Center
ba More sky puppies! Scientists discover two new species of dog-faced bat By insider.si.edu Published On :: Mon, 15 Jan 2018 16:33:57 +0000 Flitting swiftly through the darkness above the tropical forest canopy in Central and South America, a group of cute little bats with dog-like faces have […] The post More sky puppies! Scientists discover two new species of dog-faced bat appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature bats mammals National Museum of Natural History new species Smithsonian Tropical Research Institute
ba Study of bacteria inside guts of wild Canada geese shows greater danger than earlier studies exposed By insider.si.edu Published On :: Thu, 31 May 2018 13:40:08 +0000 In the early 20th century, Canada geese were considered endangered in the U.S. So in the 1950s and 1960s, birds from the Midwest were released […] The post Study of bacteria inside guts of wild Canada geese shows greater danger than earlier studies exposed appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature birds conservation biology National Museum of Natural History veterinary medicine
ba Scientists track a mysterious songbird using tiny backpack locators By insider.si.edu Published On :: Tue, 07 Aug 2018 14:27:33 +0000 Little to nothing is known about how and where a small European songbird called the bluethroat spends much of the year. Now, Smithsonian scientists have […] The post Scientists track a mysterious songbird using tiny backpack locators appeared first on Smithsonian Insider. Full Article Animals History & Culture Research News Science & Nature birds endangered species Migratory Bird Center Smithsonian's National Zoo
ba Smithsonian scientists become shark detectives to track species in the Chesapeake Bay By insider.si.edu Published On :: Thu, 13 Sep 2018 15:54:37 +0000 When many people think of the Chesapeake Bay, one of the first creatures that comes to mind is the iconic blue crab. But parts of […] The post Smithsonian scientists become shark detectives to track species in the Chesapeake Bay appeared first on Smithsonian Insider. Full Article Animals Marine Science Science & Nature Chesapeake Bay Smithsonian Environmental Research Center
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ba Structural basis of carbohydrate binding in domain C of a type I pullulanase from Paenibacillus barengoltzii By scripts.iucr.org Published On :: 2020-04-23 Pullulanase (EC 3.2.1.41) is a well known starch-debranching enzyme that catalyzes the cleavage of α-1,6-glycosidic linkages in α-glucans such as starch and pullulan. Crystal structures of a type I pullulanase from Paenibacillus barengoltzii (PbPulA) and of PbPulA in complex with maltopentaose (G5), maltohexaose (G6)/α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) were determined in order to better understand substrate binding to this enzyme. PbPulA belongs to glycoside hydrolase (GH) family 13 subfamily 14 and is composed of three domains (CBM48, A and C). Three carbohydrate-binding sites identified in PbPulA were located in CBM48, near the active site and in domain C, respectively. The binding site in CBM48 was specific for β-CD, while that in domain C has not been reported for other pullulanases. The domain C binding site had higher affinity for α-CD than for G6; a small motif (FGGEH) seemed to be one of the major determinants for carbohydrate binding in this domain. Structure-based mutations of several surface-exposed aromatic residues in CBM48 and domain C had a debilitating effect on the activity of the enzyme. These results suggest that both CBM48 and domain C play a role in binding substrates. The crystal forms described contribute to the understanding of pullulanase domain–carbohydrate interactions. Full Article text
ba New book reveals tidal freshwater wetlands are on frontlines of global change By insider.si.edu Published On :: Wed, 18 Nov 2009 17:25:10 +0000 Tidal Freshwater Wetlands focuses on wetlands found in North America and Europe near the mouths of rivers that flow into estuaries like the Chesapeake Bay. The post New book reveals tidal freshwater wetlands are on frontlines of global change appeared first on Smithsonian Insider. Full Article Book Review Marine Science Research News Science & Nature
ba DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos [RESEARCH ARTICLE] By jcs.biologists.org Published On :: 2020-04-07T06:45:08-07:00 Bipasha Dey and Richa RikhyCell shape morphogenesis from spherical to polygonal occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array. Each cortical syncytial division cycle shows circular to polygonal plasma membrane transition along with furrow extension between adjacent nuclei from interphase to metaphase. In this study, we assess the relative contribution of DE-cadherin and Myosin II at the furrow for polygonal shape transition. We show that polygonality initiates during each cortical syncytial division cycle when the furrow extends from 4.75 to 5.75 µm. Polygon plasma membrane organization correlates with increased junctional tension, increased DE-cadherin and decreased Myosin II mobility. DE-cadherin regulates furrow length and polygonality. Decreased Myosin II activity allows for polygonality to occur at a lower length than controls. Increased Myosin II activity leads to loss of lateral furrow formation and complete disruption of polygonal shape transition. Our studies show that DE-cadherin-Myosin II balance regulates an optimal lateral membrane length during each syncytial cycle for polygonal shape transition. Full Article
ba F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos [SHORT REPORT] By jcs.biologists.org Published On :: 2020-04-23T01:49:49-07:00 Aparna Sherlekar, Gayatri Mundhe, Prachi Richa, Bipasha Dey, Swati Sharma, and Richa RikhyBranched actin networks driven by Arp2/3 collaborate with actomyosin filaments in processes such as cell migration. The syncytial Drosophila blastoderm embryo also shows expansion of apical caps by Arp2/3 driven actin polymerization in interphase and buckling at contact edges by MyosinII to form furrows in metaphase. Here we study the role of Syndapin (Synd), an F-BAR domain containing protein in apical cap remodelling prior to furrow extension. synd depletion showed larger apical caps. STED super-resolution and TIRF microscopy showed long apical actin protrusions in caps in interphase and short protrusions in metaphase in control embryos. synd depletion led to sustained long protrusions even in metaphase. Loss of Arp2/3 function in synd mutants partly reverted defects in apical cap expansion and protrusion remodelling. MyosinII levels were decreased in synd mutants and MyosinII mutant embryos have been previously reported to have expanded caps. We propose that Syndapin function limits branching activity during cap expansion and affects MyosinII distribution in order to shift actin remodeling from apical cap expansion to favor lateral furrow extension. Full Article
ba Cdc24 interacts with the septins to create a positive feedback during bud site assembly in yeast [RESEARCH ARTICLE] By jcs.biologists.org Published On :: 2020-04-29T02:35:34-07:00 Julian Chollet, Alexander Dünkler, Anne Bäuerle, Laura Vivero-Pol, Medhanie A. Mulaw, Thomas Gronemeyer, and Nils JohnssonYeast cells select the position of their new bud at the beginning of each cell cycle. The recruitment of the septins to this prospective bud site is one of the critical events in a complex assembly pathway that culminates in the outgrowth of a new daughter cell. Hereby, the septin-rods follow the high concentration of Cdc42GTP that is generated by the focused localization of its GEF Cdc24. We show that shortly before budding Cdc24 not only activates Cdc42 but also transiently interacts with Cdc11, the septin subunit that caps both ends of the septin rods. Mutations in Cdc24 reducing the affinity to Cdc11 impair septin recruitment and decrease the stability of the polarity patch. The interaction between septins and Cdc24 thus reinforces bud assembly at sites where septin structures are formed. Once the septins polymerize into the ring, Cdc24 is found at the cortex of the bud and directs its further outgrowth from this position. Full Article
ba Tetrahymena Poc5 is a transient basal body component that is important for basal body maturation [RESEARCH ARTICLE] By jcs.biologists.org Published On :: 2020-04-29T02:35:34-07:00 Westley Heydeck, Brian A. Bayless, Alexander J. Stemm-Wolf, Eileen T. O'Toole, Amy S. Fabritius, Courtney Ozzello, Marina Nguyen, and Mark WineyBasal bodies (BBs) are microtubule-based organelles that template and stabilize cilia at the cell surface. Centrins ubiquitously associate with BBs and function in BB assembly, maturation, and stability. Human POC5 (hPOC5) is a highly conserved centrin-binding protein that binds centrins through Sfi1p-like repeats and is required for building full-length, mature centrioles. Here, we use the BB-rich cytoskeleton of Tetrahymena thermophila to characterize Poc5 BB functions. Tetrahymena Poc5 (TtPoc5) uniquely incorporates into assembling BBs and is then removed from mature BBs prior to ciliogenesis. Complete genomic knockout of TtPOC5 leads to a significantly increased production of BBs yet a markedly reduced ciliary density, both of which are rescued by reintroduction of TtPoc5. A second Tetrahymena POC5-like gene, SFR1, is similarly implicated in modulating BB production. When TtPOC5 and SFR1 are co-deleted, cell viability is compromised, and levels of BB overproduction are exacerbated. Overproduced BBs display defective transition zone formation and a diminished capacity for ciliogenesis. This study uncovers a requirement for Poc5 in building mature BBs, providing a possible functional link between hPOC5 mutations and impaired cilia. Full Article
ba Bombarded with ultraviolet light, the blue Hope diamond glows red By insider.si.edu Published On :: Wed, 19 Aug 2009 12:17:53 +0000 The Hope Diamond’s red glow has long been considered a unique property of that stone. Most blue diamonds produce a bluish-white phosphorescence if exposed to ultraviolet light. The few other diamonds known to emit red phosphorescence were commonly assumed to have been from the even larger original stone from which the Hope was cut. The post Bombarded with ultraviolet light, the blue Hope diamond glows red appeared first on Smithsonian Insider. Full Article Earth Science Research News Science & Nature collections geology National Gem Collection National Museum of Natural History rocks & minerals
ba Beautiful plastic sculptures tell ugly story of human garbage in the ocean By insider.si.edu Published On :: Mon, 11 Jul 2016 01:56:41 +0000 Great white sharks, killer whales, sea lions, even polar bears—the ocean is full of giant predators. But one of the ocean’s worst enemies is not […] The post Beautiful plastic sculptures tell ugly story of human garbage in the ocean appeared first on Smithsonian Insider. Full Article Animals Art Earth Science Marine Science Science & Nature biodiversity birds conservation conservation biology fishes insects pollution Smithsonian Conservation Biology Institute Smithsonian's National Zoo
ba Battle against invasive marine species comes up short as global shipping surges By insider.si.edu Published On :: Tue, 28 Mar 2017 14:11:35 +0000 In the battle against invasive species, giant commercial ships are on the front lines. But even when they follow the rules, one of their best […] The post Battle against invasive marine species comes up short as global shipping surges appeared first on Smithsonian Insider. Full Article Animals Earth Science Marine Science Research News Science & Nature Chesapeake Bay conservation biology invasive species Smithsonian Environmental Research Center
ba After a nearly 20-year search, this Jamaican bird is probably extinct By insider.si.edu Published On :: Tue, 01 May 2018 11:07:45 +0000 The Jamaican golden swallow was last seen in 1982. From 1994 to 2012, Smithsonian ornithologist Gary Graves combed the island of Jamaica to document several […] The post After a nearly 20-year search, this Jamaican bird is probably extinct appeared first on Smithsonian Insider. Full Article Animals Earth Science Science & Nature birds Caribbean conservation biology endangered species extinction National Museum of Natural History
ba Bayesian machine learning improves single-wavelength anomalous diffraction phasing By scripts.iucr.org Published On :: 2019-10-07 Single-wavelength X-ray anomalous diffraction (SAD) is a frequently employed technique to solve the phase problem in X-ray crystallography. The precision and accuracy of recovered anomalous differences are crucial for determining the correct phases. Continuous rotation (CR) and inverse-beam geometry (IBG) anomalous data collection methods have been performed on tetragonal lysozyme and monoclinic survivin crystals and analysis carried out of how correlated the pairs of Friedel's reflections are after scaling. A multivariate Bayesian model for estimating anomalous differences was tested, which takes into account the correlation between pairs of intensity observations and incorporates the a priori knowledge about the positivity of intensity. The CR and IBG data collection methods resulted in positive correlation between I(+) and I(−) observations, indicating that the anomalous difference dominates between these observations, rather than different levels of radiation damage. An alternative pairing method based on near simultaneously observed Bijvoet's pairs displayed lower correlation and it was unsuccessful for recovering useful anomalous differences when using the multivariate Bayesian model. In contrast, multivariate Bayesian treatment of Friedel's pairs improved the initial phasing of the two tested crystal systems and the two data collection methods. Full Article text
ba The atomic structure of the Bergman-type icosahedral quasicrystal based on the Ammann–Kramer–Neri tiling By scripts.iucr.org Published On :: 2020-02-11 In this study, the atomic structure of the ternary icosahedral ZnMgTm quasicrystal (QC) is investigated by means of single-crystal X-ray diffraction. The structure is found to be a member of the Bergman QC family, frequently found in Zn–Mg–rare-earth systems. The ab initio structure solution was obtained by the use of the Superflip software. The infinite structure model was founded on the atomic decoration of two golden rhombohedra, with an edge length of 21.7 Å, constituting the Ammann–Kramer–Neri tiling. The refined structure converged well with the experimental diffraction diagram, with the crystallographic R factor equal to 9.8%. The Bergman clusters were found to be bonded by four possible linkages. Only two linkages, b and c, are detected in approximant crystals and are employed to model the icosahedral QCs in the cluster approach known for the CdYb Tsai-type QC. Additional short b and a linkages are found in this study. Short interatomic distances are not generated by those linkages due to the systematic absence of atoms and the formation of split atomic positions. The presence of four linkages allows the structure to be pictured as a complete covering by rhombic triacontahedral clusters and consequently there is no need to define the interstitial part of the structure (i.e. that outside the cluster). The 6D embedding of the solved structure is discussed for the final verification of the model. Full Article text
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ba Preventing ballast-water invasions of alien species By insider.si.edu Published On :: Tue, 10 Nov 2009 16:48:31 +0000 George Smith, a marine biologist at the Smithsonian Environmental Research Center, explains his work of finding ways to prevent invasive species from being released in Baltimore Harbor in the ballast water of large ships. The post Preventing ballast-water invasions of alien species appeared first on Smithsonian Insider. Full Article Marine Science Research News Science & Nature Video Chesapeake Bay invasive species Smithsonian Environmental Research Center
ba Keeper Tracey Barnes talks about the National Zoo’s Andean bear, Billie Jean, and her two new cubs By insider.si.edu Published On :: Mon, 07 Jun 2010 17:29:09 +0000 Keeper Tracey Barnes talks about Billie Jean, an Andean bear, and her two new cubs at the Smithsonian's National Zoo. The post Keeper Tracey Barnes talks about the National Zoo’s Andean bear, Billie Jean, and her two new cubs appeared first on Smithsonian Insider. Full Article Video
ba Tropical Research Institute entomologist David Roubik talks about his life as a scientist based in Panama By insider.si.edu Published On :: Wed, 20 Apr 2011 18:53:52 +0000 "I'm getting paid to do what I like doing," says entomologist David Roubik. He loved nature and being outdoors when he was a kid, and now he does fieldwork in the tropical forests of Panama. He loves to travel, and his research takes him around the world. Can his work, then, be called a job? The post Tropical Research Institute entomologist David Roubik talks about his life as a scientist based in Panama appeared first on Smithsonian Insider. Full Article Meet Our People Video insects Tropical Research Institute
ba Smithsonian anthropologist JoAllyn Archambault speaks about the outstanding research of 19th-century anthropologist James Mooney By insider.si.edu Published On :: Thu, 05 Apr 2012 17:46:27 +0000 The post Smithsonian anthropologist JoAllyn Archambault speaks about the outstanding research of 19th-century anthropologist James Mooney appeared first on Smithsonian Insider. Full Article Anthropology Science & Nature Video National Museum of Natural History
ba Japanese acrobats ca. 1927, footage from the Smithsonian’s Human Studies Film Archive By insider.si.edu Published On :: Thu, 14 Jun 2012 21:59:24 +0000 The post Japanese acrobats ca. 1927, footage from the Smithsonian’s Human Studies Film Archive appeared first on Smithsonian Insider. Full Article Anthropology Science & Nature Video National Museum of Natural History
ba Conrad Labandiera, Smithsonian palentologist, studies fossils to learn how insects got along before flowering plants arrived By insider.si.edu Published On :: Thu, 19 Jul 2012 16:10:16 +0000 The post Conrad Labandiera, Smithsonian palentologist, studies fossils to learn how insects got along before flowering plants arrived appeared first on Smithsonian Insider. Full Article Dinosaurs & Fossils Science & Nature Video fossils insects National Museum of Natural History prehistoric rocks & minerals
ba With the recent hatching of two Cuban crocodiles, the National Zoo just got a little snappier! By insider.si.edu Published On :: Wed, 25 Jul 2012 18:05:18 +0000 The post With the recent hatching of two Cuban crocodiles, the National Zoo just got a little snappier! appeared first on Smithsonian Insider. Full Article Animals Science & Nature Video conservation conservation biology crocodiles endangered species reptiles Smithsonian's National Zoo
ba Meet our Scientist Rachel Page. She studies frog-eating bats, and other animals, in Panama By insider.si.edu Published On :: Tue, 27 Nov 2012 18:33:40 +0000 Meet Rachel Page, a Smithsonian scientist in Panama who studies frog-eating bats (fringe-lipped bats), among other topics. Her current research focuses on learning and memory in neotropical bats, combining field studies with laboratory experiments to learn about predator cognition and its effects on the evolution of their prey. The post Meet our Scientist Rachel Page. She studies frog-eating bats, and other animals, in Panama appeared first on Smithsonian Insider. Full Article Animals Meet Our People Science & Nature Video amphibian bats conservation conservation biology frogs mammals Tropical Research Institute
ba Belize’s South Water Caye Marine Reserve protects biodiversity of Belizean Barrier Reef By insider.si.edu Published On :: Mon, 25 Feb 2013 15:40:01 +0000 The post Belize’s South Water Caye Marine Reserve protects biodiversity of Belizean Barrier Reef appeared first on Smithsonian Insider. Full Article Marine Science Science & Nature Video
ba Barro Colorado Island: The Smithsonian’s research outpost in the Panama Canal By insider.si.edu Published On :: Tue, 23 Apr 2013 16:12:08 +0000 The post Barro Colorado Island: The Smithsonian’s research outpost in the Panama Canal appeared first on Smithsonian Insider. Full Article Video conservation mammals Tropical Research Institute
ba Scientists Maria Banks and Sharon Purdy explain how to take your own photo of Mars. By insider.si.edu Published On :: Tue, 25 Jun 2013 18:17:48 +0000 Smithsonian planetary geologists Sharon Purdy and Maria Banks explain how you can take your very own photo of Mars. The post Scientists Maria Banks and Sharon Purdy explain how to take your own photo of Mars. appeared first on Smithsonian Insider. Full Article Research News Science & Nature Video
ba Toadfish (Batrachoididae) babies in Bocas del Toro, Panama By insider.si.edu Published On :: Thu, 05 Sep 2013 17:35:34 +0000 Bocas Research Station’s research assistant Arcadio Castillo ran into these curious looking fish babies while working close to the dock. After some investigation, we found […] The post Toadfish (Batrachoididae) babies in Bocas del Toro, Panama appeared first on Smithsonian Insider. Full Article Animals Marine Science Research News Science & Nature Video
ba Rockin’ out: Bats learn to love heavy metal music By insider.si.edu Published On :: Wed, 08 Oct 2014 10:00:56 +0000 How do you train a wild animal to come back to you after you have set it free? If it is a fringe-lipped bat, Trachops […] The post Rockin’ out: Bats learn to love heavy metal music appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature Video bats conservation biology guitar mammals music Tropical Research Institute
ba Bao Bao’s First Snow Day By insider.si.edu Published On :: Wed, 07 Jan 2015 14:17:23 +0000 Jan. 6, 2015—As the year’s first blanket of snow coated the Washington, D.C. area today, giant panda Bao Bao at the Smithsonian’s National Zoological Park […] The post Bao Bao’s First Snow Day appeared first on Smithsonian Insider. Full Article Animals Science & Nature Video giant panda Smithsonian's National Zoo
ba Five Critically endangered Cuban crocodiles hatched at National Zoo By insider.si.edu Published On :: Thu, 13 Aug 2015 13:34:36 +0000 Five critically endangered Cuban crocodiles hatched at the National Zoo’s Reptile Discovery Center between July 29 and Aug. 7. The eggs were laid by Dorothy, […] The post Five Critically endangered Cuban crocodiles hatched at National Zoo appeared first on Smithsonian Insider. Full Article Animals Research News Science & Nature Video biodiversity conservation conservation biology crocodiles endangered species extinction new acquisitions reptiles Smithsonian's National Zoo
ba Aaron Koblin and Ben Tricklebank-Light Echoes By insider.si.edu Published On :: Mon, 13 Jun 2016 13:41:09 +0000 This video is featured in the exhibition Beauty—Cooper Hewitt Design Triennial, on view at the museum February – August 2016. About: Aaron Koblin collaborates with […] The post Aaron Koblin and Ben Tricklebank-Light Echoes appeared first on Smithsonian Insider. Full Article Art Video Cooper Hewitt visual arts
ba Basque Country & Cheese By insider.si.edu Published On :: Thu, 30 Jun 2016 16:40:26 +0000 Food is an important element of Basque life. In the Ostatua Kitchen tent at the Smithsonian’s 2016 Folklife Festival, chefs from two Basque culinary schools […] The post Basque Country & Cheese appeared first on Smithsonian Insider. Full Article History & Culture Video Smithsonian Folklife Festival
ba Basque Dance Troupe “Aukeran” at Smithsonian Folklife Festival By insider.si.edu Published On :: Tue, 15 Nov 2016 13:37:28 +0000 Aukeran is a professional dance troupe from Basque country founded in 1997 by Edu Muruamendiaraz. The beautiful and graceful professional dancers have backgrounds in both […] The post Basque Dance Troupe “Aukeran” at Smithsonian Folklife Festival appeared first on Smithsonian Insider. Full Article Art History & Culture Video Smithsonian Folklife Festival
ba Reagan and Gorbachev’s Relationship Warmed Cold War Tensions By insider.si.edu Published On :: Mon, 01 May 2017 15:17:44 +0000 The post Reagan and Gorbachev’s Relationship Warmed Cold War Tensions appeared first on Smithsonian Insider. Full Article History & Culture Video National Air and Space Museum
ba Marcia Ball at the Folklife Festival By insider.si.edu Published On :: Tue, 21 Nov 2017 17:49:59 +0000 Blues singer and pianist Marcia Ball performs “Louella” at the 2008 Smithsonian Folklife Festival. The post Marcia Ball at the Folklife Festival appeared first on Smithsonian Insider. Full Article Art History & Culture Video Smithsonian Folklife Festival
ba Installation of the Obama portraits By insider.si.edu Published On :: Thu, 22 Feb 2018 12:49:23 +0000 On February 12, 2018, the Smithsonian’s National Portrait Gallery unveiled its commissioned portraits of former President Barack Obama and Mrs. Michelle Obama by artists Kehinde […] The post Installation of the Obama portraits appeared first on Smithsonian Insider. Full Article Art History & Culture Video National Portrait Gallery