BACKGROUND The anti–programmed cell death 1 (anti–PD-1) antibody pembrolizumab is clinically active against non–small cell lung cancer (NSCLC). In addition to T cells, human natural killer (NK) cells, reported to have the potential to prolong the survival of patients with advanced NSCLC, also express PD-1. This study aimed to investigate the safety and efficacy of pembrolizumab plus allogeneic NK cells in patients with previously treated advanced NSCLC.METHODS In total, 109 enrolled patients with a programmed death ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or higher were randomly allocated to group A (n = 55 patients given pembrolizumab plus NK cells) or group B (n = 54 patients given pembrolizumab alone). The patients received i.v. pembrolizumab (10 mg/kg) once every 3 weeks and continued treatment until the occurrence of tumor progression or unacceptable toxicity. The patients in group A continuously received 2 cycles of NK cell therapy as 1 course of treatment.RESULTS In our study, patients in group A had longer survival than did patients in group B (median overall survival [OS]: 15.5 months vs. 13.3 months; median progression-free survival [PFS]: 6.5 months vs. 4.3 months; P < 0.05). In group A patients with a TPS of 50% or higher, the median OS and PFS was significantly longer. Moreover, the patients in group A treated with multiple courses of NK cell infusion had better OS (18.5 months) than did those who received a single course of NK cell infusion (13.5 months).CONCLUSIONS Pembrolizumab plus NK cell therapy yielded improved survival benefits in patients with previously treated PD-L1+ advanced NSCLC.TRIAL REGISTRATION ClinicalTrials.gov NCT02843204.FUNDING This work was supported by grants from the National Natural Science Foundation of China (NSFC) – Guangdong Joint Foundation of China (no. U1601225); the NSFC (no. 81671965); the Guangdong Provincial Key Laboratory Construction Project of China (no. 2017B030314034); and the Key Scientific and Technological Program of Guangzhou City (no. 201607020016).

Tucker Carlson: Elizabeth Warren's enemies on Wall Street and Big Tech are not really her enemies. Elizabeth Warren is really just this season's Hillary Clinton -- faithful party robot, stalwart defender of the prerogatives of the establishment. Continue reading →

IBM today announced that it will help deliver a tailored fan experience through the IBM Cloud at Atlanta’s new Mercedes-Benz Stadium, scheduled to open later this month.

IBM today announced that Mammoth Resorts, the leading four-season mountain resort operator in California, is using Watson Customer Engagement solutions on the IBM Cloud to create customized offers that are helping to drive record numbers of visitors to the resort every year.

IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales.

MineHub Technologies e IBM anunciaron hoy una colaboración para utilizar la tecnología blockchain con el objetivo de mejorar la eficiencia operativa, logística, financiamiento y reducir los costos en la cadena de suministro de concentrados minerales de alto valor, desde la mina hasta el comprador final.

IBM anunció la primer app educacional IBM MobileFirst para iOS. La app, IBM Watson Element for Educators, permite un nuevo nivel de compromiso de los maestros al proveer una visión holística en la palma de las manos de cada estudiante, incluyendo data en intereses, logros, desempeño académico, asistencia, comportamientos y actividades de aprendizaje. Como resultado, los maestros están siendo empoderados con la visión de los datos que les ayudará a abarcar necesidades individuales a fin de poder llegar potencialmente a mejores resultados a través de las experiencias de los alumnos K-12 (Primaria y Secundaria).

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1. Queen Elizabeth's VE Day speech says veterans would be proud of coronavirus effort today  ABC News
2. Queen’s VE Day TV address: Tells Brits to ‘never give up’  NEWS.com.au
3. 'Streets filled with love': The Queen gets personal in VE Day broadcast  Sydney Morning Herald
4. King George VI VE Day speech: Read poignant message 'Our will-power is inexhaustible'  Express
5. A message of hope in difficult times  Telegraph.co.uk
6. View Full coverage on Google News

Once a month (or so), I share a dozen things that have inspired me to greater personal, professional, and financial success in my life. I hope they bring similar success to your life. Please enjoy the archives of earlier collections of inspirational things. This month’s installment is heavily geared toward things that have inspired me to better writing, being a better parent, being a better husband, and keeping my head on straight during this most challenging of times. 1. Winnie […]

The post Inspiration from Brooke Foss Westcott, Handwritten Letters, Elizabeth Gilbert, and More appeared first on The Simple Dollar.

  COVID-19 is having an immediate and drastic impact on the construction industry with job sites being abandoned and workers being furloughed. A byproduct of these unprecedented pandemic-related changes has been the demobilization of

Sociologists studying emotion have opened up the inner, private feelings of anger, fear, shame, and love to reveal the far-reaching effects of social forces on our most personal experiences. This subfield has given us new words to make sense of shared experiences: emotional labor in our professional lives, collective effervescence at sporting events and concerts, […]

Brian May was admitted to a hospital earlier this week  ...for a torn butt. The guitarist/astrophysicist injured himself while gardening, which is a bit reminiscent of the line from the movie This Is Spinal Tap in which one drummer's death is attributed to a "bizarre gardening accident." May is expected to recover, but it may take some time.  

Writing on Instagram, the Queen guitarist said: “I managed to rip my gluteus maximus to shreds in a moment of overenthusiastic gardening. So suddenly I find myself in a hospital getting scanned to find out exactly how much I’ve actually damaged myself. Turns out I did a thorough job – this is a couple of days ago – and I won’t be able to walk for a while … or sleep, without a lot of assistance, because the pain is relentless.”

May is 72, and had been at his home after Queen was forced to cancel a tour due to the pandemic. Now he is recovering at home, and requests peace and quiet. -via reddit

By Dan Duddy  Published: May 08th, 2020 

I am going to explain what, in my opinion, is the correct social marketing theory. Not just that, I am also going to explain 2 ways to make good use of it in your business.

The following summarize enforcement actions the U.S. Environmental Protection Agency’s Region 10 office completed in January and February of 2020. The concluding legal document(s) typically provide details of the case and are included at the end of each summary.

SAN FRANCISCO - Today, the U.S. Environmental Protection Agency (EPA) announced nine projects across California will receive a total of nearly $4 million to assess and clean up contaminated properties under the agency’s Brownfields Program.

Early May weather finally brought spring relief to my family weary from weeks of dreary weather and sheltering in place. Inexplicably a dance party had broken out; the boys, giddy from the arrival of two rabbits — pandemic pets — were dancing with their grandmother as my wife and I looked on, sipping evening cocktails. Then an absentminded Twitter check confronted me with the shocking video of Ahmaud Arbery, a young black Georgian, being hunted down and killed by two white men.

A Brooklyn woman discovered a wayward rooster living on the streets in Park Slope, and took it home in hopes of finding out who he belonged to.

Rona Phillips, the principal of KAPPA V High School in Brownsville, is in intensive care with pneumonia, officials said. “Our thoughts are with Principal Phillips and her family for a speedy recovery, and we’ll support the school community in every way we can,” said Education Department spokeswoman Miranda Barbot.

At Stuyvesant High School in Manhattan, the city’s most selective public high school, only 10 black students and 20 Latino students got admissions offers, out of nearly 800 students accepted, data shows.

The proposal comes as city officials announced that only 11% of students admitted to specialized schools this year were black or Latino, compared to 70% of all city students, a figure virtually unchanged from years past.

Rona Phillips, the principal of KAPPA V High School in Brownsville, is in intensive care with pneumonia, officials said. “Our thoughts are with Principal Phillips and her family for a speedy recovery, and we’ll support the school community in every way we can,” said Education Department spokeswoman Miranda Barbot.

Elizabeth Warren touted her own “universal workers’ bill of rights" and said of New Yorkers, "I’m glad to see people who are picking up this idea at the state level."

Scientists injected CRISPR gene-editing machinery into unfertilized eggs still developing in female lizards’ ovaries.

Does a flat-bar gravel bike appeal to you, or is this just a mountain bike with not enough tire clearance?
( Photos: 5, Comments: 214 )

Former USC linebacker Quinton Powell is pleading for others to stay safe after being hospitalized while experiencing symptoms of the coronavirus illness.

When I came home from college because of the coronavirus outbreak, my eighth-grade English teacher, my mentor, postponed a meeting with me. She had a fever and a cough.

The Angels beat the Seattle Mariners 2-0 in a spring training game at Tempe Diablo Stadium in Tempe, Ariz.

Former Angels and Cardinals standout Jim Edmonds announces on social media he's in the hospital and undergoing testing for the coronavirus.

A pandemic, one would think, is indiscriminate, targeting rich and poor alike. But the coronavirus is making inequality worse.

(MedPage Today) -- There was no difference in risk of intubation or death in hospitalized patients with COVID-19 coronavirus infection treated with hydroxychloroquine, an antimalarial also used in the treatment of certain autoimmune diseases, compared...

Kings GM Rob Blake said the roster needed to be reshaped after he traded Kyle Clifford and Jack Campbell to Toronto. He should have known long ago.

Vin Scully is in the hospital after falling at home, but the former Dodgers broadcaster is resting comfortably, the team says.

Queen Latifah will star in a CBS reboot of the 1980s drama series "The Equalizer."

Elizabeth Warren touted her own “universal workers’ bill of rights" and said of New Yorkers, "I’m glad to see people who are picking up this idea at the state level."

"Hair Love" filmmakers Matthew A. Cherry and Karen Rupert Toliver discuss their animated short, which is nominated for a 2020 Oscar.

Nominated for her work in 'Bombshell,' Theron has turned heads on the red carpet this season.

In Los Feliz, comedy writer Tim Long sells a 1920s Colonial once owned by Katherine Heigl for $4.3 million. The new owner is Neil Finn of Fleetwood Mac.

In Los Feliz, a Spanish Colonial-style residence features original details and a tie to Bel-Air Presbyterian Church's organizing pastor. Asking price: $4.877 million.

Eels frontman Mark Oliver Everett is asking $4.4 million for his romantic Spanish villa in Los Feliz, the neighborhood where he formed the band.

QUEEN ELIZABETH II has ruled Britain for nearly 70 years, and many of us cannot remember a time when she was not on the throne. And during her long reign, one item in particular has become synonymous with the monarch.

QUEEN ELIZABETH II, 94, is the world's best-travelled monarch and has visited countries all over the world. Prince Philip, 98, often joins her on her many travels - but there's one thing he hates.

Senior caps 36-point night with winning 3-pointer