Beauveriolides, including the main beauveriolide I {systematic name: (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methyl­prop­yl)-1-oxa-4,7,10-tri­aza­cyclo­tridecane-2,5,8,11-tetrone, C27H41N3O5}, are a series of cyclo­depsipeptides that have shown promising results in the treatment of Alzheimer's disease and in the prevention of foam cell formation in atherosclerosis. Their crystal structure studies have been difficult due to their tiny crystal size and fibre-like morphology, until now. Recent developments in 3D electron diffraction methodology have made it possible to accurately study the crystal structures of submicron crystals by overcoming the problems of beam sensitivity and dynamical scattering. In this study, the absolute structure of beauveriolide I was determined by 3D electron diffraction. The cyclo­dep­si­peptide crystallizes in the space group I2 with lattice parameters a = 40.2744 (4), b = 5.0976 (5), c = 27.698 (4) Å and β = 105.729 (6)°. After dynamical refinement, its absolute structure was determined by comparing the R factors and calculating the z-scores of the two possible enanti­omorphs of beauveriolide I.

The technique of time-resolved macromolecular crystallography (TR-MX) has recently been rejuvenated at synchrotrons, resulting in the design of dedicated beamlines. Using pump–probe schemes, this should make the mechanistic study of photoactive proteins and other suitable systems possible with time resolutions down to microseconds. In order to identify relevant time delays, time-resolved spectroscopic experiments directly performed on protein crystals are often desirable. To this end, an instrument has been built at the icOS Lab (in crystallo Optical Spectroscopy Laboratory) at the European Synchrotron Radiation Facility using reflective focusing objectives with a tuneable nanosecond laser as a pump and a microsecond xenon flash lamp as a probe, called the TR-icOS (time-resolved icOS) setup. Using this instrument, pump–probe spectra can rapidly be recorded from single crystals with time delays ranging from a few microseconds to seconds and beyond. This can be repeated at various laser pulse energies to track the potential presence of artefacts arising from two-photon absorption, which amounts to a power titration of a photoreaction. This approach has been applied to monitor the rise and decay of the M state in the photocycle of crystallized bacteriorhodopsin and showed that the photocycle is increasingly altered with laser pulses of peak fluence greater than 100 mJ cm−2, providing experimental laser and delay parameters for a successful TR-MX experiment.

Since its founding in 2013, the Young Crystallographers (YC) have become one of the most active working groups not only within their parent organization, the German Crystallographic Society (DGK), but also among other young crystallographers' groups in Europe and the world. The aim of the YC is and always has been to support early-career researchers in the diverse fields of crystallography and the rejuvenation of the field on a national scale. Over the past decade, we have curated events, platforms, and educational content tailored to foster collaboration and knowledge transfer among young crystallographers. In this article, we introduce our group and show how this active and diverse community has shaped the rejuvenation of crystallography in Germany, strengthened by the support of our national society.

Canada-based fintech firm Nuvei has partnered with

Hennepin County Judge Peter Cahill sentenced former Minneapolis police officer Derek Chauvin to 22 1/2 years in prison for the murder of George Floyd.; Credit: /Court TV via AP

A Minnesota judge sentenced former Minneapolis police officer Derek Chauvin to 22 1/2 years in prison Friday for the murder of George Floyd.

Judge Peter Cahill wrote that part of the mission of the Minneapolis Police Department is to give citizens "voice and respect."

"Mr. Chauvin, rather than pursuing the MPD mission, treated Mr. Floyd without respect and denied him the dignity owed to all human beings and which he certainly would have extended to a friend or neighbor. In the Court's view, 270 months, which amounts to an additional ten years over the presumptive 150-month sentence, is the appropriate sentence."

Read Cahill's entire sentencing order and memoradum for Chauvin below.

Chauvin, 45, was convicted in April of all three charges he faced — second-degree unintentional murder, third-degree murder and second-degree manslaughter.

He was sentenced only on the first of the charges, the most serious, as is typical in Minnesota.

Cahill said Chauvin's crime included four aggravating factors: that Derek Chauvin abused a position of trust and authority as a police officer, that he treated Floyd with "particular cruelty," that he committed the crime as part of a group with at least three other people, and that children were present during the commission of the offense.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Legal responses to juvenile offending should be grounded in scientific knowledge about adolescent development and tailored to an individual offenders needs and social environment, says a new report from the National Research Council.

Every year in the United States, nearly 250,000 youths are tried, sentenced, or incarcerated as adults.

EPA should conduct an ecological risk assessment of ultraviolet filters used in sunscreens, given the evidence that aquatic ecosystems in the U.S. and possibly endangered species are exposed to these UV filters, and given the importance of these ingredients in skin cancer prevention.

Up till now, the automaker reportedly maintained that low demand for 4x4 cars has led to the absence of off-road tech in its products. In a recent conversation with TOI Auto, Shailesh Chandra, Managing Director, Tata Motors Passenger Vehicles Limited, shed some light on the future of the company’s SUV portfolio and if the 4x4 drivetrain will make a comeback.

Guittard Couverture showcases the brand's commitment to providing customers with premium chocolate in enhanced, sustainable packaging.

Cooper & Thief, producers of a portfolio of spirits barrel-aged wines, unveiled its new bourbon barrel-aged wine: Cabernet Sauvignon. 

Dr. Barbara Morrell channels years of expertise into her work with St. Joseph's University

PNI•HCM partners with Juvo Jobs to provide SMBs a holistic hiring solution. Connect with local talent, manage your workforce, and get expert HR guidance!

Destiny Limousine Ltd offers top-notch Limousine and chauffeur services in Vancouver for the upcoming cruise ship season. Destiny ensures hassle-free transfers from Vancouver Airport to Cruise Ship Terminal with transparent all-inclusive pricing.

Denis D. Sauvé earns prominent placement in Millennium Magazine's Fourteenth Edition

Dr. Deuvletian channels years of experience into his work with Clinique Veterinaire de Montreal

I Am the Greatest Project and kicks off a year-long celebration including special events, public art installations, and culminates in a community postcard art exhibit in the gallery.

Reuven Cohen, LCSW, is a distinguished expert in psychotherapy and cognitive behavioral therapy

Aesthetic Surgery Center introduces Renuvion®, a new era of skin tightening for superior cosmetic results.

Hoda Abdian Deluvia is celebrated for her two decades of success in the bridal beauty category

As a repeat winner of this prestigious award, iuvo is extremely proud and humbled by the continued recognition from The Channel Company.

Kemtrak DCP007 is designed to accurately measure UV absorbance of fluids in filtration and separation systems

Amid the prolonged COVID-19 pandemic, preparations for personal hygiene are becoming more important. In particular, smartphones, masks, and tumblers are essential items for modern people, but they are also hotbeds for germs.

iuvo named among best workplaces

Annual Channel Futures MSP 501 Identifies Best of the Best in the Managed Services Industry

CRN® Spotlights the Top IT Channel Providers for Outstanding Performance and Growth

For the 6th Time, iuvo Makes the Inc. 5000, at No. 4639 Among America's Fastest-Growing Private Companies

Among the high level of certifications – all the company's detection products are now certified for operating in harsh conditions and without any radioactive source ensuring full safety and protection to the defense and homeland security personnel.

Working in public health, Dr. Cleophas d'Auvergne is focused on caring for those affected by TB, HIV, and STIs

Silicon Valley Aesthetic Dermatology introduces a new blog post detailing the benefits of laser skin rejuvenation. San Mateo and Foster City residents can explore how these treatments help achieve youthful, glowing skin.

Luvme Hair's 1 SEC INSTALL Wigs Collection: Beginner-Friendly

Luvme Hair, a leading brand of high-quality human hair products, is pleased to announce the regular promotion of their premium Clip in Hair Extensions.

From June 20 to July 8, 2024, this limited-time event offers customers up to $90 off on their high-quality human hair wigs.

Among the high level of certifications – all the Company's detection products are TUV certified and without any radioactive source ensuring full safety and protection to the security screening personnel.

Nuvothera, a Fort Worth, Texas-based biotech company, has reached an agreement and has its revolutionary Prosoria Psoriasis Treatment System in Walgreens VillageMD clinics. Additionally, it will soon be available on Walgreens.com.

Let the Expertise of Skilled Spa and Massage Therapists Guide You Through a Relaxing and Rejuvenating Journey, Featuring Services such as Deep Tissue Massage Therapy, Microblading, Facials, and More.

Vancouver, BC – financially successful people should still invest in a comprehensive life insurance policy—here's why.

Innovative Microsoft Solution, iuvo Guardian, Recognized for Excellence in Cloud Computing and Business Technology

Providing robust security measures to safeguard sensitive data, ensure compliance, and enhance AI capabilities.

The Next Generation List Honors Innovative, Growing MSPs

At Magnolia Gardens Senior Care, we understand the challenges families face during this transition.

Vancouver, BC – with a hot spell just around the corner, now's the time to schedule air conditioning repair and maintenance in Vancouver.

Chainlink fences are a good option for creating safe outdoor spaces for tiny dogs, bunnies, and ferrets according to residential North Vancouver fencing company.

Vancouver, BC – Strategic tips on how to wisely manage a budget for a chain link fence installation.

Providing robust cybersecurity solutions to protect sensitive data, ensure compliance, and mitigate cyber threats across various industries.

Vancouver, BC – Vancouver kitchen contractors share how small, nuanced details can breathe new life into the heart of the home.

Sahar Barati Elevating Vancouver Real Estate through Exceptional Interior Design

Tips to invest in a balanced, functional, and aesthetically pleasing bathroom without overspending.

Nuvilab provide services such as, cafeteria ESG indicator management, drinking water prediction, optimization of taking and making orders, and management of eating habits for the figure as well.