Researchers interviewed scores of principals in 19 states on how they’ve coped and the lessons they’re taking away from the pandemic’s disruption.

Marloes J. A. G. Henckens
Aug 12, 2009; 29:10111-10119
BehavioralSystemsCognitive

Bruce S. McEwen
Jan 2, 2020; 40:12-21
Viewpoints

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

Take a calming breath, then watch this video to find out

In this trailer for a documentary about the acclaimed sculpturist, Louise Bourgeois discusses her life work

David Lynch | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Education As a filmmaker, Lynch has a reputation for creating dark, surreal movies such as Eraserhead, Blue Velvet and Wild at Heart as well as the TV show “Twin Peaks.” In the education world, he's becoming known for something very different: promoting inner peace. Over the past decade, the David Lynch Foundation has sponsored Transcendental Meditation classes for half a million children in places as far-flung as the Bronx, Detroit, Los Angeles, Congo and the West Bank. The program, called Quiet Time, is now at the center of one of the largest-ever studies of meditation for children—a 6,800-pupil research project conducted by the Crime Lab at the University of Chicago and designed to learn if meditation can help kids in highly stressful environments fare better at home and in school. Read more about Lynch’s work: http://smithmag.co/9sHhtm | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy

At first glance, it could seem that teenagers just really, really hate high school. But Yale researchers found deeper student engagement issues.

U.S. Secretary of Education Betsy DeVos recently spoke at Council of the Great City Schools annual legislative and policy conference in Washington, D.C. Here are some of her remarks.

Are you worried your kids are doomed to be permanently damaged by chronic stress from the pandemic? Take heart from this counselor's advice.

When students are overwhelmed, their schoolwork suffers. But two growth-mindset researchers, Jamie M. Carroll and David Yeager, say teachers can help increase kids' resilience.

Studies on teacher effectiveness, lessons from Finland, and 'The Magic School Bus' all made this year's list of most-read Teaching Now posts.

The gut microbiome doesn't just regulate digestion and metabolism; it plays a critical role in how we react to stress.

NEW CASTLE (May 15, 2020) – The Delaware Division of Substance Abuse and Mental Health (DSAMH) has launched a phone line dedicated to helping Delawareans cope with stress and address behavioral health needs during the coronavirus pandemic. The Delaware Hope Line – 1 (833) 9-HOPEDE or (833) 946-7333 – is open 24 hours a day, […]

U.S. President Joe Biden on Tuesday hosted Israel's president while President-elect Donald Trump has separately held multiple phone calls recently with Israel's head of government, Prime Minister Benjamin Netanyahu. These parallel talks have focused on the conflicts in Gaza and Lebanon and hopes for the release of hostages held by Hamas. VOA White House correspondent Anita Powell reports from Washington.

Title: Stress May Raise Risk of Premenstrual Syndrome
Category: Health News
Created: 8/26/2010 10:49:00 AM
Last Editorial Review: 8/26/2010 10:49:44 AM

Title: Stress, a 'Type A' Personality May Boost Stroke Risk
Category: Health News
Created: 8/30/2012 10:05:00 AM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: Stress Linked to Stroke
Category: Health News
Created: 8/31/2012 11:00:00 AM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Health Tip: Manage Stress to Keep Diabetes in Check
Category: Health News
Created: 8/25/2014 7:35:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM

Title: Why Your Child Is Stressed: 10 Reasons
Category: Health News
Created: 8/28/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Stress May Take Greatest Toll on Younger Women's Hearts: Study
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM

Title: More Evidence Ties Stress to Heart Trouble
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Stress, Anger May Worsen Heart Failure
Category: Health News
Created: 8/21/2020 12:00:00 AM
Last Editorial Review: 8/24/2020 12:00:00 AM

Title: Delta Variant Has Americans' Stress Levels Rising Again: Poll
Category: Health News
Created: 8/20/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Title: College Is Even More Stressful for Girls: Study
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Title: Can Stress Cause Multiple Sclerosis (MS)?
Category: Diseases and Conditions
Created: 6/18/2020 12:00:00 AM
Last Editorial Review: 7/26/2022 12:00:00 AM

Oxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of advanced glycation end product (RAGE) interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating cannabinoid type 2 receptors (CB2Rs) against diabetic complication, mainly cardiomyopathy and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding a high-fat diet with streptozotocin injections. After the development of diabetes, the animals received a 12-week oral BCP treatment at a dose of 50 mg/kg/body weight. BCP treatment showed significant improvement in glucose tolerance and insulin resistance and enhanced serum insulin levels in diabetic animals. BCP treatment effectively reversed the heart remodeling and restored the phosphorylated troponin I and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a expression. Ultrastructural examination showed reduced myocardial cell injury in DCM mice treated with BCP. The preserved myocytes were found to be associated with reduced expression of AGE/RAGE in DCM mice hearts. BCP treatment mitigated oxidative stress by inhibiting expression of NADPH oxidase 4 and activating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. Also, BCP suppressed cardiac fibrosis and endothelial-to-mesenchymal transition in DCM mice by inhibiting transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling. Further, BCP treatment suppressed nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation in DCM mice and alleviated cellular injury to the pancreatic tissues evidenced by significant elevation of the number of insulin-positive cells. To demonstrate a CB2R-dependent mechanism of BCP, another group of DCM mice were pretreated with AM630, a CB2R antagonist. AM630 was observed to abrogate the beneficial effects of BCP in DCM mice. Taken together, BCP demonstrated the potential to protect the myocardium and pancreas of DCM mice mediating CB2R-dependent mechanisms.

The sun blasted a coronal mass at Earth earlier this week, and after back-to-back major hurricanes, some are concerned it could impact the power grid.

A Kenora, Ont., resident says she wants to see more resources for people who encounter sick or injured animals after seeing a deer in her yard with a tomato cage stuck on its head. Here's how the community has responded to the incident, and what we know about the deer's status.

What is Jupiter's great red spot? Researchers have observed the red spot changing over time.

Une étude rapporte que la perturbation de l’équilibre du microbiote intestinal par le stress dérègle la fonction des cellules immunitaires.

The Indian pharmaceutical industry is advocating for enhanced fire safety measures and improved insurance coverage for employees working in pharmaceutical facilities.

Life can sometimes feel like a never-ending cycle of stress and decisions. That's usually my weekdays in a nutshell: chasing deadlines, making tough calls, and hopping between meetings. When your brain feels like it's on overdrive, it's time to hit pause. Engaging in some therapeutic activities can give your mind the breather it desperately needs. The good news? They don't have to be complicated or time-consuming. Here are some that can work wonders for your mental clarity and overall well-being. Step outside for a walk Walking is one of the simplest ways to clear your mind. It's amazing what a little fresh air at your nearby PCN can do. Just stepping outside and getting those legs moving can shift your perspective in a matter of minutes — and burn a few calories too! Disconnect from your phone and enjoy the sights and sounds of the great outdoors. I find that a 30-min walk and a change of environment works wonders for me, helping me rationally dissect my worries, such as my crushing feelings of inadequacy at work.

Gaining Independence While Living with Diabetes

Nurses who are parents are more susceptible than other groups to daily stress aggravated by sleep deprivation, revealed paper published in Journal of Sleep Research.

The COVID (and) #8208;19 pandemic developed new patient care circumstances that may have grown nurses moral distress, including COVID (and) #8208;19 transmission

Medical professionals, specifically doctors, play an important role in delivering good quality patient care. However, they are frequently confronted with

medlinkWomen/medlink face a higher risk of digital overload than men when managing work and family through technology, according to Lancaster University

Sexual performance and sperm health can be impaired through stress as per a recent study. This can further lead to infertility. The study found that

College athletes develop poor medlinkeating habits/medlink as a result of medlinkstress/medlink during intense practice sessions. According

While stress is known to significantly contribute to the onset of various health issues, a new study on Sunday showed how stress can worsen colorectal cancer (CRC) (!--ref1--).

Individuals suffering from both medlinkposttraumatic stress disorder/medlink (PTSD) and medlinktype 2 diabetes/medlink experience significantly

Hope tends to be more helpful than mindfulness in assisting people in managing their stress and maintaining their professional engagement during extended

A groundbreaking study has revealed the essential role of gut microbiota in managing stress responses through its interaction with the body's circadian rhythms.

IWMI in Pakistan organized a workshop to discuss the critical issue of water conservation and sustainable groundwater management in Balochistan.

The post Experts stress efficient groundwater use first appeared on International Water Management Institute (IWMI).

The seminar, organized by IWMI, stresses climate change awareness, its impact on agriculture, and the need for adaptation, urging informed action.

The post Speakers stress need to raise awareness about climate change first appeared on International Water Management Institute (IWMI).

Sub-chronic psychological stress may adversely affect male fertility, reports a latest study conducted in the Banares Hindu University, (BHU) a Central

Psychological medlinkstress/medlink caused by lifestyle and other factors can wreak havoc on a man's sexual life, finds a new study conducted by a