toxic

meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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toxic

Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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toxic

Toxic air chokes urban India 

Residents grapple with respiratory, cardiac, and other ailments as the air thickens




toxic

Several Delhi govt. schemes to tackle toxic air yet to take off

AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP




toxic

Delhi enveloped in toxic haze, AQI in severe zone in some areas

Data from the CPCB's Sameer app, which provides hourly AQI updates, showed that out of the 38 monitoring stations, 13 were in the severe category with readings above 400




toxic

Chhath Puja: Devotees take dip in Yamuna even as toxic foam floats over river  




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Yamuna highly toxic, says Delhi HC, bins plea to allow Chhath Puja rituals on riverbanks

Court dismisses petition against order prohibiting Chhath Puja rituals on Yamuna’s banks, says it can’t let devotees fall sick; have made ample arrangements at 1,000 ghats: Delhi govt. counsel; 4-day festival dedicated to Sun God began on Tuesday




toxic

Trump’s toxic politics of misinformation

The danger of Donald Trump’s leadership lies in his willingness to exploit and manipulate information to achieve his goals




toxic

Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses

RSC Adv., 2024, 14,35047-35063
DOI: 10.1039/D4RA06412G, Paper
Open Access
Nasima Arshad, Yasir Mehmood, Hammad Ismail, Fouzia Perveen, Aneela Javed, Pervaiz Ali Channar, Aamer Saeed, Sadia Naseem, Fatima Naseer
This work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4-d]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-d)isoxazole-based fused ring heterocyclic system.
The content of this RSS Feed (c) The Royal Society of Chemistry




toxic

Bisphenol A (BPA) toxicity assessment and insights into current remediation strategies

RSC Adv., 2024, 14,35128-35162
DOI: 10.1039/D4RA05628K, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Joshua O. Ighalo, Setyo Budi Kurniawan, Banlambhabok Khongthaw, Junaidah Buhari, P. K. Chauhan, Jordana Georgin, Dison Stracke Pfingsten Franco
To mitigate the toxic effects of BPA, there is a need to utilize hybrid remediation strategies for its removal from the aqueous environment.
The content of this RSS Feed (c) The Royal Society of Chemistry




toxic

Coinage metal(I) clusters supported by a 1,10-phenanthroline-phosphine: orange-to-NIR phosphorescence, metallophilic interactions and enhanced cytotoxicity

Dalton Trans., 2024, 53,18027-18036
DOI: 10.1039/D4DT02642J, Paper
Alexander V. Artem'ev, Maria P. Davydova, Lyubov S. Klyushova, Evgeniy H. Sadykov, Mariana I. Rakhmanova, Taisiya S. Sukhikh
Based on 2-(diphenylphosphino)-1,10-phenanthroline, a series of small metal(I) clusters, exhibiting orange to NIR phosphorescence and strong dose-dependent cytotoxicity.
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toxic

Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

Food Funct., 2024, 15,10795-10810
DOI: 10.1039/D4FO03217A, Paper
Sara Gonçalves, Francisco Peixoto, Tayse F. F. da Silveria, Lillian Barros, Isabel Gaivão
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing.
The content of this RSS Feed (c) The Royal Society of Chemistry




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FIR filed against producers of Yash-starrer Toxic 




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Unexpected link between nickel toxicity, cholesterol levels found

In a new study, fungi that lacked the Sre1 protein were found to be highly sensitive to nickel; the gene that encodes for this protein is conserved in all animals, including humans




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RSC - Toxicol. Res. latest articles




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Synthesis, Characterization, Genotoxicity Assessment and Antibacterial Applications of Zanthoxylum armatum Silver Nanoparticles (ZASNP) with Antibiotic Efficacy Enhancement Potential

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03608E, Paper
Open Access
Nikita Quadri, Manjunath M. Setty, Anshumali Awasthi, Usha Yogendra Nayak, Minakshi Singh, Sharad Sharma
The study aimed to develop alternative antibacterial treatments by combining traditional herbal knowledge with modern nanotechnology. This approach targets multiple bacterial strains, combats antibiotic resistance, and offers solutions for treating...
The content of this RSS Feed (c) The Royal Society of Chemistry




toxic

Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00159A, Paper
Shulei Zhang, Bo Zheng, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu
Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions.
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toxic

Oil and gas wastewater is a cheap fix for road dust but comes at a toxic cost

Treating roads with the wastewater may pollute the environment with radium and oil and gas compounds




toxic

Oil and gas wastewater is a cheap fix for road dust, but it comes at a toxic cost

Treating roads with wastewater may pollute the environment with radium




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Big data mining predicts toxicity better than animal tests




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Chemical toxicity assessments by U.S. EPA to be reshaped, if bill passes

Congressional committee votes to give industry and other agencies greater input and to shift responsibility for IRIS program from research office




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Poisonous lands: Pennsylvania prison built next to toxic dump

Prisoners and area residents are hit by toxic fumes that could cause fatal harm




toxic

Consensus document on composition of new soybean varieties: food and feed nutrients, anti-nutrients, toxicants and allergens

This revised document supplies basic information (compositional considerations, key constituents), useful in risk/safety assessment of food and feed using new varieties of soybean (Glycine max.). This updated publication replaces the original issue of 2001.




toxic

Predicting genetic toxicity with the QSAR Toolbox

11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for genetic toxicity and genotoxic carcinogenicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.




toxic

Predicting aquatic toxicity with the QSAR Toolbox

11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for acute aquatic toxicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.




toxic

Consensus document on compositional considerations for new varieties of oyster mushroom (Pleurotus ostreatus): Key food and feed nutrients, anti-nutrients and toxicants

This document supplies basic information useful in the risk and safety assessment of food and feed using new varieties of oyster mushroom: compositional considerations, key constituents (nutrients, anti-nutrients and toxicants). It is issued in the Novel Food and Feed Safety Series.




toxic

Ecotoxicology and Environmental Fate of Manufactured Nanomaterials: Test Guidelines

This document includes the conclusions and recommendations resulting from a workshop that addressed the ecotoxicology and environmental fate of manufactured nanomaterials, and in particular the applicability of existing OECD Test Guidelines (TG) related to these topics. A number of TG developments are underway at OECD as a follow-up to these recommendations.




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Developmental neurotoxicity: OECD/EFSA experts discuss non-animal test methods

Participants from 15 countries attended the Workshop on Developmental Neurotoxicity: The use of non-animal test methods for regulatory purposes” on 18 October 2016, in Belgium. The event, co-organised by the OECD and the European Food Safety Authority (EFSA), focused on opportunities and challenges related to alternative methods for testing and assessing the DNT potential of chemicals.




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Adverse Outcome Pathways, Molecular Screening and Toxicogenomics

Latest releases: AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. Seven New AOPs have now been published.




toxic

BRITs 2020: Maya Jama shares hilarious post about her 'toxic ex' on social media

Maya Jama partied up a storm at the Warner music afterparty at the Chiltern Firehouse on Tuesday night,  where her ex, Stormzy was also in attendance. 




toxic

Super-rich are fleeing the UK with billions due to George Osborne's 'toxic' tax policies

The number of non-doms, people who are not legally domiciled in the UK but enjoy tax advantages, fell from 98,500 to 78,300 last year, a record low. The tax they contributed also dropped by £2billion.




toxic

Toxic methylmercury-producing microbes more widespread than realized

Microbes that live in rice paddies, northern peat bogs and other previously unexpected environments are among the bacteria that can generate highly toxic methylmercury, researchers […]

The post Toxic methylmercury-producing microbes more widespread than realized appeared first on Smithsonian Insider.




toxic

Toxicity of mercury hot spots can be reduced with application of activated carbon, researchers discover

Hot spots of mercury pollution in aquatic sediments and soils can contaminate local food webs and threaten ecosystems, but cleaning them up can be expensive […]

The post Toxicity of mercury hot spots can be reduced with application of activated carbon, researchers discover appeared first on Smithsonian Insider.




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Survey pinpoints where toxic mercury accumulates in world environments

Here’s some good news that should hit you in the gut. A team of scientists searching thousands of environments for bacteria that produce the deadly […]

The post Survey pinpoints where toxic mercury accumulates in world environments appeared first on Smithsonian Insider.




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National Academies Completes Review of National Toxicology Program’s Draft Monograph on Fluoride and Neurodevelopmental and Cognitive Effects

Today the National Academies of Sciences, Engineering, and Medicine released its review of the National Toxicology Program’s (NTP) draft monograph Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.




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California toxic regulators sue FedEx over handling of hazardous shipments

The Department of Toxic Substances Control is claiming that FedEx Ground has mishandled hazardous materials in packages. ; Credit: Thomas Hawk/via Flickr

Molly Peterson

State regulators have sued FedEx Ground, claiming the company mishandled hazardous chemicals at facilities throughout California during the last 5 years.  

An investigation into a fire four years ago in San Diego prompted a wider inquiry into how FedEx handles restricted chemicals in statewide shipping at all of its facilities.

Regulators claim FedEx didn’t handle thousands of damaged and hazardous packages properly. The state’s complaint claims FedEx would remove damaged packages from shipping and store them for lengthy periods of time in salvage drums, which were moved from hubs to terminals within the company’s network of facilities.  

These packages contained goods ranging from insecticides and acids to old batteries and other flammable and toxic materials – pretty small shipments, less than 65 pounds, but investigators say they’ve found problems with more than 20 tons of goods shipped over a 5-year period.

Each violation alleged in the state’s lawsuit carries a penalty of up to 25-thousand dollars. In a written statement, FedEx spokeswoman Katie Wassmer says the company "complies with all applicable local, state and federal reporting requirements." 

The state-court complaint is the latest legal salvo in a dispute among California and local officials and FedEx.

Earlier this spring, FedEx sued the DTSC and district attorneys from three cities, including Los Angeles, seeking a declaration that federal law pre-empts California's waste handling laws, and that state officials are incorrectly interpreting laws governing FedEx. 

"To preserve our rights as a federally-registered motor carrier, FedEx Ground filed suit in federal court" said Wassmer. "We are confident that a thorough review of the regulatory framework through the judicial process will support our position."

This content is from Southern California Public Radio. View the original story at SCPR.org.




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Product design screening method helps reduce toxic materials in consumer goods

A recent study has described a simple method to screen the toxicity of materials used in consumer products. Using utility meter products as examples, the study found, for example, that stainless steel and polyvinyl chloride (PVC) had high toxicity potentials and suggests less toxic, but equally effective and priced, alternatives that could be used instead.




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Bacterial genes involved in making toxic methylmercury are identified

Research into mercury has identified two genes in bacteria that appear to be required for turning the metal into its most toxic form, methylmercury. The study adds to a growing body of research that helps us to understand the transformations that mercury undergoes in the environment and the microbes involved in these transformations.




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Sixteen-year reduction in levels of toxic PAHs in the Elbe River, Saxony

Polycyclic aromatic hydrocarbons (PAHs) are a large group of toxic molecules produced by forest fires, industrial processes and the incomplete combustion of fossil fuels. The airborne particles containing these molecules are often washed into watercourses, where they can persist. This study uses long-term monitoring data from the Elbe river, Saxony, Germany, to show how changes in PAH sources affect both the concentrations of these chemicals and the corresponding environmental risks. The researchers suggest that controlling PAHs is the best prevention of harm to aquatic and human health.




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Toxicity tests improve the assessment of harbour sediment quality

Harbour sediments should be tested for their toxic effects on living organisms in addition to being subject to the chemical, physical and biological tests usually conducted to assess water quality, according to recent research from Portugal. This would provide a better environmental assessment of dredged material to help guide port authorities’ decisions on its disposa




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Waste incinerator health risks: no evidence for toxic metal build-up

Spanish medical and public health researchers have found no clear evidence for increased heavy metal levels in adults living near a recently-built urban solid waste incinerator over two years of operation. Concentrations of lead, chromium and mercury in blood and urine samples taken around the plant were not significantly higher than for populations who lived further away.




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Plastics can concentrate toxic pollutants, endangering marine ecosystems

Plastic debris is a serious environmental concern, as a physical pollutant as well as a chemical pollutant when it breaks down in the marine environment. A new study has now shown that plastics can also concentrate other pollutants, with significantly higher concentrations of toxic pollutants adhering to soft, rubbery plastics, rather than hard, glassy plastics.




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Laboratory-scale wetlands remove toxic veterinary drugs from wastewater

Constructed wetlands can effectively remove veterinary drugs from wastewater, preventing contamination of the environment, research suggests. A recent study has demonstrated that laboratory-scale constructed wetlands were able to remove between 94 and 98% of two commonly used antibiotics from pig farm wastewater.




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<new>How predictable is the biological response to chemical toxicity?

To assess the impact on ecosystems of chemical contamination in aquatic environments, scientists need to measure not only the concentration of the contaminants, but also the extent to which they can disrupt biological processes at a cellular level in plants and animals and at an ecosystem level. According to a new study, considering these complex inter-relationships in combination will help improve the ecological status of waterways, in line with Water Framework Directive (WFD) commitments.




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Nutrients in streams can mask toxic effects of pesticides on aquatic life

Moderate levels of nitrogen in streams and rivers can make it difficult to assess the effects of pesticides on aquatic wildlife, because nutrients mask the pesticides’ impacts, according to recent research. This highlights the importance of considering nutrient levels when developing measures to protect aquatic ecosystems.




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Fin whales exposed to high levels of potentially toxic microplastics in the Mediterranean Sea

Fin whales (Balaenoptera physalus) are likely being exposed to microplastics and associated toxic additives in the Mediterranean Sea, finds new research. The research analysed levels of microplastics and biological and chemical markers of exposure in whales from the Mediterranean Sea and the comparatively pristine Sea of Cortez, off the coast of Mexico. The results suggest that the vulnerable Mediterranean fin whale may be suffering as a consequence of microplastic pollution.




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Changes in soil carbon, biodiversity and ecotoxicity should be considered when assessing environmental impact of dairy products

Considering the impact on soil carbon, biodiversity and ecotoxicity is important when assessing the environmental footprint of dairy products, suggests a new study, which explored the impacts of organic and conventional milk production in three types of system established in Western Europe. The study found that organic milk production had a significantly lower impact on ecotoxicity and biodiversity than conventional milk production, and suggests that including soil carbon changes in the assessment would result in greater reductions in the carbon footprint of organic, rather than conventional, milk — in some cases by up to 18%.




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Ecotoxicity studies of nanomaterials urgently needed

A new study by Swiss researchers has attempted to predict nanomaterial concentrations in the environment. However, the researchers say more data on environmental toxicity are needed before we can make accurate assessments of potential environmental risks from nanomaterials.




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Biology as important as chemistry in assessing toxic mixtures

Researchers have developed the first biology-based model to predict the sub-lethal effects of chemical mixtures on organisms. Sub-lethal effects do not cause death but can damage processes such as growth and reproduction. The model provided accurate predictions of the sub-lethal impacts of a chemical mixture on water fleas.




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New tool accurately predicts toxic effects of chemical mixtures

A new tool that predicts the effects of complex mixtures in water has shown promising results. It correctly predicted the impacts of toxic mixtures on the model species Daphnia magna, or water fleas, in over 90 per cent of cases.