toxic

Crocodiles baited with 'nausea-inducing chemical' to prevent them from eating toxic, invasive toad

Scientists in Australia are boosting the country's dwindling freshwater crocodile numbers by getting the animals to stop eating a poisonous toad.



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toxic

Hollywood action director JJ Perry joins the team of Yash and Geetu Mohandas’ ‘Toxic’

The film will mark Geetu’s third directorial after ‘Liar’s Dice’ and ‘Moothon’




toxic

Shock toxic water findings

QUEENSLAND’S water contamination crisis has deepended, following alarming test results which show chemical levels up 425 times the accepted maximum exposure limits.





toxic

To the Student Stuck in a Toxic Home during the Pandemic

A number of friends and mental health professionals helped me with this post. You know who you are. Thank you.

To the student for whom school is a safer place, but now you’re stuck at home in a toxic environment during the pandemic,

I see you. You’re not invisible. In fact, a lot of people see you and are thinking about you. I can’t tell you how many of my friends and colleagues have brought you up in the past few months, and expressed worry for what you're going through. Hang in there.

When schools started sending students home in March and April, I thought of you immediately. I waited with you to see if schools might open again in a few weeks, but of course that didn't happen. I waited with you hoping this country would get its shit together and start prioritizing realistic approaches to containing the pandemic, so that you'd be able to go back to school in the fall. And now it's clear that many of you won't be able to do that. It's also possible that those of you who can go back won't be able to stay there for long, though I continue to hope it won't play out that way. I, and a lot of people, wish you didn't have this uncertainty pressing down on you right now.

Hang in there!

Here are some tools from my own PTSD toolbox that might help. Some are more immediately helpful, some are stopgaps and temporary coping mechanisms. Some might spark ideas for you:

When possible, create distance from the toxicity. In my own experience, sometimes the smallest amount of distance can help. If you can safely go for a walk now and then, do it. If there's a physical spot where you can be alone sometimes, find it. If you can spend time online with friends, or even socially-distanced time outside, do it. Are you caring for siblings in some way? Is there some way in which you've been placed in the position of caring for your own parents? If so, that's a lot. If you ever have the opportunity to take some time to care for no one but yourself, I hope you won't begrudge yourself that. You deserve care as much as anyone else.

For some of you, maybe there's even some other home where you could live (if only temporarily), like the house of a safe relative or family friend. Have you considered whether that might be the case for you? Give it some serious thought. This is important, though: Before making any major decisions or drastic changes, talk it through with a trusted adult. If you don't have a trusted adult, talk it through with a youth crisis line (see below). Your safety is the most important thing, and setting off an internal family drama may not be worth it and may even be dangerous. Also, you don't want to move yourself into a situation that's just as harmful, or even more so. This leads me to the next step.

Reach out to people who can support you. This might be friends, other family members, teachers, therapists or counselors, anyone in your life who actually sees and cares who you are and what you need when they look at you. Reaching out to trustworthy supports might give you a place to vent some steam and get some validation, and it might also lead to some practical help. Don't be afraid to consider professional organizations and helplines too. The first two organizations below are geared to helping kids and teens in danger of physical and sexual violence, but according to my professional source, they'd likely help if the threat is emotional too. The third organization is open to helping with any kind of crisis:

Safe Place
https://www.nationalsafeplace.org/
Here's a link to find a Safe Place site near you.
Or, to use TXT 4 HELP, text the word “safe” and your current location (city/state/zip) to 4HELP (44357). Within seconds, you will receive a message with the closest Safe Place site and phone number for the local youth agency. You will also have the option to text interactively with a professional for more help.

SafeHouse Center
https://www.safehousecenter.org/friends-family/children-youth-services/ 
https://www.safehousecenter.org/
They have a National HelpLine, available 24/7, at 734-995-5444 (English and Spanish). Advocates and volunteers can answer questions, give support, and provide information and referrals.

Crisis Text Line
https://www.crisistextline.org/
Text HOME to 741741 from anywhere in the United States, anytime. Crisis Text Line is there for any crisis. A live, trained Crisis Counselor receives the text and responds, all from their secure online platform. In the UK, text HOME to 85258. In Ireland, text HOME to 50808.

Note that while these are (inter)national organizations, there are a lot of local organizations as well. Do a little poking around and see what might be available to you, or ask someone you trust to do so.

Journal. This one definitely isn't for everyone, but if it's something you can do safely and if it appeals to you, give writing a try. It can be immensely clarifying — and can help with plans and goals — to write what you're going through and how it feels. I have a journal now, and years of journals stashed somewhere or other, and I'll probably never look at them again… I don't know that I've ever once gone back to look at something I've journaled. But I 100% know it helps me feel understood while I'm doing it, which is what matters.

Do creative projects. Again, this one isn't for everyone, but my larger point is this: If you can find an outlet for your distress, and most especially, a way to express it, so that there can be some way you're telling the truth of your experience to the world rather than bottling it up — it can help. It can allow you to take back your ownership of yourself and your experience, and it can give you power against the lies to which other people are subjecting you. I would venture to say that everything I write is some version of this. (But you don't have to write a book! I also knit, sew, draw, do collage, take pictures, or even get pleasure out of arranging items symbolically in my house. You get to decide what creativity is, and what helps you feel better!)

Find an anthem. This is also in the category of self-expression and connection. Find artists who seem to get what you're going through, and spend time with them. (Of course it doesn't have to be musicians. A book, or a character in a TV show, can do the same thing!) Some of my anthems over the years: "Girl" by Tori Amos. "Oh Father" by Madonna (the link opens a YouTube video).  "No More Drama" by Mary J. Blige. "Cold As It Gets" by Patty Griffin.

Trust your sense of things — while having compassion for your self-doubt.
If you live in a toxic home, there's a good chance that the toxicity around you includes other people's denial of the fact that it's a toxic home. Trust your own unhappiness, anxiety, avoidance, self-loathing, fear. Trust your sense that all is not okay. This self-trust can be challenging no matter what kind of abuse you're experiencing — but I want to give a special shout-out to people experiencing emotional abuse. It can be especially hard to believe your environment is toxic if the damage is "merely" emotional. In fact, it can be hard to metabolize a word like "abuse" when the abuse is "merely" emotional. Surely no one's abusing me? Surely this is just regular life, not abuse?

It's okay if that word doesn't feel right to you. You get to decide what words apply. But trust the panicked feeling you have, the one that's driving you to want to escape. Trust your gut. Something is wrong, whatever you want to call it. A person in your situation deserves help and relief, just like anyone else.

At the same time, this is important: Depending on your situation, you may not be able to do much with your gut realizations at the moment. And if there's not a lot you can do to fix your situation right now, there might be limits to how helpful it is to realize how bad your situation is. So, also have compassion for the ways you end up doubting yourself. It's normal and okay to doubt yourself; it's not a weakness. Your self-doubt may even be a temporary survival mechanism, working hard to keep you safe and get you through this, which is important. Your self-trust, in the meantime, will outlive this situation and be a source of healing someday.

If you can, hold onto your sense of humor. This might not be possible, depending on your situation. But if it is, it can be another release. Example: I once went through a stretch of time during which I had relentlessly recurring dreams that I was moving to a new home that wasn’t emotionally safe for me. When I say relentlessly recurring, I mean that I had some version of this dream every single night for three months. Every single night for three months. Except for one night! One night during this stretch, I had a dream that I was moving to a new home and it was perfect. It had an elegant dining room, fancy staircases, a lounge — it was noticeably bigger and fancier than any of the other homes in any of the other dreams I'd had — and I belonged there, I could be myself there, I was emotionally safe there. I was so, so happy. So were all the other people who apparently lived in this home, because it seem to be sort of like… a gigantic, perfect hotel? It wasn’t until I woke up from this dream that I recognized this “hotel.” We were on the Titanic.

I'm sorry, but that's hilarious. Thank you, unconscious, for cracking me up. If there's anything right now that cracks you up… Hold onto it.

Hang on. Someday you'll be able to build your own life. You will. For now, whenever you can, do get whatever help you can. You deserve it.

I hope something on this list is helpful. If nothing else, remember that I, and so many other people, are thinking about you and pulling for you. There are even people who've dedicated their lives to looking out for you; reach out to them. We know there's light at the end of your tunnel, so hang in there. You're not invisible. We see you!

Love,
Kristin




toxic

UK farmers call for toxic weedkiller ban

Some farmers say studies suggest Paraquat could be a factor in the onset of Parkinson's Disease.




toxic

'Crisis for referees & fuel for toxic fan conspiracies'

David Coote's alleged video on Liverpool and former manager Jurgen Klopp fuels conspiracy theorists who question referees' integrity, says Phil McNulty.




toxic

Protecting Children's Health Amidst Delhi's Toxic Air Pollution

Highlights: Air pollution, especially particulate matter, poses significant health risks to children, affectin




toxic

Malaika Arora's November challenge after split with Arjun Kapoor: No alcohol, remove toxic people

Malaika Arora has penned down some big challenges for herself for the month of November. Let's take a look.




toxic

Yash shoots for Toxic in Versova; gets tight security [Watch]

Yash's Toxic is one of the most awaited films in South India. This project will mark his return to the big screen after the release of KGF: Chapter 2 in 2022. Initially set for release on April 10, 2025, the movie is said to have been delayed.




toxic

Turmeric’s Toxic Twist: Experts Warn Of Lead Risks For Children’s And Adults’ Health

Raising awareness about the risks associated with contaminated turmeric, coupled with rigorous testing, is essential to safeguarding gastrointestinal health and preventing long-term toxic exposure.  




toxic

Yash's 'Toxic' Faces Legal Trouble: Forest Department Files Case Against Makers For Illegal Tree Felling

The Karnataka Forest Department has filed an FIR against the producers of Yash's 'Toxic' and officials from Canara Bank and HMT for allegedly cutting down trees on forest land during the film's shoot in Bengaluru.




toxic

Cutting Through the Chaos : How To Keep Calm And Outsmart Toxic People Like A Boss

Every day, we encounter a mix of people-some who inspire us, others who brighten our day with their positive energy, and then there are those who test our patience with their negativity, toxicity, and drama. While dealing with toxic people can




toxic

Yash's Toxic in trouble? FIR filed against producers of KGF star's upcoming actioner for illegal...

Yash's upcoming film Toxic has landed in trouble over the alleged axing of trees on forest land in Bengaluru. Read on to know more details about the same.




toxic

Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin

Environ. Sci.: Processes Impacts, 2024, Advance Article
DOI: 10.1039/D4EM00408F, Paper
Xiaoxia Wang, Zhongneng Yang, Xiao-Min Ren, Zhenghuan Zhang, Huan He, Xuejun Pan
This study found that PS-M/NPs have a size-dependent cytotoxic effect on the human intestinal epithelial cell line Caco-2, mediated by the production of reactive oxygen species. Additionally, catechins were shown to mitigate these adverse effects.
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toxic

Toxic truths : Environmental justice and citizen science in a post-truth age [Electronic book] / ed. by Thom Davies, Alice Mah.

Manchester : Manchester University Press, [2020]




toxic

Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform

Lab Chip, 2024, 24,1887-1902
DOI: 10.1039/D3LC00507K, Paper
Open Access
Chu-Chun Liang, Po-Yen Chen, Nien-Che Liu, I-Chi Lee
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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toxic

Why Is Vicky So TOXIC Towards Ankita?

'The face of a woman being insulted, vilified, degraded by her husband in front of the whole world for literally no reason ever.'




toxic

Breaking the toxic chain of pretence

A mother, wife, daughter, friend and a colleague shares her struggle to stop pretending that she is in control and accept that it is okay not to be okay




toxic

Ti-based MOF nanosheets as a mass spectrometry imaging matrix for low molecular weight compounds to reveal the spatiotemporal content changes of hepatotoxic components during the processing of Polygonum multiflorum

Analyst, 2024, Advance Article
DOI: 10.1039/D4AN00964A, Paper
Feng-yan Kuang, De-jun Hu, Lu Wang, Fei Chen, Guang-ping Lv
The selection of the matrix is crucial for matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI).
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toxic

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(IV)/naringin complex

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00655K, Paper
Andrés G. Restrepo, Angel L. Huamani, Alexandra Velásquez Bravo, Pablo J. González, Luciana G. Naso, Evelina G. Ferrer, Patricia A. M. Williams
Replacement of phen in [VO(Narg)2] induces greater π electronic delocalization, thus improving antioxidant action. However, due to its lipophilic character, cellular uptake of V is increased, leading to enhanced pro-oxidant and anticancer effects.
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toxic

Construction of a nontoxic nano-pesticide and its co-application with natural predators for perfect cooperative pest management: an innovative strategy for pesticide reduction

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D4EN00060A, Paper
Shangyuan Wu, Qinhong Jiang, Chunyang Huang, Hailin Yang, Changhua Zhang, Meizhen Yin, Jie Shen, Shuo Yan, Hu Li
The current study develops a nano-pesticide that is nontoxic toward the predatory stinkbug but with enhanced bioactivity toward the common cutworm, which proposes to co-apply the nano-pesticide with predator as an innovative pest control technique.
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toxic

The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D3EN00929G, Critical Review
Yiqun Mo, Yue Zhang, Qunwei Zhang
This review summarized the cytotoxic, genotoxic, and carcinogenic effects of Ni-containing NPs on humans, lung cells in vitro, and rodent lungs in vivo, and the underlying mechanisms. Their extra-pulmonary effects were also briefly mentioned.
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toxic

Facile fabrication of Z-scheme g-C3N5/Gd-MOF/silver nanocubes composite as new generation visible light active photocatalyst for abatement of persistent toxic pollutants

Environ. Sci.: Nano, 2024, Accepted Manuscript
DOI: 10.1039/D3EN00913K, Paper
Varsha UshaVipinachandran, Susanta Kumar Bhunia
Some of the persistent hazardous contaminants that readily dissolve in water with a recognizable hue are hexavalent chromium and neomycin antibiotic. Herein, a Z-scheme g-C3N5/Gd-MOF/silver nanocubes (CNGdAg) ternary composite was...
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toxic

Mechanistic approaches for crosstalk between nanomaterials and plants: plant immunomodulation, defense, stress resilience, toxicity, and perspectives

Environ. Sci.: Nano, 2024, Accepted Manuscript
DOI: 10.1039/D4EN00053F, Paper
Ragini Singh, Pinky Choudhary, Santosh Kumar, Hemant Kumar Daima
Plants are confronted with unexpected and diverse environmental pressures in the era of climate change. Plant development and metabolism are significantly hindered by both abiotic and biotic stress, which leads...
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toxic

Mycogenic silver nanoparticles from Penicillium citrinum IB-CLP11 – their antimicrobial activity and potential toxicity effects on freshwater organisms

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D4EN00002A, Paper
Arthur Pérez Aguiar, Cristiane Angélica Ottoni, Claudia de Lima Ramos Aquaroli, Evelyn Caroline Vicente Mendes, Ana Lúzia de Souza Araújo, Marta Filipa Simões, Edison Barbieri
Silver nanoparticles (AgNPs) are some of the most attractive nanomaterials for commercial applications, but they can also be a very challenging issue from the point of view of cytotoxicity and phytotoxicity as agents that damage genetic information.
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toxic

Mg–Al LDH nanosheets as a nanotechnological tool in agriculture: an exploratory toxicity evaluation study

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D3EN00733B, Paper
Rafael Salinas-Jiménez, Gloria Vera, Mariola Tobar, Jeimy Moscote, Giovana Acha, Ariel Herrera-Vásquez, Diego Rojas-Rivera, Elena A. Vidal, Andrea Miyasaka Almeida, Manuel Ahumada
The possible toxicity effect of Mg–Al LDH nanosheets was evaluated on some agricultural target organisms. Overall, nanoparticle innocuity was observed at the tested concentrations, showing a low risk of toxicity for its agricultural implementation.
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toxic

Biogenic synthesis of dual-emission chlorophyll-rich carbon quantum dots for detection of toxic heavy metal ions – Hg(II) and As(III) in water and mouse fibroblast cell line NIH-3T3

Environ. Sci.: Nano, 2024, 11,1636-1653
DOI: 10.1039/D3EN00789H, Paper
Ravi Pratap, Nurul Hassan, Monika Yadav, Saurabh Kumar Srivastava, Shilpi Chaudhary, Anita Kamra Verma, Jayeeta Lahiri, Avanish S. Parmar
Due to the excessive residues and serious adverse effects, it is urgent to develop an efficient method to detect Hg2+ and As3+ in drinking water to protect human health.
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toxic

Ecotoxicity testing of nanomaterials in sediment – suggestions to improve science and regulation

Environ. Sci.: Nano, 2024, 11,1477-1486
DOI: 10.1039/D3EN00459G, Paper
Amalie Thit, Lars M. Skjolding, Steffen Foss Hansen
Sediments generally act as a sink of released manufactured nanomaterials (NMs).
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toxic

Functionalized molybdenum disulfide (MoS2) monolayer as an efficient nanosensor towards toxic nitrogen containing gases

Environ. Sci.: Nano, 2024, 11,1740-1754
DOI: 10.1039/D4EN00072B, Paper
Wadha Alfalasi, Tanveer Hussain, Nacir Tit
Selective detection of toxic nitrogen-containing gases (e.g. NO and NO2) is achieved when special transition metal (TM) atoms are selected in doping molybdenum disulfide (MoS2) monolayer. The change of magnetic state is the secret of that selectivity.
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toxic

Correction: Nano-pelargonidin modulates p53/PARP/HSP 90/XRCC1 signaling axis to combat cypermethrin-induced genotoxicity and metabolic dysfunction in fish: a molecular docking predicted in vivo approach

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D4EN90017K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Priyanka Sow, Sudatta Dey, Rishita Dey, Asmita Samadder, Sisir Nandi, Debojyoti Tarafdar, Anisur Rahman Khuda-Bukhsh
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toxic

New 8-hydroxy quinoline-polycyclic aromatic hydrocarbon (PAH) conjugates and their sulfonated derivatives: effects of sulfonation and PAH size on their structural, supramolecular and cytotoxic properties

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D4CE00105B, Paper
Suman Sehlangia, Surbhi Dogra, Prosenjit Mondal, Chullikkattil P. Pradeep
The ring size of polycyclic aromatic hydrocarbons (PAHs) and sulfonation affect the supramolecular interactions and cytotoxic properties of a new series of 8-hydroxy quinoline-PAH conjugates.
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toxic

Toxic air: Gadkari blames oil cos, wants them to do their bit

Tells Maharashtra CM to protect Mumbai from water, air pollution




toxic

Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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toxic

N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00243A, Paper
György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin Karaghiosoff
Beta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...
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toxic

'Bombay Has An Intoxicating Personality'

'It's such a mishmash of wonderful things, so many different cultures, subsections of society and weird histories.'




toxic

Tech Support - Toxicologist Answers Poison Questions From Twitter

Toxicologist Anne Chappelle answers the internet's burning questions about poison. How do antidotes work? Can a pencil give you lead poisoning? Can you overdose on vitamins? Anne answers all these questions and much more!




toxic

Tech Support - Toxicologist Answers More Poison Questions From Twitter

Toxicologist Anne Chappelle is back to answer more of the internet's burning questions about poison. What makes poison, well, poisonous? What the screaming heck is sun poisoning? How long does poison take to work? Can poison expire? Anne answers all these questions and much more!




toxic

Brands Complicit In Social Medias Toxicity, Being Held Hostage By It Too

Marketers are complicit in the toxicity of social media, they misunderstand its function and how brands should participate in it, and yet they appear to be held hostage by it. Those are some of the main paradoxes confronting brand marketers, according to a damning new report from the social media analyst at Forrester Research.




toxic

Social Media Feels Increasingly Toxic. What Do I Do?

By setting boundaries around what you post, when you're online, and who you surround yourself with in real life, you can strike a better balance between Instagram and reality




toxic

Sydney’s ‘mystery’ toxic beach balls are cosmetic waste

Around 2,000 of the mystery black balls had washed onto beaches across Sydney since October 15




toxic

Non-toxic ionic liquids for silk processing 

A team at IASST Guwahati has identified 4 different Ionic Liquids that can be effective in extracting silk proteins from raw fibres 




toxic

Importing a toxic work culture into India

The practices, including working hours, in multinationals functioning in India must be regulated




toxic

A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00404C, Paper
Open Access
Pouria Rafsanjani Nejad, Astha Lamichhane, Prasiddha Guragain, Gary Luker, Hossein Tavana
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
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toxic

A reaction based carbazole–indolium conjugate probe for the selective detection of environmentally toxic ions

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00301B, Paper
Jayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef Hatamleh
Carbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.
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toxic

​Beyond intoxication: On alcohol regulation, judicial verdict

Batting for States, the Supreme Court of India holds federal balance on regulating alcohol




toxic

Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
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toxic

Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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toxic

Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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toxic

Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00742E, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek Wimmer
A series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...
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