A New York appellate court upheld the denial of a worker’s claim for the exacerbation of her preexisting psychological condition by alleged workplace stress. Case: Matter of Gorbea v. Verizon New…

The Wyoming Supreme Court ruled that a man's heart attack on his third day of work was not due to clearly unusual or abnormal employment stress for those in his…

Research Highlights: Fear of another heart attack was a significant ongoing contributor to how heart attack survivors perceive their health, according to a new study. While anxiety and depression are recognized as common conditions after a heart ...

A surprising thing happened when researchers began exploring whether early-life stress compounds the effects of a childhood head injury on health and behavior later in life: In an animal study, stress changed the activation level of many more genes in the brain than were changed by a bump to the head.

For many people, it’s a ray of hope rooted in research. Recent research is presenting a new way of thinking about suicide prevention, and both experts and patients believe it’s already saving lives.

Life as a designer can be very stressful and fill your life with stress and tension, you can treat without naturally and without damaging your health. When stress situations reach us, sometimes we feel so anxious that We try to reduce it on our own, such as self-medication, but in the long run, this can […]

The post 5 Ways to Reduce Stress Naturally appeared first on Snap2objects.

Debt Distress and the Right to Food in Africa

More than half of low-income countries are at risk of debt distress or have already defaulted. The debt crisis, while exacerbated by recent crises, has been looming for several years. According to the United Nations, 3.3 billion people now live in countries that spend more on interest repayments than on education or health, and in […]

The post Debt Distress and the Right to Food in Africa appeared first on IFPRI.

The 2024 Global Food Policy Report Stresses Urgent Need for Transformative Action to Achieve Sustainable Healthy Diets and Improved Nutrition

Washington DC, May 29, 2024: In the face of growing challenges posed by unhealthy diets, all forms of malnutrition, and environmental constraints, the 2024 Global Food Policy Report (GFPR) — released today by the International Food Policy Research Institute (IFPRI) — underscores the importance of transforming complex global food systems to ensure sustainable healthy diets for all. Progress […]

The post The 2024 Global Food Policy Report Stresses Urgent Need for Transformative Action to Achieve Sustainable Healthy Diets and Improved Nutrition appeared first on IFPRI.

Environmental proteomics as a useful methodology for early-stage detection of stress in anammox engineered systems  ScienceDirect.com

HE SONGSTRESS by Frank Morrison is a(n) Limited Edition. The Edition is Limited to Limited Edition Of 20 pcs

THE SONGSTRESS by Frank Morrison is a(n) Limited Edition. The Edition is Limited to Limited Edition Of 5 pcs

New Lesson Plans Entry: 'Financial English word stress mazes' has just been added to the Lesson Plans area of UsingEnglish.com.

Listening carefully and communicating with clarity create a better process for all parties and help avoid issues.

Representatives of leading European fruit and vegetable supply chain organizations, gathered by Pro Food at the Fruit Logistica trade fair in Berlin, reiterated the need for a non-ideological, data-driven approach.

WARSAW, 19 April 2016 – The OSCE Chairperson-in-Office, German Foreign Minister Frank Walter Steinmeier, today visited the headquarters of the OSCE Office for Democratic Institutions and Human Rights (ODIHR), in the context of the 25th anniversary of the establishment of the Office.

Chairperson-in-Office Steinmeier, who was joined for the visit by Witold Waszczykowski, Foreign Minister of Poland, met with ODIHR Director Michael Georg Link, before addressing guests and ODIHR Staff. In his address, he highlighted the background to the decision for the establishment of ODIHR in Warsaw, while stressing the continued importance of the Office’s work.

“The first democratic elections in 1989 in Poland marked the start of great change in Europe. It was not by coincidence that Warsaw was chosen as the seat of ODIHR – with this the OSCE paid tribute to the important role of the first Polish non-communist government since 1947 in the democratic re-shaping of Europe,” the German Foreign Minister said. “Today, 25 years later, I am in Warsaw to commend ODIHR, with its team of 150 people from 34 OSCE states, for its outstanding work: You are the chief promoters and defenders of the OSCE’s principles and commitments in the Human Dimension.”

“This task is never easy – it builds on your dedication to human rights and fundamental freedoms, it requires a reliable budget and it deserves the full support of all OSCE participating States,” he added. “ODIHR can count on Germany’s commitment, as OSCE Chairmanship, but also beyond.”

Director Link took the opportunity to express his thanks to both guests for their countries’ support for the Office.

“Over the past 25 years, ODIHR has grown into the OSCE’s principal human rights body, and this work is more important today than ever,” he said. “We are grateful for our host country’s continued support and appreciate the Chairperson-in-Office’s commitment to ODIHR and its mandate to promote human rights and democracy throughout the OSCE region.”

“ODIHR plays a major role not only in the process of monitoring human rights, but also in providing assistance with the implementation of commitments undertaken in the OSCE area,” said Polish Foreign Minister Waszczykowski. “ODIHR is an institution that truly makes a difference and, therefore, we fully support the work of every member of its highly devoted team.”

ODIHR was established in 1991 – originally as the OSCE Office for Free Elections – by a decision of OSCE heads of state and government at the Paris Summit in November of the previous year. The name was changed to its current form and its mandate significantly expanded in 1992, to providing assistance to governments and civil society in OSCE participating States in improving democratic governance, guaranteeing human rights and fundamental freedoms, and promoting tolerance and non-discrimination. 

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BERLIN, 3 June 2016 – Some 20 OSCE parliamentarians were in Berlin this week for an OSCE Code of Conduct conference focused on strengthening parliamentary control of the security sector. The event, which took place 2-3 June, highlighted the important role that parliaments play in both the oversight of armed forces and in increasing the level of political support for the OSCE Code of Conduct on Politico-Military Aspects, particularly in the context of emerging security challenges.

Speaking at the opening session Thursday, OSCE PA Vice-President Alain Neri noted that at the core of the Code of Conduct is a recognition of the importance of democratic civilian control of the armed and security forces, which means that elected parliaments must have ultimate authority over the activities of the security sector. “It is up to parliamentarians,” he said, “to ensure that fundamental human rights are respected by all security and intelligence services, both public and private.”

He regretted however that “the norms and principles outlined by the Code of Conduct are being breached with a discouraging frequency” and that “there is hardly any participating State across the OSCE region with a comprehensive and fully effective oversight over the private and public security sectors.”

Neri said that members of parliament have a special role to play not only by providing needed oversight, but by increasing the Code of Conduct’s legitimacy and relevance through active political support. For the Code to fulfill its purpose, he pointed out, both experts and parliamentarians are needed to commit to fostering its implementation.

OSCE PA Treasurer and Head of the German Delegation Doris Barnett also spoke Thursday, focusing her remarks on the changing character of conflicts, including the growing number of internal and external actors that are involved in armed conflicts and the role of non-state actors. The term “hybrid warfare” has come to define discussions around security, she pointed out, with civil, economic, informational and technological means being used for aims of war instead of peace.

“To identify who is fighting against whom, with whose support, with which aims and interests – to keep a clear overview, not to mention predicting these relationships, is anything but easy, and therefore an intense inter-disciplinary, trans-sectoral, and international co-operative approach among parliamentarians is required,” said Barnett.

The OSCE PA’s Special Representative in Vienna, Amb. Andreas Nothelle, moderated a session today entitled “Parliamentary Control of Armed and Security Forces and the Role of the Code of Conduct: Perspectives on Furthering Implementation,” and delivered concluding remarks at the closing session.

“If implemented faithfully the Code of Conduct is all-encompassing and sufficiently flexible to address all new challenges of our times,” Nothelle said. “The OSCE PA, in its 2014 resolution on parliamentary oversight over the private and public security sectors, has set guidelines for meeting these challenges.”

Organized jointly by Germany’s 2016 OSCE Chairmanship and the OSCE Conflict Prevention Centre, in partnership with the OSCE Parliamentary Assembly and the Geneva Centre for the Democratic Control of Armed Forces, the event brought together over 100 participants, including parliamentarians from OSCE participating States and Partners for Co-operation, senior government officials, representatives of OSCE institutions, OSCE field presences and civil society.

OSCE parliamentarians from 13 countries participated, including several Bureau Members and Special Representatives.

For Vice-President Neri’s full remarks, please click here. Treasurer Barnett’s remarks are available (in German) here.

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The findings open the door for new microbial-based therapy for anxiety and depression, according to UCC.

Read more: Gut bacteria affects stress response, UCC scientists find

The Roofing Alliance, through a new training course and report titled “Heat Stress for Roofers,” addresses heat effects on workers in the roofing industry, offering insights and prevention strategies.

In a year where an election and international conflict are causing extra stress, roofing companies are finding ways to give back and help others in their communities.

The yearly fiscal crisis and threats of appropriation lapses affect the contractor industry no less than government employees and the programs they conduct.

The post Government shutdowns stress the whole federal ecosystem first appeared on Federal News Network.

NTT DATA, the IT services provider and industry consultancy, has announced the end of a project that used quantum computing to optimise genome assembly processes. This is claimed to be a milestone in the use of this technology in the Healthcare and Life Sciences industries.

A preprint reports increases in the volume of parts of the brain after lockdown.

Location: Electronic Resource- 

(The Center Square) — A legislative task force "to study the dissolution or absorption of fiscally distressed municipalities" set the tone in its first meeting with a vote to change its name.

Today, improving caregiver working conditions through community and collective action. Then, parental stress levels are on the raise. And, 50 years of printing books about California.

CBS's Stephen Colbert revealed on Monday's show that he has been stress eating in the days since President-elect Donald Trump won the election.

The post Stephen Colbert Reveals He Is Stress-Eating Following Trump Win appeared first on Breitbart.

How white-nose syndrome threatens bat colonies in California. Tracking college graduate earnings based on their major. Finally, how to address anxiety and stress after the election.

Denver restaurants offer holiday meal options, from turkey with traditional sides to pork loin and lasagna.

On Monday [April 2], a local vessel reported a “migrating whale found distressed with entanglement in rope or wire” and it was concluded that Bermuda at this time, “lacked the necessary specialist equipment to assist the whale.” A Bermuda Maritime Operations Centre spokesperson said, “A local vessel on Challenger Bank, reported a migrating whale found distressed […]

Members of the public stepped up to help a 44-year-old man who was “seen unresponsive in the water” at Elbow Beach. A police spokesperson said, “Around 3:45 p.m. on Thursday, October 24, 2024, police received several reports of a swimmer in distress on the public side of Elbow Beach. “Officers were informed that the swimmer, a […]

Stress is a common experience that can either drive us toward success or hinder our progress if not managed effectively. What if you could understand stress better and turn it into something you can handle and even benefit from? This article will guide you through practical strategies for managing stress by blending effective techniques with ... Read more

The post Mastering Stress Management: A Guide to Thriving, Not Just Surviving appeared first on LifeHack.

Apple is about to make losing your luggage far less of a hassle. The Cupertino tech giant is readying the… Continue reading Apple is about to eliminate the stress of losing a suitcase

The post Apple is about to eliminate the stress of losing a suitcase appeared first on ReadWrite.

Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor and that its expression can be significantly induced under H2O2 stress. CmtR can physically interact with the negative regulator Zur and de-represses the expression of the esx-3 operon, which leads to Zn2+ accumulation and promotion of reactive oxygen species detoxication in mycobacterial cells. Zn2+ can also act as an effector molecule of the CmtR regulator, using which the latter can de-repress its own expression for further inducing bacterial antioxidant adaptation. Consistently, CmtR can induce the expression of EsxH, a component of esx-3 operon involved in Zn2+ transportation that has been reported earlier, and inhibit phagosome maturation in macrophages. Lastly, CmtR significantly contributes to bacterial survival in macrophages and in the lungs of infected mice. Our findings reveal the existence of an antioxidant regulatory pathway in mycobacteria and provide novel information on stress-triggered gene regulation and its association with host–pathogen interaction.

Adult progenitor cell populations typically exist in a quiescent state within a controlled niche environment. However, various stresses or forms of damage can disrupt this state, which often leads to dysfunction and aging. We built a glucocorticoid (GC)-induced liver damage model of mice, found that GC stress induced liver damage, leading to consequences for progenitor cells expansion. However, the mechanisms by which niche factors cause progenitor cells proliferation are largely unknown. We demonstrate that, within the liver progenitor cells niche, Galectin-3 (Gal-3) is responsible for driving a subset of progenitor cells to break quiescence. We show that GC stress causes aging of the niche, which induces the up-regulation of Gal-3. The increased Gal-3 population increasingly interacts with the progenitor cell marker CD133, which triggers focal adhesion kinase (FAK)/AMP-activated kinase (AMPK) signaling. This results in the loss of quiescence and leads to the eventual stemness exhaustion of progenitor cells. Conversely, blocking Gal-3 with the inhibitor TD139 prevents the loss of stemness and improves liver function. These experiments identify a stress-dependent change in progenitor cell niche that directly influence liver progenitor cell quiescence and function.

Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of the translational machinery. At the center of this machinery is the ribosome, a ribonucleoprotein complex that depends heavily on Mg2+ for structure. Recent work has indicated that other metal cations can substitute for Mg2+, raising questions about the role different metals may play in the maintenance of the ribosome under oxidative stress conditions. Here, we assess ribosomal integrity following oxidative stress both in vitro and in cells to elucidate details of the interactions between Fe2+ and the ribosome and identify Mn2+ as a factor capable of attenuating oxidant-induced Fe2+-mediated degradation of rRNA. We report that Fe2+ promotes degradation of all rRNA species of the yeast ribosome and that it is bound directly to RNA molecules. Furthermore, we demonstrate that Mn2+ competes with Fe2+ for rRNA-binding sites and that protection of ribosomes from Fe2+-mediated rRNA hydrolysis correlates with the restoration of cell viability. Our data, therefore, suggest a relationship between these two transition metals in controlling ribosome stability under oxidative stress.

Marco De Giorgi
Dec 1, 2020; 61:1675-1686
Research Articles

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we investigated the effects of Hmgcr inhibition on nonsterol isoprenoids in the liver. We have generated new genetic models to acutely delete genes in the mevalonate pathway in the liver using AAV-mediated delivery of Cre-recombinase (AAV-Cre) or CRISPR/Cas9 (AAV-CRISPR). The genetic deletion of Hmgcr by AAV-Cre resulted in extensive hepatocyte apoptosis and compensatory liver regeneration. At the biochemical level, we observed decreased levels of sterols and depletion of the nonsterol isoprenoids, dolichol and ubiquinone. At the cellular level, Hmgcr-null hepatocytes showed ER stress and impaired N-glycosylation. We further hypothesized that the depletion of dolichol, essential for N-glycosylation, could be responsible for ER stress. Using AAV-CRISPR, we somatically disrupted dehydrodolichyl diphosphate synthase subunit (Dhdds), encoding a branch point enzyme required for dolichol biosynthesis. Dhdds-null livers showed ER stress and impaired N-glycosylation, along with apoptosis and regeneration. Finally, the combined deletion of Hmgcr and Dhdds synergistically exacerbated hepatocyte ER stress. Our data show a critical role for mevalonate-derived dolichol in the liver and suggest that dolichol depletion is at least partially responsible for ER stress and apoptosis upon potent Hmgcr inhibition.

Oxidative stress has been implicated in aging and many human diseases, notably neurodegenerative disorders and various cancers. The reactive oxygen species that are generated by aerobic metabolism and environmental stressors can chemically modify proteins and alter their biological functions. Cells possess protein repair pathways to rescue oxidized proteins and restore their functions. If these repair processes fail, oxidized proteins may become cytotoxic. Cell homeostasis and viability are therefore dependent on the removal of oxidatively damaged proteins. Numerous studies have demonstrated that the proteasome plays a pivotal role in the selective recognition and degradation of oxidized proteins. Despite extensive research, oxidative stress-triggered regulation of proteasome complexes remains poorly defined. Better understanding of molecular mechanisms underlying proteasome function in response to oxidative stress will provide a basis for developing new strategies aimed at improving cell viability and recovery as well as attenuating oxidation-induced cytotoxicity associated with aging and disease. Here we highlight recent advances in the understanding of proteasome structure and function during oxidative stress and describe how cells cope with oxidative stress through proteasome-dependent degradation pathways.

The histidine kinase Hik33 plays important roles in mediating cyanobacterial response to divergent types of abiotic stresses including cold, salt, high light (HL), and osmotic stresses. However, how these functions are regulated by Hik33 remains to be addressed. Using a hik33-deficient strain (hik33) of Synechocystis sp. PCC 6803 (Synechocystis) and quantitative proteomics, we found that Hik33 depletion induces differential protein expression highly similar to that induced by divergent types of stresses. This typically includes downregulation of proteins in photosynthesis and carbon assimilation that are necessary for cell propagation, and upregulation of heat shock proteins, chaperons, and proteases that are important for cell survival. This observation indicates that depletion of Hik33 alone mimics divergent types of abiotic stresses, and that Hik33 could be important for preventing abnormal stress response in the normal condition. Moreover, we found the majority of proteins of plasmid origin were significantly upregulated in hik33, though their biological significance remains to be addressed. Together, the systematically characterized Hik33-regulated cyanobacterial proteome, which is largely involved in stress responses, builds the molecular basis for Hik33 as a general regulator of stress responses.

March 26, 2024 — Scientists at the Department of Energy’s Oak Ridge National Laboratory have determined how to avoid costly and potentially irreparable damage to large metallic parts fabricated through […]

The post ORNL Develops Solution to Residual Stress Challenges in 3D-Printed Metal Structures appeared first on HPCwire.

From hugging to hypnosis, these stress relievers are backed by serious research—find out which one works best for you.

Study of workplace stress finds there's a better way to cope than relaxation.