Positive selection causes beneficial alleles to rise to high frequency, resulting in a selective sweep of the diversity surrounding the selected sites. Accordingly, the signature of a selective sweep in an ancestral population may still remain in its descendants. Identifying signatures of selection in the ancestor that are shared among its descendants is important to contextualize the timing of a sweep, but few methods exist for this purpose. We introduce the statistic SS-H12, which can identify genomic regions under shared positive selection across populations and is based on the theory of the expected haplotype homozygosity statistic H12, which detects recent hard and soft sweeps from the presence of high-frequency haplotypes. SS-H12 is distinct from comparable statistics because it requires a minimum of only two populations, and properly identifies and differentiates between independent convergent sweeps and true ancestral sweeps, with high power and robustness to a variety of demographic models. Furthermore, we can apply SS-H12 in conjunction with the ratio of statistics we term and to further classify identified shared sweeps as hard or soft. Finally, we identified both previously reported and novel shared sweep candidates from human whole-genome sequences. Previously reported candidates include the well-characterized ancestral sweeps at LCT and SLC24A5 in Indo-Europeans, as well as GPHN worldwide. Novel candidates include an ancestral sweep at RGS18 in sub-Saharan Africans involved in regulating the platelet response and implicated in sudden cardiac death, and a convergent sweep at C2CD5 between European and East Asian populations that may explain their different insulin responses.

Background:

Prediabetes is increasing in prevalence and is associated with risk of developing diabetes, heart disease, stroke, and retinopathy. Clinicians have limited tools to facilitate prediabetes discussions within primary care visits.

A multidisciplinary endocrinologist-led shared medical appointment (SMA) model showed statistically significant reductions in A1C from baseline over 3 years that were not significantly different from appointments with endocrinologists or primary care providers alone within a resource-poor population. Similarly, the SMA model achieved clinical outcomes on par with endocrinologist-only visits with the added benefit of improving endocrine provider productivity and specialty access for patients. Greater patient engagement with the SMA model was associated with significantly lower A1C.

BackgroundAwareness of the importance of shared decision making (SDM) is widespread; however, little research has focused on discussions surrounding investigations, despite increasing laboratory testing in primary care.AimTo explore the discussion of blood tests in routine primary care consultations.Design and settingA secondary analysis of 50 video-recorded routine primary care consultations, linked surveys, and records data (all from the One in a Million [OiaM] archive). The consultations were taken by 22 GPs across 12 practices.MethodA coding scheme was developed, using qualitative content analysis, to explore discussion of blood tests in transcripts of recorded consultations. Codes focused on instigating testing, the extent of SDM, and how results were explained. Survey data were used to compare patients’ pre-visit expectations with consultation content. Medical records were reviewed to compare tests discussed with those ordered.ResultsIn 36 out of 50 consultations that discussed ordering blood tests, 11 patients (31%) hinted that they wanted a blood test; however, none asked explicitly. Only four patients (11%) were offered alternative options. In 29 cases (81%) the GP gave some explanation of the indication, but only in six cases (17%) were the limitations of testing explained. Only 10 out of 31 patients (32%) were informed about all blood tests ordered. Of the 23 out of 50 consultations in which results were conveyed, the GP gave no explanation of the results in six cases (26%). Thirteen patients (57%) were only informed of an assessment of the results (for example, ‘normal’), rather than the actual results.ConclusionA lack of information dissemination and SDM exists around ordering tests and conveying results. Promoting SDM could reduce unnecessary testing and improve patient-centred care.

BackgroundUrinary tract infections (UTIs) are one of the most common bacterial infections managed in general practice. Many women with symptoms of uncomplicated UTI may not benefit meaningfully from antibiotic treatment, but the evidence base is complex and there is no suitable shared decision-making resource to guide antibiotic treatment and symptomatic care for use in general practice consultations.AimTo develop an evidence-based, shared decision-making intervention leaflet to optimise management of uncomplicated UTI for women aged <65 years in the primary care setting.Design and settingQualitative telephone interviews with GPs and patient focus group interviews.MethodIn-depth interviews were conducted to explore how consultation discussions around diagnosis, antibiotic use, self-care, safety netting, and prevention of UTI could be improved. Interview schedules were based on the Theoretical Domains Framework.ResultsBarriers to an effective joint consultation and appropriate prescribing included: lack of GP time, misunderstanding of depth of knowledge and miscommunication between the patient and the GP, nature of the consults (such as telephone consultations), and a history of previous antibiotic therapy.ConclusionConsultation time pressures combined with late symptom presentation are a challenge for even the most experienced of GPs: however, it is clear that enhanced patient–clinician shared decision making is urgently required when it comes to UTIs. This communication should incorporate the provision of self-care, safety netting, and preventive advice to help guide patients when to consult. A shared decision-making information leaflet was iteratively co-produced with patients, clinicians, and researchers at Public Health England using study data.

The Canadian rapper appeared on Weezy’s ‘Young Money Radio.’

Media Registration is Open for the APEC Informal Senior Officials’ Meeting

Media registration is open for the First APEC Senior Officials’ Meeting (SOM1) and related meetings in Putrajaya, Malaysia from 3 February to 22 February 2020.

Since 2013, hundreds of thousands of refugees have migrated southward to Jordan to escape the Syrian civil war. The migration has put major stress on Jordan’s water resources, a heavy burden for a country ranked among the most water-poor in the world, even prior to the influx of refugees. However, the refugee crisis also coincided […]

Promoting the gift economy and community resiliency, this man has been traveling the country for the last decade, offering free cups of tea out of his bus home.

The CATable will keep the cat off the keyboard.

Working in shared office spaces is an attractive solution for creative start-ups, and has become more and more sought-after in many of the bigger cities. Green Spaces in Manhattan has turned into a well-working

Designed for safety and comfort, this sharing bike looks similar to a standard bike, allowing friends to easily hop on and off.

Cars kept running into a big rock in a Calgary parking lot, perhaps because it didn't make eye contact.

A condo in Manhattan and a mixed use 12 story building in Portland get a boost.

It already exists, is on the roads, and has its own flashy commerical

Abhishek Bachchan has recalled his childhood experience of being on stage with father Amitabh Bachchan, in a throwback video he shared on Instagram on Friday, with a long caption post. In the video, Big B can be seen introducing his kids Shweta and Abhishek to the audience, both of whom say "hello" into the mic.

Abhishek wrote: "#flashbackfriday In 1981, my father started the trend of film actors from India doing shows on stage and performing to their songs. Before that, only playback singers did so. I have so many memories of being on the road with him, his co-stars and the immense Kalyanji and Anandji and their 40 piece orchestra helmed by a young and upcoming Viju Shah ( Kalyan ji's son and future Music Director of huge fame)."

 

 

 

View this post on Instagram

#flashbackfriday In 1981, my father started the trend of film actors from India doing shows on stage and performing to their songs. Before that, only playback singers did so. I have so many memories of being on the road with him, his co-stars and the immense Kalyanji and Anandji and their 40 piece orchestra helmed by a young and upcoming Viju Shah ( Kalyan ji's son and future Music Director of huge fame). The rehearsals, sound checks, post show dinners in my parents suite in the middle of the night where tiffin's of Gujju food ( lovingly prepared by relatives and friends of the organisers or crew members locally in whichever city they were performing in) would be served to the entire cast and musicians and everyone would discuss the show and how it went whilst a very young, relatively unknown (then) and upcoming stand-up comic would enthrall everyone for hours on end with his mimicry and comedy till it was morning and time to leave for the airport to take the flight to the next city. His name was Johnny Lever! On the flight everybody would take over the economy class, fold forward all the seats to make a huge गद्दा like setting and the musicians, singers and dad would sing and jam and maybe create a new song to be performed later that night at the next venue. This routine went on 3 days straight. I doubt they must have slept for a collective 2 hours over those weekends. Functioning purely on adrenaline! Rest during the week and the routine would resume from Friday, again. What times! As a child standing in the wings looking at the show in awe and wonderment. Not realising at that time the legends that I was blessed to witness perform live. Secretly imagining myself on that stage once I grew up. As you can see from this video, my sister couldn't wait to get off the stage and all I wanted to do was stick around. Thank you @mosessapir for sourcing out this video. It brought back such wonderful memories. @amitabhbachchan @shwetabachchan

A post shared by Abhishek Bachchan (@bachchan) onMay 7, 2020 at 11:09pm PDT

"The rehearsals, sound checks, post show dinners in my parents suite in the middle of the night where tiffin's of Gujju food ( lovingly prepared by relatives and friends of the organisers or crew members locally in whichever city they were performing in) would be served to the entire cast and musicians and everyone would discuss the show and how it went..."

Johnny Lever was an indispensable part of the stage shows. Talking about the noted comedian, Abhishek further wrote: "...A very young, relatively unknown (then) and upcoming stand-up comic would enthrall everyone for hours on end with his mimicry and comedy till it was morning and time to leave for the airport to take the flight to the next city. His name was Johnny Lever!"

While celebrities are known for traveling by business class in airlines, this group was slightly different, reveals Abhishek. He wrote: "On the flight everybody would take over the economy class, fold forward all the seats to make a huge ‘gadda' like setting and the musicians, singers and dad would sing and jam and maybe create a new song to be performed later that night at the next venue. This routine went on 3 days straight. I doubt they must have slept for a collective 2 hours over those weekends. Functioning purely on adrenaline! Rest during the week and the routine would resume from Friday, again. What times!"

Abhishek added: "As a child standing in the wings looking at the show in awe and wonderment. Not realising at that time the legends that I was blessed to witness perform live. Secretly imagining myself on that stage once I grew up. As you can see from this video, my sister couldn't wait to get off the stage and all I wanted to do was stick around."

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This publication puts forward a research agenda that advocates the importance of market competition, effective market regulation, and competition policies for achieving inclusive growth and shared prosperity in emerging and developing economies. It is the result of a global partnership and shared commitment between the World Bank Group and the OECD.

The private sector plays an important role in economic development. However to be beneficial to local populations, business must act responsibly. Part 2 of this blog focuses on how community engagement can help business achieve this, in harmony with the OECD Guidelines for Multinational Enterprises, and reinforce the link between responsible business and inclusive growth.

The coronavirus pandemic’s global presence and ubiquity in everyday life is a perfect storm for misinformation, as conspiracy theorists from different corners of the web converge on a shared news topic—the only topic, at the moment. From the earliest days of the crisis, everyone from pro-Trump QAnon conspiracists to left-leaning purveyors of dubious home remedies […]

The singer, 27, wore just a gold necklace with bubbles strategically covering her modesty. Miley flashed one bare leg that was raised up out of the water and had one arm across her breasts.

She's been dating her boyfriend, Dave Bashford, since 2017.

Abdul explained: '@NicoleScherzy I wanted to include this photo to commemorate this great football memory! Not to mistake you for Shakira.'

The 27-year-old popstar looked flawless for the night at the Microsoft Theater in Los Angeles and her ex-boyfriend's new wife, Hailey Bieber, made sure to show her approval online.

There will be few grounds in the country this weekend where you will spot home and away fans drinking together ahead of the game, but then there are no stadiums facing a situation like St Andrew's.

EXCLUSIVE: The extent to which Mo Farah's controversial former coach Alberto Salazar left the Briton exposed to potential embarrassment is revealed.

She's an actress, singer, and a songwriter, and now she's heading to Apple's new streaming platform Apple TV+ for her new series, Dickinson. Hailee Steinfeld has been doing loads of press.

In honor of US Navy Chief Petty Officer Charles Keating IV, the US special operations community created a "workout of the day."Keating, a 31-year-old Navy SEAL, was killed battling ISIS fighters in Iraq on May 3, 2016.Service members who took part in the exercise in Kuwait shared non-alcoholic "near" beer, the only authorized drink resembling the alcoholic beverage in the country, from an emptied ammunition can.Here's what the "Chuck Heavy" exercise consists of.Visit Business Insider's homepage for more stories.Members of the US Special Operations Joint Task Force stationed in Kuwait conducted a training session dubbed "Chuck Heavy" in honor of a US Navy SEAL who was killed four years ago this week during a firefight with ISIS fighters in Iraq.US Navy Chief Petty Officer Charles Keating IV,

It seems Brad Pitt formed quite the bromance with Leonardo DiCaprio while filming Once Upon a Time in Hollywood. 

Katy Perry has revealed how her new single, Never Worn White, details her fears of commitment - and how she shared those fears with fiancé Orlando Bloom. 

'You flew into my life like a rocket, lit it up beyond what i could've expected or imagined, and every day i am in awe over the love, care and nurture you show me, Evie and everyone around you.'

Lyn Boyd, who was elected to Durham County Council by 919 votes in 2017, was reported to the Labour Party on February 2 over a whole host of material allegedly shared on her Facebook timeline.

The sale price undercuts the origial $45m asking price quite considerably. Now the rocker, 49, is said to be looking for a home in Vatle and 'will probably buy it' soon with boyfriend Blake Shelton, 43.

It has been reported that Liam Payne has left the home he shared with ex Cheryl Cole in Surrey in favour for a flat in London as he sets out on tour again and starts to work on his new album.

The adverts, which include deliberate errors, are designed to be mocked online so that people share them and spread the 'stay at home' message.

RABBI LORD JONATHAN SACKS: When this bleak time is over, when schools and pubs and theatres reopen, when we no longer need fear the warmth of a handshake or the closeness of friends...

PIERS MORGAN: Amid the spat between WAGs Coleen Rooney and Rebekah Vardy one thing is clear - how can anyone think posting online to one person or 367 is going to ensure their privacy?

I am a shared ownership resident in a London block of flats who recently tried to staircase my mortgage. However, the lender was worried my balcony might be flammable. Now I can't remortgage.

Anyone with a household income of less than £80,000 in England will soon be able to buy a home through shared ownership, which has long been restricted to key workers.

IAN WHITTELL AT EWOOD PARK: Wigan Athletic climbed off the foot of the Championship table on Monday night after playing out a goalless draw with Lancashire rivals Blackburn Rovers.

Mr Laidley was photographed wearing a long blonde wig and a dress after his arrest outside a home in St Kilda on Saturday night - but the photos were soon leaked.