Tiny homes are still all the rage within the minimalist and wanderlust communities of the world, and what better place to consider tiny living than in the warmth of the big island, Hawaii? If equatorial location is on your must-have list, this tiny home might be just the serving of simplicity and decadence you’re looking for. [...]

"Never in my wildest dreams did I think it would be my brother until I saw everything the next day and saw his name," said Rosemary Gomez, 38. “I was like, ‘No, it can’t be him, it can’t be him.' Then his (estranged) wife called me. She was in a state of shock."

For years, the Cerpas sisters engaged in friendly competition, running their own dress shops. Now they've come together to make face masks.

PRINCESS Beatrice was to join her sister, Princess Eugenie, in entering married life this month before the coronavirus pandemic hit. Now, the couple will have to wait before they can finally tie the knot, similarly to Beatrice and her husband, Jack Brooksbank.

  So I thought about my brother and sister a lot this weekend. It’s not like me at all. You don’t count on people just, sort of vanishing. I’ve been talking about death since I was born, so with my Dad it was kinda different. I knew he was dying. It was strange. We both […]

Sex (Psychology) -- Social aspects.

[London] (Historic Gallery, Pall Mall) : Published by R. Bowyer, June 1804

A woman who lost her sister to COVID-19 at the start of the month is thanking the staff at Northwood who took "excellent" care of her in her final days. Jean Harrigan, 90, is being remembered for her caring and lively nature.

To a sister, till we meet again  The Tribune India

Inside Pic: Can You Identify Madhuri Dixit In This Throwback Picture with Her Sister?  సాక్షి

Source: www.mirror.co.uk - Saturday, May 09, 2020
At least the garish crystal cheetah clutches aren't as saucy as the hamper sent to Kim Kardashian from cheeky Khloé as the family shower each other with odd gifts

Periodontitis as a biofilm-associated inflammatory disease is highly prevalent worldwide. It severely affects oral health and yet closely links to systemic diseases like diabetes and cardiovascular disease. Porphyromonas gingivalis as a ‘keystone' periodontopathogen drives the shift of microbe-host symbiosis to dysbiosis, and critically contributes to the pathogenesis of periodontitis. Persisters are a tiny subset of biofilm-associated microbes highly tolerant to lethal treatment of antimicrobials, and notably metronidazole-tolerant P. gingivalis persisters have recently been identified by our group. This study further explored the interactive profiles of metronidazole-treated P. gingivalis persisters (M-PgPs) with human gingival epithelial cells (HGECs). P. gingivalis cells (ATCC 33277) at stationary phase were treated with lethal dosage of metronidazole (100 μg/ml, 6 hours) for generating M-PgPs. The interaction of M-PgPs with HGECs was assessed by microscopy, flow cytometry, cytokine profiling and qPCR. We demonstrated that the overall morphology and ultra-cellular structure of M-PgPs remained unchanged. Importantly, M-PgPs maintained the capabilities to adhere to and invade into HGECs. Moreover, M-PgPs significantly suppressed pro-inflammatory cytokine expression in HGECs at a comparable level with the untreated P. gingivalis cells, through the thermo-sensitive components. The present study reveals that P. gingivalis persisters induced by lethal treatment of antibiotics could maintain their capabilities to adhere to and invade into human gingival epithelial cells, and perturb the innate host responses. Novel strategies and approaches need to be developed for tackling P. gingivalis and favourably modulating the dysregulated immuno-inflammatory responses for oral/periodontal health and general wellbeing.

"How to annoy your sister 101," wrote Janhvi

Ekpar Asat came to the United States for the State Department’s most prestigious program for foreign citizens. Chinese security officers detained him weeks after he returned home.

Two men were arrested for the strangling deaths of three sisters who worked in Mexico's government hospital system, and authorities ruled out any link to nationwide assaults on medical staff as anxiety over the pandemic escalates.

MEXICO CITY (AP) — Two men were arrested for the strangling deaths of three sisters who...

South African Fredie Blom celebrated his 116th birthday on Friday unfazed by the coronavirus crisis, over 100 years since the Spanish flu pandemic killed his sister.“I have lived this long because of God’s grace,” said Blom, possibly one of the oldest men in the world.Lighting a cigarette, he recalled the 1918 pandemic that left tens of millions dead worldwide including his sister.Blom was born in 1904 in the rural town of Adelaide, tucked near the Great Winterberg mountain range of South…

Miley Cyrus’s sister Noah Cyrus clapped back at trolls, slamming her for her looks since she was 12

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open cavities connecting with an airway. Several commonly accepted characteristics of caseum were established during the preantibiotic era, when autopsies of deceased tuberculosis (TB) patients were common but methodologies were limited. These pioneering studies generated concepts such as acidic pH, low oxygen tension, and paucity of nutrients being the drivers of nonreplication and persistence in caseum. Here we review widely accepted beliefs about the caseum-specific stress factors thought to trigger the shift of Mycobacterium tuberculosis to drug tolerance. Our current state of knowledge reveals that M. tuberculosis is faced with a lipid-rich diet rather than nutrient deprivation in caseum. Variable caseum pH is seen across lesions, possibly transiently acidic in young lesions but overall near neutral in most mature lesions. Oxygen tension is low in the avascular caseum of closed nodules and high at the cavity surface, and a gradient of decreasing oxygen tension likely forms toward the cavity wall. Since caseum is largely made of infected and necrotized macrophages filled with lipid droplets, the microenvironmental conditions encountered by M. tuberculosis in foamy macrophages and in caseum bear many similarities. While there remain a few knowledge gaps, these findings constitute a solid starting point to develop high-throughput drug discovery assays that combine the right balance of oxygen tension, pH, lipid abundance, and lipid species to model the profound drug tolerance of M. tuberculosis in caseum.

Bacterial persisters are phenotypic variants that temporarily demonstrate an extraordinary tolerance toward antibiotics. Persisters have been linked to the recalcitrance of biofilm-related infections; hence, a complete understanding of their physiology can lead to improvement of therapeutic strategies for such infections. Mechanisms pertaining to persister formation are thought to be associated with stress response pathways triggered by intra- or extracellular stress factors. Unfortunately, studies demonstrating the effects of osmolyte- and/or pH-induced stresses on bacterial persistence are largely missing. To fill this knowledge gap within the field, we studied the effects of various osmolytes and pH conditions on Escherichia coli persistence with the use of phenotype microarrays and antibiotic tolerance assays. Although we found that a number of chemicals and pH environments, including urea, sodium nitrite, and acidic pH, significantly reduced persister formation in E. coli compared to no-osmolyte/no-buffer controls, this reduction in persister levels was less pronounced in late-stationary-phase cultures. Our results further demonstrated a positive correlation between cell growth and persister formation, which challenges the general notion in the field that slow-growing cultures have more persister cells than fast-growing cultures.

Antituberculosis (anti-TB) drug development is dependent on informative trials to secure the development of new antibiotics and combination regimens. Clofazimine (CLO) and pyrazinamide (PZA) are important components of recommended standard multidrug treatments of TB. Paradoxically, in a phase IIa trial aiming to define the early bactericidal activity (EBA) of CLO and PZA monotherapy over the first 14 days of treatment, no significant drug effect was demonstrated for the two drugs using traditional statistical analysis. Using a model-based analysis, we characterized the statistically significant exposure-response relationships for both drugs that could explain the original findings of an increase in the numbers of CFU with CLO treatment and no effect with PZA. Sensitive analyses are crucial for exploring drug effects in early clinical trials to make the right decisions for advancement to further development. We propose that this quantitative semimechanistic approach provides a rational framework for analyzing phase IIa EBA studies and can accelerate anti-TB drug development.

The 24-year-old singer has posted a glowing tribute to her sister Rina on Instagram, expressing sadness that the coronavirus lockdown has stopped

A US woman has died after contracting coronavirus more than a century after her sister was killed by the 1918 Spanish flu pandemic, according to local obituaries.

A seven-year-old boy accidentally killed his three-year-old sister after shooting her with an unsecured shotgun in Colorado, police said.

A nurse has died with coronavirus in the London hospital where she worked alongside her sister — who is now fighting for life in intensive care.

Twin sisters Nishita and Atisha Lulla talk about recording a previous single in Mumbai, the country-folk influence and more

The post Indo-American Sister Duo LULLANAS Drop Debut EP ‘Before Everything Got Real’ appeared first on My Site.

(Family Hour/Thirty Tigers)
Sean and Sara Watkins are back and in reflective mood

California’s Sean and Sara Watkins are akin to royalty in American folk circles, firstly as founding members of the hugely successful Nickel Creek, and secondly as hosts of an 18-year residency at LA’s Largo club, where they perform alongside invited guests. Brother Sister draws on both strands of their history. Like its self-titled 2015 predecessor, the album sets aside the pizzazz of Nickel Creek for a down-home approach, but instead of boisterous, star-studded cover versions come five original songs and a minimal musical palette.

Alternating on lead, the pair’s vocals remain a model of sibling harmony, while the interplay between Sean’s intricate guitar picking and Sara’s elegant fiddle is similarly impressive – the breakneck bluegrass instrumental Bella and Ivan is a case in point. Mostly, however, the mood is reflective. Lafayette and Miles of Desert Sand chronicle the search for a better life, and Fake Badge, Real Gun is an artful snipe at Trump – “Throw your tantrums but the truth will be waiting”. Warren Zevon’s forlorn Accidentally Like a Martyr fits in neatly, while Charley Jordan’s ribald Keep It Clean is a gleeful example of a Largo session.

The Quiz star says she still feels like she constantly has to prove herself as an actor

Coronavirus: The symptoms

Tamieka and Teya Garcia are making inroads in the boxing industry despite a life-threatening health condition that complicates their efforts to step inside the ring.

Five sisters make up a quarter of their tiny town's under-16s Aussie Rules team. They can't compete right now, but they are all determined to break into the professional ranks one day.

Loretta and Tracey Fergerson were indicted by a federal grand jury in the Middle District of Alabama on a variety of charges stemming from an identity theft and tax fraud conspiracy.

Loretta Fergerson and her sister, Tracey Fergerson, both of Montgomery, Ala., were each sentenced to 115 months prison for their involvement in a conspiracy to file claims for false income tax refunds using stolen identities, the Justice Department and Internal Revenue Service (IRS) announced today. U.S. District Judge Mark Fuller ordered the Fergerson sisters to pay $504,305 in restitution to the IRS.

Solar Sister showcased just some of the efforts taking place around the world. Here, the Women Barefoot Solar Engineers of Mauritania install solar panels in their villages. They received training in Rajasthan, India. Image: Barefoot Photographers of

http://www.giantitp.com/comics/oots1193.html

Kartik Aaryan has a knack to take social media by storm with his remarkable videos and post and even his hit series. After seeking help from the netizens to help him to decide whether he must remove his facial fuzz or grow a quarantine beard, the actor now leaves us in splits with a fun video with his sister Dr. Kritika.

Kartik Aaryan has posted an adorable video where he's showing his displeasure as he comps into a roti made by her sister. The perfectionist that the actor is believes in not taking this lightly and decides to teach his sister a lesson, obviously all in a joke. Kritika who's seen with a rolling-pin in her hand is animatedly flung around by Aaryan and almost thrown out of the balcony. Aaryan ends the video looking nonchalant with the harsh (and obviously funny) treatment and the rolling pin in his hand.

The actor has captioned the video wittily saying, 'no compromises on quality!' Now that's one funny video that made our not-so-happening-Sunday, brighter and better. These siblings are always seen pulling each other's leg and always indulging in tomfoolery like any normal siblings do. We love this actor and his amazing sense of humour.

Have a look right here:

 

 

 

View this post on Instagram

No Compromise on Quality😇 #KokiToki

A post shared by KARTIK AARYAN (@kartikaaryan) onApr 19, 2020 at 4:34am PDT

Kartik Aaryan has been doing every bit to fight the pandemic and educate the masses. His internet-breaking show Koki Poochega has been trending on all platforms ever since its inception. Moreover the actor's heroic act to pledge Rs 1 crore to the PM Cares Relief Funds, is truly commendable. Kartik Aaryan's wit and his nobles' causes are truly making him a true-blue hero in every sense in these tough times. Hats off to the youth icon!

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The last few weeks haven't been easy for Zoa Morani and her family. They all were tested Coronavirus positive and it came as a shock to a lot of people and they were worried about their health. Zoa Morani and Shaza Morani were the first ones to be tested positive and then their father and film producer Karim Morani. Zoa and Shaza recovered a few days back while Karim was still tested positive. But now he too is back and doing well.

First, let's talk about Zoa's recent Instagram post where she shared a family picture and announced happily that they all are Coronavirus negative now. It was indeed a moment of celebration that they all successfully combated the virus. It was a long post straight from the heart.

Read it right here:

 

 

 

View this post on Instagram

#positiverecovery ☀ï¸Â Anddddd my father got home last night , treatment over and now our entire household is Covid-19 negative ! 😁 All of us home now , healthy and in good spirits !!!🌻 Whirlwind of an experience but so happy to be on the other side of it.. Each one of us had a different experience with it in terms of symptoms, so for any advice the best thing is to get in touch with a Doctor or hospital... My Father - no symptoms (9 days in hospital) Sister - head ache and fever (6 days in hospital) Me - fever , fatigue , cough , chest congestion , shortness of breath and head ache ( 7 days in hospital) They were mild , and manageable. To sum it up in short - a flu with a strange over all feeling .. The Doctors and medical staff were fearless , positive and extremely helpful and caring ... @my_bmc @mybmchealthdept were on point with following up with us at every step , from making sure we are getting the right treatment to getting our entire building and road sanitised ! To making sure the other residents in our building are safe ! And yes they are ☀ï¸Â 14 days of self isolation at home along with healthy eating , rest and vitamins has been advised.. So grateful for our Government for dealing with this Pandemic hands on ! Thank you Nanavati Hospital for taking care of my Father and Sister and sending them home fully cured 🌼 Thank you Kokilaben hospital ! Indebted forever ! Thank youuuu everyone from the bottom of my heart for all the concern and warm wishes 🥰 So grateful to be on the positive recovery side of this Pandemic . Sincere and deep prayers for the entire world and their families who got hit with the serious side of the illness ... 🤲🏽 #CovidRecovered #covid #ThankYouGod

A post shared by Zoa💫 (@zoamorani) onApr 17, 2020 at 10:34pm PDT

And now, talking to Mumbai Mirror about the same, Zoa poured her heart out on what the experience taught her and why she's now going to donate her blood. She said, "The most important thing that I have learned is how to be your own best friend. When I was in the hospital, I couldn't tell my parents and my sister I am scared. I had to be strong enough to be able to console myself. I have been very attached and dependent on people in the past, didn't have faith and confidence in myself."

And since the entire family, as stated above, is back home, how are they spending time? Zoa said, "We are all staying in the same house but maintaining distance from each other. We are not having dinner together or doing things together. The isolation period for me and my sister will get over. But it is still time for my father's isolation period to get over." She also revealed that she will be donating her blood this weekend.

"This weekend, we are going to be donating our blood. Apparently, after 14 days once you are tested negative, you can give your blood to other people because you have antibodies in your blood. It might help other people heal and recover." She also spoke about how she and her sister felt after they were tested COVID-19 positive. She stated, "My sister got a terrible headache and fever, I, on the other hand, had developed all these symptoms."

She added, "I was not able to breathe properly and I thought something was stuck in my chest. In the beginning, we all thought it was normal flu, my sister got a fever and the next day I got a fever. On the 8th day, it was pretty bad and we decided to get tested." It's heartening to know that the Morani family has finally recovered and we wish they continue to stay happy, hale, and hearty.

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Now that Khushi Kapoor is back from the US to be with her family amid the coronavirus lockdown, it seems like elder sister Janhvi can't handle the joy of reuniting with her baby sister. Janhvi Kapoor frequently shares photos of herself with Khushi, and those pictures too were full of love and affection for her sibling.

Janhvi recently shared an Instagram story in which she is seen offering a carrot cake made by her for baby sister Khushi. The star kid was seen a little reluctant to eat the cake but after taking a bite, she says, "it is good". However, she gives up when the Dhadak 2 actress asks her to eat more.

Eager to watch the fun banter the Kapoor sister had? Watch this video:

 

 

 

View this post on Instagram

#JanhviKapoor bakes a carrot cake and #KhushiKapoor expression is 🙄🙄 #StayHomeStaySafe #india #manavmanglani

A post shared by Manav Manglani (@manav.manglani) onApr 21, 2020 at 10:21am PDT

Janhvi Kapoor frequently shared photos of herself with Khushi, and those pictures too were full of love and affection for her sibling. Janhvi recently shared an Instagram story that shows her cuddling up with Khushi on the sofa, who looks quite amused with the former's shenanigans.

Before this, she uploaded a video where she can be seen getting her hair done by Khushi. "Getting me all dressed up to go nowhere," she captioned the video.

Meanwhile, on the work front, Janhvi Kapoor will be next seen in Gunjan Saxena, where the actress is portraying a real-life person for the first time in her career. Based on Gunjan Saxena, who is one of the first female pilots to fly in combat, Janhvi plays an important role in rescuing injured soldiers during the Kargil War in 1999 and was awarded the gallantry Shaurya Vir Award for displaying courage during the war.

Directed by Sharan Sharma, the film also stars Vineet Kumar Singh, Angad Bedi and Manav Vij in pivotal roles. She will also be seen in Karan Johar's multi-starrer Takht alongside Kareena Kapoor Khan, Ranveer Singh, Alia Bhatt, Vicky Kaushal, Bhumi Bednekar and Anil Kapoor, and Roohi Afza opposite Rajkummar Rao.

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Bollywood actor Saif Ali Khan's son Ibrahim is using the COVID-19 lockdown period to strengthen his bond with mother Amrita Singh and sister Sara Ali Khan. "I'm spending quarantine, strengthening my bond with my mother and sister as we take charge of the household chores," Ibrahim wrote on Instagram.

"I came across a video which is a simple reminder to support our extended families of our neighborhood, especially the elderly who are the most in need amid the COVID-19 crisis. It's time we strengthen bonds and #ShowWeCare by helping them with essentials and ensure their well-being," he added.

 

 

 

View this post on Instagram

I'm spending quarantine, strengthening my bond with my mother and sister as we take charge of the household chores. This video by @vicks_india is a simple reminder to support the extended families of our neighborhood, especially the elderly who are the most in need amid the COVID-19 crisis. It's time we strengthen bonds and #ShowWeCare by helping them with essentials and ensure their well-being. #IndiaFightsCorona #QuarantineLife #FightCoronaTogether #StaySafe #covid_19 #StrongerTogether #TogetherWeCan #VicksPartner

A post shared by Ibrahim Ali Khan (@iakpataudi) onApr 22, 2020 at 5:33am PDT

Recently, Ibrahim also joined celebrities including Virat Kolhi and Siddhant Chaturvedi to voice concern for senior citizens amid the ongoing health crisis.

Kolhi used social media to request his fans to step up during the difficult time and check if senior citizens living in their vicinity are in need of any essentials or any other support. Siddhant, famous for his role as 'MC Sher' in "Gully Boy", called senior citizens living in his building and checked on their well-being. He told his fans on social media how simple acts of care towards the most in need while practicing social distancing can go a long way in emerging out stronger as a nation.

Kohli, Siddhant and Ibrahim were urging people to extend care for the elderly in an initiative by P&G Vicks.

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A police complaint has been filed against Bollywood actress Kangana Ranaut for allegedly referring to people of a particular community as "terrorist" and coming out in support of her sister Rangoli Chandel, whose Twitter account recently got suspended for alleged hate speech.

The complaint has been filed by by Advocate Ali Kaashif Khan Deshmukh, a resident of Mumbai. In a copy of the complaint lying with IANS, it has been mentioned: "It is pertinent to note that one sister calls for genocide killings, violence and the other sister not just support her for the same despite nationwide criticism and suspension of her Twitter account but also gives a label of terrorist to a sect..."

The complaint accused the actress and her sister-cum-manager Rangoli of "misusing their stardom, fanbase, fame, money, power and influence with an aim and intent to promote hatred, disbalance, fights in the country for their personal benefits and gains".

In a recently shared video on Instagram, Kangana Ranaut said if anyone can find a tweet where Rangoli says anything offensive, "then we both will publicly apologize".

The actress further mentioned: "My sister Rangoli Chandel had specifically mentioned that people who have attacked doctors and police personnel should be shot dead," adding that celebrities like "Farah Ali Khan ji and Reema Kagti ji made a false allegation" that Rangoli's comment was community-specific.

The actress had also stated in the video message that she and her sister did not believe that every person "attacking doctors and cops" belonged to any particular community.

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A police complaint has been filed against Bollywood actress Kangana Ranaut for allegedly referring to people of a particular community as "terrorist" and coming out in support of her sister Rangoli Chandel, whose Twitter account recently got suspended for alleged hate speech.

The complaint has been filed by Advocate Ali Kaashif Khan Deshmukh, a resident of Mumbai. In a copy of the complaint lying with IANS, it has been mentioned: "It is pertinent to note that one sister calls for genocide killings, violence and the other sister not just support her for the same despite nationwide criticism and suspension of her Twitter account but also gives a label of terrorist to a sect..."

The complaint accused the actress and her sister-cum-manager Rangoli of "misusing their stardom, fanbase, fame, money, power and influence with an aim and intent to promote hatred, disbalance, fights in the country for their personal benefits and gains".

In a recently shared video on Instagram, Kangana Ranaut said if anyone can find a tweet where Rangoli says anything offensive, "then we both will publicly apologize".

The actress further mentioned: "My sister Rangoli Chandel had specifically mentioned that people who have attacked doctors and police personnel should be shot dead," adding that celebrities like "Farah Ali Khan ji and Reema Kagti ji made a false allegation" that Rangoli's comment was community-specific.

The actress had also stated in the video message that she and her sister did not believe that every person "attacking doctors and cops" belonged to any particular community.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

A 24-year-old man's parents hatched a plan to kill him after they were physically abused by him on more than one occasion. On Saturday, Waliv Police arrested the parents, sister and her husband of the deceased person. Upon enquiry, the accused told the police that the deceased person would physically and verbally harass them often.

As per the police investigations, the deceased, Rohit Chaudhary, who was a driver, was found lying dead in a pit in Bhoiwada, Bhyander. Initially, the identity of the man was unknown. His mother later filed a missing complaint. After probing the matter, the police found injury marks on the face and neck of the individual and later managed to identify him. The police then registered a murder case.

After checking mobile records, it was revealed to the cops that the last call to the deceased was made by his sister. Upon suspicion, cops then questioned the family and found out that Rohit would beat and abuse them.

During questioning, the family confessed to the crime. They stated that they recently visited their native place in Uttar Pradesh and hired two men to kill Rohit for an amount of Rs 2 and a half lakh. An advance amount of Rs 1 lakh was transferred in the bank of the contract killers.

The police have arrested the father Lalchand, mother Sunita, sister Shruti and her husband Anup. Police are currently on the hunt for the contract killers in Uttar Pradesh.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

A 26-year-old man from Kalyan in Maharashtra's Thane district has been booked for allegedly molesting his sister-in-law, police said Monday.

The woman in her complaint stated that she was living in her mother-in-law's home as her husband was bedridden following a paralytic attack and was being nursed there, said an official.

At her mother-in-law's home, the accused made sexual advances towards her, the victim said in her complaint. "After the victim rejected his overtures, the accused assaulted her ailing husband. She was molested by the accused when she intervened.

Neighbours rushed in and saved the couple," he said. The woman filed a complaint with MFC police station in Kalyan Sunday evening following which the man was booked, he said, adding that no arrest has been made so far.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever