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Galacto-oligosaccharides regulates intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper
Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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Influence of dairy matrix on the prebiotic effects of inulin related to gut metabolic activity and bone health

Food Funct., 2024, 15,11129-11140
DOI: 10.1039/D4FO01635A, Paper
Xiaorui Zhao, Weiwei He, Louise M. A. Jakobsen, Farhad M. Panah, Banny Silva Barbosa Correia, Dennis Sandris Nielsen, Axel K. Hansen, Hanne Christine Bertram
This study investigated if the prebiotic efficacy of inulin depends on the dairy matrix used as vehicle.
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Dynamic changes in the gel properties, microbial community, and volatile flavor profile of Spanish mackerel (Scomberomorus niphonius) sausages inoculated with Lactiplantibacillus plantarum CY1-2

Food Funct., 2024, 15,11060-11071
DOI: 10.1039/D4FO03841J, Paper
Xinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin Yi
This study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.
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Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder

Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper
Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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Taliban appoint ‘Acting Consul’ at the Afghan Consulate General in Mumbai

Ikramuddin Kamil has been appointed as the ‘Acting Consul’ at the Afghan mission in Mumbai, Bakhtar News Agency said.




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First brown dwarf ever found throws up surprise three decades later

Brown dwarfs are neither a star nor a planet, but something in between




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Medicinal foods: A missing category on the regulator’s plate

When medicinal foods are regulated as foods, they are subjected to lower efficacy and safety standards than if they were medicines, putting consumers at risk




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India’s first analog space mission to simulate extra-terrestrial conditions on Mars and Moon kicks off 




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RSC - Toxicol. Res. latest articles




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Unsupervised pattern recognition on the surface of simulated metal nanoparticles for catalytic applications

Catal. Sci. Technol., 2024, 14,6651-6661
DOI: 10.1039/D4CY01000K, Paper
Jonathan Y. C. Ting, George Opletal, Amanda S. Barnard
The structural patterns and catalytic activities of the surface atoms of simulated metal nanoparticles are characterised by an automatable data-driven unsupervised machine learning approach.
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High sensing performance flexible nanocomposite sensor with a hybrid nanostructure constructed via nanoscale confined motion of nanofibers and nanoplatelets

Nanoscale, 2024, 16,20288-20303
DOI: 10.1039/D4NR02541E, Paper
Zhenghui Xie, Feiran Meng, Junlong Yang, Yuhong Wang, Chul B. Park, Pengjian Gong, Guangxian Li
Hybrid 1D nanofiber/2D nanoplatelet nanocomposite foam sensor and Monte-Carlo modelling of complex 1D/2D sensing nanostructure.
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Dual metal centers within a water-stable Co/Ni bimetallic metal-triazolate framework contribute to durable photocatalysis for water treatment

Nanoscale, 2024, 16,20082-20088
DOI: 10.1039/D4NR03940H, Communication
Minling Zheng, Yubo Liu, Qifu Zhang, Wenjing Li, Yong Zhang, Guangxue Feng, Yating Hu, Shaoming Huang
A bimetallic CoNi-MET with fixed metal occupancy combines the strong water resistance of Co-MET with the high porosity of a Ni-MET.
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Glycosylated AIE-active Fe (III) photosensitizer activated by tumor microenvironment for synergistic type I photodynamic and chemodynamic therapy

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03871A, Paper
Gai-li Feng, Wei Zhou, Jinping Qiao, Guang-Jian Liu, Guo-Wen Xing
Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are both promising cancer treatments to inhibit tumor cells by generating highly cytotoxic reactive oxygen species (ROS). Herein, we report a novel tumor...
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DON encapsulated carbon dot–vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR00426D, Paper
Afreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh, Prasanta Kumar Das
HACD–TMAV, a carbon dot–vesicle conjugate, selectively delivered glutamine inhibitor DON to CD44-enriched cancer cells, inducing ROS triggered apoptosis by dual targeting CD44 and SLC1A5 through downregulation of PI3K/AKT/mTOR signalling cascade.
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A liposome-based assay for cancer biomarker detection: exploring the correlation between platelet-derived microvesicles and NSCLC-associated miRNAs

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03704A, Paper
Mohamed Aimene Benariba, Kanza Hannachi, Sha Zhu, Yuting Zhang, Xiaoli Wang, Nandi Zhou
This research reveals a significant correlation between PMVs and their associated miRNA. Additionally, the liposome-based assay demonstrates enhanced sensitivity with calcium-induced platelet activation.
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Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Biomater. Sci., 2024, 12,1801-1821
DOI: 10.1039/D3BM01688A, Paper
Manju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti Panda
The graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.
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A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00003J, Paper
Jing Liu, Jie Zhang, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu, Xianglong Hu, Weiling He
Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.
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Escape sites from the endo-lysosomal trafficking route manipulate exocytosis of nanoparticles in polar epithelium

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00174E, Paper
Lingling Wang, Yuting Li, Xi Liu, Liyun Xing, Ruinan Wu, Yuan Huang
MNPs escaping from early endosomes and late endosomes are prone to entering the ER/GA for efficient basolateral exocytosis. However, MNPs escaping from lysosomes are detained within cells by autophagosomes.
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Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01055D, Review Article
Ziba Zakeri, Morteza Heiderzadeh, Azra Kocaarslan, Ecem Metin, Seyed Nasir Hosseini Karimi, Sepideh Saghati, Atay Vural, Göktuğ Akyoldaş, Kemal Baysal, Yusuf Yağcı, Yasemin Gürsoy-Özdemir, Savaş Taşoğlu, Reza Rahbarghazi, Emel Sokullu
The targeted delivery of pharmacologically active molecules, metabolites, and growth factors to the brain parenchyma has become one of the major challenges following the onset of neurodegeneration and pathological conditions.
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A nanoparticle reinforced microporous methacrylated silk fibroin hydrogel to promote bone regeneration

Biomater. Sci., 2024, 12,2121-2135
DOI: 10.1039/D3BM01901B, Paper
Ruideng Wang, Xi He, Zhengyang Chen, Shilong Su, Jinwu Bai, Haifeng Liu, Fang Zhou
A photo-crosslinked nanocomposite hydrogel was prepared by incorporating an osteo-inductive inorganic nanoparticle for endogenous bone regeneration.
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Recent progress in nanomaterials for bacteria-related tumor therapy

Biomater. Sci., 2024, 12,1965-1980
DOI: 10.1039/D3BM01952G, Review Article
Fuping Zhang, Shuyu Wang, Shuo Yang, Feihe Ma, Hui Gao
Recent progress in nanomaterials for bacteria-related tumor therapy in terms of chemotherapy, immunotherapy and synergistic therapy is summarized in this review in order to provide some insights into this emerging and rapidly growing research area.
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css-tricks.com and FOUC on latest Firefox

Hi guys. I am experiencing FOUC when visiting css-tricks.com on latest Firefox Developer Edition. Do you have the same problem?

Here is the video demo video




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Fold into the future with Samsung’s latest line-up

Foldables, smartwatches and the all-new smart ring




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Centre warns of action against latecomers to work, early goers 

Punctuality of employees to be taken into account while considering important assignments, deputations and postings




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Block printing & book illustration in Japan / by Louise Norton Brown ; with forty-three plates (eighteen in colours). and copious indexes of titles and artists.

London : George Routledge & Sons, Ltd. ; New York : E. P. Dutton & Co., 1924.




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Bacon is Shake-speare, by Sir Edwin Durning-Lawrence, bt. Together with a reprint of Bacon's Promus of formularies and elegancies collated, with the original MS. by the late F. B. Bickley and revised by F. A. Herbert, of the British Musuem.

London : Gay & Hancock, Ltd., 12 & 13, Henrietta Street, Covent Garden, W.C., and New York, MCMX. [1910]




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Twenty sermons, on various subjects. / by the late Reverend Mr Jonathan Edwards, President of the College of New-Jersey.

Edinburgh: : Printed by Alex. Lawrie and Co. for John Fairbairn and Ogle & Aikman; and W. Coke, Leith., 1804.




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The Queen's pardon : the story of two deserters / told by Rev. J. R. Walkey, M.A., C.B.E. late Chaplain-in-Chief, R.A.F.

[Wimbledon] : [Arthur Mercer], [1946]




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The communicant's companion: : or, instructions and helps for the right receiving of the Lord's supper. / By Mr. Matthew Henry late Minister of the Gospel..

Edinburgh : Printed by Thomas Lumisden and John Robertson, and sold at their printing-house in the Fish-market, M.DCC.XXXVII [1737]




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Mishru’s latest drop fuses botanical elements with architectural inspirations 

Mishru’s new couture edit of lehengas, cocktail dresses, and jumpsuits, showcases a fusion of botanical elements and architectural inspirations 




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Designer Sanjay Garg of Raw Mango fuses Mughal and Rajputana traditions in his latest festive line

Raw Mango’s Sanjay Garg fuses Mughal and Rajputana traditions to create a joyful line in jewel tones for the festive season




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Cricket has much on its plate, including a new disruptor — Jay Shah

As caretaker of the game’s treasure chest, Jay Shah might be the most powerful man in cricket ever — no W.G. Grace, Don Bradman or Sachin Tendulkar can match his combination of political, filial and financial heft.




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COP29: What is the latest science on climate change?

The last global scientific consensus on climate change was released in 2021 through the Intergovernmental Panel on Climate Change, however scientists say that evidence shows global warming and its impacts are unfolding faster than expected




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AT&C loss widens: Centre suggests States to calculate technical & commercial losses separately

The total outstanding debt of Discoms is currently around ₹6.84 lakh crore. Accumulated losses stand at ₹6.46 lakh crore.




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Nothing Phone (1): Improved camera, 5G support and ARCore with latest OS version

Nothing Phone (1) and Reliance has already collaborated on Jio True 5G support




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Trump effect on the Indian stock markets a day later

Metal and technology stocks led the slide




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Regulate supply of commodities to fair price shops, say employees